Abstract: The invention relates to an oral, multiparticulate form of administration, comprising pellets in the size ranging from 50 to 2500 $g(m)m which are substantially constituted of a) an inner matrix layer containing nanoparticles that contain a nucleic acid active ingredient and being embedded in a matrix of a polymer having a mucoadhesive effect, and b) an outer film coating, substantially consisting of an anionic polymer or copolymer that is optionally formulated with pharmaceutically conventional adjuvants, especially emollients.

Abstract: Axles and spindle assemblies for wheeled vehicles. More particularly, in at least one embodiment, this invention relates to a substantially curvilinear axle for wheeled vehicles, alone or in combination with a spindle assembly, having a substantially continuous radius of curvature extending from one end of the axle to the other. In at least one additional embodiment, this invention relates to fabricated spindle assemblies having gusset arms for mechanical attachment to axle ends.

Abstract: A multi-piece steering knuckle having at least one boss which is adjustable in position along an axis of a king pin. More particularly, a steering knuckle including at least one boss which can be assembled, employing unique methodology, to minimize space tolerances between the steering knuckle boss and an axle. In preferred embodiments, a steering knuckle boss which can be installed by press-fit methods to be selectively positioned in a desired position along an axis of a king pin in a non-finite number of incremental positions. In another embodiment, a steering knuckle boss having, optionally, an inner wall composed of, at least in part, a nickel-aluminum bronze alloy.

Abstract: A multi-piece axle employing assembly hardware for forming a rigid axle structure which, in addition, connects the multi-piece axle to a suspension, thereby eliminating conventional axle seats. More specifically, a multi-piece axle having dual function hardware for simultaneously assembling the axle into a single rigid member as well as assembling a suspension portion thereto.

Abstract: This invention relates to a recombinant deoxyribonucleic acid (DNA) which can be isolated from Aspergillus soyae, characterised in that it codes for a leucine aminopeptidase (LAP) and comprises a nucleotide sequence corresponding to the nucleotide sequence given in SEQ ID NO: 1 for the mature LAP or to a nucleotide sequence derived therefrom which hybridises under stringent conditions with the nucleotide sequence given in SEQ ID NO: 1 for the mature LAP. The invention further relates to vectors and transformed host organisms, and also relates to methods of producing LAP. Enzyme products for the production of protein hydrolysates, as well as protein hydrolysates which are produced correspondingly, also form part of the invention.

Abstract: A novel xylanase, obtained from Bacillus subtilis strains, is provided which improves the consistency and increases the volume of bread and baked goods containing it. B. subtilis DSM 7147 containing the plasmid pIK 91 produces the xylanase. Genetic engineering insertion of the gene encoding the xylanase in the plasmid pUB110 is described.