Abstract: Activity-inducible fusion proteins whose activity is post-translationally regulated utilizing a hsp90 binding domain and a drug molecule are described. In the absence of the drug molecule, the activity-inducible fusion proteins are inactivated but can be activated by a relevant physiological parameter in the presence of the drug molecule. Examples of the activity-inducible fusion proteins include chimeric antigen receptors (CAR) wherein the relevant physiological parameter is antigen binding.

Abstract: The following description is directed to a configurable logic platform. In one example, a configurable logic platform includes host logic and a reconfigurable logic region. The reconfigurable logic region can include logic blocks that are configurable to implement application logic. The host logic can be used for encapsulating the reconfigurable logic region. The host logic can include a host interface for communicating with a processor. The host logic can include a management function accessible via the host interface. The management function can be adapted to cause the reconfigurable logic region to be configured with the application logic in response to an authorized request from the host interface. The host logic can include a data path function accessible via the host interface. The data path function can include a layer for formatting data transfers between the host interface and the application logic.

Abstract: Disclosed are methods for coating aluminum alloy heat exchangers that include the use of a waterborne top coating. By using a waterborne top coating, relative to a solvent borne, useful advantages can be achieved, such as improved penetration depth of the top coating. An example method includes cleaning a surface of a heat exchanger; contacting the surface of the heat exchanger with a first mixture to provide a passivation layer on the surface of the heat exchanger; contacting the passivation layer with a second mixture in a bath and applying a positive charge to the bath to provide an electro-coating on a surface of the passivation layer; and contacting the electro-coating with a third mixture, the third mixture including water and a polymer resin having anti-corrosion and ultraviolet protection properties, to provide a top coating including the polymer resin on a surface of the electro-coating.

Abstract: A method or system for testing and benchmarking commits made on source code. The system extracts commits from a history of a first code history that records a sequence of commits made thereon. The extracted commits are then combined into a sequence of patches, each of which includes changes made during consecutive commits. The system also establishes a connection with a system under test (SUT) having a second code repository corresponding to a historical version of the first code repository before the extracted commits were made, and sequentially applies the sequence of the patches to the second code repository. Performance of the SUT is monitored during the application of the sequence of the patches to determine whether the SUT performs as expected after the application of each patch.

Abstract: A footbed system having a footbed and a removeable foot support with a bumper to adjust the size, fit and/or comfort of a shoe.

Abstract: A footbed having a plurality of pods that can be added, removed and/or replaced to adjust the fit and/or comfort of a shoe.

Abstract: The present disclosure is directed to alcohol and amine containing exatecan derivatives, and pharmaceutically acceptable salts or solvates thereof, comprising a structure of formula I: wherein X is defined in the disclosure. The disclosure is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of cancers and/or tumors.

Abstract: Described herein are compositions and methods for the storage and release of hydrogen gas using covalent organic frameworks (COFs). Advantageously, the compositions and methods described herein may be used for the facile and rapid release of hydrogen gas at near ambient temperatures. The described COFs allow for photoactivation, where the release of gas is initiated or the rate of release is increased with the COF is exposed to electromagnetic radiation, for example, UV light.

Abstract: A method for providing a dynamically-updated electronic report of assets available for transaction to a user is provided. The electronic report is provided to a computing device operated by the user. The electronic report includes one or more entries that each corresponds to an asset for sale. Each entry can include a link for the corresponding asset. In response to receiving user selection of a link on the report, one or more characteristics of the asset corresponding to the selected link are determined. One or more additional assets are determined based on the one or more characteristics. The electronic report is dynamically updated to include one or more entries corresponding to the one or more additional assets. A user profile of the user can also be updated in response to the user's selection.

Abstract: The present disclosure provides a display system. The display system includes a backlight configured to emit substantially collimated polarized light from an emission surface thereof. The emitted polarized light is polarized along a polarization direction. The display system further includes a display panel configured to receive an illumination light and form an image. The display system further includes a grating system substantially coextensive in length and width with the display panel and the emission surface. The grating system includes a plurality of substantially parallel elongated features extending along an in-plane first direction and arranged along an orthogonal in-plane second direction. The grating system is configured to receive and transmit an incident polarized light as a first transmitted light having different first and second polarization states in response to different respective first and second signals applied to the grating system.

Abstract: Various implementation described herein are directed to a method for providing access control. User information is received at a device. A request to provide access control is generated by the device based on the received user information. The request is transmitted via a network to an access manager. A response to the request is received from the access manager. Access control via the device is provided based on the response to the request.

Abstract: Provided herein are pharmaceutically acceptable compositions containing a selective cyclooxygenase-2 (COX-2) inhibitor (coxib) and optionally buprenorphine. In particular, compositions containing a coxib formulated for oral, topical or subcutaneous administration to treat pain or inflammation are described.

Abstract: Aspects and embodiments relate to a gas flow alarm apparatus and gas flow alarm method. The apparatus comprises: a device configurable to introduce back pressure into a flow of gas, a supply sensor configured to determine whether gas flow to the device is enabled; a pressure sensor configured to determine whether a flow of gas through the device has developed back pressure; and logic circuitry in communication with the supply sensor and the pressure sensor configured to determine whether gas flow to the device is enabled and whether a flow of gas through the device has developed back pressure and, if not, to activate an alarm condition. Aspects and embodiments can provide a system which operates to warn a user against various adverse conditions in which a flow of therapeutic gas to a patient is required, yet not being provided.

Abstract: Embodiments herein relate to fenestrations exhibiting coastal impact performance. In an embodiment, a fenestration unit includes a frame assembly forming a first lower corner and a second lower corner. A first sill corner bracket can fit on a top of a sill and extend from the first lower corner partway along the top of the sill and partway along one side jamb of the frame assembly. A second sill corner bracket can be configured to fit on the top of the sill and extend from the second lower corner partway along the top of the sill and partway along the other side jamb. A bottom sash can include a bottom rail defining a channel to receive at least a portion of the first corner bracket and the second corner bracket therein when the bottom sash is in the closed position. Other embodiments are also included herein.

Abstract: A method for manufacturing a tool having one or more internal channels includes forming one or more channel cores by additive manufacturing, coating a metal onto the one or more channel cores to form a metal tube on each of the one or more channel cores, positioning the one or more metal tubes into a casting mold having a shape of a tool, and casting a molten metal into the casting mold to form the tool having the one or more internal channels corresponding to the one or more channel cores.

Abstract: A control system for a double-acting air cylinder of an agricultural implement includes a valve assembly configured to control a base end air pressure and a rod end air pressure of the double-acting air cylinder. The control system also includes a controller communicatively coupled to the valve assembly. The controller is configured to determine a target base end air pressure and a target rod end air pressure based on a target force of the double-acting air cylinder and a target damping factor of the double-acting air cylinder. The controller is also configured to control the valve assembly such that a first difference between the base end air pressure and the target base end air pressure is less than a first threshold value and a second difference between the rod end air pressure and the target rod end air pressure is less than a second threshold value.

Abstract: Disclosed herein are embodiments of stabilizers for use in delivering a replacement heart valve. The stabilizers can receive a portion of a delivery system, such as a handle, to prevent unwanted motion of the delivery system. The stabilizer can include a linear actuator for adjusting a position of the delivery system once held within the stabilizer.