Abstract: Implantable devices such as stents having a biosoluble coating with linear over time mass loss are provided. Also disclosed are methods of making and using the implantable device.

Abstract: Drug-delivery systems such as drug-delivery stents having an anti-proliferative agent such as everolimus and an anti-flammatory agent such as clobetasol are provided. Also disclosed are methods of treating a vascular impairment such as restenosis or vulnerable plaque.

Abstract: The present invention provides a block copolymer for a coating on an implantable device for controlling release of drug and methods of making and using the same.

Abstract: The present invention provides a block copolymer for a coating on an implantable device for controlling release of drug and methods of making and using the same.

Abstract: This invention is generally related to methods of forming coatings for implantable medical devices, such as drug delivery vascular stents. The methods are for forming coatings to control the release of a peptide such as RGD, and a hydrophobic drug. Both single layer and multiple layer coating constructs are encompassed in the various embodiments of the present invention.

Abstract: The present invention is directed to polymeric materials (e.g., coatings) comprising biodegradable copolymers and implantable devices (e.g., drug-delivery stents) formed of such materials. The biodegradable copolymers are derived from at least two relatively polar monomers and at least one relatively nonpolar monomer. Incorporation of at least one relatively nonpolar monomer into the copolymer improves controlled release of a hydrophobic drug from the polymeric material by increasing the copolymer's miscibility with and permeability to the hydrophobic drug. The polymeric materials can also contain at least one biocompatible moiety, at least one non-fouling moiety, at least one biobeneficial material, at least one bioactive agent, or a combination thereof. The polymeric materials are designed to improve the mechanical, physical and biological properties of implantable devices formed thereof.

Abstract: The present invention provides an implantable device having a coating including a slow dissolving polymer or material and the methods of making and using the same.

Abstract: The present invention relates to implantable medical devices coated with polymer having tunable hydrophobicity and their use in the treatment of vascular diseases.

Abstract: A poly(ester amide) polymer having free carboxylic acid pendant groups and method of making and using the same are disclosed.

Abstract: A poly(thioester ester amide) copolymer and method of making and using the same are disclosed.

Abstract: A coating comprising a polymer that comprises units derived from an aliphatic thioester on a medical device is provided.

Abstract: An optical memory card including a substrate with a data zone covered by an information carrying layer, at least one diffractive optical element (DOE) that is positioned on the substrate, and a metal element coupled to the substrate. The data zone advantageously has a small inner radius, e.g., 12 mm. The DOE may be embossed in the substrate within the data zone formed on the substrate. The metal element may include a hole or protrusion to align the card with a driver. A method for making the card includes embossing a substrate with DOE and grooves, and provides an information carrying layer. A driver for the memory card including a magnetic chuck and a reading laser.