Patents by Inventor Michael Hamill

Michael Hamill has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Nutritive Polypeptides and Formulations Thereof, and Methods of Production and Use Thereof
    Publication number: 20200188481
    Abstract: Nutritive polypeptides are provided herein. Also provided are various other embodiments including nucleic acids encoding the polypeptides, recombinant microorganisms that make the polypeptides, vectors for expressing the polypeptides, methods of making the polypeptides using recombinant microorganisms, compositions and formulations that comprise the polypeptides, and methods of using the polypeptides, compositions and formulations.
    Type: Application
    Filed: September 27, 2019
    Publication date: June 18, 2020
    Inventors: Michael Hamill, Brett Boghigian, Caitlyn Harvey, David Berry, David Young, Geoffrey Von Maltzahn, John Kramarczyk, Jameson Rogers, Kathryn Heard, Michael Doherty, Nathaniel Silver, Phillip Samayoa, Subhayu Basu, Shaila Rahman, Vimal Vaidya, Ying-Ja Chen
  • Compositions and methods for the treatment of liver diseases and disorders associated with one or both of hyperammonemia or muscle wasting
    Patent number: 10682325
    Abstract: This disclosure provides compositions and methods for treating or preventing liver diseases and disorders with hyperammonemia or muscle wasting in a subject.
    Type: Grant
    Filed: August 14, 2018
    Date of Patent: June 16, 2020
    Assignee: AXCELLA HEALTH INC.
    Inventors: William Comb, Sean Carroll, Raffi Afeyan, Michael Hamill
  • Compositions and methods for the treatment of liver diseases and disorders associated with one or both of hyperammonemia or muscle wasting
    Patent number: 10660870
    Abstract: This disclosure provides compositions and methods for treating or preventing liver diseases and disorders with hyperammonemia or muscle wasting in a subject.
    Type: Grant
    Filed: April 29, 2019
    Date of Patent: May 26, 2020
    Assignee: AXCELLA HEALTH INC.
    Inventors: William Comb, Sean Carroll, Raffi Afeyan, Michael Hamill
  • Charged Nutritive Proteins and Methods
    Publication number: 20200109175
    Abstract: Charged nutritive proteins are provided. In some embodiments the nutritive proteins an aqueous solubility of at least 12.5 g/L at pH 7. In some embodiments the nutritive proteins an aqueous solubility of at least 50 g/L at pH 7. In some embodiments the nutritive proteins an aqueous solubility of at least 100 g/L at pH 7.
    Type: Application
    Filed: September 10, 2019
    Publication date: April 9, 2020
    Inventors: David Arthur Berry, Brett Adam Boghigian, Nathaniel W. Silver, Geoffrey von Maltzahn, Michael Hamill, Rajeev Chillakuru, John F. Kramarczyk
  • Compositions and methods for the treatment of fat infiltration in muscle
    Patent number: 10596136
    Abstract: This disclosure provides methods of using compositions comprising amino acid entities to reduce fat infiltration in muscle, particularly under conditions of muscle atrophy. The disclosure also provides methods for enhancing muscle function by reducing fat infiltration in the muscle comprising administering an effective amount of the compositions to a subject in need thereof.
    Type: Grant
    Filed: June 19, 2019
    Date of Patent: March 24, 2020
    Assignee: AXCELLA HEALTH INC.
    Inventors: Manu Chakravarthy, William Comb, Michael Hamill, Tony Tramontin
  • COMPOSITIONS AND METHODS FOR THE TREATMENT OF FAT INFILTRATION IN MUSCLE
    Publication number: 20200016104
    Abstract: This disclosure provides methods of using compositions comprising amino acid entities to reduce fat infiltration in muscle, particularly under conditions of muscle atrophy. The disclosure also provides methods for enhancing muscle function by reducing fat infiltration in the muscle comprising administering an effective amount of the compositions to a subject in need thereof.
    Type: Application
    Filed: June 19, 2019
    Publication date: January 16, 2020
    Inventors: Manu Chakravarthy, William Comb, Michael Hamill, Tony Tramontin
  • COMPOSITIONS AND METHODS FOR THE TREATMENT OF LIVER DISEASES AND DISORDERS
    Publication number: 20190388377
    Abstract: This disclosure provides compositions and methods for improving liver function, e.g., in a subject having a liver disease or disorder, or treating a liver disease or disorder.
    Type: Application
    Filed: June 19, 2019
    Publication date: December 26, 2019
    Inventors: Michael Hamill, Tony Tramontin, Manu Chakravarthy, Raffi Afeyan, Svetlana Marukian
  • Amino acid compositions and methods for the treatment of liver diseases
    Patent number: 10471034
    Abstract: This disclosure provides pharmaceutical compositions comprising amino acid entities and uses thereof. Methods for improving liver function and for treating liver diseases comprising administering an effective amount of the compositions to a subject in need thereof are also disclosed.
    Type: Grant
    Filed: December 5, 2018
    Date of Patent: November 12, 2019
    Assignee: AXCELLA HEALTH INC.
    Inventors: Michael Hamill, Raffi Afeyan, Chung-Wei Lee, Harry Luithardt
  • Nutritive polypeptides and formulations thereof, and methods of production and use thereof
    Patent number: 10463711
    Abstract: Nutritive polypeptides are provided herein. Also provided are various other embodiments including nucleic acids encoding the polypeptides, recombinant microorganisms that make the polypeptides, vectors for expressing the polypeptides, methods of making the polypeptides using recombinant microorganisms, compositions and formulations that comprise the polypeptides, and methods of using the polypeptides, compositions and formulations.
    Type: Grant
    Filed: March 25, 2016
    Date of Patent: November 5, 2019
    Assignee: Axcella Health Inc.
    Inventors: Michael Hamill, Brett Boghigian, Caitlyn Harvey, David Berry, David Young, Geoffrey Von Maltzahn, John Kramarczyk, Jameson Rogers, Kathryn Heard, Michael Doherty, Nathaniel Silver, Phillip Samayoa, Subhayu Basu, Shaila Rahman, Vimal Vaidya, Ying-Ja Chen
  • Charged nutritive proteins and methods
    Patent number: 10450350
    Abstract: Charged nutritive proteins are provided. In some embodiments the nutritive proteins an aqueous solubility of at least 12.5 g/L at pH 7. In some embodiments the nutritive proteins an aqueous solubility of at least 50 g/L at pH 7. In some embodiments the nutritive proteins an aqueous solubility of at least 100 g/L at pH 7.
    Type: Grant
    Filed: February 10, 2017
    Date of Patent: October 22, 2019
    Assignee: Axcella Health Inc.
    Inventors: David Arthur Berry, Brett Adam Boghigian, Nathaniel W. Silver, Geoffrey von Maltzahn, Michael Hamill, Rajeev Chillakuru, John F. Kramarczyk
  • COMPOSITIONS AND METHODS FOR THE TREATMENT OF LIVER DISEASES AND DISORDERS ASSOCIATED WITH ONE OR BOTH OF HYPERAMMONEMIA OR MUSCLE WASTING
    Publication number: 20190247351
    Abstract: This disclosure provides compositions and methods for treating or preventing liver diseases and disorders with hyperammonemia or muscle wasting in a subject.
    Type: Application
    Filed: April 29, 2019
    Publication date: August 15, 2019
    Inventors: William Comb, Sean Carroll, Raffi Afeyan, Michael Hamill
  • AMINO ACID COMPOSITIONS AND METHODS FOR THE TREATMENT OF LIVER DISEASES
    Publication number: 20190105294
    Abstract: This disclosure provides pharmaceutical compositions comprising amino acid entities and uses thereof. Methods for improving liver function and for treating liver diseases comprising administering an effective amount of the compositions to a subject in need thereof are also disclosed.
    Type: Application
    Filed: December 5, 2018
    Publication date: April 11, 2019
    Inventors: Michael Hamill, Raffi Afeyan, Chung-Wei Lee, Harry Luithardt
  • Amino acid compositions and methods for the treatment of liver diseases
    Patent number: 10238617
    Abstract: This disclosure provides pharmaceutical compositions comprising amino acid entities and uses thereof. Methods for improving liver function and for treating liver diseases comprising administering an effective amount of the compositions to a subject in need thereof are also disclosed.
    Type: Grant
    Filed: December 29, 2017
    Date of Patent: March 26, 2019
    Assignee: AXCELLA HEALTH INC.
    Inventors: Michael Hamill, Raffi Afeyan, Chung-Wei Lee, Harry Luithardt, David Berry
  • COMPOSITIONS AND METHODS FOR THE TREATMENT OF LIVER DISEASES AND DISORDERS ASSOCIATED WITH ONE OR BOTH OF HYPERAMMONEMIA OR MUSCLE WASTING
    Publication number: 20190046487
    Abstract: This disclosure provides compositions and methods for treating or preventing liver diseases and disorders with hyperammonemia or muscle wasting in a subject.
    Type: Application
    Filed: August 14, 2018
    Publication date: February 14, 2019
    Inventors: William Comb, Sean Carroll, Raffi Afeyan, Michael Hamill
  • Amino acid compositions and methods for the treatment of liver diseases
    Patent number: 10201513
    Abstract: This disclosure provides pharmaceutical compositions comprising amino acid entities and uses thereof. Methods for improving liver function and for treating liver diseases comprising administering an effective amount of the compositions to a subject in need thereof are also disclosed.
    Type: Grant
    Filed: June 11, 2018
    Date of Patent: February 12, 2019
    Assignee: AXCELLA HEALTH INC.
    Inventors: Michael Hamill, Raffi Afeyan
  • AMINO ACID COMPOSITIONS AND METHODS FOR THE TREATMENT OF LIVER DISEASES
    Publication number: 20180296516
    Abstract: This disclosure provides pharmaceutical compositions comprising amino acid entities and uses thereof. Methods for improving liver function and for treating liver diseases comprising administering an effective amount of the compositions to a subject in need thereof are also disclosed.
    Type: Application
    Filed: June 11, 2018
    Publication date: October 18, 2018
    Inventors: Michael Hamill, Raffi Afeyan, Chung-Wei Lee, Harry Luithardt, David Arthur Berry
  • AMINO ACID COMPOSITIONS AND METHODS FOR THE TREATMENT OF LIVER DISEASES
    Publication number: 20180207118
    Abstract: This disclosure provides pharmaceutical compositions comprising amino acid entities and uses thereof. Methods for improving liver function and for treating liver diseases comprising administering an effective amount of the compositions to a subject in need thereof are also disclosed.
    Type: Application
    Filed: December 19, 2017
    Publication date: July 26, 2018
    Inventors: Michael Hamill, Raffi Afeyan, Chung-Wei Lee, Harry Luithardt, David Berry
  • AMINO ACID COMPOSITIONS AND METHODS FOR THE TREATMENT OF MUSCLE DISEASES AND DISORDERS
    Publication number: 20180207119
    Abstract: This disclosure provides compositions comprising amino acid entities. The disclosure also provides methods for enhancing muscle function comprising administering an effective amount of the compositions to a subject in need thereof.
    Type: Application
    Filed: December 19, 2017
    Publication date: July 26, 2018
    Inventors: Michael Hamill, Raffi Afeyan, William Comb
  • AMINO ACID COMPOSITIONS AND METHODS FOR THE TREATMENT OF LIVER DISEASES
    Publication number: 20180169045
    Abstract: This disclosure provides pharmaceutical compositions comprising amino acid entities and uses thereof. Methods for improving liver function and for treating liver diseases comprising administering an effective amount of the compositions to a subject in need thereof are also disclosed.
    Type: Application
    Filed: December 29, 2017
    Publication date: June 21, 2018
    Inventors: Michael Hamill, Raffi Afeyan, Chung-Wei Lee, Harry Luithardt, David Berry
  • AMINO ACID COMPOSITIONS AND METHODS FOR THE TREATMENT OF MUSCLE DISEASES AND DISORDERS
    Publication number: 20180169046
    Abstract: This disclosure provides compositions comprising amino acid entities. The disclosure also provides methods for enhancing muscle function comprising administering an effective amount of the compositions to a subject in need thereof.
    Type: Application
    Filed: December 29, 2017
    Publication date: June 21, 2018
    Inventors: Michael Hamill, Raffi Afeyan, William Comb