Patents by Inventor Michael Klein
Michael Klein has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 12270056Abstract: Provided herein are engineered variants of archaeal, prokaryotic, and eukaryotic polymerases that exhibit enhanced thermostability, enhanced incorporation of 3? modified nucleotides, and improved uracil-tolerance, in polymerase-catalyzed nucleotide extension reactions relative to wild type polymerase enzymes. Also provided are uses of the engineered polymerases for forming complexed polymerases, forming binding complexes and forming ternary complexes, and uses for conducting nucleic acid sequencing reactions.Type: GrantFiled: March 25, 2022Date of Patent: April 8, 2025Assignee: ELEMENT BIOSCIENCES, INC.Inventors: Mark Ambroso, Tyler Lopez, Michael Klein, Virginia Saade, Matthew Kellinger
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Patent number: 12262740Abstract: An inhaler vaporizer cartridge includes a housing body with a flow channel, a liquid storage tank, and a vaporizer unit. The vaporizer unit has a wick member and heating member and is liquid-permeable such that liquid is conveyed from the tank through the vaporizer unit to the flow channel. The housing body has a cavity forming the tank and a wick member receiving chamber, and housing is divided by an intermediate wall and a flow channel section. An access opening from the receiving chamber to the flow channel is formed in the intermediate wall and covered by the heating member. Granular grains in the receiving chamber form the wick member and bear against the heating member. The grains form microchannels and are retained by a cover element. An access opening, covered with a liquid-permeable grid structure, establishes a liquid connection from the tank to receiving chamber in the intermediate wall.Type: GrantFiled: June 17, 2020Date of Patent: April 1, 2025Assignee: KÖRBER TECHNOLOGIES GMBHInventors: Max Bergmann, Lasse Cornils, Matthias Giese, Christian Hanneken, Jan Jaklin, Marc Kessler, Michael Kleine Wächter, Thomas Müller, Niklas Romming, Rene Schmidt, Christof Schuster, Tobias Wuttke
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Publication number: 20250104098Abstract: A method for determining a trust indicator is provided. The method may include interpreting, via an Internet of Things Universal Identifier (IoT UID) processing circuit, an IoT UID corresponding to a device and identifying, via a record management circuit and based at least in part on the IoT UID, a record in a database corresponding to the device. The method may further include determining, via a trust analysis circuit and based at least in part on the record, a risk indicator of the device and transmitting, via an indicator provisioning circuit, the risk indicator.Type: ApplicationFiled: December 5, 2024Publication date: March 27, 2025Inventors: Eduardo Correia da Silva Brazao, Steven Norman Brumer, Ian Michael Klein, Li Kong, Marc Rudloff Plante, Sridhar Ramachandran, Kimberly Tashner Shyu, Robert Janusz Sliwa, Jeffrey Scott Smith, Christopher Anton Wendt, Haofang Yu
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Publication number: 20250101390Abstract: Provided herein are engineered variants of archaeal polymerases that exhibit exonuclease-minus activity, enhanced thermostability, enhanced incorporation of 3? modified nucleotides, improved uracil-tolerance and/or reduce sequence-specific errors in polymerase-catalyzed nucleotide binding and extension reactions relative to wild type polymerase enzymes. Also provided are uses of the engineered polymerases for forming complexed polymerases and forming binding complexes, and uses for conducting nucleic acid sequencing reactions.Type: ApplicationFiled: December 10, 2024Publication date: March 27, 2025Inventors: Jendrik BOOTHBY-HENTSCHEL, Michael KLEIN, Mark AMBROSO, Tyler LOPEZ, Matthew KELLINGER, Virginia SAADE, Ramkrishna ADHIKARY
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Patent number: 12253270Abstract: Example embodiment relate to an air conditioner. A fastening device fastens a compressor on a bottom of a housing via a mounting component. A clamping element is arranged within a guiding element. The guiding element is arranged in a recess of the bottom of the housing and has a smaller length than the recess. Two stop elements are each associated with a front side of the clamping element, an axial distance between the stop elements being variable in the unassembled state and being fixed in an assembled state.Type: GrantFiled: October 25, 2021Date of Patent: March 18, 2025Assignee: TRUMA GERAETETECHNIK GMBH & CO. KGInventors: Michael Klein, Wolfgang Muselmann
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Publication number: 20250084478Abstract: The present disclosure provides nucleotide conjugates each configured to include a core attached to multiple nucleotide-arms, where the nucleotide-arms are modular and comprise (i) a core attachment moiety, (ii) a spacer, (iii) a linker, and (iv) a nucleotide unit. The nucleotide unit of each nucleotide-arm can bind a polymerase which is complexed with a nucleic acid template and nucleic acid primer. The nucleotide unit can bind the 3? end of the primer at a position that is opposite a complementary nucleotide in the template strand. Under suitable conditions, the nucleotide unit of the nucleotide conjugates binds the primer strand but does not undergo polymerase-catalyzed incorporation. The binding event can be detected, and the specific base of the nucleotide unit can be identified. The nucleotide conjugates described herein are useful for nucleic acid sequencing methods, particularly for massively parallel sequencing methods employed for next gen sequencing platforms.Type: ApplicationFiled: November 22, 2024Publication date: March 13, 2025Inventors: MICHAEL PREVITE, MARK AMBROSO, TYLER LOPEZ, MICHAEL KLEIN, VIRGINIA SAADE, MATTHEW KELLINGER
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Publication number: 20250076579Abstract: Embodiments of the disclosure provide apparatuses, systems, and methods related to controlling film thickness in photonic-integrated apparatus. In some embodiments, a bottom cladding layer is deposited on a substrate, a thickness map of the bottom cladding layer is generated, thickness trimming is performed on the bottom cladding layer based on the thickness map for the bottom cladding layer; a waveguide core layer is deposited on the bottom cladding layer, a thickness map of the waveguide core layer is generated, thickness trimming is performed on the waveguide core layer based on the thickness map for the bottom waveguide core layer; a top cladding layer is deposited on the waveguide core layer, a thickness map of the top cladding layer is generated; and thickness trimming is performed on the top cladding layer based on the thickness map for the top cladding layer.Type: ApplicationFiled: September 4, 2024Publication date: March 6, 2025Inventors: Christopher T. Ertsgaard, Todd Michael Klein, Christopher John Carron, Eugene Freeman
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Patent number: 12241851Abstract: A signal processing system used for GMR-based detection of a target analyte in a sample under test, comprising: a measurement circuit configuration unit configured to build a GMR sensor measurement circuit by routing in at least one GMR sensor, and to build a reference resistor measurement circuit by routing in at least one reference resistor; a magnetic field excitation unit configured to apply an AC magnetic field of frequency ?2 to the at least one GMR sensor; a carrier signal applying unit configured to apply a carrier signal of frequency ?1 to the GMR sensor measurement circuit, and apply carrier signals of frequency ?1, ?1+?2, and ?1??2 to the reference resistor measurement circuit; a measurement signal pick-up unit coupled to the measurement circuits, configured to collect reference resistor measurement signals from the reference resistor measurement circuit and GMR sensor measurement signals from the GMR sensor measurement circuit; and a phase sensitive solution unit coupled to the measurement signalType: GrantFiled: July 26, 2019Date of Patent: March 4, 2025Assignee: Zepto Life Technology, Inc.Inventors: Todd Michael Klein, Michael Monroe Reinhart Sandstedt, Keping Song
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Patent number: 12236435Abstract: A method for registering one or more Greenfield devices via a virtual Internet of Things Universal Identifier (IoT UID) is provided. The method includes identifying one or more Brownfield devices, generating device property data based at least in part on the one or more Brownfield devices, and transmitting, to an IoT device registrar server, a registration request that includes the device property data. The method further includes interpreting one or more IoT UIDs generated in response to the transmitting of the registration request.Type: GrantFiled: April 15, 2022Date of Patent: February 25, 2025Assignee: Somos, Inc.Inventors: Eduardo Correia da Silva Brazao, Steven Norman Brumer, Ian Michael Klein, Li Kong, Marc Rudloff Plante, Sridhar Ramachandran, Kimberly Tashner Shyu, Robert Janusz Sliwa, Jeffrey Scott Smith, Christopher Anton Wendt, Haofang Yu
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Patent number: 12219995Abstract: A vaporizer cartridge for an inhaler has a hollow body with a continuous flow channel and liquid storage tank. The tank has an access opening to the channel and a vaporizer unit extending over the entire access opening. The vaporizer unit has a wick member and a heating member. The vaporizer unit is liquid-permeable such that liquid is conveyed at least initially in a capillary manner from the storage tank through the vaporizer unit in the direction of the flow channel. The wick member is formed from a plurality of granular grains which, as a result of their fill and/or formation, form microchannels which establish a fluid connection between the storage tank and the flow channel, continuously from an entry side to an exit side of the wick member. An additional securing means is provided which is holds the granular wick member in position. A corresponding inhaler is also provided.Type: GrantFiled: June 17, 2020Date of Patent: February 11, 2025Assignee: KÖRBER TECHNOLOGIES GMBHInventors: Max Bergmann, Lasse Cornils, Matthias Giese, Christian Hanneken, Jan Jaklin, Marc Kessler, Michael Kleine Wächter, Thomas Müller, Niklas Romming, Rene Schmidt, Christof Schuster, Tobias Wuttke
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Publication number: 20250047673Abstract: An apparatus for an Internet of Things device registry display includes a user input processing circuit structured to interpret one or more user input command values, an Internet of Things Universal Identification (IoT UID) identification circuit structured to determine one or more IoT UIDs, based at least in part on the one or more user input command values, a device lookup circuit structured to: generate a query that includes the one or more IoT UIDs, and retrieve device property data corresponding to the one or more IoT UIDs, a query provisioning circuit structured to transmit the query to an IoT device registrar server, a device property processing circuit structured to interpret the device property data generated by the IoT device registrar server in response to the query, and a display circuit structured to display the device property data with the corresponding one or more IoT UIDs.Type: ApplicationFiled: October 23, 2024Publication date: February 6, 2025Inventors: Sridhar Ramachandran, Eduardo Correia da Silva Brazao, Steven Norman Brumer, Ian Michael Klein, Li Kong, Marc Rudloff Plante, Kimberly Tashner Shyu, Robert Janusz Sliwa, Jeffrey Scott Smith, Christopher Anton Wendt, Haofang Yu
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Patent number: 12198147Abstract: A method for determining a trust indicator is provided. The method may include interpreting, via an Internet of Things Universal Identifier (IoT UID) processing circuit, an IoT UID corresponding to a device and identifying, via a record management circuit and based at least in part on the IoT UID, a record in a database corresponding to the device. The method may further include determining, via a trust analysis circuit and based at least in part on the record, a risk indicator of the device and transmitting, via an indicator provisioning circuit, the risk indicator.Type: GrantFiled: April 15, 2022Date of Patent: January 14, 2025Assignee: Somos, Inc.Inventors: Eduardo Correia da Silva Brazao, Steven Norman Brumer, Ian Michael Klein, Li Kong, Marc Rudloff Plante, Sridhar Ramachandran, Kimberly Tashner Shyu, Robert Janusz Sliwa, Jeffrey Scott Smith, Christopher Anton Wendt, Haofang Yu
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Patent number: 12190078Abstract: Rounding hexadecimal floating point numbers using binary incrementors, including: incrementing, by a first incrementor, a first subset of bits of an operand comprising a binary hexadecimal floating point operand; incrementing, by a second incrementor, a second subset of bits of the operand; generate an intermediate result based on a carryout of the second incrementor; and generate an incremented result based on a carryout of the first incrementor and one or more of: a first bit of the intermediate result or the carryout of the second incrementor.Type: GrantFiled: March 25, 2022Date of Patent: January 7, 2025Assignee: INTERNATIONAL BUSINESS MACHINES CORPORATIONInventors: Michael Klein, Petra Leber, Cedric Lichtenau, Stefan Payer, Kerstin Claudia Schelm
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Patent number: 12176678Abstract: In at least one embodiment of the method of operating a laser device (100) having a plurality of laser diodes (1) which can be controlled independently of one another, wherein controlled laser diodes are each operated with an operating current (I), and wherein each laser diode can be operated for a proper operation in a nominal current range (?I), a step A) is carried out in which an input current (I_0) or an input voltage (U_0) is applied to the laser device. Furthermore, a step B) is carried out in which a characteristic value is determined that is representative of a number N of laser diodes that can be operated in the respective nominal current range with the input current applied in step A) or with the input voltage applied in step A). If the characteristic value is representative of N?1, M laser diodes are controlled in a step C) in such a way that the M laser diodes are each operated in the nominal current range, wherein 1?M?N is selected.Type: GrantFiled: November 29, 2018Date of Patent: December 24, 2024Assignee: OSRAM OLED GMBHInventors: Roland Heinrich Enzmann, Hubert Halbritter, Michael Klein
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Patent number: 12174135Abstract: A system for detecting analytes in a test sample, and a method for processing the same, is provided. The system includes a cartridge reader unit that has a control unit and a pneumatic system, and a cartridge assembly that prepares the samples with mixing material(s) through communication channels. The assembly has a memory chip with parameters for preparing the sample and at least one sensor. The assembly, pneumatic system, and control unit operate together to prepare the sample and provide the prepared sample to the sensor for detecting analytes, and also process measurements from the sensor to generate test results.Type: GrantFiled: December 2, 2022Date of Patent: December 24, 2024Assignee: Zepto Life Technology, Inc.Inventors: Todd Michael Klein, Michael Monroe Reinhart Sandstedt, John Frank Provos, Chad Brian Rheault
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Patent number: 12163163Abstract: Provided herein are engineered variants of archaeal polymerases that exhibit exonuclease-minus activity, enhanced thermostability, enhanced incorporation of 3? modified nucleotides, improved uracil-tolerance and/or reduce sequence-specific errors in polymerase-catalyzed nucleotide binding and extension reactions relative to wild type polymerase enzymes. Also provided are uses of the engineered polymerases for forming complexed polymerases and forming binding complexes, and uses for conducting nucleic acid sequencing reactions.Type: GrantFiled: January 27, 2023Date of Patent: December 10, 2024Assignee: ELEMENT BIOSCIENCES, INC.Inventors: Jendrik Boothby-Hentschel, Tyler Lopez, Michael Klein, Virginia Saade, Matthew Kellinger, Mark Ambroso
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Patent number: 12155657Abstract: An Internet of Things device registry display that includes a user input processing circuit structured to interpret one or more user input command values, an Internet of Things Universal Identification (IoT UID) identification circuit structured to determine one or more IoT UIDs, based at least in part on the one or more user input command values, a device lookup circuit structured to: generate a query that includes the one or more IoT UIDs, and retrieve device property data corresponding to the one or more IoT UIDs, a query provisioning circuit structured to transmit the query to an IoT device registrar server, a device property processing circuit structured to interpret the device property data generated by the IoT device registrar server in response to the query, and a display circuit structured to display the device property data with the corresponding one or more IoT UIDs.Type: GrantFiled: April 15, 2022Date of Patent: November 26, 2024Assignee: Somos, Inc.Inventors: Sridhar Ramachandran, Eduardo Correia da Silva Brazao, Steven Norman Brumer, Ian Michael Klein, Li Kong, Marc Rudloff Plante, Kimberly Tashner Shyu, Robert Janusz Sliwa, Jeffrey Scott Smith, Christopher Anton Wendt, Haofang Yu, Sriram Sharma, Michael Kimmel, Suk Yee Wong, William Carter, Manisha Bhat, Pamela J. Carter, Sanjeev Chauhan, Ryan Karnas, Alan Stiffler, Dewang Lakhani
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Patent number: 12139727Abstract: Provided herein are engineered variants of archaeal, prokaryotic, and eukaryotic polymerases that exhibit enhanced thermostability, enhanced incorporation of 3? modified nucleotides, and improved uracil-tolerance, in polymerase-catalyzed nucleotide extension reactions relative to wild type polymerase enzymes. Also provided are uses of the engineered polymerases for forming complexed polymerases, forming binding complexes and forming ternary complexes, and uses for conducting nucleic acid sequencing reactions.Type: GrantFiled: March 25, 2022Date of Patent: November 12, 2024Assignee: ELEMENT BIOSCIENCES, INC.Inventors: Mark Ambroso, Tyler Lopez, Michael Klein, Virginia Saade, Matthew Kellinger
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Publication number: 20240371539Abstract: A composite confinement apparatus assembly is provided. The composite confinement apparatus assembly includes a quantum object confinement apparatus and a photonic platform. The confinement apparatus includes one or more electrical components and is fabricated on a confinement apparatus substrate. The photonic platform includes one or more photonic components that are hosted by a photonic platform substrate. The photonic platform substrate is mechanically coupled to the confinement apparatus substrate to form the composite confinement apparatus assembly.Type: ApplicationFiled: October 2, 2023Publication date: November 7, 2024Inventors: Adam Jay Ollanik, Mary A. Rowe, Molly R. Krogstad, Bryan DeBono, Matthew J. Bohn, Curtis Volin, Matthew Blain, Todd Michael Klein, Christopher T. Ertsgaard, John Pagnucci Gaebler, Rezlind Bushati, David M. Gaudiosi
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Patent number: D1071864Type: GrantFiled: July 11, 2022Date of Patent: April 22, 2025Assignee: Flender GmbHInventors: Christoph Bruns, Michael Klein-Hitpass, Michael Tegelkamp, Eugen Schlegel