Abstract: A tool includes a housing, a drive assembly including an output shaft extending from the housing such that a tool element for performing work on a workpiece is attachable to the output shaft, and a bushing disposed within the housing. The bushing rotatably supports the output shaft. The bushing is impregnated with lubricant such that the bushing is self-lubricating, and the bushing has an impregnation ratio between about 5% and about 25%.

Abstract: In some examples, a system includes an article of personal protective equipment (PPE) having at least one sensor configured to generate a stream of usage data; and an analytical stream processing component comprising: a communication component that receives the stream of usage data; a memory configured to store at least a portion of the stream of usage data and at least one model for detecting a safety event signature, wherein the at least one model is trained based as least in part on a set of usage data generated by one or more other articles of PPE of a same type as the article of PPE; and one or more computer processors configured to: detect the safety event signature in the stream of usage data based on processing the stream of usage data with the model, and generate an output in response to detecting the safety event signature.

Abstract: A coated substrate comprising a coating extending over at least a part of the substrate. The coating is obtainable from a coating composition comprising (a) a polymeric binder; and (b) a feathering reducing agent comprising a carboxylic acid reactive functional group. The coated portion of the substrate comprises a pretreatment layer. The pretreatment layer is obtainable from a pretreatment composition that comprises a trivalent chromium compound. The invention extends to a method of coating a pre-treated substrate and a coated package, such as a metal can.

Abstract: A system, apparatus, and/or method is disclosed for—inter alia—producing a product. One or more financial characteristics relating to one or more sample products may be received. For each of the sample products, a value for each of one or more respective properties of the sample product may be received. The received values of the one or more respective properties of the sample products, the one or more received financial characteristics relating to the sample products, and a desired financial characteristic for a potential product may be input into the machine learning model. A value for each of the one or more respective properties for the potential product may be determined based on the desired financial characteristic for the potential product. A product having the determined value for each of the one or more respective properties for the potential product may be produced.

Abstract: The present invention provides compounds useful for the treatment of narcolepsy or cataplexy in a subject in need thereof. Related pharmaceutical compositions and methods are also provided herein.

Abstract: Described herein are systems and methods for performing peritoneal dialysis. According to one aspect, the disclosure provides a sterile interface connection for connecting a water purification system to a disposable source of dialysate concentrates. The sterile interface connection can include a chamber comprising an inlet adapted to be connected to the water purification system on a proximal end and a valve on a distal end. The sterile interface connection can also include spring-loaded needle disposed in the chamber. The spring-loaded needle can move between a retracted configuration in which the spring-loaded needle is fully retracted into the chamber and the valve is closed and sealed, and an extended configuration in which the spring-loaded needle extends through the valve into the disposable source of dialysate concentrates.

Abstract: Embodiments of the disclosure are in the field of advanced integrated circuit structure fabrication and, in particular, 10 nanometer node and smaller integrated circuit structure fabrication and the resulting structures. In an example, an integrated circuit structure includes a semiconductor substrate comprising an N well region having a semiconductor fin protruding therefrom. A trench isolation layer is on the semiconductor substrate around the semiconductor fin, wherein the semiconductor fin extends above the trench isolation layer. A gate dielectric layer is over the semiconductor fin. A conductive layer is over the gate dielectric layer over the semiconductor fin, the conductive layer comprising titanium, nitrogen and oxygen. A P-type metal gate layer is over the conductive layer over the semiconductor fin.

Abstract: Provided herein are compounds and compositions thereof for modulating IRAK4. In some embodiments, the compounds and compositions are provided for treatment of inflammatory or autoimmune diseases.

Abstract: Compounds having formula (I), and enantiomers, and diastereomers, stereoisomers, pharmaceutically-acceptable salts thereof, are useful as kinase modulators, including RIPK1 modulation. All the variables are as defined herein.

Abstract: Azaindole compounds and their use as inhibitors of HPK1 are described. The compounds are useful in treating HPK1-dependent disorders and enhancing an immune response. Also described are methods of inhibiting HPK1, methods of treating HPK1-dependent disorders, methods for enhancing an immune response, and methods for preparing the azaindole compounds.

Abstract: A method, system and computer-usable medium are disclosed for operating an endpoint agent at an endpoint device. Certain embodiments include a computer-implemented method for operating an endpoint agent at an endpoint device, including: operating the endpoint agent to selectively subscribe to events corresponding to activities occurring at an endpoint platform; processing events received from a message bus by the endpoint agent, where the events processed by the endpoint agent are events to which the endpoint agent has subscribed; and communicating, to a service, information corresponding to the events processed by the endpoint agent. Other embodiments of this aspect of the invention may include corresponding stand-alone and/or network computer systems, apparatus, and computer programs recorded on one or more computer storage devices, each configured to perform one or more of these actions.

Abstract: A coating composition comprising (a) a polyester binder material; and (b) a feathering reducing agent. The feathering reducing agent is selected from (i) an acrylic feathering reducing agent comprising a functional group selected from hydroxyl, epoxide, phosphatized epoxide and/or acid-functional; (ii) a hydroxy-functional polyester feathering reducing agent; (iii) a feathering reducing agent comprising a functional group selected from amine, amide, imine and/or nitrile; (iv) a phosphatized epoxy feathering reducing agent; (v) a phenolic resin feathering reducing agent; and/or (vi) a feathering reducing agent comprising an oxazolyl functional group. The invention extends to a substrate coated with the coating composition and use of the coating composition to reduce feathering.

Abstract: A battery electrode for an electrochemical cell that cycles lithium ions is described and includes: a first separator layer including a first side and a second side; a first conductive porous layer located on the first side of the first separator layer; and an active material layer to cycle lithium ions and including a first side and a second side, where the first side of the active material layer is in contact with the first conductive porous layer.

Abstract: Apparatus and methods for deployment of fixtures. The apparatus may include a system for controlling deployed fixtures. The system may receive user commands different devices in different formats. The fixtures may be independently addressable. The fixtures may be magnetically supported by a fixture support. A brace may join two or more fixture supports without reducing space available to support fixtures. The brace may join a fixture support to a fixture support accessory. An accessory may include a variable-angle junction. The fixture may include articulating joints for controlling the direction of a beam. The fixture may include a lens having an electrically controllable beam spread angle. The fixture may be stowable in the fixture support. The fixture may be slidable along a cord to adjust a height of the fixture. The fixture may include an extendable ring. The system may coordinate motions of the fixtures to follow a target. The fixture may include an elongated board.

Abstract: Systems and methods for use by a person lying in a generally prone or generally lateral position on a resting surface are disclosed. A system may include a head-mountable image display device that when used by the person at least partially occludes the person's view of a surrounding environment. The system may further include a support assembly configured to support at least a portion of the person's head in a raised position above or level with at least one of the resting surface and the head-mountable image display device. An opening may be formed in the support assembly that is sized to permit the person, while lying in the generally prone or generally lateral position, to view at least a portion of the head-mountable image display device through a portion of the support assembly. Methods of using such a system in a medical or other procedure are also disclosed.

Abstract: Apparatus and methods for deployment of fixtures. The apparatus may include a system for controlling deployed fixtures. The system may receive user commands different devices in different formats. The fixtures may be independently addressable. The fixtures may be magnetically supported by a fixture support. A brace may join two or more fixture supports without reducing space available to support fixtures. The brace may join a fixture support to a fixture support accessory. An accessory may include a variable-angle junction. The fixture may include articulating joints for controlling the direction of a beam. The fixture may include a lens having an electrically controllable beam spread angle. The fixture may be stowable in the fixture support. The fixture may be slidable along a cord to adjust a height of the fixture. The fixture may include an extendable ring. The system may coordinate motions of the fixtures to follow a target. The fixture may include an elongated board.

Abstract: A computer-implemented method of receiving and incrementally processing hierarchical data in a computing environment. Receiving hierarchical data within a computing environment. The computing environment including a plurality of interrelated components. Incrementally processing the hierarchical data to obtain processed portions. The incremental processing of the portions of hierarchical data able to be initiated with requiring receipt of the entirety of the hierarchical data. Maintaining an indexed representation of previously processed portions of the hierarchical data to prevent unnecessarily processing a same portion of the hierarchical data.

Abstract: Systems and methods described herein provide a high availability DHCP server capable of serving multiple tenants in a data center. The DHCP server may use a different logical DHCP server instance for each tenant, and may be implemented as one process without the use of namespaces. A DHCP server is executed on a gateway virtual machine (VM) that is capable of hosting a plurality of logical DHCP servers. For each tenant in a data center, a logical network and a corresponding logical DHCP server instance are implemented. The DHCP server may service requests for DHCP services from VMs via their physical host by determining the tenant that the VM originates from and leasing a DHCP resource from that tenant's corresponding logical DHCP server instance.

Abstract: A method for cooperative active-standby failover between service routers based on health of services configured on the service routers is presented. In an embodiment, a method comprises determining, by a first service router (“SR”) of a SR cluster, a plurality of aggregate score values for a plurality of SRs of the SR clusters. The SR cluster comprises the first SR which is active, and a second SR. An aggregate score value, of the plurality of aggregate score values, indicates health of one or more services configured on a SR. The method further comprises determining, based on the plurality of aggregate score values, whether the first SR, of the SR cluster, is healthier than the second SR. In response to determining that the first SR is healthier than the second SR, the first SR continues to operate in the active mode; otherwise, the first SR switches to a standby mode.

Abstract: This disclosure relates to methods, polynucleotides, vectors, viral particles, cells, and systems or the engineering of human tissues. One aspect of the disclosure relates to using lineage-specific miRNA binding molecules to bias tissue lineage. Another aspect of the disclosure relates to using lineage-specific transcription factor overexpression to bias tissue lineage.