Patents by Inventor Michael Gruss

Michael Gruss has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • HCl Polymorphs of 3-((2-(Dimethylamino)methyl-(cyclohex-1-yl))phenol
    Publication number: 20100076085
    Abstract: A crystalline salt of 3-[2-(dimethylamino)methyl(cyclohex-1-yl)]phenol and hydrogen chloride, preferably in a 1:1 composition, including various crystalline forms of this salt, processes for preparing the various crystalline forms of this salt, pharmaceutical compositions containing the various crystalline forms of this salt, and the use of this salt as a pharmacologically active agent in a pharmaceutical composition to treat or inhibit pain or other disorders or disease states.
    Type: Application
    Filed: November 30, 2009
    Publication date: March 25, 2010
    Applicant: Gruenenthal GmbH
    Inventors: Michael Gruss, Andreas Fischer, Markus Kegel, Wolfgang Hell, Markus Von Raumer, Joerg Berghausen, Susan Margaret Paul
  • Spirocyclic Cyclohexane Compounds
    Publication number: 20100048554
    Abstract: Spirocyclic cyclohexane compounds corresponding to formula I In which R1, R2, R3 and R5 through R10 and X have defined meanings, a process for their preparation, pharmaceutical compositions containing such compounds, and the use of such spirocyclic cyclohexane compounds in the treatment and/or inhibition of pain and other conditions mediated by the ORL-1 or the ?-opioid receptor.
    Type: Application
    Filed: August 21, 2009
    Publication date: February 25, 2010
    Applicant: Gruenenthal GmbH
    Inventors: Stefan Schunk, Saskia Zemolka, Derek Saunders, Michael Gruss, Heinz Graubaum
  • Crystalline Forms of (-)-(1R,2R)-3-(3-dimethylamino-1-ethyl-2-methylpropyl)-phenol hydrochloride
    Publication number: 20090186947
    Abstract: A hitherto unknown crystalline form of (?)-(1R,2R)-3-(3-dimethylamino-1-ethyl-2-methylpropyl)-phenol hydrochloride, pharmaceutical compositions containing the new crystalline form, methods of producing the new crystalline form, and a related method of use including treatment of, e.g., pain and/or urinary incontinence.
    Type: Application
    Filed: November 20, 2008
    Publication date: July 23, 2009
    Applicant: Gruenenthal GmbH
    Inventors: Andreas Fischer, Helmut Buschmann, Michael Gruss, Dagmar Lischke
  • Crystalline modifications of (1R,2R)-3-(3-Dimethylamino-1-ethyl-2-methyl-propyl)-phenol
    Publication number: 20090149534
    Abstract: Crystalline modifications of (1R,2R)-3-(3-dimethylamino-1-ethyl-2-methyl-propyl)-phenol, pharmaceutical compositions which contain these modifications, and the use thereof to treat pain or other conditions.
    Type: Application
    Filed: December 5, 2008
    Publication date: June 11, 2009
    Applicant: GRUENENTHAL GmbH
    Inventor: Michael Gruss
  • HCI POLYMORPHS OF 3-((2-(DIMETHYLAMINO)METHYL(CYCLOHEX-1-YL)) PHENOL
    Publication number: 20080255242
    Abstract: A crystalline salt of 3-[2-(dimethylamino)methyl(cyclohex-1-yl)] phenol and hydrogen chloride, preferably in a 1:1 composition, including various crystalline forms of this salt, processes for preparing the various crystalline forms of this salt, pharmaceutical compositions containing the various crystalline forms of this salt, and the use of this salt as a pharmacologically active agent in a pharmaceutical composition to treat or inhibit pain or other disorders or disease states.
    Type: Application
    Filed: January 18, 2008
    Publication date: October 16, 2008
    Applicant: Gruenenthal GmbH
    Inventors: Michael Gruss, Andreas Fischer, Markus Kegel, Wolfgang Hell, Markus Von Raumer, Joerg Berghausen, Susan Margaret Paul
  • Polymorph of Clarithromycin (Form V)
    Publication number: 20080249035
    Abstract: A polymorphic form of clarithromycin (form V) which exhibits a characteristic X-ray diffraction pattern, a method for producing such polymorphic clarithromycin, and the use of such polymorphic clarithromycin to treat bacterial infections.
    Type: Application
    Filed: April 1, 2008
    Publication date: October 9, 2008
    Applicant: Gruenenthal GmbH
    Inventor: Michael GRUSS
  • Crystalline forms of (-)-(1R,2R)-3-(3-dimethylamino-1-ethyl-2-methylpropyl)-phenol hydrochloride
    Publication number: 20070213405
    Abstract: A novel crystalline form of a (?)-(1R,2R)-3-(3-dimethylamino-1-ethyl-2-methylpropyl)-phenol hydrochloride compound, methods of producing the compound, and related methods of use including treatment methods and pharmaceutical compositions containing the compound.
    Type: Application
    Filed: December 28, 2006
    Publication date: September 13, 2007
    Applicant: Gruenenthal GmbH
    Inventors: Andreas Fischer, Helmut Buschmann, Michael Gruss, Dagmar Lischke
  • Salt of dimethylaminomethyl-phenyl-cyclohexane and crystalline forms thereof
    Publication number: 20070032552
    Abstract: Novel 3-[2-(dimethylamino)methyl-(cyclohex-1-yl)]-phenol maleate compounds corresponding to formula I and processes for preparing these compounds are provided. Pharmaceutical compositions including these compounds and methods of treating or alleviating pain with these compounds are also provided.
    Type: Application
    Filed: July 24, 2006
    Publication date: February 8, 2007
    Applicant: GRUENENTHAL GMBH
    Inventors: Michael Gruss, Wolfgang Hell, Martin Szelagiewicz, Joerg Berghausen, Susan De Paul, Markus Von Raumer
  • Salt of dimethylaminomethyl-phenyl-cyclohexane and crystalline forms thereof
    Publication number: 20070032551
    Abstract: Novel 3-[2-(dimethylamino)methyl-(cyclohex-1-yl)]-phenol fumarate compounds corresponding to formula I: and processes for preparing these compounds are provided. Pharmaceutical compositions including these compounds and methods of treating or alleviating pain with these compounds are also provided.
    Type: Application
    Filed: July 24, 2006
    Publication date: February 8, 2007
    Applicant: GRUENENTHAL GMBH
    Inventors: Michael Gruss, Wolfgang Hell, Joerg Berghausen, Martin Szelagiewicz, Markus Von Raumer, Susan De Paul
  • Phosphate salts of 6-dimethylaminomethyl-1-(3-methoxyphenyl)-1,3-dihydroxy-cyclohexane compounds
    Publication number: 20060211887
    Abstract: Novel 6-dimethylaminomethyl-1-(3-methoxyphenyl)-1,3-dihydroxy-cyclohexane compounds in the form of phosphate salts, related polymorphs of these compounds, processes for their preparation, pharmaceutical formulations including these compounds and polymorphs and related methods of treating or inhibiting certain diseases or conditions.
    Type: Application
    Filed: February 27, 2006
    Publication date: September 21, 2006
    Applicant: GRUENENTHAL GMBH
    Inventors: Michael Gruss, Andreas Fischer, Wolfgang Hell