Abstract: Isolated DNAs (e.g., cDNAs or genomic fragments) encoding MIS receptors, inhibin receptors, bone morphogenic protein receptors, or other novel members of the TGF-.beta. family of receptors, or soluble, ligand-binding fragments thereof; vectors or cells which contain such DNAs; and substantially pure polypeptides encoded by such DNAs, whether produced by expression of the isolated DNAs, by isolation from natural sources, or by chemical synthesis.

Abstract: Isolated DNAs (e.g., cDNAs or genomic fragments) encoding TGF-.beta. type I receptors, or soluble, ligand-binding fragments thereof; vectors or cells which contain such DNAs; and substantially pure polypeptides encoded by such DNAs, whether produced by expression of the isolated DNAs, by isolation from natural sources, or by chemical synthesis.

Abstract: Drilling apparatus is adapted for use with a computer controlled plotter to selectively use the plotter as an automatically positionable hole drilling device. A drill motor of the drilling apparatus is carried and manipulated by a carrier mechanism of the plotter in a manner similar to that in which a conventional plotter instrument is manipulated. A coupling apparatus is attached to the carrier mechanism for the purpose of selectively mechanically connecting to and establishing a pneumatic seal for supplying pressurized gas to operate the drill motor. An alignment apparatus is connected between the carrier mechanism and the drilling apparatus to position an axis through the drill bit of the drill motor orthogonal to the plotter table. An actuator apparatus moves the drill motor toward the plotter table to drill holes in the material positioned on the plotter table.