Abstract: The present invention provides the use of all-trans retinoic acid for the production of a pharmaceutical composition for the treatment of acute myeloid leukemia, which use is characterized in that the patients are selected from the group of non-M3 acute myeloid leukemia patients according to a physiologic concentration, e.g. a level of MN1 below a certain critical level analysed in total blood cells, preferably analysed in bone marrow cells. The critical level of MN1 can be determined according to known methods, e.g. by specific determination of the presence of MN1, e.g. using specific anti-MN1 antibody, e.g. in an ELISA or in another immuno specific assay. Preferably, the level of MN1 is determined at its transcription level, e.g. as the concentration of mRNA encoding MN1.

Abstract: The invention provides an analytical method for the determination of the susceptibility of a human patient suffering from breast cancer to anti-cancer treatment by providing an analytical method for determining the genetic predisposition of a patient in respect of susceptibility, e.g. responsiveness, to anti-cancer treatment, especially treatment using at least one chemotherapeutical agent and/or at least one anti-hormonal agent on the basis of analysis of a genetic marker.

Abstract: The invention provides methods, uses, kits and compositions comprising a therapeutically effective amount of the microRNA miR-223 for treating myelogenous leukemia in a subject in need of such treatment. The invention further comprises methods encompassing the use of miR-223 for promoting the differentiation of a leukemia stem cell that is resistant to a differentiating agent, and a method of screening for candidate compounds capable of treating a myeloid leukemia by comparison of the therapeutic activity of the candidate compound with the therapeutic activity of miR-233.

Abstract: An optical control system including a mount for an optical component is disclosed that provides the flexibility of independently adjusting the position and orientation of the optical component along and about one or more axes. In an exemplary embodiment, the mount includes a support element for supporting the optical component; one or more rotational adjustment elements for rotating said support element independently about one or more axes, respectively; and one or more linear adjustment elements for moving said support element independently along one or more axes. The adjustment elements may be manually adjustable and/or may be adjustable by an actuator. In the latter case, the actuator may be electronically controlled by a controller. The optical component may be a reflective, transmissive, or reflective/transmissive optical device, such as diffraction gratings, mirrors, beam splitters, and others.

Abstract: The invention relates to the use of a genetic marker in a process for analysis of leukemia patients, especially for use in the prediction of the suitability of chemotherapy in a group of leukemia patients. Further, the invention relates to chemotherapeutical agents for use in the therapy of leukemia patients that have been diagnosed to be at least heterozygous for the relevant allele of the genetic marker.

Abstract: An optical control system including a mount for an optical component is disclosed that provides the flexibility of independently adjusting the position and orientation of the optical component along and about one or more axes. In an exemplary embodiment, the mount includes a support element for supporting the optical component; one or more rotational adjustment elements for rotating said support element independently about one or more axes, respectively; and one or more linear adjustment elements for moving said support element independently along one or more axes. The adjustment elements may be manually adjustable and/or may be adjustable by an actuator. In the latter case, the actuator may be electronically controlled by a controller. The optical component may be a reflective, transmissive, or reflective/transmissive optical device, such as diffraction gratings, mirrors, beam splitters, and others.

Abstract: The present invention provides the use of all-trans retinoic acid for the production of a pharmaceutical composition for the treatment of acute myeloid leukemia, which use is characterized in that the patients are selected from the group of non-M3 acute myeloid leukemia patients according to a physiologic concentration, e.g. a level of MN1 below a certain critical level analysed in total blood cells, preferably analysed in bone marrow cells. The critical level of MN1 can be determined according to known methods, e.g. by specific determination of the presence of MN1, e.g. using specific anti-MN1 antibody, e.g. in an ELISA or in another immuno specific assay. Preferably, the level of MN1 is determined at its transcription level, e.g. as the concentration of mRNA encoding MN1.

Abstract: The present application disclosed various embodiments of kinematic optical mounts which include a first body member having at least one hinge extension defining at least one hinge passage extending therefrom and a mount surface configured to receive at least one optical component thereon, one or more positioning registers formed on the hinge extension, a second body member having a hinge recess sized to receive the hinge extension therein and at least one coupling body, one or more positioning elements in communication with the second body member and configured to be force biased to engage the positioning registers, and at least one biasing member configured to apply a constant biasing force to one or more hinge bearing members, thereby forcing the bearing members engage at least one bearing engaging member in communication with the second body member thereby coupling the first body member to the second body member.

Abstract: The invention pertains to a navigation system, for example, for a motor vehicle, as well as to a method for simultaneously displaying isolines and a road map. The navigation system comprises a processor as well as a display device for displaying a road map. The invention is characterized in that the processor is designed for selecting isoline data and for displaying isolines (1, 2, 3, 4 . . . ) on the display device, wherein the illustrated road map and the isolines that correspond to the illustrated road map can be superimposed on the display device. The invention allows a much better and intuitive orientation for the user with the aid of the expanded illustration on the monitor of the navigation system. The method and navigation system ensure a technically robust combination of existing road maps and separate isoline data, namely of any arbitrary origin, which can be realized in a cost-efficient fashion.

Abstract: A mount for an optical component is disclosed that provides the flexibility of independently adjusting the position and orientation of the optical component along and about one or more axes. In an exemplary embodiment, the mount includes a support element for supporting the optical component; one or more rotational adjustment elements for rotating said support element independently about one or more axes, respectively; and one or more linear adjustment elements for moving said support element independently along one or more axes. The adjustment elements may be manually adjustable and/or may be adjustable by an actuator. In the latter case, the actuator may be electronically controlled by a controller. The optical component may be a reflective, transmissive, or reflective/transmissive optical device, such as diffraction gratings, mirrors, beam splitters, and others.

Abstract: The present application disclosed various embodiments of kinematic optical mounts which include a first body member having at least one hinge extension defining at least one hinge passage extending therefrom and a mount surface configured to receive at least one optical component thereon, one or more positioning registers formed on the hinge extension, a second body member having a hinge recess sized to receive the hinge extension therein and at least one coupling body, one or more positioning elements in communication with the second body member and configured to be force biased to engage the positioning registers, and at least one biasing member configured to apply a constant biasing force to one or more hinge bearing members, thereby forcing the bearing members engage at least one bearing engaging member in communication with the second body member thereby coupling the first body member to the second body member.

Abstract: A device for supporting at least one optical component is disclosed and includes an optical component mount configured to engage and retain at least one optical component therein, a support member attached to the optical component mount, a support body having at least one longitudinal passage sized to receive the support member therein, the longitudinal passage in communication with at least one opening formed on the support body, a radial compression member in communication with the longitudinal passage and configured to radially compress the support member thereby coupling the support member to the support body, and at least one securing device attachable to the support body and configured to radially compress the radial compression member.

Abstract: An automatic handling assembly that can load and unload photonic package components into a laser station. The laser station may include three lasers that weld the package components in a horizontal position. The package components may include a sleeve coupled to an optical fiber and a fiber package. The package may be mounted to a yoke that may “gimbal” about tooling plates. The yoke may include vacuum pulled friction bands that lock and unlock the position of the package. The package tooling may also have an actuator to apply a biasing force to the yoke to offset the affects of gravity. Additionally, the package tooling may have an actuator that can couple and de-couple electrical contacts to the yoke.

Abstract: An automatic handling assembly that can load and unload photonic package components into a laser station. The laser station may include three lasers that weld the package components in a horizontal position. The package components may include a sleeve coupled to an optical fiber and a fiber package. The package may be mounted to a yoke that may “gimbal” about tooling plates. The yoke may include vacuum pulled friction bands that lock and unlock the position of the package. The package tooling may also have an actuator to apply a biasing force to the yoke to offset the affects of gravity. Additionally, the package tooling may have an actuator that can couple and de-couple electrical contacts to the yoke.