Abstract: Methods and systems for analysis of image data generated from various reference points. Particularly, the methods and systems provided are useful for real time analysis of image and sequence data generated during DNA sequencing methodologies.

Abstract: Methods and systems for analysis of image data generated from various reference points. Particularly, the methods and systems provided are useful for real time analysis of image and sequence data generated during DNA sequencing methodologies.

Abstract: This invention relates to a tire with high performance tread of rubber composition for promoting tread durability and traction. For such purpose, a tread rubber composition is provided which contains a high Tg solvent solution polymerization prepared styrene/butadiene elastomer (SSBR) together with precipitated silica reinforcement and traction resin. The invention includes extension of the uncured high Tg SSBR by triglyceride vegetable oil instead of petroleum based oil.

Abstract: The invention provides a novel class of therapeutic agents that are safe and effective TYK2 inhibitors and pharmaceutical compositions of these compounds and methods of preparation and use thereof against various TYK2-mediated diseases and disorders.

Abstract: The invention provides a novel class of orally and/or topically available, selective and potent JAK inhibitors as safe and effective therapeutics against various diseases and disorders. The invention also provides pharmaceutical composition of these compounds and methods of their preparation and use thereof.

Abstract: A fiber routing system including a plurality of two/multi fiber cables terminated at each end a two/multi fiber connector, wherein each of the two/multi fiber cables is a key up to key down arrangement; a plurality of two/multi fiber adapters each connecting two of the two/multi fiber connectors of two two/multi fiber cables, wherein the two two/multi fiber cables are connected end to end, wherein each of the two/multi fiber adapters have a key up to key down arrangement. The cables connect first equipment and to second equipment. A plurality of transition cable arrays can be included, each including a plurality of optical fibers, wherein a plurality of two/multi fiber connectors are at the first end, and wherein at least one MPO fiber connector is at the second end.

Abstract: A system and method for user friendly replacement of printer platen rolls includes a roll assembly having a support shaft with a bearing seated in a flange at one end. A crescent notch in a printer chassis receives the shaft into an interior of the notch. The assembly is moved axially so that a flange neck nests in the notch with a flange lip contacting a surface of the chassis. A lock contacts the lip to prevent axial motion of the assembly when installed. An opposed side of the shaft is placed in a bearing on an opposite side of the chassis.

Abstract: The present application provides a beverage dispenser for dispensing a beverage in a contactless fashion. The beverage dispenser may include a number of adjacent dispensing valves with each of the dispensing valves including a nozzle and a contactless dispensing valve system. The contactless dispensing valve system includes one or more proximity sensors positioned under the nozzle of each of the adjacent dispensing valves.

Abstract: Methods and systems for analysis of image data generated from various reference points. Particularly, the methods and systems provided are useful for real time analysis of image and sequence data generated during DNA sequencing methodologies.

Abstract: The invention provides a novel class of therapeutics that are safe and effective inhibitors of Janus kinase 1 and pharmaceutical composition and methods of preparation and use thereof in the treatment of various diseases and disorders (e.g., inflammatory diseases, immune-mediated diseases or cancer).

Abstract: The present invention provides thiazole compounds of Formula I wherein W, Y, R0, R2, R4, R1, R6, R7, X1, X2, X3 and X4 are as defined herein, or a stereoisomer, tautomer, pharmaceutically acceptable salt, prodrug ester or solvate form thereof, wherein all of the variables are as defined herein. These compounds are inhibitors of platelet aggregation and thus can be used as medicaments for treating or preventing thromboembolic disorders.

Abstract: Embodiments described herein relate to electrochemical cells with one or more current collectors divided into segments, and methods of producing the same. A current collector divided into segments comprises a substantially planar conductive material including a connection region and an electrode region. The electrode region includes one or more dividers defining a plurality of electron flow paths. The plurality of electron flow paths direct the flow of electrons from the electrode region to the connection region. In some embodiments, the current collector includes a fuse section disposed between the electrode region and the connection region. In some embodiments, the fuse section can include a thin strip of conductive material, such that the thin strip of conductive material melts at a melting temperature and substantially prevent electron movement between the electrode region and the connection region.

Abstract: Surgical devices that are made from a shape memory alloy (SMA) that is then processed via a multiple memory material process to impart at least altered property via at least one processed region. In use, when a predetermined temperature is applied to the surgical device, the at least one processed regions responds to the predetermined temperature and provides a predetermined functionality.

Abstract: The present invention provides compounds of Formula (I): wherein all variables are as defined in the specification, and compositions comprising any of such novel compounds. These compounds are APJ agonists which may be used as medicaments.

Abstract: Provided in the present disclosure is crystal form I of compound 1, and a preparation method thereof and the use thereof.

Abstract: A helmet accessory mounting system includes a mounting device configured to couple to an outer surface of a side of a helmet. The mounting device includes a plurality of mounting locations configured to removeably couple to at least one accessory. A plurality of the plurality of mounting locations each includes an electrical node. A power supply is coupled to the mounting device. An electrical supply line electrically couples the power supply to each of the electrical nodes and the electrical supply line is contained at least partially within the mounting device.

Abstract: Provided in the present disclosure is crystal form I of compound 1, and a preparation method thereof and the use thereof.

Abstract: The present disclosure relates to converters for converting a male fiber optic connector to a female fiber optic connector. The converters can include configurations that are environmentally sealed and ruggedized.

Abstract: Embodiments described herein relate to electrochemical devices and electrochemical cells with vents and venting mechanisms. In some aspects, an electrochemical device can include an anode disposed on an anode current collector, a cathode disposed on a cathode current collector, a separator disposed between the anode and the cathode, a first film disposed on the anode current collector and having outer edges extending beyond outer edges of the anode current collector, and a second film disposed on the cathode current collector and having outer edges extending beyond outer edges of the cathode current collector, the second film bonded to the first film along a sealing region to form a pouch, the pouch having an internal pressure, the sealing region including a first portion and a second portion, the second portion configured to fail at a lower internal pressure than the first portion.

Abstract: The invention provides a novel class of therapeutic agents that are safe and effective TYK2 inhibitors and pharmaceutical compositions of these compounds and methods of preparation and use thereof against various TYK2-mediated diseases and disorders.