Abstract: 4-(4-methylpiperazin-1-ylmethyl)-N-[4-methyl-3-(4-pyridin-3-yl)pyrimidin-2-ylamino)phenyl]-benzamide of the formula I or a pharmaceutically acceptable salt thereof can be used in the treatment of seminomas.

Abstract: The present invention utilizes nucleic acid microarray technology to identify changes in the host endothelial cell transcription pattern that occurs during the latent and lytic phase of the KSHV life cycle. The production or activity of some genes up regulated during the lytic cycle were subsequently inhibited, and two such targets were shown to have a role in expression of late viral genes. Using this combined approach we have identified cellular pathways previously unknown to be important for KSHV infection, and present evidence for the efficiency of the novel antiviral approaches thus discovered. In addition, the present invention identifies a wide variety of endothelial cells genes and pathways that are involved in a variety of endothelial cell-mediated activity, including angiogenesis and transformation.

Abstract: A rotary milking parlor milker detacher having a pivoting support arm and retracting chain arrangement that is synchronized with a rotating platform position to move the detacher between a storage position, a presentation position, and a milking position to protect the detacher from damage and provide a superior ergonomic design that reduces operator fatigue and turnover.

Abstract: A hand brake lever, especially for a motor vehicle, includes at least two tubes (2, 3) telescopically inserted into each other for actuating a locking device (5) of a parking brake. The tubes (2, 3) automatically lock in any pulled-out position and actuation of a device corresponding to the tubes (2, 3) causes the release of the locking device (5).

Abstract: The present invention relates to a method for determining the enantioselectivity of kinetic resolution processes and of asymmetrically proceeding reactions of prochiral compounds bearing enantiotopic groups by using isotope-labeled substrates so that the reaction products can be quantitatively determined with an isotope-specific detection system, e.g., an ESI mass spectrometer. In connection with automated sample charging, the method can be employed for high throughput screening. The relevant enantioselective conversions can be induced by chiral homogeneous or heterogeneous catalysts, biocatalysts or stoichiometric amounts of optically active agents.

Abstract: A rotary milking parlor milker detacher having a pivoting support arm and retracting chain arrangement that is synchronized with a rotating platform position to move the detacher between a storage position, a presentation position, and a milking position to protect the detacher from damage and provide a superior ergonomic design that reduces operator fatigue and turnover.

Abstract: Use of the N-phenyl-2-pyrimidine-amine derivatives of formula I, in which the symbols and substituents have the meaning as given herein in free form or in pharmaceutically acceptable salt form in the manufacture of a pharmaceutical composition for the treatment of allergic rhinitis, allergic dermatitis, drug allergy or food allergy, angioedema, urticaria, sudden infant death syndrome, bronchopulmonary aspergillosis, multiple sclerosis or mastocytosis.

Abstract: A rotary milking parlor milker detacher having a pivoting support arm and retracting chain arrangement that is synchronized with a rotating platform position to move the detacher between a storage position, a presentation position, and a milking position to protect the detacher from damage and provide a superior ergonomic design that reduces operator fatigue and turnover.

Abstract: 4-(4-methylpiperazin-1-ylmethyl)-N-[4-methyl-3-(4-pyridin-3-yl)pyrimidin-2-ylamino)phenyl]-benzamide of the formula I 1

Abstract: The present invention utilizes nucleic acid microarray technology to identify changes in the host endothelial cell transcription pattern that occurs during the latent and lytic phase of the KSHV life cycle. The production or activity of some genes up regulated during the lytic cycle were subsequently inhibited, and two such targets were shown to have a role in expression of late viral genes. Using this combined approach we have identified cellular pathways previously unknown to be important for KSHV infection, and present evidence for the efficiency of the novel antiviral approaches thus discovered. In addition, the present invention identifies a wide variety of endothelial cells genes and pathways that are involved in a variety of endothelial cell-mediated activity, including angiogenesis and transformation.

Abstract: The present invention provides an inexpensive and sensitive system and method for detecting analytes present in a medium. The system comprises a diffraction enhancing element, such as functionalized microspheres, which are modified such that they are capable of binding with a target analyte. Additionally, the system comprises a polymer film, which may include a metal coating, upon which is printed a specific, predetermined pattern of a analyte-specific receptors. Finally, the system includes a wicking agent which permits the system to be a single step system which avoids the necessity of any additional rinsing steps. Upon attachment of a target analyte to select areas of the polymer film, either directly or with the diffraction enhancing element, diffraction of transmitted and/or reflected light occurs via the physical dimensions and defined, precise placement of the analyte. A diffraction image, such as a hologram, is produced which can be easily seen with the eye or, optionally, with a sensing device.

Abstract: A mechanical shape sensor measures and provides a two-dimensional representation of the contour of a person's thighs and buttocks or the dorsal and lateral surfaces of a person's trunk for facilitating the fabrication of custom contoured seat cushions such as for use in a wheelchair. The mechanical shape sensor is integrated in a chair-like base capable of multiple adjustments to accommodate a range of dimensions and sizes of persons being measured. The mechanical shape sensor converts the three-dimensional contoured support surface of a person seated on an array of movable support elements into a two-dimensional format which is recorded on a data sheet in a form which is easily transmitted via telecommunications link to a central locatin for fabricating a custom contoured seat cushion. Each of the moveable support elements is coupled to a position marker in the data recorder.

Abstract: A seating system includes seat and back internal support frames disposed within respective foam-filled seat and back cushions which each have an outer fabric cover. The back assembly is provided with a pair of quick-release clip locks, while the seat assembly includes a plurality of support hooks in combination with mounting brackets and locking mechanisms to facilitate quick mounting and removal of the seat from a support frame such as a wheelchair base. The seat and back assemblies are coupled together in a pivoting manner by means of a handle assembly which allows the seat to be compactly folded and easily carried when removed from a support base. The back inner support frame includes upper and lower support subassemblies pivotally coupled by means of a hinge joint which allows for extension of the lumbar region when the upper support subassembly is moved rearwardly to a reclined position.

Abstract: A seating system includes seat and back internal support frames disposed within respective foam-filled seat and back cushions which each have an outer fabric cover. The back assembly is provided with a pair of quick-release clip locks, while the seat assembly includes a plurality of support hooks in combination with mounting brackets and locking mechanism to facilitate quick mounting and removal of the seat from a support frame such as a wheelchair base. The seat and back assemblies are coupled together in a pivoting manner by means of a handle assembly which alows the seat to be compactly folded and easily carried when removed from a support base. The back inner support frame includes upper and lower support subassemblies pivotally coupled by means of a hinge joint which allows for extension of the lumbar region when the upper support subassembly is moved rearwardly to a reclined position.

Abstract: Apparatus for taking body measurements of a seated person for making individually sized seat and back support cushions includes a foldable frame having a first leg/buttocks rule and a second height rule pivotally coupled together and adapted for positioning adjacent the leg/buttocks and back portions, respectively, of a person positioned thereon. The height rule is moveable along the length of the leg/buttocks rule upon which the person being measured is seated for measuring the distance from the seated person's buttocks to his or her knees. A moveable, generally V-shaped bracket adapted for engaging the person's shoulders is attached to the height rule and allows the person's seat-to-shoulder dimension to be measured. A moveable third rule attached to the leg/buttocks rule and disposed between its knee engaging end and the height rule includes a pair of moveable hip engaging paddles for measuring the person's hip width.

Abstract: A seating system includes seat and back internal support frames disposed within respective foam-filled seat and back cushions which each have an outer fabric cover. The back assembly is provided with a pair of quick-release clip locks, while the seat assembly includes a plurality of support hooks in combination with mounting brackets and locking mechanisms to facilitate quick mounting and removal of the seat from a support frame such as a wheelchair base. The seat and back assemblies are coupled together in a pivoting manner by means of a handle assembly which allows the seat to be compactly folded and easily carried when removed from a support base. The back inner support frame includes upper and lower support subassemblies pivotally coupled by means of a hinge joint which allows for extension of the lumbar region when the upper support subassembly is moved rearwardly to a reclined position.

Abstract: A seating system includes seat and back internal support frames disposed within respective foam-filled seat and back cushions which each have an outer fabric cover. The back assembly is provided with a pair of quick-release clip locks, while the seat assembly includes a plurality of support hooks in combination with mounting brackets and locking mechanisms to facilitate quick mounting and removal of the seat from a support frame such as a wheelchair base. The seat and back assemblies are coupled together in a pivoting manner by means of a handle assembly which allows the seat to be compactly folded and easily carried when removed from a support base. The back inner support frame includes upper and lower support subassemblies pivotally coupled by means of a hinge joint which allows for extension of the lumbar region when the upper support subassembly is moved rearwardly to a reclined position.

Abstract: Apparatus for measuring and providing a two-dimensional representation of the contour of a person's thighs and buttocks or the dorsal and lateral surfaces of a person's trunk facilitates the fabrication of custom contoured seat cushions such as for use by wheelchair users. The apparatus includes a frame having a rectangular matrix of compressible, resilient support elements with a generally flat upper surface. Attached to the upper surface of each support element is one end of a flexible, incompressible cable which is inserted through a conduit with a 90.degree. bend for directing the cable toward and beyond a side of the frame. Second end portions of the cable and conduit combinations are in parallel, planar alignment. The cable is free to move within and along the length of the conduit such that downward displacement of the upper surface of a support element and first end of a cable coupled thereto causes the cable's second end to be moved outward from the frame.