Abstract: This disclosure relates to methods of reducing itch in patients with atopic dermatitis and treating patients with atopic dermatitis by administering a topical 0.75% or 1.5% ruxolitinib cream two times per day.

Abstract: This disclosure relates to methods of reducing itch in patients with atopic dermatitis and treating patients with atopic dermatitis by administering a topical 0.75% or 1.5% ruxolitinib cream two times per day.

Abstract: A post joint assembly and a method are provided. The assembly includes an upper cup member having a flat top wall, a tubular wall, a flange portion, and a threaded stud. The assembly further includes a lower cup member having a parabolic dish portion, a tubular portion, and a beaded edge portion. An outer surface of the parabolic dish portion is disposed against an inner surface of the flange portion of the upper cup member such that the threaded stud extends through a first hole in the lower cup member. The assembly further includes a tensioner cup having a second hole with the threaded stud extending therethrough. The assembly further includes a nut threadably coupled to the threaded stud such that the nut urges the tensioner cup against the lower cup member, and further urges the lower cup member against the upper cup member.

Abstract: Disclosed herein is a method of quantifying mutation burden of skin based on genomic mutations. In some instances, also described herein are methods of reducing skin cancer risk, such as that caused by UV damage or other environmental factor.

Abstract: A post joint assembly and a method are provided. The assembly includes an upper cup member having a flat top wall, a tubular wall, a flange portion, and a threaded stud. The assembly further includes a lower cup member having a parabolic dish portion, a tubular portion, and a beaded edge portion. An outer surface of the parabolic dish portion is disposed against an inner surface of the flange portion of the upper cup member such that the threaded stud extends through a first hole in the lower cup member. The assembly further includes a tensioner cup having a second hole with the threaded stud extending therethrough. The assembly further includes a nut threadably coupled to the threaded stud such that the nut urges the tensioner cup against the lower cup member, and further urges the lower cup member against the upper cup member.

Abstract: The aerosol actuator includes a shroud. An actuation member situated within the shroud has a stem bore pocket adapted to receive the valve stem of the aerosol container. In high speed production, entrance of the stem into the pocket as the shroud is mounted on the aerosol container is facilitated by providing the pocket with a plurality of inwardly extending compressible ribs and a tab extending from the shroud which stabilizes the actuation member within the shroud. The tab is pivoted out of the path of movement of the actuation member upon initial depression of the actuation member by the user. To prevent accidental depression of the actuation member by a top load, the shroud wall is extended above the plane of the surface of the actuation member.

Abstract: This disclosure relates to methods of reducing itch in patients with atopic dermatitis and treating patients with atopic dermatitis by administering a topical 0.75% or 1.5% ruxolitinib cream two times per day.

Abstract: Systems and methods with variable and customized functionality for pumping milk from a breast, wherein the milk is expressed from the breast under suction and milk is expulsed from the pumping mechanism to a collection container under positive pressure.

Abstract: The present disclosure relates to topical treatment of vitiligo using ruxolitinib, or a pharmaceutically acceptable salt thereof.

Abstract: The present disclosure relates to topical treatment of vitiligo using ruxolitinib, or a pharmaceutically acceptable salt thereof.

Abstract: The present disclosure relates to topical treatment of vitiligo using ruxolitinib, or a pharmaceutically acceptable salt thereof.

Abstract: The present invention relates to anti-IL-36R binding compounds, in particular new anti-IL-36R antibodies and therapeutic and diagnostic methods and compositions for using the same.

Abstract: A heuristically-driven platform and method for hiring based on previously-supported jobs and collected metrics solves the problem of efficiently connecting hiring agents and suitable job candidates. A portal application includes an inventory of successful placements and successful listings, allowing hiring agents to build job searches against a database of historical jobs. Leveraging the portal's inventory of placements and listings, the hiring agent may build a listing and design a candidate search based on previous listings, search venues for the same job type and metrics collected against each. An embodiment may provide the hiring agent a listing of the hiring agent's jobs, a list of applicants for each listed job and the detail for each applicant. The platform monitors applicant flow, online interviews, and site usage analytics for each position, suggesting alternatives and course corrections to the hiring agent if the performance of the job search is sub-par based on benchmarks.

Abstract: Embodiments of the present disclosure include a pig ramp for receiving and supporting a pig in a pig receiver includes a frame portion having an inner diameter, the inner diameter of the ring being larger than an outer diameter of a pig. The pig ramp also includes one or more ramp segments extending longitudinally away from the frame portion, the one or more ramp segments being coupled to a back side of the frame portion at a lower portion and positioned to receive and support the pig when positioned thereon to elevate the pig above a bottom of a tubular.

Abstract: An inhaler housing is described having a body for receiving an inhaler canister and a mouthpiece through which a dose from the inhaler canister is to be delivered. The body and the mouthpiece are rotatably coupled so that by turning the mouthpiece relative to the body the inhaler housing is converted between a carry configuration in which the mouthpiece and body are mutually aligned, and a use configuration in which the mouthpiece projects laterally from the body. The inhaler housing has a member which is variably elastically deformed as the mouthpiece is turned, investing the member with elastic potential energy minima corresponding to the carry configuration and the use configuration. Rotation of the mouthpiece relative to the body tends to stop when either of these configurations is reached.

Abstract: The present invention relates to anti-interleukin-36R (anti-IL-36R) binding compounds, in particular new anti-IL-36R antibodies and therapeutic and diagnostic methods and compositions for using the same.

Abstract: There is herein described a method and apparatus for the calibration and validation of motion picture scans.

Abstract: Embodiments of the present disclosure include a pig ramp for receiving and supporting a pig in a pig receiver includes a frame portion having an inner diameter, the inner diameter of the ring being larger than an outer diameter of a pig. The pig ramp also includes one or more ramp segments extending longitudinally away from the frame portion, the one or more ramp segments being coupled to a back side of the frame portion at a lower portion and positioned to receive and support the pig when positioned thereon to elevate the pig above a bottom of a tubular.

Abstract: A client device presents a user interface including a macro entry field for defining a macro indicator from a plurality of macro indicators and transmits the macro indicator. A server stores a database of macro-based diagnoses, each macro-based diagnosis associated with one or more elements of an accession, and one or more specimens associated with the accession. The server also receives the macro indicator from the client device, retrieves an initial diagnosis from the database of macro-based diagnoses responsive to the macro indicator, and transmits the initial diagnosis. The client device, receives the initial diagnosis, pre-populates one or more text boxes on the user interface with information from the initial diagnosis, and enables the user to edit the pre-populated one or more text boxes.