Abstract: The invention relates to the chitosan polymer derivatives of formula I: and pharmaceutically acceptable salts and esters thereof, wherein Y, X1, X4, R1, R2, and n are defined in the detailed description and claims. The chitosan polymer derivatives of formula I bind to or associate with alpha-4-beta-1 (?4?1) and alpha-V-beta-3 (? V?3) integrin dimers and can be used in delivery formulations to deliver drugs, nucleic acids, or other therapeutic compounds to tissues or cells expressing such integrins.

Abstract: A colored asphalt-based sealcoat composition comprising asphalt emulsion, water, extender, polymer, clay, colorant, and titanium oxide particles is provided. In some embodiments, a highly solar reflective, colored asphalt-based sealcoat composition comprising titanium oxide particles is provided. In some embodiments, a colored asphalt-based sealcoat composition comprising titanium oxide particles capable of reducing surface temperatures of asphalt treated with the composition is provided. In some embodiments, a colored asphalt-based sealcoat composition comprising titanium oxide particles capable of reducing atmospheric pollutants is provided. In some embodiments, methods for preparing colored asphalt-based sealcoat compositions as well as their application to asphalt surfaces is provided.

Abstract: A data collection device may communicate with one or more onboard systems of a first vehicle. The data collection device may receive payload data from the one or more onboard systems that indicate one or more faults with the one or more onboard systems. An analysis controller that may obtain the payload data from the data collection device, compare the payload data from the data collection device with other payload data obtained from other vehicles, and calculate a valuation of the first vehicle based on the payload data and comparing the payload data with the other payload data.

Abstract: The disclosed computer-implemented method may include a process for monitoring and improving end-to-end video quality based on scaled and/or interpolated perceptual quality scores across various video views. The method may also include a process for improving search experience for user expectations. Additionally, the method may include a process for providing hardware virtualization and simulation for server hosting. Furthermore, the method may include a process for filtering network traffic in a hosting environment. The method may additionally include a process for testing applications in a hosting environment. The method may further include a process for supporting multi-touch applications. The method may also include a process for optimized graphics rendering. Various other related methods and systems are also disclosed.

Abstract: Systems, methods, and machine-readable media to facilitate installation and adjustment of railway components are disclosed. Aligning of a railway anchor manipulator and a railway fastener installer with respect to a railway tie may be caused. The railway anchor manipulator may be slidably coupled with a frame assembly of a railway workhead, and may include anchor tools. The railway fastener installer may be slidably coupled with the main shaft structure, may include a hammer assembly, and may be operable to install railway fasteners through holes of a railway tie plate. The railway fastener installer may be caused to install the railway fasteners. The railway anchor manipulator may be lowered to a deployed position, and railway anchors may be adjusted with the anchor tools.

Abstract: Disclosed are various embodiments for an electronic search interface to identify artisan sellers. A search query is received from a client. An electronic item database is then searched to identify items that are relevant to the search query. Two or more items may be offered by each of multiple sellers. A search result listing is generated that includes one item offered by each seller with a greatest display prominence. Other items offered by the sellers may be excluded or displayed with a lesser prominence.

Abstract: Retention devices, and methods for retention devices, to retain a railway tie plate are disclosed. The retention devices may include a head section with one or more protrusions adapted to engage a railway rail. The retention devices may include an insert section adapted to fit in a spike hole of a railway tie plate and including one or more flexible members extending from the head section. Each flexible member may allow flex adjustment when the insert section is inserted in the spike hole of the railway tie plate. When the insert section is inserted in the spike hole of the railway tie plate, the head section may engage the railway rail and the insert section may engage the railway tie plate to mechanically interlock the railway tie plate with the railway rail to allow suspension of the railway tie plate from the railway rail.

Abstract: Systems, methods, and machine-readable media to facilitate installation and adjustment of railway components are disclosed. Aligning of a railway anchor manipulator and a railway fastener installer with respect to a railway tie may be caused. The railway anchor manipulator may be slidably coupled with a frame assembly of a railway workhead, and may include anchor tools. The railway fastener installer may be slidably coupled with the main shaft structure, may include a hammer assembly, and may be operable to install railway fasteners through holes of a railway tie plate. The railway fastener installer may be caused to install the railway fasteners. The railway anchor manipulator may be lowered to a deployed position, and railway anchors may be adjusted with the anchor tools.

Abstract: A sheet music search and discovery system is disclosed that uses specific mathematical rules to analyze and characterize sheet music and provides functionality for users to identify sheet music based on those characterizations. The system stores sheet music data and metadata characterizing each composition, provides a graphical user interface that provides functionality for users to search the sheet music data for compositions, and generates search results based at least in part on the metadata characterizing each composition. In one embodiment, metadata describing structured sheet music data is generated using a global vector space that includes semantic representations of elements extracted from a large corpus. In another embodiment, metadata describing unstructured sheet music data is generated using machine learning-based pattern recognition.

Abstract: The present disclosure provides a pipe 10 with center influent branch 20 and opposing side influent branches 30. Each of the influent branches 20, 30 also have a concentric reducer 40 at their terminus.

Abstract: Retention devices, and methods for retention devices, to retain a railway tie plate are disclosed. The retention devices may include a head section with one or more protrusions adapted to engage a railway rail. The retention devices may include an insert section adapted to fit in a spike hole of a railway tie plate and including one or more flexible members extending from the head section. Each flexible member may allow flex adjustment when the insert section is inserted in the spike hole of the railway tie plate. When the insert section is inserted in the spike hole of the railway tie plate, the head section may engage the railway rail and the insert section may engage the railway tie plate to mechanically interlock the railway tie plate with the railway rail to allow suspension of the railway tie plate from the railway rail.

Abstract: The present invention relates to a polymer composition comprising at least one block copolymer and a specific amount of at least one oil component. The block copolymer, which is the polymeric matrix of the inventive composition, is built up from at least one vinyl aromatic monomer MA and at least one conjugated diene monomer MB, in particular the block copolymer is a styrene butadiene block copolymer (SBC).

Abstract: System, methods, and machine-readable media to facilitate monitoring and control of a railway maintenance assembly are disclosed. A railway workhead component monitor may be adapted to be disposed at a railway maintenance assembly. The railway workhead component monitor may be configured to perform one or a combination of the following. One or more conditions of at least a portion of the railway maintenance assembly may be monitored. Based at least in part on the monitoring, a plurality of monitoring data corresponding to operations of the railway maintenance assembly may be stored. Reporting data may be generated based at least in part on the stored plurality of monitoring data. A wireless communication may be transmitted toward a railway device controller that is remote from the railway maintenance assembly, the wireless communication including the reporting data.

Abstract: Disclosed herein are compounds which inhibit RIPK1, pharmaceutical compositions, and methods of treatment of RIPK1-mediated diseases, such as neurodegenerative disorders, inflammatory disorders, and cancer.

Abstract: Systems, methods, and non-transitory, machine-readable media for extracting railway fasteners and adjusting railway anchors are disclosed. A tie plate manipulator may be slidably coupled with a frame assembly and may include tie plate tools in an opposing arrangement and slidably coupled with a support framework. A fastener extractor may include fastener-extracting arms and pivot joints pivotably coupling the fastener-extracting arms with a subassembly. The fastener extractor may be slidably coupled with the frame assembly so that at least part of the fastener extractor is disposed over the tie plate manipulator. The fastener extractor may be coupled with the tie plate manipulator at least in part with a cylinder system. Each fastener-extracting arm may be adjustable to selectively engage and extract a railway fastener. The tie plate manipulator may be operable to engage and adjust a tie plate on the railway tie with the pair of tie plate tools.

Abstract: The present invention provides novel medical devices for use in surgical procedures and methods for manufacturing novel medical devices. In some embodiments, the novel medical devices can include surgical needles that are capable of being repeatedly passed through tissue using minimal force. More particularly, the surgical needles can be manufactured with one or more coatings that provide the surgical needles with both durability and lubricity for ease of repeated and successive passes through tissue. Novel methods for manufacturing the surgical needles and for providing and applying coatings to the surgical needles are also provided.

Abstract: The present invention provides novel medical devices for use in surgical procedures and methods for manufacturing novel medical devices. In some embodiments, the novel medical devices can include surgical needles that are capable of being repeatedly passed through tissue using minimal force. More particularly, the surgical needles can be manufactured with one or more coatings that provide the surgical needles with both durability and lubricity for ease of repeated and successive passes through tissue. Novel methods for manufacturing the surgical needles and for providing and applying coatings to the surgical needles are also provided.

Abstract: A method and a combined streaming platform for broadcasting a video game are provided. The combined streaming platform receives a first stream of the video game from a first user device, and a second stream of the video game from a second user device. The first stream and the second stream comprise one or more of an audio and a plurality of images representing a gameplay of the video game. The combined streaming platform creates a video game stream comprising the first stream and the second stream of the video game. The video game stream is configured to be displayed on a viewer device for simultaneously displaying the first stream and the second stream of the video game. The combined streaming platform broadcasts the video game stream to one or more viewer devices.

Abstract: An inspection fixture includes a base member, a support member coupled to base member, and an intermediate member coupled to the support member or the base member. The support member includes a radiolucent material for limiting artifacts in imagery of an industrial article supported by the inspection fixture. Inspection arrangements and imaging methods are also described.

Abstract: Systems, methods, and non-transitory, machine-readable media for extracting railway fasteners and adjusting railway anchors are disclosed. A tie plate manipulator may be slidably coupled with a frame assembly and may include tie plate tools in an opposing arrangement and slidably coupled with a support framework. A fastener extractor may include fastener-extracting arms and pivot joints pivotably coupling the fastener-extracting arms with a subassembly. The fastener extractor may be slidably coupled with the frame assembly so that at least part of the fastener extractor is disposed over the tie plate manipulator. The fastener extractor may be coupled with the tie plate manipulator at least in part with a cylinder system. Each fastener-extracting arm may be adjustable to selectively engage and extract a railway fastener. The tie plate manipulator may be operable to engage and adjust a tie plate on the railway tie with the pair of tie plate tools.