Patents by Inventor Michael Hamill

Michael Hamill has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • AMINO ACID COMPOSITIONS AND METHODS FOR THE TREATMENT OF LIVER DISEASES
    Publication number: 20240041810
    Abstract: This disclosure provides pharmaceutical compositions comprising amino acid entities and uses thereof. Methods for improving liver function and for treating liver diseases comprising administering an effective amount of the compositions to a subject in need thereof are also disclosed.
    Type: Application
    Filed: March 8, 2023
    Publication date: February 8, 2024
    Inventors: Michael Hamill, Raffi Afeyan, Chung-Wei Lee, Harry Luithardt
  • Compositions and methods for the treatment of fat infiltration in muscle
    Patent number: 11833127
    Abstract: This disclosure provides methods of using compositions comprising amino acid entities to reduce fat infiltration in muscle, particularly under conditions of muscle atrophy. The disclosure also provides methods for enhancing muscle function by reducing fat infiltration in the muscle comprising administering an effective amount of the compositions to a subject in need thereof.
    Type: Grant
    Filed: March 2, 2021
    Date of Patent: December 5, 2023
    Assignee: AXCELLA HEALTH INC.
    Inventors: Manu Chakravarthy, William Comb, Michael Hamill, Anthony Tramontin
  • Amino acid compositions and methods for the treatment of post-acute sequelae of COVID-19
    Patent number: 11737999
    Abstract: This disclosure provides pharmaceutical compositions comprising amino acid entities and uses thereof. Methods for treating post-acute sequelae of COVID-19 comprising administering an effective amount of the compositions to a subject in need thereof are also disclosed.
    Type: Grant
    Filed: July 25, 2022
    Date of Patent: August 29, 2023
    Assignee: AXCELLA HEALTH INC.
    Inventors: Revati Wani, Alison Schecter, Michael Hamill, Margaret Koziel, Matthew Russell, Karim Azer, Karen Lavery, Joel Pradines
  • COMPOSITIONS AND METHODS FOR THE TREATMENT OF LIVER DISEASES AND DISORDERS
    Publication number: 20230105984
    Abstract: This disclosure provides combinations and methods for improving liver function, e.g., in a subject having a liver disease or disorder, or treating or preventing a liver disease or disorder, e.g., with hyperammonemia or muscle wasting in a subject.
    Type: Application
    Filed: December 23, 2020
    Publication date: April 6, 2023
    Inventors: Nadine Daou, William Comb, Alison Williams, Svetlana Marukian, Michael Hamill, Raffi Afeyan, Sean Carroll, Anthony Tramontin, Manu Chakravarthy
  • Amino acid compositions and methods for the treatment of liver diseases
    Patent number: 11602511
    Abstract: This disclosure provides pharmaceutical compositions comprising amino acid entities and uses thereof. Methods for improving liver function and for treating liver diseases comprising administering an effective amount of the compositions to a subject in need thereof are also disclosed.
    Type: Grant
    Filed: July 1, 2020
    Date of Patent: March 14, 2023
    Assignee: AXCELLA HEALTH INC.
    Inventors: Michael Hamill, Raffi Afeyan, Chung-Wei Lee, Harry Luithardt
  • AMINO ACID COMPOSITIONS AND METHODS FOR THE TREATMENT OF POST-ACUTE SEQUELAE OF COVID-19
    Publication number: 20230038163
    Abstract: This disclosure provides pharmaceutical compositions comprising amino acid entities and uses thereof. Methods for treating post-acute sequelae of COVID-19 comprising administering an effective amount of the compositions to a subject in need thereof are also disclosed.
    Type: Application
    Filed: July 25, 2022
    Publication date: February 9, 2023
    Inventors: Revati Wani, Alison Schecter, Michael Hamill, Margaret Koziel, Matthew Russell, Karim Azer, Karen Lavery, Joel Pradines
  • Compositions and methods for the treatment of liver diseases and disorders associated with one or both of hyperammonemia or muscle wasting
    Patent number: 11571404
    Abstract: This disclosure provides compositions and methods for treating or preventing liver diseases and disorders with hyperammonemia or muscle wasting in a subject.
    Type: Grant
    Filed: April 15, 2020
    Date of Patent: February 7, 2023
    Assignee: AXCELLA HEALTH INC.
    Inventors: William Comb, Sean Carroll, Raffi Afeyan, Michael Hamill
  • Nutritive polypeptides and formulations thereof, and methods of production and use thereof
    Patent number: 11357824
    Abstract: Nutritive polypeptides are provided herein. Also provided are various other embodiments including nucleic acids encoding the polypeptides, recombinant microorganisms that make the polypeptides, vectors for expressing the polypeptides, methods of making the polypeptides using recombinant microorganisms, compositions and formulations that comprise the polypeptides, and methods of using the polypeptides, compositions and formulations.
    Type: Grant
    Filed: March 16, 2020
    Date of Patent: June 14, 2022
    Assignee: Axcella Health Inc.
    Inventors: Michael Hamill, Brett Boghigian, Caitlyn Harvey, David Berry, David Young, Geoffrey Von Maltzahn, John Kramarczyk, Jameson Rogers, Kathryn Heard, Michael Doherty, Nathaniel Silver, Phillip Samayoa, Subhayu Basu, Shaila Rahman, Vimal Vaidya, Ying-Ja Chen
  • Amino acid compositions and methods for the treatment of liver diseases
    Patent number: 11129804
    Abstract: This disclosure provides pharmaceutical compositions comprising amino acid entities and uses thereof. Methods for improving liver function and for treating liver diseases comprising administering an effective amount of the compositions to a subject in need thereof are also disclosed.
    Type: Grant
    Filed: December 19, 2017
    Date of Patent: September 28, 2021
    Assignee: AXCELLA HEALTH INC.
    Inventors: Michael Hamill, Raffi Afeyan, Chung-Wei Lee, Harry Luithardt, David Berry
  • COMPOSITIONS AND METHODS FOR THE TREATMENT OF FAT INFILTRATION IN MUSCLE
    Publication number: 20210290573
    Abstract: This disclosure provides methods of using compositions comprising amino acid entities to reduce fat infiltration in muscle, particularly under conditions of muscle atrophy. The disclosure also provides methods for enhancing muscle function by reducing fat infiltration in the muscle comprising administering an effective amount of the compositions to a subject in need thereof.
    Type: Application
    Filed: March 2, 2021
    Publication date: September 23, 2021
    Inventors: Manu Chakravarthy, William Comb, Michael Hamill, Anthony Tramontin
  • COMPOSITIONS AND METHODS FOR THE REDUCTION OR TREATMENT OF INSULIN RESISTANCE AND METABOLIC CONDITIONS
    Publication number: 20210275479
    Abstract: This disclosure provides compositions and methods for reducing or treating insulin resistance in a subject.
    Type: Application
    Filed: June 19, 2019
    Publication date: September 9, 2021
    Inventors: Michael Hamill, Raffi Afeyan, Chung-Wei Lee, Harry Luithardt, William Comb, Nadine Daou, Svetlana Marukian
  • COMPOSITIONS AND METHODS FOR THE REDUCTION OR TREATMENT OF FIBROSIS
    Publication number: 20210275480
    Abstract: This disclosure provides compositions and methods for reducing or treating fibrosis, e.g., in a subject having a fibrotic condition or disorder.
    Type: Application
    Filed: June 19, 2019
    Publication date: September 9, 2021
    Inventors: Michael Hamill, Raffi Afeyan, Chung-Wei Lee, Harry Luithardt, Luke S. Hamm, Svetlana Marukian, Nadine Daou
  • COMPOSITIONS AND METHODS FOR THE REDUCTION OR TREATMENT OF INFLAMMATION
    Publication number: 20210260010
    Abstract: This disclosure provides compositions and methods for reducing or treating inflammation, e.g., in a subject having an inflammatory condition or disorder.
    Type: Application
    Filed: June 19, 2019
    Publication date: August 26, 2021
    Inventors: Michael Hamill, Raffi Afeyan, Chung-Wei Lee, Harry Luithardt, Simon Aoyama, Svetlana Marukian, Nadine Daou
  • Amino acid compositions and methods for the treatment of liver diseases
    Patent number: 11096914
    Abstract: This disclosure provides pharmaceutical compositions comprising amino acid entities and uses thereof. Methods for improving liver function and for treating liver diseases comprising administering an effective amount of the compositions to a subject in need thereof are also disclosed.
    Type: Grant
    Filed: December 19, 2017
    Date of Patent: August 24, 2021
    Assignee: AXCELLA HEALTH INC.
    Inventors: Michael Hamill, Raffi Afeyan, Chung-Wei Lee, Harry Luithardt, David Berry
  • Compositions and methods for the treatment of fat infiltration in muscle
    Patent number: 10973793
    Abstract: This disclosure provides methods of using compositions comprising amino acid entities to reduce fat infiltration in muscle, particularly under conditions of muscle atrophy. The disclosure also provides methods for enhancing muscle function by reducing fat infiltration in the muscle comprising administering an effective amount of the compositions to a subject in need thereof.
    Type: Grant
    Filed: February 7, 2020
    Date of Patent: April 13, 2021
    Assignee: AXCELLA HEALTH INC.
    Inventors: William Comb, Michael Hamill, Raffi Afeyan
  • AMINO ACID COMPOSITIONS AND METHODS FOR THE TREATMENT OF LIVER DISEASES
    Publication number: 20200330417
    Abstract: This disclosure provides pharmaceutical compositions comprising amino acid entities and uses thereof. Methods for improving liver function and for treating liver diseases comprising administering an effective amount of the compositions to a subject in need thereof are also disclosed.
    Type: Application
    Filed: July 1, 2020
    Publication date: October 22, 2020
    Inventors: Michael Hamill, Raffi Afeyan, Chung-Wei Lee, Harry Luithardt
  • COMPOSITIONS AND METHODS FOR THE TREATMENT OF LIVER DISEASES AND DISORDERS ASSOCIATED WITH ONE OR BOTH OF HYPERAMMONEMIA OR MUSCLE WASTING
    Publication number: 20200306214
    Abstract: This disclosure provides compositions and methods for treating or preventing liver diseases and disorders with hyperammonemia or muscle wasting in a subject.
    Type: Application
    Filed: April 15, 2020
    Publication date: October 1, 2020
    Inventors: William Comb, Sean Carroll, Raffi Afeyan, Michael Hamill
  • Nutritive Polypeptides and Formulations Thereof, and Methods of Production and Use Thereof
    Publication number: 20200306342
    Abstract: Nutritive polypeptides are provided herein. Also provided are various other embodiments including nucleic acids encoding the polypeptides, recombinant microorganisms that make the polypeptides, vectors for expressing the polypeptides, methods of making the polypeptides using recombinant microorganisms, compositions and formulations that comprise the polypeptides, and methods of using the polypeptides, compositions and formulations.
    Type: Application
    Filed: March 16, 2020
    Publication date: October 1, 2020
    Inventors: Michael Hamill, Brett Boghigian, Caitlyn Harvey, David Berry, David Young, Geoffrey Von Maltzahn, John Kramarczyk, Jameson Rogers, Kathryn Heard, Michael Doherty, Nathaniel Silver, Phillip Samayoa, Subhayu Basu, Shaila Rahman, Vimal Vaidya, Ying-Ja Chen
  • COMPOSITIONS AND METHODS FOR THE TREATMENT OF FAT INFILTRATION IN MUSCLE
    Publication number: 20200281882
    Abstract: This disclosure provides methods of using compositions comprising amino acid entities to reduce fat infiltration in muscle, particularly under conditions of muscle atrophy. The disclosure also provides methods for enhancing muscle function by reducing fat infiltration in the muscle comprising administering an effective amount of the compositions to a subject in need thereof.
    Type: Application
    Filed: February 7, 2020
    Publication date: September 10, 2020
    Inventors: Manu Chakravarthy, William Comb, Michael Hamill, Tony Tramontin
  • Nutritive Polypeptides and Formulations Thereof, and Methods of Production and Use Thereof
    Publication number: 20200188481
    Abstract: Nutritive polypeptides are provided herein. Also provided are various other embodiments including nucleic acids encoding the polypeptides, recombinant microorganisms that make the polypeptides, vectors for expressing the polypeptides, methods of making the polypeptides using recombinant microorganisms, compositions and formulations that comprise the polypeptides, and methods of using the polypeptides, compositions and formulations.
    Type: Application
    Filed: September 27, 2019
    Publication date: June 18, 2020
    Inventors: Michael Hamill, Brett Boghigian, Caitlyn Harvey, David Berry, David Young, Geoffrey Von Maltzahn, John Kramarczyk, Jameson Rogers, Kathryn Heard, Michael Doherty, Nathaniel Silver, Phillip Samayoa, Subhayu Basu, Shaila Rahman, Vimal Vaidya, Ying-Ja Chen