Patents by Inventor Michael Gruss

Michael Gruss has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • HCl Polymorphs of 3-((2-(Dimethylamino)methyl(cyclohex-1-yl))phenol
    Publication number: 20130245125
    Abstract: A crystalline salt of 3-[2-(dimethylamino)methyl(cyclohex-1-yl)] phenol and hydrogen chloride, preferably in a 1:1 composition, including various crystalline forms of this salt, processes for preparing the various crystalline forms of this salt, pharmaceutical compositions containing the various crystalline forms of this salt, and the use of this salt as a pharmacologically active agent in a pharmaceutical composition to treat or inhibit pain or other disorders or disease states.
    Type: Application
    Filed: May 1, 2013
    Publication date: September 19, 2013
    Applicant: GRUENENTHAL GmbH
    Inventors: Michael GRUSS, Andreas FISCHER, Markus KEGEL, Wolfgang HELL, Markus VON RAUMER, Joerg BERGHAUSEN, Susan Margaret DE PAUL
  • Crystalline (1r,4r)-6'-fluoro-N,N-dimethyl-4-phenyl-4',9'-dihydro-3'H-spiro[cyclohexane-1,1'-pyrano[3,4,b]indol]-4-amine
    Publication number: 20130231381
    Abstract: Crystalline forms of (1r,4r)-6?-fluoro-N,N-dimethyl-4-phenyl-4?,9?-dihydro-3?H-spiro[cyclohexane-1,1?-pyrano[3,4,b]indol]-4-amine, pharmaceutical compositions and medicaments comprising these crystalline modifications, the use of these modifications as well as a process for the enrichment of such crystalline modifications.
    Type: Application
    Filed: March 15, 2013
    Publication date: September 5, 2013
    Applicant: GRUENENTHAL GMBH
    Inventors: Michael GRUSS, Stefan KLUGE, Sefan PRUEHS
  • Spirocyclic cyclohexane compounds
    Patent number: 8404740
    Abstract: Spirocyclic cyclohexane compounds corresponding to formula I In which R1, R2, R3 and R5 through R10 and X have defined meanings, a process for their preparation, pharmaceutical compositions containing such compounds, and the use of such spirocyclic cyclohexane compounds in the treatment and/or inhibition of pain and other conditions mediated by the ORL-1 or the ?-opioid receptor.
    Type: Grant
    Filed: August 21, 2009
    Date of Patent: March 26, 2013
    Assignee: Gruenenthal GmbH
    Inventors: Stefan Schunk, Saskia Zemolka, Derek Saunders, Michael Gruss, Heinz Graubaum
  • CRYSTALLINE (1R,4R)-6'-FLUORO-N,N-DIMETHYL-4-PHENYL-4',9'-DIHYDRO-3'H-SPIRO[CYCLOHEXANE-1,1'-PYRANO[3,4,B]INDOL]-4-AMINE
    Publication number: 20130012563
    Abstract: Crystalline forms of (1r,4r)-6?-fluoro-N,N-dimethyl-4-phenyl-4?,9?-dihydro-3?H-spiro[cyclohexane-1,1?-pyrano[3,4,b]indol]-4-amine, pharmaceutical compositions and medicaments comprising these crystalline modifications, the use of these modifications as well as a process for the enrichment of such crystalline modifications.
    Type: Application
    Filed: July 6, 2012
    Publication date: January 10, 2013
    Applicant: Gruenenthal GmbH
    Inventors: Michael Gruss, Stefan Kluge, Stefan Pruehs
  • Crystalline Forms of (-)-(1R,2R)-3-(3-dimethylamino-1-ethyl-2-methylpropyl)-phenol Hydrochloride
    Publication number: 20120302643
    Abstract: A hitherto unknown crystalline form of (?)-(1R,2R)-3-(3-dimethylamino-1-ethyl-2-methylpropyl)-phenol hydrochloride, pharmaceutical compositions containing the new crystalline form, methods of producing the new crystalline form, and a related method of use including treatment of, e.g., pain and/or urinary incontinence.
    Type: Application
    Filed: August 3, 2012
    Publication date: November 29, 2012
    Applicant: Gruenenthal GmbH
    Inventors: Andreas FISCHER, Helmut BUSCHMANN, Michael GRUSS, Dagmar LISCHKE
  • Crystalline forms of (1RS,3RS,6RS)-6-dimethylaminomethyl-1-(3-methoxyphenyl)cyclohexane-1,3-diol hydrochloride
    Patent number: 8309610
    Abstract: This invention relates to solid crystalline forms of (1RS,3RS,6RS)-6-Dimethylaminomethyl-1-(3-methoxy-phenyl)cyclohexane-1,3-diol hydrochloride (1), methods of producing 1, methods of use of 1, use of 1 as analgesics and pharmaceutical compositions comprising 1.
    Type: Grant
    Filed: February 21, 2006
    Date of Patent: November 13, 2012
    Assignee: Gruenenthal GmbH
    Inventors: Michael Gruss, Helmut Buschmann, Andreas Fischer, Wolfgang Hell, Dagmar Lischke
  • Salt of Dimethylaminomethyl-Phenyl-Cyclohexane and Crystalline Forms Thereof
    Publication number: 20120178809
    Abstract: Novel 3-[2-(dimethylamino)methyl-(cyclohex-1-yl)]-phenol maleate compounds corresponding to formula I and processes for preparing these compounds are provided. Pharmaceutical compositions including these compounds and methods of treating or alleviating pain with these compounds are also provided.
    Type: Application
    Filed: March 14, 2012
    Publication date: July 12, 2012
    Applicant: Gruenenthal GmbH
    Inventors: Michael GRUSS, Wolfgang Hell, Martin Szelagiewicz, Joerg Berghausen, Susan Margaret De Paul, Markus Von Raumer
  • Crystalline modifications of (1R,2R)-3-(3-dimethylamino-1-ethyl-2-methyl-propyl)-phenol
    Patent number: 8134032
    Abstract: Crystalline modifications of (1R,2R)-3-(3-dimethylamino-1-ethyl-2-methyl-propyl)-phenol, pharmaceutical compositions which contain these modifications, and the use thereof to treat pain or other conditions.
    Type: Grant
    Filed: December 5, 2008
    Date of Patent: March 13, 2012
    Assignee: Gruenenthal GmbH
    Inventor: Michael Gruss
  • Salts or Co-Crystals of 3-(3-dimethylamino-1-ethyl-2-methyl-propyl)-phenol
    Publication number: 20120022117
    Abstract: A salt or cocrystal of 3-(3-dimethylamino-1-ethyl-2-methyl-propyl)-phenol (component a) and at least one acid component (b1) or at least one acid component (b2), wherein the salt or cocrystal of component (a) and component (b2) is present in crystalline and/or amorphous form, a pharmaceutical composition comprising said salt or cocrystal, and a method of treating pain in a subject in need thereof by administering an effective amount of said salt or cocrystal.
    Type: Application
    Filed: July 22, 2011
    Publication date: January 26, 2012
    Applicant: Gruenenthal GmbH
    Inventors: Michael GRUSS, Magda KRASZEWSKI
  • CRYSTALLINE FORMS OF (1RS,2RS,6RS)-6-DIMETHYLAMINOMETHYL-1-(3-METHOXYPHENYL)CYCLOHEXANE-1,3-DIOL HYDROCHLORIDE
    Publication number: 20110306673
    Abstract: This invention relates to solid crystalline forms of (1RS,3RS,6RS)-6-Dimethylaminomethyl-1-(3-methoxy-phenyl)cyclohexane-1,3-diol hydrochloride (1), methods of producing 1, methods of use of 1, use of 1 as analgesics and pharmaceutical compositions comprising 1.
    Type: Application
    Filed: February 21, 2006
    Publication date: December 15, 2011
    Applicant: GRUENENTHAL GMBH
    Inventors: Michael Gruss, Helmut Buschmann, Andreas Fischer, Wolfgang Hell, Dagmar Lischke
  • Crystalline Forms of (-)-(1R,2R)-3-(3-dimethylamino-1-ethyl-2-methylpropyl)-phenol Hydrochloride
    Publication number: 20110294898
    Abstract: A hitherto unknown crystalline form of (?)-(1R,2R)-3-(3-dimethylamino-1-ethyl-2-methylpropyl)-phenol hydrochloride, pharmaceutical compositions containing the new crystalline form, methods of producing the new crystalline form, and a related method of use including treatment of, e.g., pain and/or urinary incontinence.
    Type: Application
    Filed: June 29, 2011
    Publication date: December 1, 2011
    Applicant: Gruenenthal GmbH
    Inventors: Andreas FISCHER, Helmut Buschmann, Michael Gruss, Dagmar Lischke
  • HCI polymorphs of 3-((2-(dimethylamino)methyl(cyclohex-1-yl)) phenol
    Patent number: 8058476
    Abstract: A crystalline salt of 3-[2-(dimethylamino)methyl(cyclohex-1-yl)]phenol and hydrogen chloride, preferably in a 1:1 composition, including various crystalline forms of this salt, processes for preparing the various crystalline forms of this salt, pharmaceutical compositions containing the various crystalline forms of this salt, and the use of this salt as a pharmacologically active agent in a pharmaceutical composition to treat or inhibit pain or other disorders or disease states.
    Type: Grant
    Filed: January 18, 2008
    Date of Patent: November 15, 2011
    Assignee: Gruenenthal GmbH
    Inventors: Michael Gruss, Andreas Fischer, Markus Kegel, Wolfgang Hell, Markus Von Raumer, Joerg Berghausen, Susan Margaret Paul
  • Reactor Array for Producing and Analyzing Products
    Publication number: 20110257048
    Abstract: The present invention relates to a reactor array for producing and/or analysing products, comprising a plurality of vessels in which products can be produced on a preparative or analytical scale.
    Type: Application
    Filed: April 25, 2011
    Publication date: October 20, 2011
    Applicant: GRUENENTHAL GMBH
    Inventors: Michael GRUSS, Matthias RIDDER
  • Crystalline salts and/or co-crystals of O-desmethyltramadol
    Publication number: 20110251286
    Abstract: Salts and/or co-crystals of (+)-3-[2-(dimethylamino)-methyl-1-hydroxycyclohexyl]-phenol or of (?)-3-[2-(dimethylamino)methyl-1-hydroxy-cyclohexyl]phenol, present in crystalline form, with cinnamic acid, C8- to C10-alkane-monocarboxylic acids, C6- to C10-alkanedicarboxylic acids, C15- to C17-alkane-monocarboxylic acids, fumaric acid, tartaric acid, mandelic acid, hippuric acid and/or embonic acid, a process for their production, and the use of such salts and/or co-crystals as medicaments.
    Type: Application
    Filed: March 9, 2011
    Publication date: October 13, 2011
    Applicant: GRUENENTHAL GmbH
    Inventors: Michael GRUSS, Oswald Zimmer
  • HCI POLYMORPHS OF 3-((2-(DIMETHYLAMINO)METHYL (CYCLOHEX-1-YL))PHENOL
    Publication number: 20110251287
    Abstract: A crystalline salt of 3-[2-(dimethylamino)methyl(cyclohex-1-yl)]phenol and hydrogen chloride, preferably in a 1:1 composition, including various crystalline forms of this salt, processes for preparing the various crystalline forms of this salt, pharmaceutical compositions containing the various crystalline forms of this salt, and the use of this salt as a pharmacologically active agent in a pharmaceutical composition to treat or inhibit pain or other disorders or disease states.
    Type: Application
    Filed: June 21, 2011
    Publication date: October 13, 2011
    Applicant: Gruenenthal GmbH
    Inventors: Michael GRUSS, Andreas Fischer, Markus Kegel, Wolfgang Hell, Markus Von Raumer, Joerg Berghausen, Susan Margaret Paul
  • Crystalline forms of (?)-(1R,2R)-3-(3-dimethylamino-1-ethyl-2-methylpropyl)-phenol hydrochloride
    Patent number: 7994364
    Abstract: A hitherto unknown crystalline form of (?)-(1R,2R)-3-(3-dimethylamino-1-ethyl-2-methylpropyl)-phenol hydrochloride, pharmaceutical compositions containing the new crystalline form, methods of producing the new crystalline form, and a related method of use including treatment of, e.g., pain and/or urinary incontinence.
    Type: Grant
    Filed: December 10, 2009
    Date of Patent: August 9, 2011
    Assignee: Gruenenthal GmbH
    Inventors: Andreas Fischer, Helmut Buschmann, Michael Gruss, Dagmar Lischke
  • Crystalline Modifications of 6-Dimethylaminomethyl-1-(3-methoxyphenyl)-cyclohexane-1,3-diol
    Publication number: 20110060053
    Abstract: Crystalline modifications of (1R,3R,6R)-6-dimethylaminomethyl-1-(3-methoxyphenyl)-cyclohexane-1,3-diol, (1S,3S,6S)-6-dimethylaminomethyl-1-(3-methoxyphenyl)-cyclohexane-1,3-diol and mixtures thereof, pharmaceutical compositions and medicaments comprising these modifications, the use of these modifications as well as to a process for the enrichment of (1R,3R,6R)- or (1S,3S,6S)-6-dimethylaminomethyl-1-(3-methoxyphenyl)-cyclohexane-1,3-diol.
    Type: Application
    Filed: September 13, 2010
    Publication date: March 10, 2011
    Applicant: Gruenenthal GmbH
    Inventors: Michael Gruss, Helmut Heinrich Buschmann
  • Salt of Dimethylaminomethyl-Phenyl-Cyclohexane and Crystalline Forms Thereof
    Publication number: 20110046230
    Abstract: Novel 3-[2-(dimethylamino)methyl-(cyclohex-1-yl)]-phenol maleate compounds corresponding to formula I and processes for preparing these compounds are provided. Pharmaceutical compositions including these compounds and methods of treating or alleviating pain with these compounds are also provided.
    Type: Application
    Filed: August 12, 2010
    Publication date: February 24, 2011
    Applicant: Gruenenthal GmbH
    Inventors: Michael GRUSS, Wolfgang Hell, Martin Szelagiewicz, Joerg Berghausen, Susan Margaret De Paul, Markus Von Raumer
  • Salt of dimethylaminomethyl-phenyl-cyclohexane and crystalline forms thereof
    Patent number: 7884247
    Abstract: Novel 3-[2-(dimethylamino)methyl-(cyclohex-1-yl)]-phenol maleate compounds corresponding to formula I and processes for preparing these compounds are provided. Pharmaceutical compositions including these compounds and methods of treating or alleviating pain with these compounds are also provided.
    Type: Grant
    Filed: July 24, 2006
    Date of Patent: February 8, 2011
    Assignee: Gruenenthal GmbH
    Inventors: Michael Gruss, Wolfgang Hell, Martin Szelagiewicz, Joerg Berghausen, Susan Margaret De Paul, Markus Von Raumer
  • Crystalline Forms of (-)-(1R,2R)-3-(3-dimethylamino-1-ethyl-2-methylpropyl)-phenol hydrochloride
    Publication number: 20100160447
    Abstract: A hitherto unknown crystalline form of (?)-(1R,2R)-3-(3-dimethylamino-1-ethyl-2-methylpropyl)-phenol hydrochloride, pharmaceutical compositions containing the new crystalline form, methods of producing the new crystalline form, and a related method of use including treatment of, e.g., pain and/or urinary incontinence.
    Type: Application
    Filed: December 10, 2009
    Publication date: June 24, 2010
    Applicant: Gruenenthal GmbH
    Inventors: Andreas Fischer, Helmut Buschmann, Michael Gruss, Dagmar Lischke