Patents by Inventor Michael J. Hawkins

Michael J. Hawkins has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PYRAZOLOTHIAZOLE CARBOXAMIDES AND THEIR USES AS PDGFR INHIBITORS
    Publication number: 20240109917
    Abstract: The disclosure is directed to compounds of formula (I), and pharmaceutically acceptable salts thereof. Pharmaceutical compositions comprising compounds of formula (I), as well as methods of their use and preparation, are also described.
    Type: Application
    Filed: December 22, 2021
    Publication date: April 4, 2024
    Inventors: David BAUMAN, Zhijie LIU, Tianbao LU, Bin ZHU, Van NGUYEN, Marchello CAVITT, Michael J. HAWKINS
  • Lateral spondylolisthesis reduction cage
    Patent number: 11911287
    Abstract: An intervertebral fusion device comprising inferior and superior fusion cage devices that provide an ability to correct spondylolisthesis via in-situ adjustment.
    Type: Grant
    Filed: September 26, 2019
    Date of Patent: February 27, 2024
    Assignee: DePuy Synthes Products, Inc.
    Inventors: Michael J. O'Neil, Hassan Serhan, Douglas Raymond, John Riley Hawkins
  • Methods for treating cancers
    Patent number: 9974792
    Abstract: Disclosed are methods for treating a cancer in a subject (e.g., a human) in need thereof, comprising administering to the subject a therapeutically effective amount of a compound of formula I: or a pharmaceutically acceptable salt thereof. The subject may be very high risk or high risk for the cancer. The subject who has the cancer may also be refractory to at least one chemotherapy treatment, or is in relapse after treatment with chemotherapy, or both. The cancer may be a hematologic malignancy, such as leukemia or lymphoma.
    Type: Grant
    Filed: May 24, 2017
    Date of Patent: May 22, 2018
    Assignee: Gilead Sciences, Inc.
    Inventors: Julie Di Paolo, Michael J. Hawkins, Jing Hu, Feng Jin, Flordeliza Melchor-Khan, Anita Reddy
  • ANTIBODIES TO MATRIX METALLOPROTEINASE 9
    Publication number: 20180002446
    Abstract: The present disclosure provides compositions and methods of use involving binding proteins, e.g., antibodies and antigen-binding fragments thereof, that bind to the matrix metalloproteinase-9 (MMP9) protein (MMP9 is also known as gelatinase-B), such as where the binding proteins comprise an immunoglobulin (Ig) heavy chain (or functional fragment thereof) and an Ig light chain (or functional fragment thereof).
    Type: Application
    Filed: July 7, 2017
    Publication date: January 4, 2018
    Inventors: Joanne I. ADAMKEWICZ, Victoria SMITH, Zung THAI, Michael J. HAWKINS
  • METHODS FOR TREATING CANCERS
    Publication number: 20170258804
    Abstract: Disclosed are methods for treating a cancer in a subject (e.g., a human) in need thereof, comprising administering to the subject a therapeutically effective amount of a compound of formula I: or a pharmaceutically acceptable salt thereof. The subject may be very high risk or high risk for the cancer. The subject who has the cancer may also be refractory to at least one chemotherapy treatment, or is in relapse after treatment with chemotherapy, or both. The cancer may be a hematologic malignancy, such as leukemia or lymphoma.
    Type: Application
    Filed: May 24, 2017
    Publication date: September 14, 2017
    Inventors: Julie Di Paolo, Michael J. Hawkins, Jing Hu, Feng Jin, Flordeliza Melchor-Khan, Anita Reddy
  • Methods of treating rheumatoid arthritis using antibodies to matrix metalloproteinase 9
    Patent number: 9732156
    Abstract: The present disclosure provides compositions and methods of use involving binding proteins, e.g., antibodies and antigen-binding fragments thereof, that bind to the matrix metalloproteinase-9 (MMP9) protein (MMP9 is also known as gelatinase-B), such as where the binding proteins comprise an immunoglobulin (Ig) heavy chain (or functional fragment thereof) and an Ig light chain (or functional fragment thereof).
    Type: Grant
    Filed: February 28, 2013
    Date of Patent: August 15, 2017
    Assignee: Gilead Biologics, Inc.
    Inventors: Joanne I. Adamkewicz, Victoria Smith, Zung Thai, Michael J. Hawkins
  • Methods for treating cancers
    Patent number: 9687492
    Abstract: Disclosed are methods for treating a cancer in a subject (e.g., a human) in need thereof, comprising administering to the subject a therapeutically effective amount of a compound of formula I: or a pharmaceutically acceptable salt thereof. The subject may be very high risk or high risk for the cancer. The subject who has the cancer may also be refractory to at least one chemotherapy treatment, or is in relapse after treatment with chemotherapy, or both. The cancer may be a hematologic malignancy, such as leukemia or lymphoma.
    Type: Grant
    Filed: December 3, 2014
    Date of Patent: June 27, 2017
    Assignee: Gilead Sciences, Inc.
    Inventors: Julie Di Paolo, Michael J. Hawkins, Jing Hu, Feng Jin, Flordeliza Melchor-Khan, Anita Reddy
  • METHODS FOR TREATING CANCERS
    Publication number: 20150150881
    Abstract: Disclosed are methods for treating a cancer in a subject (e.g., a human) in need thereof, comprising administering to the subject a therapeutically effective amount of a compound of formula I: or a pharmaceutically acceptable salt thereof. The subject may be very high risk or high risk for the cancer. The subject who has the cancer may also be refractory to at least one chemotherapy treatment, or is in relapse after treatment with chemotherapy, or both. The cancer may be a hematologic malignancy, such as leukemia or lymphoma.
    Type: Application
    Filed: December 3, 2014
    Publication date: June 4, 2015
    Inventors: Julie Di Paolo, Michael J. Hawkins, Jing Hu, Feng Jin, Flordeliza Melchor-Khan, Anita Reddy
  • Phosphonic acid compounds as inhibitors of serine proteases
    Patent number: 8703957
    Abstract: The present invention is directed to phosphonic acid compounds useful as serine protease inhibitors, compositions thereof and methods for treating inflammatory and serine protease mediated disorders.
    Type: Grant
    Filed: June 19, 2013
    Date of Patent: April 22, 2014
    Assignee: Janssen Pharmaceutica NV
    Inventors: Michael N. Greco, Harold R. Almond, Jr., Michael J. Hawkins, Eugene Powell
  • Phosphonic acid compounds as inhibitors of serine proteases
    Patent number: 8609888
    Abstract: The present invention is directed to phosphonic acid compounds useful as serine protease inhibitors, compositions thereof and methods for treating inflammatory and serine protease mediated disorders.
    Type: Grant
    Filed: July 17, 2012
    Date of Patent: December 17, 2013
    Inventors: Michael N. Greco, Harold R. Almond, Jr., Michael J. Hawkins, Eugene Powell
  • NOVEL PHOSPHONIC ACID COMPOUNDS AS INHIBITORS OF SERINE PROTEASES
    Publication number: 20130281407
    Abstract: The present invention is directed to phosphonic acid compounds useful as serine protease inhibitors, compositions thereof and methods for treating inflammatory and serine protease mediated disorders.
    Type: Application
    Filed: June 19, 2013
    Publication date: October 24, 2013
    Inventors: Michael N. Greco, Harold R. Almond, Michael J. Hawkins, Eugene Powell
  • Method of treating asthma
    Patent number: 8546358
    Abstract: The present invention is directed to a method for treating or ameliorating asthma in a subject in need thereof comprising administering to the subject a therapeutically effective amount of compound 17:
    Type: Grant
    Filed: September 26, 2011
    Date of Patent: October 1, 2013
    Assignee: Janssen Pharmaceutica NV
    Inventors: Michael J. Hawkins, Michael N. Greco, Eugene Powell, Lawrence de Garavilla, Bruce E. Maryanoff
  • Phosphonic acid compounds as inhibitors of serine proteases
    Patent number: 8497373
    Abstract: The present invention is directed to phosphonic acid compounds useful as serine protease inhibitors, compositions thereof and methods for treating inflammatory and serine protease mediated disorders.
    Type: Grant
    Filed: May 15, 2012
    Date of Patent: July 30, 2013
    Assignee: Ortho-McNeil Pharmaceutical, Inc.
    Inventors: Michael N. Greco, Harold R. Almond, Jr., Lawrence de Garavilla, Michael J. Hawkins, Michael J. Humora, Yun Qian, Donald Gilmore Walker, Sergio Cesco-Cancian, Christopher Norman Nilsen, Mitul N. Patel, Kirk Leonard Sorgi, Eugene Powell
  • Phosphonic acid compounds as inhibitors of serine proteases
    Patent number: 8461195
    Abstract: The present invention is directed to phosphonic acid compounds useful as serine protease inhibitors, compositions thereof and methods for treating inflammatory and serine protease mediated disorders.
    Type: Grant
    Filed: December 20, 2010
    Date of Patent: June 11, 2013
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Michael N. Greco, Harold R. Almond, Jr., Michael J. Hawkins, Eugene Powell
  • Phosphonic acid compounds as inhibitors of serine proteases
    Patent number: 8394804
    Abstract: The present invention is directed to phosphonic acid compounds useful as serine protease inhibitors, compositions thereof and methods for treating inflammatory and serine protease mediated disorders.
    Type: Grant
    Filed: October 24, 2008
    Date of Patent: March 12, 2013
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Michael N. Greco, Harold R. Almond, Jr., Lawrence de Garavilla, Michael J. Hawkins, Michael J. Humora, Yun Qian, Donald Gilmore Walker, Sergio Cesco-Cancian, Christopher Norman Nilsen, Mitul N. Patel, Kirk Leonerd Sorgi, Eugene Powell
  • NOVEL PHOSPHONIC ACID COMPOUNDS AS INHIBITORS OF SERINE PROTEASES
    Publication number: 20120283221
    Abstract: The present invention is directed to phosphonic acid compounds useful as serine protease inhibitors, compositions thereof and methods for treating inflammatory and serine protease mediated disorders.
    Type: Application
    Filed: July 17, 2012
    Publication date: November 8, 2012
    Inventors: Michael N. Greco, Harold R. Almond, JR., Lawrence de Garavilla, Michael J. Hawkins, Michael J. Humora, Yun Qian, Donald Gilmore Walker, Sergio Cesco-Cancian, Christopher Norman Nillsen, Mitul N. Patel, Kirk Leonard Sorgi, Eugene Powell
  • Phosphonic acid compounds as inhibitors of serine proteases
    Patent number: 8304430
    Abstract: The present invention is directed to phosphonic acid compounds useful as serine protease inhibitors, compositions thereof and methods for treating inflammatory and serine protease mediated disorders.
    Type: Grant
    Filed: December 20, 2010
    Date of Patent: November 6, 2012
    Assignee: Ortho-McNeil Pharmaceutical, Inc.
    Inventors: Michael N. Greco, Harold R. Almond, Jr., Michael J. Hawkins, Eugene Powell
  • NOVEL PHOSPHONIC ACID COMPOUNDS AS INHIBITORS OF SERINE PROTEASES
    Publication number: 20120238528
    Abstract: The present invention is directed to phosphonic acid compounds useful as serine protease inhibitors, compositions thereof and methods for treating inflammatory and serine protease mediated disorders.
    Type: Application
    Filed: May 15, 2012
    Publication date: September 20, 2012
    Inventors: Michael N. Greco, Harold R. Almond, JR., Lawrence de Garavilla, Michael J. Hawkins, Michael J. Humora, Yun Qian, Donald Gilmore Walker, Sergio Cesco-Cancian, Christopher Norman Nilsen, Mitul N. Patel, Kirk Leonard Sorgi, Eugene Powell
  • Phosphonic acid compounds as inhibitors of serine proteases
    Patent number: 8247599
    Abstract: The present invention is directed to phosphonic acid compounds useful as serine protease inhibitors, compositions thereof and methods for treating inflammatory and serine protease mediated disorders.
    Type: Grant
    Filed: October 24, 2008
    Date of Patent: August 21, 2012
    Assignee: Ortho-McNeil Pharmaceutical, Inc.
    Inventors: Michael N. Greco, Harold R. Almond, Jr., Michael J. Hawkins, Eugene Powell
  • Phosphonic acid compounds as inhibitors of serine proteases
    Patent number: 8212039
    Abstract: The present invention is directed to phosphonic acid compounds useful as serine protease inhibitors, compositions thereof and methods for treating inflammatory and serine protease mediated disorders.
    Type: Grant
    Filed: December 20, 2010
    Date of Patent: July 3, 2012
    Assignee: Ortho-McNeil Pharmaceutical, Inc.
    Inventors: Michael N. Greco, Harold R. Almond, Jr., Michael J. Hawkins, Eugene Powell