Abstract: A fire suppressant storage device (20) comprising: a tank (22) having a first port and an interior for storing fire suppressant; and a discharge assembly mounted to the first port. The discharge assembly has a discharge valve (48) and a discharge conduit (50) at least partially within the interior. The discharge conduit has an interior surface (60) and an exterior surface (58). The discharge assembly further comprises a gauge (80) on the discharge conduit.

Abstract: A server of an on-premises data center used for a software platform identifies a condition impacting real-time communication services at a premises housing devices accessing the software platform. The server transmits, to a device of an administrator associated with the premises via a messaging application for real-time communication between two or more human-operated devices, a message indicating the condition and including one or more selectable elements each associated with a different action for addressing the condition. The server receives an indication of a selectable element selected from amongst the one or more selectable elements at the device of the administrator. The server causes performance of the action associated with the selected selectable element.

Abstract: A method of modifying a CAD system model performed on a data processing system includes receiving a dataset of co-ordinates representing an article in 2d, or in 3d and receiving 2d or 3d constraints respectively, to be applied to any changes to the dataset of co-ordinates for the article. A modification to be applied to the dataset is received and combined with the relevant 2d and 3d constraints to produce a constrained modification for each of the article and associated article. The constrained modification is solved in 2d and in 3d to determine whether a solution exists in which all constraints are met. If the solve is successful, the constrained modification is applied to each dataset simultaneously and, updated datasets are stored. If the solve fails, the constraints may be reduced and the solve step repeated, or the process is terminated.

Abstract: Described herein are battery packs and electric vehicles using these packs. In some examples, a battery pack comprises two portions/covers and a set of battery modules positioned within the enclosed cavity formed by these portions. A battery pack may comprise a set of pressure-relief valves positioned in and protruding through a wall of at least one portion. Each valve can be coaxial with a corresponding gap provided between two adjacent modules. The valve is configured to provide a fluid path (to the exterior of the battery pack) when the pressure inside the pack exceeds a set threshold. In some examples, the battery pack comprises an inlet tube fluidically coupled to the inlet port of each module and an outlet tube fluidically coupled to the outlet port of each module. A set of specially configured orifices or controllable valves is positioned on the fluid path through each module.

Abstract: A gas turbine engine having a waste heat recovery system is provided. The gas turbine engine includes a compressor section, a combustion section, a turbine section, and an exhaust section in serial flow order and together defining a core air flowpath, the exhaust section including a primary exhaust flowpath and a waste heat recovery flowpath parallel to the primary exhaust flowpath; and the waste heat recovery system includes a heat source exchanger positioned in thermal communication with a first portion of the waste heat recovery flowpath.

Abstract: Simulated motion of the papillary muscles in a heart simulator is provided that simulates natural motion of the papillary muscles. This improves heart valve simulation. This can be done with a six degree of freedom robotic actuator (e.g., a Stewart platform or the like) appropriately driven by a controller. This can also be done with a robotic actuator that provides constrained motion of its effector by including a mechanical linkage, as long as the resulting simulated papillary muscle motion includes time-varying position and orientation of the papillary muscle.

Abstract: The present invention pertains to novel treatments of neuropathic pain; in particular chemotherapy induced peripheral neuropathic pain (CIPNP). The invention provides antagonists cytochrome P450 epoxygenases (CYP), and more specifically antagonists of CYP2J2, as therapeutics for use in the treatment of neuropathic pain such as CIPNP. CYP2J2 antagonists were identified to alleviate CIPNP in-vivo, and therefore are provided additionally in combination with chemotherapeutics for the treatment of diseases such as cancer or other proliferative disorders. The CYP2J2 antagonists reduce chemotherapeutic induced pain and therefore allow for a higher dosing of the chemotherapeutic during cancer treatment. In addition the invention relates to the use of CYP2J2 agonists, or metabolites of CYP2J2, for sensitizing TRPV1.

Abstract: This invention provides, in part, various compositions and methods for protecting the gastrointestinal microbiome from antibiotic disruption.

Abstract: A suspension system for supporting a body relative to at least four points, including: a respective front left, front right, back left and back right support arrangement between the respective point and the body, each respective support arrangement including a respective resilience arrangement and a respective control ram, each respective control ram including a respective compression chamber forming at least part of a respective compression control volume; a control arrangement including a first and a second diagonal reversible pump for displacing fluid between diagonally opposite compression control volumes. Each respective resilience arrangement can include a respective damping arrangement to restrict and/or selectively prevent compression and/or expansion of at least a portion of the respective resilience arrangement. Each respective control ram can further include a respective rebound chamber, the front control rams being cross connected and the back control rams being cross connected.

Abstract: A filter extender that comprises a quadrilateral tube is provided, along with an air filter configured to mate with the same.

Abstract: The systems and methods described herein allow for data produced by an HVAC device to be selectively shared with a third party, such as a contractor used to perform maintenance services on the HVAC device. The system and methods also allow for HVAC devices to be remotely configured to share data based on certain triggering conditions. Specifically, a controller built into an HVAC device may include a configuration file, which may dictate rules associated with collection and transmission of data by the HVAC device. A remote server may be configured to passively listen for data transmissions from any HVAC devices.

Abstract: Devices and methods method of tiled rendering are provided which comprises dividing a frame to be rendered, into a plurality of tiles, receiving commands to execute a plurality of subpasses of the tiles, interleaving execution of same subpasses of multiple tiles of the frame by executing one or more subpasses as skip operations, storing visibility data, for subsequently ordered subpasses of the tiles, at memory addresses allocated for data of corresponding adjacent tiles in a first direction of traversal and rendering the tiles for the subsequently ordered subpasses using the visibility data stored at the memory addresses allocated for corresponding adjacent tiles in a second direction of traversal, opposite the first direction of traversal.

Abstract: The present disclosure generally relates to methods and systems for engineering antibodies, and antigen-binding fragments thereof, to have altered characteristics. The present disclosure also provides a high-throughput method useful for identifying the engineered antibodies, or antigen-binding fragments thereof, that acquired the altered characteristics having performed the methods. These methods and systems have implications, for example, in the rapid development of biotherapeutics having desired and/or improved, e.g., affinity, specificity and/or activity-related, characteristics.

Abstract: Provided herein are methods that include introducing into an inner ear of a mammal a therapeutically effective amount of an adeno-associated virus (AAV) vector that includes a nucleotide sequence encoding (a) a polypeptide including an antibody heavy chain variable domain operably linked to a signal peptide and a polypeptide including an antibody light chain variable domain operably linked to a signal peptide; (b) a polypeptide including an antigen-binding antibody fragment operably linked to a signal peptide; or (c) a soluble vascular endothelial growth factor receptor operably linked to a signal peptide.

Abstract: Devices, methods and systems for transmitting signals through a device located in a blood vessel of an animal, for stimulating and/or sensing activity of media proximal to the device, wherein the media includes tissue and/or fluid.

Abstract: Block data load with transpose techniques are described. In one example, an input is received, at a control unit, specifying an instruction to load a block of data to at least one memory module using a transpose operation. Responsive to the receiving the input by the control unit, the block of data is caused to be loaded to the at least one memory module by transposing the block of data to form a transposed block of data and storing the transposed block of data in the at least one memory.

Abstract: A device includes an amplifying device that when in operation transmits a data signal and a reference signal to a decision feedback equalizer (DFE) circuit. The amplifying device includes a variable gain amplifier (VGA) that when in operation generates the reference signal as having a predetermined gain relative to a received input signal and a continuous-time linear equalizer (CTLE) that operate to mitigate inter-symbol interference (IR) on the data signal from a data stream comprising the data signal. The device further includes correction circuitry coupled to the amplifying device, wherein the correction circuitry when in operation mitigates variation in the predetermined gain of the VGA or variation in an output common-mode voltage of the VGA.

Abstract: A system and method are disclosed for identifying a plurality of past videos posted via a first group of channels, determining, for each channel of a second group, an average number of access requests that a future video to be posted via a respective channel is predicted to receive within a first time interval after posting, determining, for each channel of the second group, a plurality of adjusted average numbers of access requests that the future video to be posted via the respective channel of the second group is predicted to receive within the first time interval, wherein each of the plurality of adjusted average numbers of access requests is determined using an adjustment factor reflecting a number of access requests received by a past video posted via a respective channel of the first group, and determining whether the second group of channels satisfies a predetermined access criterion.

Abstract: The techniques herein are directed generally to a “zero-knowledge” data management network. Users are able to share verifiable proof of data and/or identity information, and businesses are able to request, consume, and act on the data—all without a data storage server or those businesses ever seeing or having access to the raw sensitive information (where server-stored data is viewable only by the intended recipients, which may even be selected after storage). In one embodiment, source data is encrypted with a source encryption key (e.g., source public key), with a rekeying key being an encrypting combination of a source decryption key (e.g., source private key) and a recipient's public key. Without being able to decrypt the data, the storage server can use the rekeying key to re-encrypt the source data with the recipient's public key, to then be decrypted only by the corresponding recipient using its private key, accordingly.

Abstract: A wall-mountable perch includes: a frame including: first horizontal side members; a first cross member connected to each of the first horizontal side members proximate to a respective distal end of each of the first horizontal side members; second horizontal side members connected to the first horizontal side members; a platform connected to the second horizontal side members; a plurality of support arms each having a proximal end connected proximate to a proximal end of the frame, each support arm extending vertically upward from the frame and being configured to be flexible to bend along a respective length of each of the plurality of support arms; tension arms each connected to a respective horizontal side member; and adjusting means for producing tension in the tension arms and for causing a second cross member of the wall-mountable perch to move closer to the platform.