Abstract: This document provides methods and materials related to assessing a mammal for the presence or absence of a genetic mutation. For example, methods for determining whether or not a mammal contains a genetic mutation in an RyR2 sequence are provided. In addition, isolated nucleic acid molecules containing an RyR2 sequence and encoding a mutation are provided herein.

Abstract: The invention features methods to detect T wave lability in an individual, and methods of using T wave lability to detect or monitor abnormal cardiac activities. An individual can be assessed for the risk of sudden death due to cardiovascular pathology using methods provided by the invention. The invention also features methods of obtaining a T wave lability index for an individual. The invention further features a computer-readable storage medium for calculating an individual's T wave lability index and an apparatus for obtaining same. In addition, the invention features an article of manufacture for chemically stressing an individual for the purpose of determining a T wave lability index.

Abstract: The present invention discloses four groups of SCN5A variants that represent the most common SCN5A variants in humans. A specific mutation in one of the variants has been shown to display a different phenotype in relation to a human heart disease than other variants and known human sodium channel &agr; subunits with corresponding mutations. The present invention provides new tools to study mutations and to design or identify new diagnostic and treatment strategies or agents for sodium channel related diseases or conditions.

Abstract: The invention features methods to detect T wave lability in an individual, and methods of using T wave lability to detect or monitor abnormal cardiac activities. An individual can be assessed for the risk of sudden death due to cardiovascular pathology using methods provided by the invention. The invention also features methods of obtaining a T wave lability index for an individual. The invention further features a computer-readable storage medium for calculating an individual's T wave lability index and an apparatus for obtaining same. In addition, the invention features an article of manufacture for chemically stressing an individual for the purpose of determining a T wave lability index.