Patents by Inventor Michael J. Rice

Michael J. Rice has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Aryloxy and arylalkyleneoxy substituted imidazoquinolines
    Patent number: 8263594
    Abstract: Imidazoquinoline compounds with an aryloxy or arylalkyleneoxy substituent at the 6, 7, 8, or 9-position, pharmaceutical compositions containing the compounds, intermediates, and methods of use of these compounds as immunomodulators, for modulating cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases, are disclosed.
    Type: Grant
    Filed: January 18, 2011
    Date of Patent: September 11, 2012
    Assignee: 3M Innovative Properties Company
    Inventors: Kyle J. Lindstrom, Hugues M. H. Martin, Bryon A. Merrill, Michael J. Rice, Joshua R. Wurst, Chad A. Haraldson, Philip D. Heppner, Shri Niwas, Matthew R. Radmer
  • Substituted fused [1,2]imidazo[4,5-C] ring compounds and methods
    Patent number: 8093390
    Abstract: Fused [1,2]imidazo[4,5-c] ring compounds, e.g., fused [1,2]imidazo[4,5-c]quinolines and [1,2]imidazo[4,5-c]naphthyridines, with a substituent, e.g., a substituted alkoxy substituent, at the 6, 7, 8, or 9-position, pharmaceutical compositions containing the compounds, intermediates, methods of making and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are disclosed.
    Type: Grant
    Filed: February 10, 2006
    Date of Patent: January 10, 2012
    Assignee: 3M Innovative Properties Company
    Inventors: Michael J. Rice, Bryon A. Merrill, Philip D. Heppner
  • Aryloxy and arylalkyleneoxy substituted thiazoloquinolines and thiazolonaphthyridines
    Patent number: 8026366
    Abstract: Thiazoloquinoline and thiazolonaphthyridine compounds having an aryloxy or arylalkyleneoxy substituent at the 6-, 7-, 8-, or 9-position, pharmaceutical compositions containing the compounds, intermediates, and methods of making and methods of use of these compounds as immunomodulators, for modulating cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are disclosed.
    Type: Grant
    Filed: June 17, 2005
    Date of Patent: September 27, 2011
    Assignee: 3M Innovative Properties Company
    Inventors: Ryan B. Prince, Michael J. Rice, Joshua R. Wurst, Bryon A. Merrill, Tushar A. Kshirsagar, Philip D. Heppner
  • CHIRAL FUSED [1,2]IMIDAZO[4,5-c] RING COMPOUNDS
    Publication number: 20110207725
    Abstract: Fused [1,2]imidazo[4,5-c] ring compounds (e.g., imidazo[4,5-c]quinolines, 6,7,8,9-tetrahydroimidazo[4,5-c]quinolines, imidazo[4,5-c]naphthyridines, and 6,7,8,9-tetrahydroimidazo[4,5-c]naphthyridines) with a —CH(—X1—R1)-group in the fused ring at the 1-position of the imidazo ring, pharmaceutical compositions containing the compounds, intermediates, methods of making the compounds, and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases, are disclosed.
    Type: Application
    Filed: April 20, 2011
    Publication date: August 25, 2011
    Inventors: George W. Griesgraber, Tushar A. Kshirsagar, Azim A. Celebi, Sara J. Slania, Michael E. Danielson, Michael J. Rice, Joshua R. Wurst
  • ARYLOXY AND ARYLALKYLENEOXY SUBSTITUTED IMIDAZOQUINOLINES
    Publication number: 20110144099
    Abstract: Imidazoquinoline compounds with an aryloxy or arylalkyleneoxy substituent at the 6, 7, 8, or 9-position, pharmaceutical compositions containing the compounds, intermediates, and methods of use of these compounds as immunomodulators, for modulating cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases, are disclosed.
    Type: Application
    Filed: January 18, 2011
    Publication date: June 16, 2011
    Inventors: Kyle J. LINDSTROM, Hugues M. H. MARTIN, Bryon A. MERRILL, Michael J. RICE, Joshua R. WURST, Chad A. HARALDSON, Philip D. HEPPNER, Shri NIWAS, Matthew R. RADMER
  • Chiral fused [1,2]imidazo[4,5-C] ring compounds
    Patent number: 7943609
    Abstract: Fused [1,2]imidazo[4,5-c] ring compounds (e.g., imidazo[4,5-c]quinolines, 6,7,8,9-tetrahydroimidazo[4,5-c]quinolines, imidazo[4,5-c]naphthyridines, and 6,7,8,9-tetrahydroimidazo[4,5-c]naphthyridines) with a —CH(—X1—R1)-group in the fused ring at the 1-position of the imidazo ring, pharmaceutical compositions containing the compounds, intermediates, methods of making the compounds, and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases, are disclosed.
    Type: Grant
    Filed: December 29, 2005
    Date of Patent: May 17, 2011
    Assignee: 3M Innovative Proprerties Company
    Inventors: George W. Griesgraber, Tushar A. Kshirsagar, Azim A. Celebi, Sarah J. Slania, Michael E. Danielson, Michael J. Rice, Joshua R. Wurst
  • Aryloxy and arylalkyleneoxy substituted imidazoquinolines
    Patent number: 7897597
    Abstract: Imidazoquinoline compounds with an aryloxy or arylalkyleneoxy or hydroxy substituent at the 6, 7, 8, or 9-position, pharmaceutical compositions containing the compounds, intermediates, and methods of use of these compounds as immunomodulators, for modulating cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases, are disclosed.
    Type: Grant
    Filed: August 27, 2004
    Date of Patent: March 1, 2011
    Assignee: 3M Innovative Properties Company
    Inventors: Kyle J. Lindstrom, Hugues M. H. Martin, Bryon A. Merrill, Michael J. Rice, Joshua R. Wurst, Chad A. Haraldson, Tushar A. Kshirsagar, Philip D. Heppner, Shri Niwas, George W. Griesgraber, Matthew R. Radmer
  • Intermediates for imidazonaphthyridines
    Patent number: 7678918
    Abstract: Imidazonaphthyridine and tetrahydroimidazonaphthyridine compounds induce the biosynthesis of cytokines such as interferon and tumor necrosis factor. The compounds exhibit antiviral and antitumor properties. Methods of preparing the compounds and intermediates useful in the preparation of the compounds are disclosed.
    Type: Grant
    Filed: December 6, 2007
    Date of Patent: March 16, 2010
    Assignees: 3M Innovative Properties Company, Graceway Pharmaceuticals, LLC
    Inventors: John F. Gerster, Kyle J. Lindstrom, Stephen L. Crooks, Philip D. Heppner, Gregory J. Marszalek, Peter V. Maye, Bryon A. Merrill, John W. Mickelson, Michael J. Rice
  • Aryl substituted imidazoquinolines
    Patent number: 7598382
    Abstract: Aryl substituted imidazoquinoline compounds, pharmaceutical compositions containing the compounds, intermediates, and methods of use of these compounds as immunomodulators, for inducing or inhibiting cytokine biosynthesis in animals and in the treatment of diseases including viral, and neoplastic, are disclosed.
    Type: Grant
    Filed: January 13, 2006
    Date of Patent: October 6, 2009
    Assignee: Coley Pharmaceutical Group, Inc.
    Inventors: David S. Hays, Tushar Kshirsagar, Philip D. Heppner, Bryon A. Merrill, Michael E. Danielson, John F. Gerster, Chad A. Haraldson, Sarah Johannessen, Maureen A. Kavanagh, Kyle J. Lindstrom, Michael J. Rice, David J. Squire, Sarah A. Strong, Joshua R. Wurst
  • Polymorphs of 1-(2-Methylpropyl)-1H-Imidazo[4,5-C][1,5]Naphthyridin-4-Amine Ethane-Sulfonate
    Publication number: 20090124652
    Abstract: The invention provides various crystalline forms of 1-(2-methylpropyl)-1H-imidazo[4,5-c][1,5]naphthyridin-4-amine ethanesulfonate, pharmaceutical compositions, methods of making, and methods of use.
    Type: Application
    Filed: December 28, 2005
    Publication date: May 14, 2009
    Inventors: David Ach, Hughes Martin, Anna Van, Joel R. Jacobson, Junshi Y. Wu, Kyle J. Lindstrom, Tai T. Tran, Myles L. Brostrom, Michael J. Rice, Raymond D. Skwierczynski
  • Substituted Imidazoquinolines and Imidazonaphthyridines
    Publication number: 20090099161
    Abstract: Imidazoquinolines and imidazonaphthyridines with a substituent containing a functional group, e.g., an amide, sulfonamide, urea, or heterocyclyl group, at the 6, 7, 8, or 9-position, pharmaceutical compositions containing the compounds, intermediates, methods of making and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are disclosed.
    Type: Application
    Filed: February 10, 2006
    Publication date: April 16, 2009
    Applicant: Coley Pharmaceutial Group, Inc.
    Inventors: Michael J. Rice, Chad A. Haraldson, John F. Gerster, Joshua R. Wurst, Philip D. Heppner, Bryon A. Merrill, Tushar A. Kshirsagar
  • AMIDE SUBSTITUTED IMIDAZOQUINOLINES
    Publication number: 20090023722
    Abstract: Imidazoquinoline and tetrahydroimidazoquinoline compounds that contain amide functionality at the 1-position are useful as immune response modifiers. The compounds and compositions of the invention can induce the biosynthesis of various cytokines and are useful in the treatment of a variety of conditions including viral diseases and neoplastic diseases.
    Type: Application
    Filed: June 30, 2008
    Publication date: January 22, 2009
    Inventors: Patrick L. Coleman, Stephen L. Crooks, George W. Griesgraber, Kyle J. Lindstrom, Bryon A. Merrill, Michael J. Rice
  • Aryloxy and Arylalkyleneoxy Substituted Imidazoquinolines
    Publication number: 20090018122
    Abstract: Imidazoquinoline compounds with an aryloxy or arylalkyleneoxy or hydroxy substituent at the 6, 7, 8, or 9-position, pharmaceutical compositions containing the compounds, intermediates, and methods of use of these compounds as immunomodulators, for modulating cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases, are disclosed.
    Type: Application
    Filed: August 27, 2004
    Publication date: January 15, 2009
    Inventors: Kyle J. Lindstrom, Hugues M.H. Martin, Bryon A. Merrill, Michael J. Rice, Joshua R. Wurst, Chad A. Haraldson, Tushar A. Kshirsagar, Philip D. Heppner, Shri Niwas, George W. Griesgraber, Matthew R. Radmer
  • Substituted Fused [1,2]Imidazo[4,5-C] Ring Compounds and Methods
    Publication number: 20090005371
    Abstract: Fused [1,2]imidazo[4,5-c] ring compounds, e.g., fused [1,2]imidazo[4,5-c]quinolines and [1,2]imidazo[4,5-c]naphthyridines, with a substituent, e.g., a substituted alkoxy substituent, at the 6, 7, 8, or 9-position, pharmaceutical compositions containing the compounds, intermediates, methods of making and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are disclosed.
    Type: Application
    Filed: February 10, 2006
    Publication date: January 1, 2009
    Inventors: Michael J. Rice, Bryon A. Merrill, Philip D. Heppner
  • Alkyloxy Substituted Thiazoloquinolines and Thiazolonaphthyridines
    Publication number: 20080318998
    Abstract: Thiazoloquinolines and thiazolonaphthyridines with an alkoxy substituent at the 6, 7, 8, or 9-position, pharmaceutical compositions containing the compounds, intermediates, methods of making and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are disclosed.
    Type: Application
    Filed: February 8, 2006
    Publication date: December 25, 2008
    Applicant: COLEY PHARMACEUTICAL GROUP, INC.
    Inventors: Ryan B. Prince, Bryon A. Merrill, Philip D. Heppner, Tushar M. Kshirsagar, Joshua R. Wurst, Karl J. Manske, Michael J. Rice
  • Chiral Fused [1,2]Imidazo[4,5-C] Ring Compounds
    Publication number: 20080269192
    Abstract: Fused [1,2]imidazo[4,5-c] ring compounds (e.g., imidazo[4,5-c]quinolines, 6,7,8,9-tetrahydroimidazo[4,5-c]quinolines, imidazo[4,5-c]naphthyridines, and 6,7,8,9-tetrahydroimidazo[4,5-c]naphthyridines) with a —CH(—X1—R1)-group in the fused ring at the 1-position of the imidazo ring, pharmaceutical compositions containing the compounds, intermediates, methods of making the compounds, and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases, are disclosed.
    Type: Application
    Filed: December 29, 2005
    Publication date: October 30, 2008
    Applicant: Coley Pharmaceutical Group, Inc.
    Inventors: George W. Griesgraber, Tushar A. Kshirsagar, Azim A. Celebi, Sarah J. Slania, Michael E. Danielson, Michael J. Rice, Joshua R. Wurst
  • Amide substituted imidazoquinolines
    Patent number: 7393859
    Abstract: Imidazoquinoline and tetrahydroimidazoquinoline compounds that contain amide functionality at the 1-position are useful as immune response modifiers. The compounds and compositions of the invention can induce the biosynthesis of various cytokines and are useful in the treatment of a variety of conditions including viral diseases and neoplastic diseases.
    Type: Grant
    Filed: May 19, 2004
    Date of Patent: July 1, 2008
    Assignee: Coley Pharmaceutical Group, Inc.
    Inventors: Patrick L. Coleman, Stephen L. Crooks, George W. Griesgraber, Kyle J. Lindstrom, Bryon A. Merrill, Michael J. Rice
  • Intermediates for imidazonaphthyridines
    Patent number: 7335773
    Abstract: Imidazonaphthyridine and tetrahydroimidazonaphthyridine compounds induce the biosynthesis of cytokines such as interferon and tumor necrosis factor. The compounds exhibit antiviral and antitumor properties. Methods of preparing the compounds and intermediates useful in the preparation of the compounds are disclosed.
    Type: Grant
    Filed: February 13, 2006
    Date of Patent: February 26, 2008
    Assignee: Graceway Pharmaceuticals, LLC
    Inventors: John F. Gerster, Kyle J. Lindstrom, Stephen L. Crooks, Philip D. Heppner, Gregory J. Marszalek, Peter V. Maye, Bryon A. Merrill, John W. Mickelson, Michael J. Rice
  • Urea substituted imidazoquinolines
    Patent number: 7157453
    Abstract: Imidazoquinoline and tetrahydroimidazoquinoline compounds that contain urea, thiourea, acylurea, or sulfonylurea functionality at the 1-position are useful as immune response modifiers. The compounds and compositions of the invention can induce the biosynthesis of various cytokines and are useful in the treatment of a variety of conditions including viral diseases and neoplastic diseases.
    Type: Grant
    Filed: January 20, 2005
    Date of Patent: January 2, 2007
    Assignee: 3M Innovation Properties Company
    Inventors: Stephen L. Crooks, Michael J. Rice
  • Aryl substituted Imidazoquinolines
    Patent number: 7091214
    Abstract: Aryl substituted imidazoquinoline compounds, pharmaceutical compositions containing the compounds, intermediates, and methods of use of these compounds as immunomodulators, for inducing or inhibiting cytokine biosynthesis in animals and in the treatment of diseases including viral, and neoplastic, are disclosed.
    Type: Grant
    Filed: December 18, 2003
    Date of Patent: August 15, 2006
    Assignee: 3M Innovative Properties Co.
    Inventors: David S. Hays, Shri Niwas, Tushar Kshirsagar, Philip D. Heppner, Bryon A. Merrill, Michael E. Danielson, John F. Gerster, Chad A. Haraldson, Maureen A. Kavanagh, Michael J. Rice, Sarah A. Strong, Joshua R. Wurst