Abstract: The present embodiments are directed, in part, to compounds, or pharmaceutically acceptable salts thereof, or pharmaceutical compositions thereof for modulating the activity of S1P1 receptor and methods of using the same.

Abstract: The present embodiments are directed, in part, to compounds, or pharmaceutically acceptable salts thereof, or pharmaceutical compositions thereof for modulating the activity of delta opioid receptor, biased and/or unbiased, and/or methods for treating pain, migraines, headaches, depression, Parkinsons Disease, anxiety, and/or overactive bladder, and other disorders and conditions described herein or any combination thereof.

Abstract: Enhanced metadata with optimized output. In an embodiment, a content object is received. First metadata to be associated with the content object is determined. At least one metadata field to be acquired is determined based on an association, within a stored knowledge structure, of the at least one metadata field with the first metadata. Second metadata to be associated with the content object is acquired based on the at least one metadata field. A metadata structure and markup format for the content object are determined. The metadata structure incorporates both the first metadata and the second metadata. The content object is output with the metadata structure and in the markup format.

Abstract: Enhanced metadata with optimized output. In an embodiment, a content object is received. First metadata to be associated with the content object is determined. At least one metadata field to be acquired is determined based on an association, within a stored knowledge structure, of the at least one metadata field with the first metadata. Second metadata to be associated with the content object is acquired based on the at least one metadata field. A metadata structure and markup format for the content object are determined. The metadata structure incorporates both the first metadata and the second metadata. The content object is output with the metadata structure and in the markup format.

Abstract: The disclosure is directed to compounds of Formula (I) and Formula (II), Formula (I) and Formula (II) and pharmaceutically acceptable salts or solvates thereof. Pharmaceutical compositions comprising compounds of Formula (I) or Formula (II), as well as methods of their use and preparation, are also described.

Abstract: The disclosure is directed to compounds of Formula (I) and Formula (II). Formula (I) and Formula (II) and pharmaceutically acceptable salts or solvates thereof. Pharmaceutical compositions comprising compounds of Formula (I) or Formula (II), as well as methods of their use and preparation, are also described.

Abstract: A railroad crosstie (tie) may be fabricated from a composite material including a fiber reinforced polymer shell manufactured by pultrusion or other process, and filled by a suitable material, typically selected from expanded elastomeric polymer (such as polyurethane resin or other polymer), concrete, lightweight concrete formed by conventional aggregate, sand, cement, water, and an ultra light filler such as natural materials, sawdust, beads of expanded polymer such as expanded polystyrene, microspheres of glass or plastic, a recycled wooden tie in conjunction with any of the above, or the like. Fasteners may be driven such as spikes, threaded, such as screws, lag screws, spreading screws, rivets, or the like into apertures, pilot holes, or directly into fill absent apertures therein.

Abstract: The disclosure is directed to compounds of Formula I Pharmaceutical compositions comprising compounds of Formula I, as well as methods of their use and preparation, are also described.

Abstract: A railroad crosstie (tie) may be fabricated from a composite material including a fiber reinforced polymer shell manufactured by pultrusion or other process, and filled by a suitable material, typically selected from expanded elastomeric polymer (such as polyurethane resin or other polymer), concrete, lightweight concrete formed by conventional aggregate, sand, cement, water, and an ultra light filler such as natural materials, sawdust, beads of expanded polymer such as expanded polystyrene, microspheres of glass or plastic, a recycled wooden tie in conjunction with any of the above, or the like. Fasteners may be driven such as spikes, threaded, such as screws, lag screws, spreading screws, rivets, or the like into apertures, pilot holes, or directly into fill absent apertures therein.

Abstract: The disclosure is directed to compounds of Formula I Pharmaceutical compositions comprising compounds of Formula I, as well as methods of their use and preparation, are also described.

Abstract: The disclosure is directed to methods of treating disease using compounds of Formula (I).

Abstract: The disclosure is directed to methods of treatment using compounds of Formula (I).

Abstract: This invention relates to novel methods to prepare substituted pyrido[2,3-d]pyrimidin-7(8H)-ones, and salts and stereoisomers thereof, as well as intermediates useful for the preparation of such compounds.

Abstract: The disclosure is directed to compounds of Formula I Pharmaceutical compositions comprising compounds of Formula I, as well as methods of their use and preparation, are also described.

Abstract: The disclosure is directed to compounds of Formula I Pharmaceutical compositions comprising compounds of Formula I, as well as methods of their use and preparation, are also described.

Abstract: The disclosure is directed to compounds of Formula (I) and Formula (II). Formula (I) and Formula (II) and pharmaceutically acceptable salts or solvates thereof. Pharmaceutical compositions comprising compounds of Formula (I) or Formula (II), as well as methods of their use and preparation, are also described.

Abstract: The disclosure is directed to compounds of Formula I Pharmaceutical compositions comprising compounds of Formula I, as well as methods of their use and preparation, are also described.

Abstract: Enhanced metadata with optimized output. In an embodiment, a content object is received. First metadata to be associated with the content object is determined. At least one metadata field to be acquired is determined based on an association, within a stored knowledge structure, of the at least one metadata field with the first metadata. Second metadata to be associated with the content object is acquired based on the at least one metadata field. A metadata structure and markup format for the content object are determined. The metadata structure incorporates both the first metadata and the second metadata. The content object is output with the metadata structure and in the markup format.

Abstract: A system has a conveyor for carrying at least two categories of scrap particles positioned at random on a surface of the conveyor, with at least some of the particles comprising metal. The system has a sensor array with a series of analog inductive proximity sensors arranged transversely across the conveyor. An active sensing end face of each sensor lies in a sensing plane, and the sensing plane is generally parallel with the surface of the conveyor. A control system of is configured to sample and quantize analog signals from the series of sensors in the array, and locate and classify a scrap particle on the conveyor passing over the array into one of at least two categories of material based on the quantized signals. A method for sorting the particles is also provided.