Abstract: The instant disclosure provides antibodies that specifically bind to CD73 (e.g., human CD73) and antagonize CD73 function. Also provided are anti-CD73 antibodies that further comprise a TGF?-binding moiety or a VEGF-binding moiety. The instant disclosure additionally provides pharmaceutical compositions comprising these antibodies, nucleic acids encoding these antibodies, expression vectors and host cells for making these antibodies, and methods of treating a subject using these antibodies.

Abstract: Methods, systems, and computer programs are presented for determining employment start dates for members of a social network that have not indicated their employment start date in their profiles to generate employment market reports. One method includes an operation for receiving a request to infer a member start date for a member with an unknown member start date at a company. A distribution over time of known member start dates is determined for members of the social network with a known employment start date at the company, and a time interval is identified defining the boundaries for the member start date. A cohort group is selected from several cohort groups, that include members with known member start dates having a same cohort feature value as the member. A start-date probability distribution is determined based on the distribution of the known member start dates, the cohort group, and the time interval.

Abstract: Methods, systems, and computer programs are presented for generating custom hiring metrics based on configurable filters to assist in a company's recruiting efforts. One method includes an operation for determining job metrics, for a global pool of users, that are based on job-post communications received by the global pool. The method further includes operations for receiving filters for generating a report, and for identifying a talent pool based on the filters, which are applied to the global pool based on user profile data. A talent-pool metric is determined based on the job-post communications received by the talent pool, and a hiring demand index (HDI) is determined based on the talent-pool metric and the job metrics for the global pool of users, where the HDI provides a degree of difficulty for hiring users from the talent pool. Further, the report including the HDI for the talent pool is presented.

Abstract: Methods, systems, and computer programs are presented for analyzing and generating employee-mobility information. One method includes an operation for determining transitions of users of a social network based on user profiles. Each transition includes a change of employment. Further, the method includes creating a member table based on the determined transitions and the user profiles. The member table includes fields for a company identifier and a previous company identifier, where the previous company identifier indicates a transition from the source company that is associated with the previous company identifier to the destination company that is associated with the company identifier. The method further includes operations for providing a user interface for receiving user input to create a report based on the determined transitions, accessing the member table to generate report data based on the received user input, and for causing presentation of the report based on the report data.

Abstract: Methods, systems, and computer programs are presented for generating company-comparison reports based on a company ranking for hiring and retaining employees. One method includes an operation for determining transitions of users of a social network based on their profiles. Each transition comprises a change of employment from a source to a destination company. A transition graph is created, for a group of companies, including a node for each company and links between the nodes. Each link comprises a number of employees that transitioned from the source to the destination company. A weight, calculated for each link in the transition graph, is based on a number of employees of the destination company and a number of users transitioning between companies (both directions). A company score is calculated for each company based on the transition graph and the weights of the links. A report based on the company scores is then presented.

Abstract: A reformer unit and high temperature, pressure, or both variable orifice flow controller is provided. The reformer unit may have a reforming section, a heat exchanging section, and a bypass section. The bypass section provides a flow path for the hydrocarbon-containing fuel around the reforming section and has a variable orifice flow controller positioned in the bypassing flow path.

Abstract: A reforming unit for a fuel cell system is provided. The reforming unit may comprise a reforming section, a heat exchanging section and a bypass plenum. The reforming section reforms a hydrocarbon containing fuel. The heat exchanging section effects a heat transfer between a fluid flowing therethrough and the fluid flowing through the reforming section, the bypass plenum, or both. The bypass plenum provides a flowpath for the hydrocarbon-containing fuel to bypass the reforming section. The bypass plenum may comprise a flow restrictor in the outlet of the bypass plenum to control the amount of fluid communication between the outlet of the bypass plenum and the outlet of the reforming section.

Abstract: A microphone circuit having an amplifier with an input operably coupled to a microphone motor also includes a low pass filter operably coupled to the output of the amplifier and a positive feedback network that operably couples to an output of the low-pass filter and to the amplifier input. For many useful application settings the aforementioned amplifier has unity gain while the positive feedback network has a fractional gain less than unity.

Abstract: The instant disclosure provides antibodies that specifically bind to LAG-3 (e.g., human LAG-3) and antagonize LAG-3 function. Also provided are pharmaceutical compositions comprising these antibodies, nucleic acids encoding these antibodies, expression vectors and host cells for making these antibodies, and methods of treating a subject using these antibodies.

Abstract: A reforming unit for a fuel cell system is provided. The reforming unit may comprise a reforming section, a heat exchanging section and a bypass plenum. The reforming section reforms a hydrocarbon containing fuel. The heat exchanging section effects a heat transfer between a fluid flowing therethrough and the fluid flowing through the reforming section, the bypass plenum, or both. The bypass plenum provides a flowpath for the hydrocarbon-containing fuel to bypass the reforming section. The bypass plenum may comprise a flow restrictor in the outlet of the bypass plenum to control the amount of fluid communication between the outlet of the bypass plenum and the outlet of the reforming section.

Abstract: A fuel cell system having a fuel cell stack, comprising an anode portion and a cathode portion, a source of hydrocarbon fuel, and a reformer unit having one or more cold-side, reforming passages, a fuel supply conduit, a reformate exhaust conduit, one or more hot-side channels, a cathode exhaust conduit, a cathode inlet conduit, one or more bypass channels having non-reforming passages for fuel to bypass the cold-side channels, and a flow controller for controlling the flowrate in the bypass channels, and methods for operating the same, is provided.

Abstract: A reformer unit and high temperature, pressure, or both variable orifice flow controller is provided. The reformer unit may have a reforming section, a heat exchanging section, and a bypass section. The bypass section provides a flow path for the hydrocarbon-containing fuel around the reforming section and has a variable orifice flow controller positioned in the bypassing flow path.

Abstract: A system and method for analyzing network service usage is provided. In example embodiments, model users of the network service are identified using a number of target events and in-scope events. Users of the network service generate interaction data by interacting with the network service. The interaction data of the identified model users can be compared to the interaction data of the non-model users without exposing the interaction data.

Abstract: A MOSFET active-disable switch is configured to clip an incoming signal in opposing directions when in an off state. By one approach the clipping is symmetrical and accordingly the switch clips both positive and negative peaks of the incoming signal. In many application settings it is useful for the clipping to serve to decrease a predetermined kind of resultant distortion such as even order distortion. In the on state this MOSFET active-disable switch is configured to not clip the incoming signal in opposing directions.

Abstract: A direct current (DC) bias maintenance circuit operably couples to the input of a primary amplifier. The DC bias maintenance circuit employs feedback to maintain the desired DC bias but lacks any coupling to the output of the primary amplifier. By one approach the DC bias maintenance circuit includes a secondary amplifier that replicates at least some near real-time performance characteristics of the primary amplifier. For example, the secondary amplifier can replicate at least certain DC properties of the primary amplifier such that DC-based changes appearing at the output of the primary amplifier are mirrored at an output of the secondary amplifier notwithstanding a lack of any coupling between the output of the primary amplifier and the DC bias maintenance circuit.

Abstract: A direct current (DC) bias maintenance circuit operably couples to the input of a primary amplifier. The DC bias maintenance circuit employs feedback to maintain the desired DC bias but lacks any coupling to the output of the primary amplifier. By one approach the DC bias maintenance circuit includes a secondary amplifier that replicates at least some near real-time performance characteristics of the primary amplifier. For example, the secondary amplifier can replicate at least certain DC properties of the primary amplifier such that DC-based changes appearing at the output of the primary amplifier are mirrored at an output of the secondary amplifier notwithstanding a lack of any coupling between the output of the primary amplifier and the DC bias maintenance circuit.

Abstract: A MOSFET active-disable switch is configured to clip an incoming signal in opposing directions when in an off state. By one approach the clipping is symmetrical and accordingly the switch clips both positive and negative peaks of the incoming signal. In many application settings it is useful for the clipping to serve to decrease a predetermined kind of resultant distortion such as even order distortion. In the on state this MOSFET active-disable switch is configured to not clip the incoming signal in opposing directions.

Abstract: These teachings provide for detecting an offset voltage corresponding to a circuit element having an input and an output. (The approaches taught herein will accommodate detecting that offset voltage at either the input and/or the output as desired.) Upon detecting the offset voltage a switch that connects the input of the circuit element to ground automatically closes to thereby ground the input. That switch remains open in the absence of detecting an offset voltage.

Abstract: A single-stage buffer apparatus includes a first transistor, a second transistor, and a high pass filter network. The first transistor is configured to receive an input signal from a microphone. The second transistor is configured to operate as a cascode transistor. The high pass filter network is coupled to the first transistor and the second transistor. The second transistor electrically decouples the first transistor from an output of the single-stage buffer apparatus. A gate terminal of the second transistor is driven by the high-pass filter network, and the high-pass filter network is driven by the first transistor.