Abstract: A modified portal protein of a bacteriophage DNA packaging motor, wherein the modified portal protein is capable of direct insertion into a membrane and wherein the portal protein is modified compared to the wild type portal protein such that one or more amino acid residues on the outer surface of the portal protein is substituted by one or more other amino acid residue, and/or wherein a one or more amino acid residue is inserted on the outer surface of the portal protein so as to alter the outer surface hydrophobicity of the modified portal protein compared to the wild type portal protein.

Abstract: The present invention relates to novel protein pores and their uses in analyte detection and characterisation. The invention particularly relates to an isolated pore complex formed by a CsgG-like pore and a modified CsgF peptide, or a homologue or mutant thereof, thereby incorporating an additional channel constriction or reader head in the nanopore. The invention further relates to a transmembrane pore complex and methods for production of the pore complex and for use in molecular sensing and nucleic acid sequencing applications.

Abstract: The present disclosure relates to an input assembly including: a support, an input part, and at least one light source, wherein the input part has at least one input layer having an input surface intended to be touched by an operator, and a light guide for guiding light of the light source towards the display region for backlighting the latter, and wherein the light guide is disposed on the side of the input part facing away from the input surface, a touch-detection device for detecting a touch on the input surface by the operator and/or an actuation detection device for detecting an actuation of the input part by the operator, and an electromagnetic actuator for exciting a movement of the input part along the direction of movement by means of an electric control signal in order to generate a haptic feedback, wherein the actuator includes an electromagnet.

Abstract: A mining machine including a motor, an adjustable speed drive providing a voltage to the motor, the voltage having an excitation component comprising a magnitude and a frequency for operating the motor at a desired speed and including an additional voltage component for use in detecting a ground fault condition, and a ground fault relay for detecting a ground fault current when the ground fault current exceeds a predetermined threshold.

Abstract: Provided is a method of characterising a polynucleotide using a transmembrane pore, wherein the pore is a double pore comprising a first Csg G pore, or a homologue thereof, and a second CsgG pore, or a homologue thereof.

Abstract: A tracking tag is disclosed that includes an identification tag fashioned from virgin paper, a pocket fashioned from the identification tag or adjacent the identification tag, the pocket housing a radio frequency identification (RFID) chip, and a laminate layer encasing the identification tag and pocket. A method of fashioning the tracking tag is also disclosed.

Abstract: The present invention relates to novel protein pores and their uses in analyte detection and characterisation. The invention particularly relates to an isolated pore complex formed by a CsgG-like pore and a modified CsgF peptide, or a homologue or mutant thereof, thereby incorporating an additional channel constriction or reader head in the nanopore. The invention further relates to a transmembrane pore complex and methods for production of the pore complex and for use in molecular sensing and nucleic acid sequencing applications.

Abstract: A resin including up to 99.99 weight percent (wt. %) of a first polyolefin grafted with a functional group selected from an ethylenically unsaturated carboxylic acid, a carboxylic acid anhydride, an ester functional group or a combination thereof; and 0.01 to 3.0 wt. % of a tin oxide-based catalyst, where the resin includes 0.2 wt. % to 1.5 wt. % of the functional group from the first polyolefin, the wt. % based on a total weight of the resin. The first polyolefin can be selected from a polyethylene, a polypropylene, an ethylene/alpha-olefin copolymer, a propylene/alpha-olefin copolymer and combinations thereof. The tin oxide-based catalyst can be selected from dibutyltin oxide, dioctyltin oxide and combinations thereof. The resin can be used in a multilayer structure, where a Layer A comprises the resin and a Layer B comprises a polyester, where a first major surface of Layer A is in adhering contact with the second major surface of Layer B.

Abstract: The present invention relates to compounds of Formula I that function as inhibitors of RET (rearranged during transfection) kinase enzyme activity: wherein HET, bonds a, b, c and d, X1, X2, X3, X4, R2, and R3 are each as defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, as well as other diseases or conditions in which RET kinase activity is implicated.

Abstract: Provided is a method of characterising a polynucleotide using a transmembrane pore, wherein the pore is a double pore comprising a first Csg G pore, or a homologue thereof, and a second CsgG pore, or a homologue thereof.

Abstract: Disclosed herein are compositions and methods that involve inserting connector protein channels of bacteriophage DNA packaging motors into copolymeric membranes via liposome-polymer fusion, which can be used as nanopore sensors for biomedical applications such as high throughput protein sequencing or cancer diagnosis. For example, disclosed are compositions comprising a copolymeric membrane into which a connector protein channel of a bacteriophage packaging motor has been inserted.

Abstract: The present invention relates to compounds of Formula I that function as inhibitors of RET (rearranged during transfection) kinase enzyme activity: wherein HET, bonds a, b, c and d, X1, X2, X3, X4, R2, and R3 are each as defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, as well as other diseases or conditions in which RET kinase activity is implicated.

Abstract: The present invention relates to compounds of formula I that function as inhibitors of RET (rearranged during transfection) kinase enzyme activity: wherein HET, X1, X2, X3, X4, integer a and R3 are each as defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, as well as other diseases or conditions in which RET kinase activity is implicated.

Abstract: A tracking tag is disclosed that includes an identification tag fashioned from virgin paper, a pocket fashioned from the identification tag or adjacent the identification tag, the pocket housing a radio frequency identification (RFID) chip, and a laminate layer encasing the identification tag and pocket. A method of fashioning the tracking tag is also disclosed.

Abstract: Methods and apparatus are disclosed to determine a power state of a device. An example apparatus includes a chart generator to determine respective counts for a plurality of measurements during a calibration period, the measurements indicative of an amount of power drawn by the device, a calculator to determine a first threshold and a second threshold based on at least one of the counts, the first threshold determined using most frequently logged measurement values, the most frequently logged measurement values based on counts performed after expiration of the calibration period, and a comparator to compare a measurement to the first threshold and to the second threshold.

Abstract: The present invention relates to compounds of formula I that function as inhibitors of RET (rearranged during transfection) kinase enzyme activity: wherein HET, X1, X2, X3, X4, integer a and R3 are each as defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, as well as other diseases or conditions in which RET kinase activity is implicated.

Abstract: Techniques for remote monitoring of a patient and corresponding medical device(s) are described. The remote monitoring comprises providing an interactive session configured to allow a user to navigate a plurality of sub sessions, determining a first set of data items in accordance with a first subsession, the first set of data items including the image data, determining a second set of data items in accordance with a second subsession of the interactive session, determining, based at least in part on the first set of data items and the second set of data items, an abnormality, and outputting a post-implant report of the interactive session.

Abstract: Methods and apparatus are disclosed to determine a power state of a device. An example apparatus includes a chart generator to determine respective counts for a plurality of measurements during a calibration period, the measurements indicative of an amount of power drawn by the device, the counts indicating respective numbers of times the respective measurements were detected. The example apparatus also includes a calculator to identify a first threshold based on at least one of the counts, and determine a second threshold. The example apparatus also includes a comparator to compare a measurement to the first threshold and to the second threshold, and a state detector to store an indication that the device is in an indeterminate state if the measurement is greater than the first threshold and less than the second threshold.