Abstract: A system and method for growing and maintaining biological material including producing a protein associated with the tissue, selecting cells associated with the tissue, expanding the cells, creating at least one tissue bio-ink including the expanded cells, printing the at least one tissue bio-ink in at least one tissue growth medium mixture, growing the tissue from the printed at least one tissue bio-ink, and maintaining viability of the tissue.

Abstract: An autonomous vehicle having sensors advantageously varied in capabilities, advantageously positioned, and advantageously impervious to environmental conditions. A system executing on the autonomous vehicle that can receive a map including, for example, substantially discontinuous surface features along with data from the sensors, create an occupancy grid based upon the map and the data, and change the configuration of the autonomous vehicle based upon the type of surface on which the autonomous vehicle navigates. The device can safely navigate surfaces and surface features, including traversing discontinuous surfaces and other obstacles.

Abstract: Systems and methods for monitoring patients with respiratory diseases are described. A system may include a sensor circuit configured to sense one or more physiological signals indicative of respiratory sounds, and a spectral analyzer to generate first and second spectral contents at respective first and second frequency bands. The system may produce a respiratory anomaly indicator using the first and second spectral contents, or additionally with other physiological parameters. The system may detect an onset or progression of a target respiratory condition such as asthma or chronic obstructive pulmonary disease using the respiratory anomaly indicator, or to trigger or adjust a therapy.

Abstract: Embodiments herein relate to interactive medical visualization systems for visualizing stimulation lead placements and related methods. In an embodiment, a medical visualization system can be included having a video processing circuit, a central processing circuit in communication with the video processing circuit, and a user interface. The user interface can be generated by the video processing circuit and can include a three-dimensional model. The three-dimensional model can include at least a portion of a subject's anatomy and a graphic representation including at least one cancer therapy stimulation lead, and a visual thermal heating zone associated with the graphic representation of the at least one cancer therapy stimulation lead and/or a visual electrical field strength zone associated with the graphic representation of the at least one cancer therapy stimulation lead. Other embodiments are also included herein.

Abstract: A ventricularly implantable medical device that includes a sensing module that is configured to detect an atrial fiducial and identify an atrial contraction based at least on part on the detected atrial fiducial. Control circuitry in the implantable medical device is configured to deliver a ventricular pacing therapy to a patient's heart based at least in part on the identified atrial contraction, and can automatically switch or revert the ventricular pacing therapies on the fly.

Abstract: Systems and methods for implantable medical devices and headers are described. In an example, an implantable medical device includes a device container including an electronic module within the device container. A modular header core includes a first core module including a first bore hole portion of a first bore hole, the first bore hole portion configured to couple a first electrical component with the electronic module. A second core module includes a second bore hole portion of a second bore hole different than the first bore hole, the second bore hole portion configured to couple a second electrical component with the electronic module. The first core module is detachably engaged with the second core module. A header shell is disposed around the modular header core and attached to the device container.

Abstract: Embodiments herein relate to implantable cancer therapy electrodes with reduced magnetic resonance imaging artifacts. In an embodiment, a lead for a cancer treatment system can include a lead body with a proximal end and a distal end and defining a lumen, and one or more electric field generating electrodes, wherein the one or more electric field generating electrodes can be disposed along a length of the lead body. The one or more electric field generating electrodes include a ribbon wire with a thickness of the ribbon wire in a radial direction with respect to the lead body of less than 0.005 inches, or a walled tube with a thickness of the walled tube less than 0.005 inches, or a sputter coating with a thickness of the sputter coating in a radial direction with respect to a lead body of less than 0.005 inches. Other embodiments are also included herein.

Abstract: Systems and methods for implantable medical devices and headers are described. In an example, an implantable medical device includes a device container including an electronic module within the device container. A modular header core includes a first core module including a first bore hole portion of a first bore hole, the first bore hole portion configured to couple a first electrical component with the electronic module. A second core module includes a second bore hole portion of a second bore hole different than the first bore hole, the second bore hole portion configured to couple a second electrical component with the electronic module. The first core module is detachably engaged with the second core module. A header shell is disposed around the modular header core and attached to the device container.

Abstract: A system for delivering an implantable medical device includes a handle housing. An outer sheath is coupler secured to a proximal end of an outer sheath that is configured to cover at least a portion of the implantable medical device. An outer sheath drive assembly is operably coupled to the outer sheath coupler and is configured to translate the outer sheath relative to the handle housing. An actuation shaft coupler is secured to a proximal end of an activation shaft. An actuation shaft drive assembly is operably coupled to the actuation shaft coupler and is configured to cause the actuation shaft to translate relative to the handle housing and shift the implantable medical device from a first position and a second position in which the implantable medical device is radially expanded relative to the first position.

Abstract: A method of making a feed-thru connector assembly includes inserting a conductor within an opening within a housing of a pulse generator and dispensing a sealant in a gap between the conductor and portions of the housing adjacent to the conductor that define the opening of the housing and curing the sealant to form a seal comprising a polyisobutylene cross-linked network.

Abstract: Systems and methods for managing communication strategies between implanted medical devices. Methods include temporal optimization relative to one or more identified conditions in the body. A selected characteristic, such as a signal representative or linked to a biological function, is assessed to determine its likely impact on communication capabilities, and one or more communication strategies may be developed to optimize intra-body communication.

Abstract: A system and method is disclosed for controlling the performance of a pneumatically sealed trocar, wherein the system includes a controller for delivering variable DC voltage to a DC motor, a DC motor operatively connected to the controller for driving a pump operatively connected to a pneumatically sealed trocar, a pump driven by the DC motor for circulating pressurized gas through the pneumatically sealed trocar, and a sensor for sensing pressure and flow parameters between the pump and the pneumatically sealed trocar to provide a feedback control signal to the controller so that the controller can vary the voltage delivered to the DC motor to affect the output pressure and flow of the pump during a laparoscopic surgical procedure.

Abstract: This document discusses, among other things, systems and methods to determine an indication of contractility of a heart of a patient using received physiologic information, and to determine blood pressure information of the patient using the heart sound information and the determined indication of contractility of the heart. The system can include an assessment circuit configured to determine an indication of contractility of a heart of the patient using first heart sound (S1) information of the patient, and to determine blood pressure information of the patient using second heart sound (S2) information of the patient and the determined indication of contractility of the heart.

Abstract: Embodiments herein relate to medical device systems including electric field shaping elements for use in treating cancerous tumors within a bodily tissue. In an embodiment, a medical device system for treating a cancerous tumor is described. The medical device system can include one or more electric field generating electrodes and an electric field shaping element configured to be implanted along with the one or more electric field generating electrodes. The electric field shaping element can be made from a material that alters the spatial area of tissue exposed to the electric field. Other embodiments are also included herein.

Abstract: Embodiments herein relate to implantable medical devices including a fibrous cover layer. In an embodiment, an implantable medical device is included having a housing, an optical chemical sensing element disposed along the housing, and a fibrous electrospun cover layer, wherein the fibrous electrospun cover layer is disposed over the optical chemical sensing element. In another embodiment, a method of making an implantable medical device is included. The method can specifically include depositing an optical chemical sensing element into a sensor optical carrier attached to a housing and applying a fibrous electrospun cover layer over the optical chemical sensing element. Other embodiments are also included herein.

Abstract: Embodiments herein relate to chemical sensing elements including a rolled multilayer structure. In a first aspect, a method of making a chemical sensor element is included, the method including depositing a polymer layer onto a deposition substrate, infusing a chemical sensor composition into the polymer layer, applying a hydrogel layer over the polymer layer to form a multilayer film, rolling the multilayer film down the deposition substrate, and slicing the multilayer film to form the chemical sensor element. Other embodiments are also included herein.

Abstract: Embodiments herein relate to integrated thermo-photonic chemical sensors as part of an implantable sensing device. In a first aspect, an implantable sensing device is included having a sensing element, an optical excitation assembly configured to illuminate the sensing element, an optical detection assembly configured to receive optical signals from the sensing element, and a control circuit, wherein the control circuit is configured to receive signals from the optical detection assembly, receive signals reflecting temperature, and process signals from the optical detection assembly while adjusting for the signals reflecting temperature. Other embodiments are also included herein.

Abstract: An implantable medical device (IMD) that includes a housing, a first electrode secured relative to the housing, a second electrode secured relative to the housing, and a gyroscope secured relative to the housing. The IMD may include circuitry in the housing in communication with the first electrode, the second electrode, and the gyroscope. The circuitry may be configured to determine and store a plurality of torsion data measurements, from which a representation of a twist profile may be determined.

Abstract: A delivery system for an implantable medical device includes an outer shaft defining an outer shaft lumen and an inner shaft translatable within the outer shaft lumen, the inner shaft defining a lumen extending through the inner shaft. An actuation mechanism extends through the lumen and includes a coupler, a force translation rod that extends proximally from the coupler and a plurality of push pull rods that extend distally from the coupler and that releasably couple to the implantable medical device. The force translation rod includes a transition in electromagnetic permeability. The delivery system includes an inductive coil disposed relative to the force translation rod and positioned to detect a change in inductance resulting from the transition in electromagnetic permeability passing through the inductive coil.

Abstract: Systems and methods for rate-adaptive pacing are disclosed. In one illustrative embodiment, a medical device for delivering electrical stimulation to a heart may include a housing configured to be implanted on the heart or within a chamber of the heart, one or more electrodes connected to the housing, and a controller disposed within the housing. The controller may be configured to sense a first signal and determine a respiration rate based at least in part on the sensed first signal. In at least some embodiments, the controller may be further configured to adjust a rate of delivery of electrical stimulation by the medical device based at least in part on the determined respiration rate.