Abstract: A roller casting method produces a spiral structure, in particular a spiral structure for use in electric machines. Molten metal is supplied between a first roller and a second roller miming opposite thereto, wherein the first roller has first teeth, and the second roller has second teeth, said first and/or second teeth having tooth flanks with cavities for receiving the supplied molten metal. The teeth are designed and aligned such that the cavity of at least one tooth is at least temporarily delimited by the surface of a tooth of the other roller when the rollers are rotating such that the supplied molten metal is molded between the teeth while cooling and is molded into a section of the spiral structure.

Abstract: The present invention relates to an arrangement for low-pressure casting of refractory metals, with a furnace chamber with one or a plurality of gas supply openings (6) and gas outlet openings (7), and a riser pipe (8) through a cover (5) of the furnace chamber, a melting container (3, 12) for the refractory metals arranged in the furnace chamber, and a heating device for heating the refractory metals in the melting container (3, 12). In the proposed arrangement, the melting container (3, 12) is formed as an exchangeable insert for a receiving mould (2) supporting the melting container (3, 12), which is arranged in the furnace chamber, wherein a thermally insulating layer (4, 17) is formed between the receiving mould (2) and the melting container (3, 12), or is integrated into the melting container (3, 12). With the proposed arrangement, a quick and easy exchange of the melting container for different alloys can also be carried out in the low-pressure casting of refractory metals.

Abstract: The invention relates to an electrotechnical coil, to a method for producing same, and to an electromagnet or an electric machine comprising at least one such coil. The aim of the invention is to produce and use an electrotechnical coil for achieving an increased slot fill factor reliably and easily in a reproducible and economical manner. This is achieved in that the method according to the invention has the steps: step A: casting an electrotechnical coil with at least one winding which runs about a coil axis; and step B: shaping the coil, thereby changing the cross-section Q, Q? of the at least one winding, such that the centroid FS, FS? of the cross-section Q, Q? of the at least one winding is displaced at least partly in the radial direction R relative to the coil axis A.

Abstract: The present invention relates to an arrangement for low-pressure casting of refractory metals, with a furnace chamber with one or a plurality of gas supply openings (6) and gas outlet openings (7), and a riser pipe (8) through a cover (5) of the furnace chamber, a melting container (3, 12) for the refractory metals arranged in the furnace chamber, and a heating device for heating the refractory metals in the melting container (3, 12). In the proposed arrangement, the melting container (3, 12) is formed as an exchangeable insert for a receiving mould (2) supporting the melting container (3, 12), which is arranged in the furnace chamber, wherein a thermally insulating layer (4, 17) is formed between the receiving mould (2) and the melting container (3, 12), or is integrated into the melting container (3, 12). With the proposed arrangement, a quick and easy exchange of the melting container for different alloys can also be carried out in the low-pressure casting of refractory metals.

Abstract: The invention relates to a method for producing a helix (2). A permanent mold with mold halves which can be joined together on a mold separation plane is provided. The mold halves of the permanent mold are joined together such that the permanent mold has a cavity, which defines the shape of the helix (2) or the shape of a bent-up helix, when the permanent mold is joined together. The specified helix (2) or the bent-up helix has a flattened profiled winding cross-section which has two opposite flat faces (2.1, 2.1?), an outer face and an inner face (2.3) opposite the outer face. The mold separation plane runs at least partly along the flat faces (2.1, 2.1?) from the inner face to the outer face (2.3), wherein the permanent mold has a bulge (2.5) which extends along the mold separation plane and protrudes into the cavity at least in a region in which the mold separation plane runs along one of the flat faces (2.1, 2.1?) such that the cast body is provided with recesses (2.5) on the flat faces (2.1, 2.1?).

Abstract: The invention relates to a roller casting method for producing a spiral structure, in particular a spiral structure for use in electric machines. Molten metal is supplied between a first roller and a second roller miming opposite thereto, wherein the first roller has first teeth, and the second roller has second teeth, said first and/or second teeth having tooth flanks with cavities for receiving the supplied molten metal. The teeth are designed and aligned such that the cavity of at least one tooth is at least temporarily delimited by the surface of a tooth of the other roller when the rollers are rotating such that the supplied molten metal is molded between the teeth while cooling and is molded into a section of the spiral structure.

Abstract: The invention relates to a method for producing a helical metal body (?), in which initially a preformed, helical metal body is produced in a mould by a casting method and is subsequently compressed along its longitudinal axis by deformation.

Abstract: The invention relates to a method for producing a helix (2), having a step of providing a permanent mold (1) with mold halves (1.1, 1.2) which can be joined together on a mold parting line (1.5). The method additionally has a step of joining together the mold halves (1.1, 1.2) of the permanent mold (1) such that the permanent mold (1) has a cavity (1.3), which defines the shape of the helix (2) or the shape of a bent-up helix (2?), when the permanent mold is joined together, wherein the specified helix (2) or the bent-up helix (2?) has a flattened profiled winding cross-section which has two opposite flat sides (2.1, 2.1?), an outer side (2.2) and an inner side (2.3) opposite the outer side (2.2), and the mold parting line (1.5) runs at least partly along the outer side (2.2) and/or the inner side (2.1) and/or edges of the profiled winding cross-section. The method additionally has a step of removing burrs (3) extending on the outer side (2.2) and/or the inner side (2.

Abstract: The invention relates to a method for producing a coil (6), in which, by means of casting, a semi-finished product (5) in the form of an elongate conductor is formed in a cavity (2) of a casting tool and the coil (6) is formed following a demolding of the semi-finished product (5) by shaping this semi-finished product (5), wherein the form of the semi-finished product (5) may be derived from a shape of the finished coil (6) by stretching along a longitudinal axis of the coil (6) and/or by bending this longitudinal axis, and wherein the semi-finished product (5), during the shaping, is bent and compressed so that windings of the coil (5) already present in the semi-finished product (5) are brought closer to one another at least in some regions during the shaping and are brought into an arrangement along the longitudinal axis of the finished coil (6), wherein the conductor, whilst being shaped, is twisted or bent by no more than a right angle over the course of each individual turn.

Abstract: A casting device having a casting mold and a core for producing a helical casting is described. The may have an expendable core that can be dissolved after the casting process. Advantageous effects of the device and process can be achieved by virtue of the fact that the female mold for accommodating the helical casting during the casting process is formed completely within the outer contour of the core, the female mold being delimited by the core and, at the peripheral boundary surfaces of the female mold, by the casting mold.

Abstract: The present invention relates to combinations of at least two components, component A and component B, component A being an inhibitor of mlDH 1, and component B being a DNA hypomethylating agent. Another aspect of the present invention relates to the use of such combinations as described supra for the preparation of a medicament for the treatment or prophylaxis of a disease.

Abstract: A casting device having a casting mold and a core for producing a helical casting is described. The may have an expendable core that can be dissolved after the casting process. Advantageous effects of the device and process can be achieved by virtue of the fact that the female mold for accommodating the helical casting during the casting process is formed completely within the outer contour of the core, the female mold being delimited by the core and, at the peripheral boundary surfaces of the female mold, by the casting mold.

Abstract: A method for producing an electrically conductive component having a cavity is described. An efficient production method for such a component, which allows a high variability of the wall thickness of the component, is implemented by applying a load-bearing layer consisting of an electrically conductive material to a soluble substrate and then dissolving and at least partially removing the substrate.

Abstract: One method for producing a cast body is described. The method may have one step for producing one or more insert parts. The one or more insert parts are provided in a casting mold of an injection molding tool such that a cavity corresponding to the shape of the cast body is formed by the one or more insert parts or by the one or more insert parts together with the casting mold. The cavity is filled with a molding compound containing a powder of a sinterable material. A green part may be produced by solidifying the molding compound. An intermediate product may be removed from the injection molding tool where the intermediate part may have the green part and the one or more insert parts. The one or more insert parts may be removed from the intermediate product. Further, the green part may be debinded and sintered.

Abstract: The invention relates to an electrotechnical coil, to a method for producing same, and to an electromagnet or an electric machine comprising at least one such coil. The aim of the invention is to produce and use an electrotechnical coil for achieving an increased slot fill factor reliably and easily in a reproducible and economical manner. This is achieved in that the method according to the invention has the steps: step A: casting an electrotechnical coil with at least one winding which runs about a coil axis; and step B: shaping the coil, thereby changing the cross-section Q, Q? of the at least one winding, such that the centroid FS, FS? of the cross-section Q, Q? of the at least one winding is displaced at least partly in the radial direction R relative to the coil axis A.

Abstract: A metal casting method and a plastic injection molding method in which an insert is molded in molten material such that no molten material enters the interior of the insert. The usage of a wire thread insert as insert has the advantage that for example in an aluminum cast part thread holes can be produced already as part of the casting process. For this purpose, the casting mold, the insert, as well as the casting method are described.

Abstract: The present invention relates to a pharmaceutical composition comprising a compound of formula (I) and methods of treating or preventing cell proliferation disorders comprising administering to a subject a therapeutically active amount or a preventive amount of such a compound.

Abstract: A metal casting method and a plastic injection molding method in which an insert is molded in molten material such that no molten material enters the interior of the insert. At the usage of a wire thread insert as insert this has the advantage that for example in an aluminum cast part thread holes can be produced already as part of the casting process. For this purpose, the present disclosure describes an the casting mold, the insert as well as the casting method.

Abstract: The present invention relates to a pharmaceutical composition comprising a compound of formula (I) and methods of treating or preventing cell proliferation disorders comprising administering to a subject a therapeutically active amount or a preventive amount of such a compound.

Abstract: The invention provides methods, uses, kits and compositions comprising a therapeutically effective amount of the microRNA miR-223 for treating myelogenous leukemia in a subject in need of such treatment. The invention further comprises methods encompassing the use of miR-223 for promoting the differentiation of a leukemia stem cell that is resistant to a differentiating agent, and a method of screening for candidate compounds capable of treating a myeloid leukemia by comparison of the therapeutic activity of the candidate compound with the therapeutic activity of miR-233.