Abstract: Embodiments include method, systems and computer program products for prioritizing delivery of messages across multiple communication systems. Aspects include receiving a message for a recipient via one or more messaging systems and determining a priority level for the message based on an analysis of the message and a user profile of the recipient. Aspects also include delivering the message to a desired communication device via a desired communication system, wherein the desired communication device and the desired communication system are selected based on the priority level and the user profile and receiving feedback from the recipient regarding the priority level and responsively updating the user profile based on the feedback.

Abstract: A computer program product for managing a user's multiple electronic devices is provided. The computer program product includes a computer readable storage medium having program instructions embodied therewith. The program instructions are readable and executable by processing circuits of at least the multiple electronic devices to cause the processing circuits to calculate primacy scores of each of the multiple electronic devices, share the calculated primacy scores among the multiple electronic devices, determine which one or more of the multiple electronic devices is a primary device based on the shared primacy scores and a characteristic of a notification upon generation of the notification at any one of the multiple electronic devices or a central computing device and forward the notification from the one of the multiple electronic devices or the central computing device to only the one or more of the multiple electronic devices determined to be a primary device.

Abstract: Disclosed is a method for recovering protein hydrolysates from high-fat protein concentrates. The method can be used, for example, to produce a whey protein hydrolysate from the by-product retentate of the manufacture of whey protein isolates, as well as to isolate the milk fat globule membrane from a high-fat whey protein concentrate starting material.

Abstract: The present invention relates to biocompatible compositions for transplantation into a sub-retinal space of the human eye. The compositions include a biodegradable polyester film, preferably a polycaprolactone (PCL) film, and a layer of human retinal progenitor cells. The compositions of the invention can be used as scaffolds for the treatment a number of ocular diseases, including retinitis pigmentosa and age-related macular degeneration.

Abstract: The present invention relates to substantially homogenous populations of human retinal progenitor cells having the following positive surface markers: SSEA4, CD73, PTK7 and PSA-NCAM. The invention also relates to method for preparing such substantially homogeneous cell populations from human tissue using cell sorting techniques.

Abstract: The present invention relates to methods for culturing human retinal progenitor cells under low oxygen conditions to allow the cells to retain the ability to differentiate into photoreceptors following transplantation. The described methods provide cells that can treat a number of ocular diseases, including retinitis pigmentosa and age-related macular degeneration.

Abstract: A surgical drape includes a first sheet of surgical drape material secured to a second sheet of surgical drape material by a removable adhesive disposed along an overlapping joint. A pre-defined work-through area is defined in a central portion of the surgical drape, and the overlapping joint intersects with the work-through. Optionally, removable areas of pre-defined size and shape around the work-through area are defined by frangible paths so that the work-through area can be selectively enlarged by tearing along one or more of the frangible paths to remove one or more of the removable areas. A tab facilitates gripping by a user for separating the first sheet from the second sheet. The work-through area may be a pre-cut opening or a pre-defined tear-away removable portion of the first and/or second sheets.

Abstract: The present invention relates to methods for culturing human retinal progenitor cells under low oxygen conditions to allow the cells to retain the ability to differentiate into photoreceptors following transplantation. The described methods provide cells that can treat a number of ocular diseases, including retinitis pigmentosa and age-related macular degeneration.

Abstract: A surgical drape made of a sheet of surgical drape material, includes a frangible outline defined on the sheet that defines a removable area of the sheet that is separable from the sheet by tearing along the first frangible outline to define a first fenestration through the sheet. A frangible line extends from the frangible outline to an outer peripheral edge of the sheet and defines a pre-defined path of tearing along which the sheet may be torn from the removable area to the outer peripheral edge.

Abstract: The present invention relates to biocompatible compositions for transplantation into a sub-retinal space of the human eye. The compositions include a biodegradable polyester film, preferably a polycaprolactone (PCL) film, and a layer of human retinal progenitor cells. The compositions of the invention can be used as scaffolds for the treatment a number of ocular diseases, including retinitis pigmentosa and age-related macular degeneration.

Abstract: The present invention relates to methods for culturing human retinal progenitor cells under low oxygen conditions to allow the cells to retain the ability to differentiate into photoreceptors following transplantation. The described methods provide cells that can treat a number of ocular diseases, including retinitis pigmentosa and age-related macular degeneration.

Abstract: During the growth and study of NSCs, a range of molecules present on the surface of multipotent neural stem and progenitor cells (NSCs) were identified. These markers were identified using a number of human and murine neural stem cell lines, including retinal stem cells (RSCs). The NSC-specific markers identified included gene products as well as non-protein molecules and sugar epitopes not directly coded in the genome. Together with surface markers which were determined to be absent from the surface of hNSCs, the molecules described herein provide a means to enrich for neural stem cells, or neural progenitor subpopulations, particularly using combinatorial cell sorting strategies. These same molecules also represent targets for pharmacological manipulation of NSC populations and subpopulations, both in vivo and ex vivo.

Abstract: The present invention provides ocular scaffolds composed of poly (e-caprolactone) configured to be inserted into the sub-retinal space of a subject, as well as methods for treating eye disease (e.g., age-related macular degeneration) with such scaffolds. The present invention also provides methods of making such scaffolds.

Abstract: The present invention relates to the isolation, in vitro propagation, and transplantation and integration of non-pigmented retinal stem cells derived from the neuroretina of the eye, ex vivo and in vivo.

Abstract: The present invention relates to the isolation, in vitro propagation, and transplantation and integration of non-pigmented retinal stem cells derived from the neuroretina of the eye, ex vivo and in vivo.

Abstract: During the growth and study of NSCs, a range of molecules present on the surface of multipotent neural stem and progenitor cells (NSCs) were identified. These markers were identified using a number of human and murine neural stem cell lines, including retinal stem cells (RSCs). The NSC-specific markers identified included gene products as well as non-protein molecules and sugar epitopes not directly coded in the genome. Together with surface markers which were determined to be absent from the surface of hNSCs, the molecules described herein provide a means to enrich for neural stem cells, or neural progenitor subpopulations, particularly using combinatorial cell sorting strategies. These same molecules also represent targets for pharmacological manipulation of NSC populations and subpopulations, both in vivo and ex vivo.

Abstract: During the growth and study of NSCs, a range of molecules present on the surface of multipotent neural stem and progenitor cells (NSCs) were identified. These markers were identified using a number of human and murine neural stem cell lines, including retinal stem cells (RSCs). The NSC-specific markers identified included gene products as well as non-protein molecules and sugar epitopes not directly coded in the genome. Together with surface markers which were determined to be absent from the surface of hNSCs, the molecules described herein provide a means to enrich for neural stem cells, or neural progenitor subpopulations, particularly using combinatorial cell sorting strategies. These same molecules also represent targets for pharmacological manipulation of NSC populations and subpopulations, both in vivo and ex vivo.

Abstract: An enterprise integration system is coupled to a number of legacy data sources. The data sources each use different data formats and different access methods. The integration system includes a back-end interface configured to convert input data source information to input XML documents and to convert output XML document to output data source information. A front-end interface converts the output XML documents to output HTML forms and the input HTML forms to the XML documents. A middle tier includes a rules engine and a rules database. Design tools are used to define the conversion and the XML documents. A network couples the back-end interface, the front-end interface, the middle tier, the design tools, and the data sources. Mobile agents are configured to communicate the XML documents over the network and to process the XML documents according to the rules.

Abstract: The present invention relates to the isolation, in vitro propagation, and transplantation and integration of non-pigmented retinal stem cells derived from the neuroretina of the eye, ex vivo and in vivo.

Abstract: During the growth and study of NSCs, a range of molecules present on the surface of multipotent neural stem and progenitor cells (NSCs) were identified. These markers were identified using a number of human and murine neural stem cell lines, including retinal stem cells (RSCs). The NSC-specific markers identified included gene products as well as non-protein molecules and sugar epitopes not directly coded in the genome. Together with surface markers which were determined to be absent from the surface of hNSCs, the molecules described herein provide a means to enrich for neural stem cells, or neural progenitor subpopulations, particularly using combinatorial cell sorting strategies. These same molecules also represent targets for pharmacological manipulation of NSC populations and subpopulations, both in vivo and ex vivo.