Abstract: This disclosure provides a system for preventing or reducing side effects in a patent undergoing immunotherapy to remove diseased cells that express a target antigen: for example, by CAR T cell therapy. Side effects can ensue from concurrent depletion of hematopoietic cells bearing the same target antigen. A population of engineered hematopoietic cells is prepared by obtaining healthy hematopoietic cells from the patient or a third party donor, and using them to produce engineered hematopoietic cells. The engineered cells either do not express the target antigen, express it at a lower density, or express it in a modified form. The engineered hematopoietic cells are formulated for administration to the patient, whereupon they reconstitute hematopoietic cell function, thereby preventing or reducing the side effects.

Abstract: This disclosure provides a system for preventing or reducing side effects in a patent undergoing immunotherapy to remove diseased cells that express a target antigen: for example, by CAR T cell therapy. Side effects can ensue from concurrent depletion of hematopoietic cells bearing the same target antigen. A population of engineered hematopoietic cells is prepared by obtaining healthy hematopoietic cells from the patient or a third party donor, and using them to produce engineered hematopoietic cells. The engineered cells either do not express the target antigen, express it at a lower density, or express it in a modified form. The engineered hematopoietic cells are formulated for administration to the patient, whereupon they reconstitute hematopoietic cell function, thereby preventing or reducing the side effects.

Abstract: The present invention pertains to an improved chemical synthesis method for Ahp-cyclodepsipeptides which allows straight forward and easy synthesis of tailor-made Ahp-cyclodepsipeptides. The invention further provides Ahp-cyclodepsipeptides for use as HTRA protease inhibitors and their medical use.

Abstract: The invention provides a system that comprises pharmaceutical agents for use in immunotherapy for reducing the side-effects of an antigen-recognizing receptor against antigen-expressing non-target cells in an individual. The system includes an antigen-recognizing receptor that specifically recognizes an antigen on target cells and at least on one hematopoietic cell type in the individual. The antigen-recognizing receptor is exemplified by chimeric antigen receptors (CAR) be expressed on the surface of an immune effector cells. The system also includes hematopoietic cells resistant to recognition of the same antigen by the antigen-recognizing receptor.

Abstract: The present invention relates to a method for reducing the amount of specific salts of sulfonic acid, sulfonamide or sulfonimide derivatives in waste waters obtained in the preparation of a polycarbonate composition containing these specific salts. The invention also relates to a use of branched polycarbonate in a polycarbonate composition for reducing the amount of specific salts of sulfonic acid, sulfonamide or sulfonimide derivatives in waste waters obtained in the preparation of this polycarbonate composition containing these specific salts.

Abstract: Electrical connectors with integrated touch protection are described. An example electrical connector has a conductor element, a fastening element that contacts the conductor element, a contact ring, an annular collar, and a protective sleeve. The protective sleeve fixed to the contact ring and partially covering the fastening element. The annular collar surrounding the contact ring. The annular collar and the protective sleeve form a touch protection that prevents unintentional contact of the contact ring and the fastening element.

Abstract: The present invention relates to compositions containing linear polycarbonate, branched polycarbonate and a small amount of salts of sulfonic acid, sulfonamide or sulfonimide derivatives. The invention likewise relates to the use of branched polycarbonate in a polycarbonate composition for achieving a classification according to UL94 of V-0 at a layer thickness of 2.00 mm.

Abstract: A method of preparing a polyolefin is disclosed. In some examples, the method comprises contacting an olefin monomer with an olefin polymerization precatalyst and a photoacid generator (PAG) to provide an olefin polymerization mixture; and irradiating the olefin polymerization matrix for a first period of time with ultraviolet or visible light, activating the precatalyst to catalyze polymerization of the olefin monomer, thereby preparing a polyolefin. Additive manufacturing approaches employing the methods are also disclosed, as are ink compositions comprising an olefin polymerization precatalyst and a PAG.

Abstract: A method adapts an apparatus to a motor-driven tool from a set of different types of motor-driven tools. The apparatus is arranged on the tool. The method has the steps of: capturing an identifier of the tool by way of the apparatus, and transmitting an item of type-specific configuration information from a database to the apparatus on the basis of the captured identifier in such a manner that the apparatus is designed to process operating data of the tool in a type-specific manner.

Abstract: A method is provided for operating a suction device that includes a suction unit and a removable filtering device. The suction unit generates a suction flow that flows through the filtering device when arranged on the suction device, in which, after the suction unit is started up, a check is performed of whether the filtering device is present, and if detected as not present, the suction unit is switched off. An evaluation unit uses check data to determine whether a switch-off signal is to be generated for the suction unit. The evaluation unit uses an algorithm or a table to arrive at a decision on switching off the suction unit based on the check data. The table contains at least one threshold value or the algorithm defines at least one threshold value, wherein the at least one threshold value is a threshold value for switching off the suction unit.

Abstract: Exemplary arrangements include devices that are operable to output three-dimensional images. Such devices may utilize a matrix of relatively movable light guides. The light guides are utilized to display visual images therethrough and may also be selectively movable axially to provide three-dimensional contours to displayed images. Other exemplary arrangements may utilize a matrix of light guides or similar structures that are displaceable, to provide inputs that can be correlated with data or other information and utilized for various purposes. Other exemplary arrangements may be utilized to provide visual representations corresponding to audible signals or other signals to provide improved multisensory experiences. Devices and methods of the types described can be utilized in many different contexts and applications to provide benefits and useful results.

Abstract: A power tool has a first electrical energy store and an operating data detection device for detecting operating data of the power tool. The operating data detection device includes an integrated circuit for wirelessly transmitting detected operating data. The power tool has a second electrical energy store, wherein the integrated circuit can be supplied from the first electrical energy store or from the second electrical energy store. The power tool has a circuit for reducing the rate of voltage rise, which circuit is designed to reduce a rate of voltage rise of a supply voltage of the integrated circuit when the supply of the integrated circuit from the second energy store is switched over to the first energy store.

Abstract: Crosslinkable compositions based on organopolysiloxanes containing organyloxy groups which have improved wetting behavior, and especially improved early stability, contain (A) organopolysiloxanes composed of units RaR1b(OR2)cSiO(4?a?b?c)/2??(I), (B) organosilicon compounds (R4O)dSiR3(4?d)??(II), and/or their partial hydrolysates, and (C) organosilicon compounds containing basic nitrogen (R6O)eSiR5(4?e)??(III), and/or their partial hydrolysates.

Abstract: A tugger cart includes a tugger frame having a first side member, a second side member, and a clasping member. A plurality of wheels are coupled to a bottom of the tugger frame. Each of the first side member and the second side member include a plurality of roller wheels rotatably coupled to an inner side and rotatable about a horizontal axis. The plurality of roller wheels align along an angled plane that declines from a rear of the tugger frame to a front of the tugger frame. The clasping member includes at least one fixed arm, at least one telescoping arm, an actuator, and a grab arm extendable and retractable from the at least one telescoping arm. The actuator converts the telescoping arm between an extended position and a retracted position.

Abstract: A tugger cart includes a tugger frame having a first side member, a second side member, and a clasping member. A plurality of wheels are coupled to a bottom of the tugger frame. Each of the first side member and the second side member include a plurality of roller wheels rotatably coupled to an inner side and rotatable about a horizontal axis. The plurality of roller wheels align along an angled plane that declines from a rear of the tugger frame to a front of the tugger frame. The clasping member includes at least one fixed arm, at least one telescoping arm, an actuator, and a grab arm extendable and retractable from the at least one telescoping arm. The actuator converts the telescoping arm between an extended position and a retracted position.

Abstract: A device records operating data of a motorized tool. The device is arranged on the tool, wherein the device has: a recording and/or evaluation device, wherein the recording and/or evaluation device is designed to record at least one variable, wherein the variable is dependent on an operating state of the tool, and to evaluate the recorded variable in order to identify the operating data, and/or to record the operating data. An operating data memory is provided, wherein the operating data memory is designed to store the identified and/or recorded operating data. A communication interface is designed, in a state connected to an external appliance, to wirelessly transmit the stored operating data thereto.

Abstract: A method adapts an apparatus to a motor-driven tool from a set of different types of motor-driven tools. The apparatus is arranged on the tool. The method has the steps of: capturing an identifier of the tool by way of the apparatus, and transmitting an item of type-specific configuration information from a database to the apparatus on the basis of the captured identifier in such a manner that the apparatus is designed to process operating data of the tool in a type-specific manner.

Abstract: According to some embodiments, an improved tugger and rider cart assembly system is presented. The system comprising a tugger cart with a central space to receive a rider cart; the tugger cart having both front side and rear side pluralities of transport wheels approximately parallel to, but not touching, ground; a front side and a rear side loading wheel positioned closer to the ground than the transport wheels; a rider cart having a first wing and a second wing, both wings having a curved portion; and wherein the loading wheels and wing curved portions can be operatively connected to allow a user to move the rider cart onto the tugger cart thereby allowing the tugger cart to transport the rider cart.

Abstract: Crosslinkable compositions based on organopolysiloxanes containing organyloxy groups which have improved wetting behavior, and especially improved early stability, contain (A) organopolysiloxanes composed of units RaR1b(OR2)cSiO(4-a-b-c)/2??(I), (B) organosilicon compounds (R4O)dSiR3(4-d)??(II), and/or their partial hydrolysates, and (C) organosilicon compounds containing basic nitrogen (R6O)eSiR5(4-e)??(III), and/or their partial hydrolysates.

Abstract: A training system includes a computer system, a display system and a motion capture device. During use the training system presents a computer simulation of a virtual subject capable of exhibiting nystagmus to a trainee. The movements of the trainee are captured using the computer system during the administration of an HGN test to the virtual subject. During the administration of the HGN test to the virtual subject, the training system simulates nystagmus in the virtual subject.