Abstract: A colored asphalt-based sealcoat composition comprising asphalt emulsion, water, extender, polymer, clay, colorant, and titanium oxide particles is provided. In some embodiments, a highly solar reflective, colored asphalt-based sealcoat composition comprising titanium oxide particles is provided. In some embodiments, a colored asphalt-based sealcoat composition comprising titanium oxide particles capable of reducing surface temperatures of asphalt treated with the composition is provided. In some embodiments, a colored asphalt-based sealcoat composition comprising titanium oxide particles capable of reducing atmospheric pollutants is provided. In some embodiments, methods for preparing colored asphalt-based sealcoat compositions as well as their application to asphalt surfaces is provided.

Abstract: Disclosed herein are compounds which inhibit RIPK1, pharmaceutical compositions, and methods of treatment of RIPK1-mediated diseases, such as neurodegenerative disorders, inflammatory disorders, and cancer.

Abstract: Disclosed herein are compounds which inhibit RIPK1, pharmaceutical compositions, and methods of treatment of RIPK1-mediated diseases, such as neurodegenerative disorders, inflammatory disorders, and cancer.

Abstract: System, methods, and machine-readable media to facilitate monitoring and control of a railway maintenance assembly are disclosed. A railway workhead component monitor may be adapted to be disposed at a railway maintenance assembly. The railway workhead component monitor may be configured to perform one or a combination of the following. One or more conditions of at least a portion of the railway maintenance assembly may be monitored. Based at least in part on the monitoring, a plurality of monitoring data corresponding to operations of the railway maintenance assembly may be stored. Reporting data may be generated based at least in part on the stored plurality of monitoring data. A wireless communication may be transmitted toward a railway device controller that is remote from the railway maintenance assembly, the wireless communication including the reporting data.

Abstract: Systems, methods, and non-transitory, machine-readable media for extracting railway fasteners and adjusting railway anchors are disclosed. A tie plate manipulator may be slidably coupled with a frame assembly and may include tie plate tools in an opposing arrangement and slidably coupled with a support framework. A fastener extractor may include fastener-extracting arms and pivot joints pivotably coupling the fastener-extracting arms with a subassembly. The fastener extractor may be slidably coupled with the frame assembly so that at least part of the fastener extractor is disposed over the tie plate manipulator. The fastener extractor may be coupled with the tie plate manipulator at least in part with a cylinder system. Each fastener-extracting arm may be adjustable to selectively engage and extract a railway fastener. The tie plate manipulator may be operable to engage and adjust a tie plate on the railway tie with the pair of tie plate tools.

Abstract: System, methods, and machine-readable media to facilitate monitoring and control of a railway maintenance assembly are disclosed. A railway workhead component monitor may be adapted to be disposed at a railway maintenance assembly. The railway workhead component monitor may be configured to perform one or a combination of the following. One or more conditions of at least a portion of the railway maintenance assembly may be monitored. Based at least in part on the monitoring, a plurality of monitoring data corresponding to operations of the railway maintenance assembly may be stored. Reporting data may be generated based at least in part on the stored plurality of monitoring data. A wireless communication may be transmitted toward a railway device controller that is remote from the railway maintenance assembly, the wireless communication including the reporting data.

Abstract: The present disclosure is directed to simulating patterns of reflected radar energy off of reference objects using motion data associated with these reference objects. This motion data may identify start times, start locations, end times, and end locations of a limited number reference objects in a set of discrete scenes. Each of these discrete scenes may also have a same time duration. Motion of these specific objects between a start time and an end time of each discrete scene may be interpolated. Once the locations of the objects are interpolated for a given scene, simulations may be performed to estimate the appearance of reflected radar signals that would be received by a radar apparatus. These simulations may identify patterns of reflected radar energy after radar signals have been emitted from the radar apparatus and these patterns may then be provided to train a machine learning apparatus.

Abstract: Systems and methods for docking vehicles for towing are disclosed herein. An example docking assembly for a vehicle includes a mounting interface to be coupled to the vehicle, an interface component rotatably coupled to the mounting interface at a joint defining an axis, the interface component to be coupled to a corresponding interface component on another vehicle, and a compliance mechanism. The compliance mechanism is operable between: a first mode in which the interface component is locked from rotating about the axis; a second mode in which the interface component is rotatable about the axis and biased to a central position; and a third mode in which the interface component is freely rotatable about the axis.

Abstract: Systems and methods for docking vehicles for towing are disclosed herein. An example docking system to mechanically couple a first vehicle and a second vehicle includes a first docking assembly and a second docking assembly. The first docking assembly includes a first mounting interface to be coupled to the first vehicle and a receiver rotatably coupled to the first mounting interface to enable the receiver to rotate about a pitch axis relative to the first vehicle. The receiver defines an opening. The second docking assembly includes a second mounting interface to be coupled to the second vehicle and a plug to be inserted into the opening of the receiver. The plug is rotatably coupled the second mounting interface to enable the plug to rotate about a yaw axis relative to the second vehicle and rotate about a roll axis relative to the second vehicle.

Abstract: Systems, methods, and non-transitory, machine-readable media for extracting railway fasteners and adjusting railway anchors are disclosed. A tie plate manipulator may be slidably coupled with a frame assembly and may include tie plate tools in an opposing arrangement and slidably coupled with a support framework. A fastener extractor may include fastener-extracting arms and pivot joints pivotably coupling the fastener-extracting arms with a subassembly. The fastener extractor may be slidably coupled with the frame assembly so that at least part of the fastener extractor is disposed over the tie plate manipulator. The fastener extractor may be coupled with the tie plate manipulator at least in part with a cylinder system. Each fastener-extracting arm may be adjustable to selectively engage and extract a railway fastener. The tie plate manipulator may be operable to engage and adjust a tie plate on the railway tie with the pair of tie plate tools.

Abstract: Disclosed herein are compounds which inhibit RIPK1, pharmaceutical compositions, and methods of treatment of RIPK1-mediated diseases, such as neurodegenerative disorders, inflammatory disorders, and cancer.

Abstract: Retention devices, and methods for retention devices, to retain a railway tie plate are disclosed. The retention devices may include a head section with one or more protrusions adapted to engage a railway rail. The retention devices may include an insert section adapted to fit in a spike hole of a railway tie plate and including one or more flexible members extending from the head section. Each flexible member may allow flex adjustment when the insert section is inserted in the spike hole of the railway tie plate. When the insert section is inserted in the spike hole of the railway tie plate, the head section may engage the railway rail and the insert section may engage the railway tie plate to mechanically interlock the railway tie plate with the railway rail to allow suspension of the railway tie plate from the railway rail.

Abstract: Systems, methods, and non-transitory, machine-readable media for extracting railway fasteners and adjusting railway anchors are disclosed. A tie plate manipulator may be slidably coupled with a frame assembly and may include tie plate tools in an opposing arrangement and slidably coupled with a support framework. A fastener extractor may include fastener-extracting arms and pivot joints pivotably coupling the fastener-extracting arms with a subassembly. The fastener extractor may be slidably coupled with the frame assembly so that at least part of the fastener extractor is disposed over the tie plate manipulator. The fastener extractor may be coupled with the tie plate manipulator at least in part with a cylinder system. Each fastener-extracting arm may be adjustable to selectively engage and extract a railway fastener. The tie plate manipulator may be operable to engage and adjust a tie plate on the railway tie with the pair of tie plate tools.

Abstract: Systems and methods for improving an end-to-end (E2E) vehicle simulation in replicating a real-world driving scene based on a continuous feedback loop are provided. For example, a method includes receiving first data collected from a real-world driving scene, the first data associated with the real-world driving scene and a performance of a real-world vehicle in the real-world driving scene; and adjusting, for a current iteration, a parameter associated with an E2E vehicle simulation that simulates operations of a simulated vehicle driving in a simulated driving scene, wherein the adjustment is based on a fidelity value of the E2E vehicle simulation in a previous iteration, and the fidelity value is based on a comparison between second data collected from the E2E simulation in the previous iteration and the first data.

Abstract: Systems and methods for evaluating a fidelity of a simulation in replicating a real-world driving scene are provided. A computer-implemented system including one or more non-transitory computer-readable media storing instructions, when executed by one or more processing units, cause the one or more processing units to perform operations including receiving first data collected from a reference driving scene, the first data associated with the reference driving scene and a driving behavior of a first vehicle in the reference driving scene; receiving second data collected from a driving simulation that generates a simulated driving scene and operations of a second vehicle in the simulated driving scene, wherein the simulated driving scene is a simulation of the reference driving scene; and determining a fidelity of the driving simulation based on a comparison between the first data and the second data.

Abstract: System, methods, and machine-readable media to facilitate monitoring and control of a railway maintenance assembly are disclosed. A railway workhead component monitor may be adapted to be disposed at a railway maintenance assembly. The railway workhead component monitor may be configured to perform one or a combination of the following. One or more conditions of at least a portion of the railway maintenance assembly may be monitored. Based at least in part on the monitoring, a plurality of monitoring data corresponding to operations of the railway maintenance assembly may be stored. Reporting data may be generated based at least in part on the stored plurality of monitoring data. A wireless communication may be transmitted toward a railway device controller that is remote from the railway maintenance assembly, the wireless communication including the reporting data.

Abstract: Disclosed herein are compounds which inhibit RIPK1, pharmaceutical compositions, and methods of treatment of RIPK1-mediated diseases, such as neurodegenerative disorders, inflammatory disorders, and cancer.

Abstract: The present invention provides novel medical devices for use in surgical procedures and methods for manufacturing novel medical devices. In some embodiments, the novel medical devices can include surgical needles that are capable of being repeatedly passed through tissue using minimal force. More particularly, the surgical needles can be manufactured with one or more coatings that provide the surgical needles with both durability and lubricity for ease of repeated and successive passes through tissue. Novel methods for manufacturing the surgical needles and for providing and applying coatings to the surgical needles are also provided.

Abstract: The present disclosure is directed to simulating patterns of reflected radar energy off of reference objects using motion data associated with these reference objects. This motion data may identify start times, start locations, end times, and end locations of a limited number reference objects in a set of discrete scenes. Each of these discrete scenes may also have a same time duration. Motion of these specific objects between a start time and an end time of each discrete scene may be interpolated. Once the locations of the objects are interpolated for a given scene, simulations may be performed to estimate the appearance of reflected radar signals that would be received by a radar apparatus. These simulations may identify patterns of reflected radar energy after radar signals have been emitted from the radar apparatus and these patterns may then be provided to train a machine learning apparatus.

Abstract: The invention relates to the chitosan polymer derivatives of formula I: and pharmaceutically acceptable salts and esters thereof, wherein Y, X1, X4, R1, R2, and n are defined in the detailed description and claims. The chitosan polymer derivatives of formula I bind to or associate with alpha-4-beta-1 (?4?1) and alpha-V-beta-3 (? V?3) integrin dimers and can be used in delivery formulations to deliver drugs, nucleic acids, or other therapeutic compounds to tissues or cells expressing such integrins.