Abstract: Methods and materials for treating a mammal having a congenital disease (e.g., a congenital heart disease such as congenital long QT syndrome) are provided herein. For example, this document provides methods and materials for generating and using nucleic acids to treat a mammal having a congenital disease, where the nucleic acids can suppress expression of mutant disease-related alleles in the mammal while providing a replacement cDNA that does not contain the disease-related mutation(s).

Abstract: Systems, methods, devices, and techniques for analyzing and applying features of a T-wave derived from an electrocardiogram. A computing system can receive a set of data that characterizes an electrocardiogram of a patient. The system can analyze the set of data to identify a T-wave that occurs in the electrocardiogram. The system can determine values of one or more features of the T-wave and provide the information that identifies the values of the one or more features of the T-wave to a user.

Abstract: Systems, methods, and other techniques for estimating the level of an analyte present in a patient during a time interval using electrocardiogram (ECG) signals. The estimate can be improved using information about the patient's posture.

Abstract: Systems, methods, devices, and techniques for analyzing and applying features of a T-wave derived from an electrocardiogram. A computing system can receive a set of data that characterizes an electrocardiogram of a patient. The system can analyze the set of data to identify a T-wave that occurs in the electrocardiogram. The system can determine values of one or more features of the T-wave and provide the information that identifies the values of the one or more features of the T-wave to a user.

Abstract: Systems, methods, and other techniques for estimating the level of an analyte present in a patient during a time interval using electrocardiogram (ECG) signals. The estimate can be improved using information about the patient's posture.

Abstract: Among the techniques described herein is a method that includes obtaining data indicating electrocardiogram results from a human. A plurality of beats represented in the electrocardiogram results can be identified. For each beat in the plurality of beats represented in the electrocardiogram results, a value for a first feature of the beat can be determined. Statistical analysis can be performed on the values for the first feature of the plurality of beats. An indication of the level of the analyte within the human can be generated based on a result of the statistical analysis performed on the values for the first feature of the plurality of beats. The indication of the level of the analyte within the human can be provided.

Abstract: This document describes, among other things, a computer-implemented method that includes accessing, by a computer system, electrogram data for a patient, wherein the electrogram data is obtained using one or more leads that sense physiological electrical activity of the patient. The computer system can identify one or more waveform features from the electrogram data, and one or more correlations between values of the one or more waveform features and analyte levels. One or more estimated analyte levels in the patient are determined based on 1) the one or more waveform features identified from the electrogram data and 2) the one or more correlations. The computer system can output information related to the one or more estimated analyte levels.

Abstract: The present invention relates to a powered vehicle. The powered vehicle includes a first frame assembly and a second frame assembly. A first axle is coupled to the first frame assembly and a second axle is coupled to the second frame assembly. The powered vehicle further includes a first powertrain assembly and a second powertrain assembly. The first powertrain assembly and second powertrain assembly are interchangeably coupled to the first axle and second axle.

Abstract: A work machine powered by an internal combustion engine having an exhaust aftertreatment device and air cleaner positioned over the top portion of the engine, which is mounted in the work machine chassis. A frame is releasably connected to the chassis through an adjustable mounting with three axis adjustment and the air cleaner is mounted to the frame. A carriage is releasably mounted to the frame and carries the exhaust aftertreatment device to enable independent removal for servicing and/or replacement.

Abstract: A method and associated apparatus for controlling fluid levels within an axle tube, the method comprising: (a) establishing a first predetermined level of a liquid lubricant within a transmission and an electric motor operatively coupled to the electric motor, the axle tube housing the electric motor and the transmission, where a cavity interposing a wall of the axle tube and the electric motor is occupied by the liquid lubricant reservoir at a second predetermined level; and, (b) lowering the first predetermined level of a liquid lubricant within the electric motor and the transmission by changing a gas pressure exerted upon the liquid lubricant, where changing the gas pressure exerted upon the liquid lubricant within the axle tube raises the second predetermined level of liquid lubricant within the cavity.

Abstract: The present disclosure provides a work machine having a frame and a front and rear wheel axle. The machine includes a cab coupled to the frame. The cab is configured to include controls for controlling the operation of the work machine. The machine also includes an electrically-powered drive assembly coupled to the frame and front and rear axles and an inverter electrically coupled to the electrically-powered drive assembly. The machine further includes a platform assembly disposed adjacent the cab and coupled to the frame. The platform assembly comprises an outer wall at least partially surrounding the inverter.

Abstract: The present disclosure provides a work machine having a frame and a front and rear wheel axle. The machine includes a cab coupled to the frame. The cab is configured to include controls for controlling the operation of the work machine. The machine also includes an electrically-powered drive assembly coupled to the frame and front and rear axles and an inverter electrically coupled to the electrically-powered drive assembly. The machine further includes a platform assembly disposed adjacent the cab and coupled to the frame. The platform assembly comprises an outer wall at least partially surrounding the inverter.

Abstract: A work machine powered by an internal combustion engine having an exhaust aftertreatment device and air cleaner positioned over the top portion of the engine, which is mounted in the work machine chassis. A frame is releasably connected to the chassis through an adjustable mounting with three axis adjustment and the air cleaner is mounted to the frame. A carriage is releasably mounted to the frame and carries the exhaust aftertreatment device to enable independent removal for servicing and/or replacement.

Abstract: A method and associated apparatus for controlling fluid levels within an axle tube, the method comprising: (a) establishing a first predetermined level of a liquid lubricant within a transmission and an electric motor operatively coupled to the electric motor, the axle tube housing the electric motor and the transmission, where a cavity interposing a wall of the axle tube and the electric motor is occupied by the liquid lubricant reservoir at a second predetermined level; and, (b) lowering the first predetermined level of a liquid lubricant within the electric motor and the transmission by changing a gas pressure exerted upon the liquid lubricant, where changing the gas pressure exerted upon the liquid lubricant within the axle tube raises the second predetermined level of liquid lubricant within the cavity.

Abstract: The present invention relates to a powered vehicle. The powered vehicle includes a first frame assembly and a second frame assembly. A first axle is coupled to the first frame assembly and a second axle is coupled to the second frame assembly. The powered vehicle further includes a first powertrain assembly and a second powertrain assembly. The first powertrain assembly and second powertrain assembly are interchangeably coupled to the first axle and second axle.

Abstract: Cells engineered to express a detectable hERG 1b polypeptide and methods for identifying agents that facilitate hERG 1b maturation using such cells are provided. A method for analyzing a biological sample for the presence of an amino acid substitution at position 8 of the hERG 1b N-terminus is further provided.

Abstract: This document provides methods and materials related to identifying, assessing, and predicting hypertrophic cardiomyopathy (HCM) in mammals. For example, methods and materials for using mutations (e.g., mutations in ZASP and MYBPC3 nucleic acids) to identify, assess, and predict HCM in mammals (e.g., humans) are provided.

Abstract: The present invention discloses four groups of SCN5A variants that represent the most common SCN5A variants in humans. A specific mutation in one of the variants has been shown to display a different phenotype in relation to a human heart disease than other variants and known human sodium channel ? subunits with corresponding mutations. The present invention provides new tools to study mutations and to design or identify new diagnostic and treatment strategies or agents for sodium channel related diseases or conditions.