Abstract: Provided are compounds of Formula (I): including compounds of Formulas (II), (III) and (IV), wherein X, R1, R2, R3 and n are as defined herein, and pharmaceutically acceptable salts thereof, and methods for their use and production. These compounds can be useful, e.g., in the treatment of disorders responsive to the inhibition of apoptosis signal-regulating kinase 1 (ASK1).

Abstract: The present invention relates to methods, devices and systems for associating consumable data with an assay consumable used in a biological assay. Provided are assay systems and associated consumables, wherein the assay system adjusts one or more steps of an assay protocol based on consumable data specific for that consumable. Various types of consumable data are described, as well as methods of using such data in the conduct of an assay by an assay system. The present invention also relates to consumables (e.g., kits and reagent containers), software, data deployable bundles, computer-readable media, loading carts, instruments, systems, and methods, for performing automated biological assays.

Abstract: A head-mounted device is provided that includes one or more cameras configured to acquire a raw video feed and one or more displays configured to present a passthrough video feed to a user. Generation of the passthrough video feed can involve processing the raw video feed using an image signal processor and auxiliary compute blocks. One or more of the auxiliary compute blocks can be bypassed in response to detecting one or more failures associated with the auxiliary compute blocks. Configured and operated in this way, the head-mounted device can fall back to a more reliable passthrough video feed without having to power cycle the head-mounted device when a failure occurs.

Abstract: Provided is a modular directional charge system that can be assembled in different configurations depending on the target. The system includes a removable energetic material, a molded plastic shell comprising a main body and a front cover, a removable fragmentation insert, a removable breaching insert, an initiator well insert, and initiator adapter nuts. The main body comprises an internal energetic material receiving compartment, a first and second tripod mount, a threaded adapter, and a pair of pin receivers, while the front cover comprises an internal removable insert compartment. The main body and front cover are held together with a multi-position adjustable toothed locking interface that adjustably permits the cover to intimately contact the energetic material when the internal removable insert compartment contains a fragmentation insert, a breaching insert, or no insert at all. A method of use is also provided.

Abstract: Provided is a modular directional charge system that can be assembled in different configurations depending on the target. The system includes a removable energetic material, a molded plastic shell comprising a main body and a front cover, a removable fragmentation insert, a removable breaching insert, an initiator well insert, and initiator adapter nuts. The main body comprises an internal energetic material receiving compartment, a first and second tripod mount, a threaded adapter, and a pair of pin receivers, while the front cover comprises an internal removable insert compartment. The main body and front cover are held together with a multi-position adjustable toothed locking interface that adjustably permits the cover to intimately contact the energetic material when the internal removable insert compartment contains a fragmentation insert, a breaching insert, or no insert at all. A method of use is also provided.

Abstract: A take-down rifle including modular components. A first and a second rifle section comprising first and second receiver portions, respectively, allow the rifle to be quickly assembled and disassembled. The first rifle section also includes a rifle barrel. Mounting points on the first rifle section allow a coupled optical sight to remain fixed in relation to the barrel after assembly or disassembly so that the optical sight remains zeroed.

Abstract: A take-down rifle is provided which may be broken down for transport, reassembled, and employed to engage a target up to 500 meters away without the need to re-zero rifle before engagement.

Abstract: In an example, an apparatus, such as a microfluidic assembly, can include or can include using a channel including a valve seat, a valve film configured to adjust position with respect to the valve seat, and a first electrode configured to actuate the valve film electrostatically to adjust the position of the valve film to control a flow of a fluid in the channel laterally across the valve seat, the flow in a direction substantially parallel to the film.

Abstract: The invention relates to sensors for detecting chemical and biological material and for chemical actuation. In particular, the sensors of the present invention incorporates membranes or beams that are deformable in the presence of chemical adsorption on its surface. The sensor of the present invention contains a polymeric membrane or beam (102) that is clamped at least at two opposing ends (104) and (106).

Abstract: In an example, an apparatus, such as a microfluidic assembly, can include or can include using a channel including a valve seat, a valve film configured to adjust position with respect to the valve seat, and a first electrode configured to actuate the valve film electrostatically to adjust the position of the valve film to control a flow of a fluid in the channel laterally across the valve seat, the flow in a direction substantially parallel to the film.

Abstract: The present invention relates to microfluidic devices, and in particular, flow management in such devices. In particular, the present invention provides an electrostatic valve for flow manipulation in a microfluidic device. The valve of the present invention sits on a valve seat in a microchannel and deflects away from the valve seat by electrostatic actuation to assume an opened configuration to allow fluid flow.

Abstract: Genes each encoding a novel transcriptional regulator having a bromodomain have been successfully isolated from a human testis cDNA library using primers prepared based on an EST sequence found using the bromodomain sequence of the transcriptional regulator. These genes are structurally analogous to each other.

Abstract: The invention relates to sensors for detecting chemical and biological material and for chemical actuation. In particular, the sensors of the present invention incorporates membranes or beams that are deformable in the presence of chemical adsorption on its surface. The sensor of the present invention contains a polymeric membrane or beam (102) that is clamped at least at two opposing ends (104) and (106).

Abstract: The present invention relates to microfluidic devices, and in particular, flow management in such devices. In particular, the present invention provides an electrostatic valve for flow manipulation in a microfluidic device. The valve of the present invention sits on a valve seat in a microchannel and deflects away from the valve seat by electrostatic actuation to assume an opened configuration to allow fluid flow.

Abstract: A computer program product for facilitating an expression of emotion in an application, is provided and calls for: providing a field for expressing a range of emotions; providing a location indicator for setting a location within the field; associating a unique expression of emotion with each location for the location indicator; and accepting a user input for changing a location of the location indicator to change the unique expression according to the emotion of the user.

Abstract: BLAST search was done on the EST database by using various nucleotide sequences encoding known bromodomain motifs to discover several ESTs likely encoding bromodomain genes. Next, testicular cDNAs were PCR cloned by using primers designed based on the sequence of EST (W17142), which is one of the ESTs discovered above. By using the thus obtained PCR product as a probe, the testicular library was screened. The obtained cDNA clone was used as a probe to re-screen the testicular cDNA library, thereby successfully isolating a full-length cDNA corresponding to EST (W17142). The protein encoded by the thus isolated cDNA had, in addition to the bromodomain, several regions and domains conserved in transcription regulatory factors. Moreover, the protein interacted with proteins associated with the chromatin-mediated transcriptional regulatory mechanism and a transcription co-activator.

Abstract: Genes each encoding a novel transcriptional regulator having a bromodomain have been successfully isolated from a human testis cDNA library using primers prepared based on an EST sequence found using the bromodomain sequence of the transcriptional regulator. These genes are structurally analogous to each other.

Abstract: An igniter's housing is bored continuously there through to define, in succession, several bore regions. A firing pin, slidingly fit in the first bore region, terminates in a tip that protrudes into a primer-filled second bore region when the firing pin is fully seated in the first bore region. An air-filled third bore region follows the second bore region. An open-ended cup is fitted substantially in and sealed to the fourth bore region with the cup's closed end being structurally weakened at a portion thereof. A bored out slug of pyrotechnic material is fitted in the cup.

Abstract: BLAST search was done on the EST database by using various nucleotide sequences encoding known bromodomain motifs to discover several ESTs likely encoding bromodomain genes. Next, testicular cDNAs were PCR cloned by using primers designed based on the sequence of EST (W17142), which is one of the ESTs discovered above. By using the thus obtained PCR product as a probe, the testicular library was screened. The obtained cDNA clone was used as a probe to re-screen the testicular cDNA library, thereby successfully isolating a full-length cDNA corresponding to EST (W17142). The protein encoded by the thus isolated cDNA had, in addition to the bromodomain, several regions and domains conserved in transcription regulatory factors. Moreover, the protein interacted with proteins associated with the chromatin-mediated transcriptional regulatory mechanism and a transcription co-activator.

Abstract: The present inventors determined that the expression of a disease gene can be monitored using as an indicator the expression of genes (cluster genes) that are identified as a cluster located downstream of the disease-related gene. Analysis of the expression of the disease gene via microarrays using the expression of the cluster genes as an indicator enables efficient and exhaustive screening of candidate compounds for the treatment of the disease.