Abstract: Disclosed herein are apparatuses and methods that account for exercise in closed loop insulin delivery systems. Rather than increasing a target insulin on board (IOB) as glucose levels rise, which would increase insulin delivery to address the raised glucose levels, when a user indicates that the user will be exercising raised glucose levels are addressed by reducing the target IOB within the closed loop algorithm. By reducing the target IOB, the algorithm responds less aggressively to pre-exercise food, and does not build up the IOB that can cause dangerously low glucose levels once the exercise also begins lowering glucose levels.

Abstract: Disclosed herein are particles and methods of using said particles in assays for detection of biomolecules in a sample. Various methods of the present disclosure utilize particles for biomolecule adsorption. In some aspects, the present disclosure provides methods which utilize multiple particle concentrations to differentially fractionate biological samples. In further aspects, the present disclosure provides methods which utilize low particle concentrations to enhance adsorbed biomolecule diversity.

Abstract: Disclosed herein are systems and methods for mitigating the risk of insulin stacking in automated insulin delivery systems. In AID systems configured to both automatically calculate insulin delivery based on glucose levels and receive manual programming of meal boluses configured to counteract carbohydrates in a meal, insulin stacking can result if the system automatically increases insulin delivery based on a rise in glucose levels in response to consumption of a meal and the user later programs a meal bolus for the meal. The risk of such double dosing is mitigated by the systems and methods disclosed herein by enabling the system to account for recent automated insulin increases when a meal bolus is programmed.

Abstract: An ROR1 CAR or ROR1/CD19 Dual CAR for the treatment of tumors. The T cells expressing ROR1 CAR or ROR1/CD19 Dual CAR can be stimulated by ROR1-positive or ROR1/CD19-positive cells, and have cytotoxicity against ROR1-positive or ROR1/CD19-positive cells.

Abstract: The present application provides novel fusion proteins for dephosphorylating proteins that regulate T cell activation through the TCR signaling pathway, nucleic acids encoding said proteins, vectors comprising said nucleic acids, compositions comprising said nucleic acids or vectors, host cells comprising said nucleic acids, vectors or compositions or related pharmaceutical compositions. The present application also provides methods for dephosphorylation of proteins that regulate T cell activation through the TCR signaling pathway of a cell, methods of producing a cell having dephosphorylated proteins that regulate T cell activation through the TCR signaling pathway (e.g. a CAR T cell having dephosphorylated Immunoreceptor Tyrosine-based Activation Motifs (ITAMs) of endogenous CD3), methods of treating a disease, and methods of reducing or preventing GvHD in a subject associated with the administration of one or more CAR T-cells to the subject.

Abstract: Systems and methods including a framework for migration of live data. The method may comprised, by one or more hardware processors executing program instructions, receiving, at a migration proxy of the framework, code for reading data and writing data compatible with each of a plurality of states of a migration of data in a data store, wherein a service is at least intermittently reading data from and writing data to the data store; determining, by a migration runner of the framework, to perform the migration of the data; initiating, by the migration runner, the migration of the data, wherein the migration comprises a plurality of stages; storing, as the migration progresses through the plurality of stages, and at a migration data store of the framework, a current stage of the migration; and during the migration, using the migration proxy to read data from and write data to the data store.

Abstract: A display assembly for a vehicle includes a support chassis having a recess, and a display module at least partially received within the recess, the display module having a front side and a back side. A cover lens is attached to the front side of the display module with a bonding material and coupled to the support chassis in a floating mounting arrangement using a flexible adhesive.

Abstract: A system and method for utilizing a carbide-derived carbon (CDC) fiber in solid-phase micro extraction. Optically pumping the carbide-derived carbon (CDC) fiber, as compared to using thermal desorption, enhances performance of the system. CDC provides for a broad based sorbent that is insensitive to high humidity. Optical pumping may be done axially or radially on a modified gas chromatography needle. In some cases, staged, or pulsed, optical pumping is used to drive off solvent or other lower boiling compounds first and then the desorption of the remaining analytes is cleaner and the instrumentation is less likely to be overloaded.

Abstract: A content management system may maintain a scene description that represents a 3D virtual environment and a publish/subscribe model in which clients subscribe to content items that correspond to respective portions of the shared scene description. When changes are made to content, the changes may be served to subscribing clients. Rather than transferring entire descriptions of assets to propagate changes, differences between versions of content may be exchanged, which may be used construct updated versions of the content. Portions of scene description may reference other content items and clients may determine whether to request and load these content items for lazy loading. Content items may be identified by Uniform Resource Identifiers (URIs) used to reference the content items. The content management system may maintain states for client connections including for authentication, for the set of subscriptions in the publish/subscribe model, and for their corresponding version identifiers.

Abstract: An in-situ current sensing apparatus for a plasma processing system has one or more sections defining a plasma channel, the plasma processing system configured to form a plasma in the plasma channel using a process gas. The in-situ current sensing apparatus includes an assembly including an electrically conductive housing coupled to a dielectric coating layer, wherein a surface of the dielectric coating layer is configured to physically contact at least one of the process gas or the plasma in the plasma channel. The in-situ current sensing apparatus also includes a current probe, inductively or electrically connected to the assembly, for sensing a capacitively-coupled current within the assembly caused by the formation of plasma in the plasma channel. The in-situ current-sensing apparatus further includes at least one dielectric break for electrically isolating the assembly from the one or more sections. The assembly may include an electrode embedded within the housing.

Abstract: Disclosed is an injection stretch blow molded (ISBM) container containing a surface having a static coefficient of friction (COF) of 0.15 to 0.21, a dynamic COF of 0.06 to 0.1, wherein the surface retains a water contact angle of 76° or higher for up to three minutes after wetting of the surface with a water drop of 14 to 16 mm diameter and the container is made with a polymeric composition containing a high density polyethylene (HDPE) having a dispersity (Mw/Mn) of 9 or higher as measured by GPC; a MI2 of 1 g/10 min or higher as measured by ASTM D-1238; 190° C./2.16 kg, as measured by ASTM D-1238; and an environmental stress crack resistance (ESCR) at 100% Igepal of >150 hours as measured by ASTM D-1693, B.

Abstract: Methods and systems are provided for an imaging system. In one example, the imaging system includes a plurality of microscope assemblies arranged radially around a central axis of the imaging system, coupled to vertically oriented plates with a set of objectives arranged at tops of the plurality of microscope assemblies and wherein the plates are oriented to extend away from the central axis in a radial direction to form an x-shaped configuration.

Abstract: Systems and methods for delivering active ingredients, such as pharmaceutically active ingredients, to substrates are described herein. The active ingredients are delivered as fluids to a fluid-dispensing device for the creation of one or more drops for deposition onto substrates such as for the creation of microdoses. The invention further includes microdoses made by such processes.

Abstract: Compounds of the Formula (I), pharmaceutical compositions comprising compounds of the Formula (I), and their use for treating or preventing an infection caused by Human Cytomegalovirus (HCMV), Epstein-Barr virus (EBV), or Human Immunodeficiency Virus (HIV):

Abstract: A plasma apparatus of a plasma processing system is provided. The plasma apparatus defines a toroidal plasma channel and includes multiple end blocks defining respective portions of the toroidal plasma channel. Each end block includes an end-block tube constructed from a first electrically conductive material and a dielectric coating disposed on an interior surface of the end-block tube. The plasma apparatus also includes multiple mid-blocks defining respective portions of the toroidal plasma channel. Each mid-block includes at least one heat sink located adjacent to a substantially linear tube with a thermal interface disposed therebetween. The thermal interface is in physical communication with the tube and the at least one heat sink. The mid-block tube has a substantially uniform wall thickness and is constructed from a dielectric material. The at least one heat sink is constructed from a second electrically conductive material.

Abstract: Water-based compositions that are resistant to dirt pickup, efflorescence, tannin bleed-through and surfactant leaching are described. The water-based composition includes a latex or water-dispersible polymer and a non-VOC UV-VIS (preferably, ultraviolet) absorber as a dirt pickup resistance additive. Methods of making water-based compositions including a non-VOC UV-VIS absorber as an additive are also described.

Abstract: System, methods, and other embodiments described herein relate to providing visual cues on a steering apparatus of a vehicle. In one embodiment, a method includes determining a difference between a current angle of a steering apparatus of a vehicle and a recommended angle of the steering apparatus. The method further includes illuminating a region of a grip of the steering apparatus based upon the difference and a position of a hand of an operator of the vehicle on the grip. The method additionally includes unilluminating the region as the steering apparatus is rotated from the current angle to the recommended angle.

Abstract: A steering system for a medical device may include a first drive member having a central longitudinal axis; a central shaft extending through the first drive member; a control knob coupled to the first drive member; a braking knob coupled to the central shaft and including a first protrusion; and a brake shoe member coupled to the central shaft between the control knob and the braking knob. The first protrusion may be positioned within a first channel of the brake shoe member; the first protrusion may be configured to engage the brake shoe member to move a first arm of the brake shoe member radially outward towards a wall of the control knob when the braking knob is rotated in a first direction; and the first arm may be configured to move away from the wall when the braking knob is rotated in a second direction.

Abstract: Fill-finish assemblies facilitating the manufacture of a drug delivery device are disclosed. The fill-finish assembly may include a container, an insertion mechanism, a fluid pathway connection assembly disposed between the container and the insertion mechanism, and a carrier. The insertion mechanism may include a delivery member and an insertion mechanism housing. The insertion mechanism may be configured to move the delivery member from a retracted position inside the insertion mechanism housing to a deployed position outside the insertion mechanism housing. The fluid pathway connection assembly may be selectively activatable to establish fluid communication between the container and the delivery member. The carrier may have a hollow interior containing at least a portion of each of the container, the insertion mechanism, and the fluid pathway connection assembly.

Abstract: Systems and methods including a framework for migration of live data. The method may comprised, by one or more hardware processors executing program instructions, receiving, at a migration proxy of the framework, code for reading data and writing data compatible with each of a plurality of states of a migration of data in a data store, wherein a service is at least intermittently reading data from and writing data to the data store; determining, by a migration runner of the framework, to perform the migration of the data; initiating, by the migration runner, the migration of the data, wherein the migration comprises a plurality of stages; storing, as the migration progresses through the plurality of stages, and at a migration data store of the framework, a current stage of the migration; and during the migration, using the migration proxy to read data from and write data to the data store.