Abstract: The present invention provides compounds of Formula (I): wherein all variables are as defined in the specification, and compositions comprising any of such novel compounds. These compounds are APJ agonists which may be used as medicaments.

Abstract: Provided in the present disclosure is crystal form I of compound 1, and a preparation method thereof and the use thereof.

Abstract: A helmet accessory mounting system includes a mounting device configured to couple to an outer surface of a side of a helmet. The mounting device includes a plurality of mounting locations configured to removeably couple to at least one accessory. A plurality of the plurality of mounting locations each includes an electrical node. A power supply is coupled to the mounting device. An electrical supply line electrically couples the power supply to each of the electrical nodes and the electrical supply line is contained at least partially within the mounting device.

Abstract: Provided in the present disclosure is crystal form I of compound 1, and a preparation method thereof and the use thereof.

Abstract: The present disclosure relates to converters for converting a male fiber optic connector to a female fiber optic connector. The converters can include configurations that are environmentally sealed and ruggedized.

Abstract: The invention provides a novel class of therapeutic agents that are safe and effective TYK2 inhibitors and pharmaceutical compositions of these compounds and methods of preparation and use thereof against various TYK2-mediated diseases and disorders.

Abstract: A rubber composition suited for forming a tire tread includes 100 phr of elastomers, at least 30 phr of reinforcing fillers, such as carbon black and silica. The high surface area silica has a CTAB surface area of at least 220 m2/g. A ratio of the carbon black to the high surface area silica is at least 4:1. The composition further includes one or more processing aids and a sulfur-containing cure package.

Abstract: A data processing system implements receiving a first textual prompt from a first user via a first user interface of a first client device, the first textual prompt includes a textual description of content to be generated by a generative model; providing the first textual prompt as a first input to the generative model to obtain as an output first collaborative content based on the first textual prompt; receiving an edited version of the first collaborative content from the first client device that includes edits to the first collaborative content provided by the first user; providing the edited version of the first collaborative content as a second input to the generative model to obtain as an output second collaborative content based on the edited version of the first collaborative content; and causing the first client device to present the second collaborative content on the first user interface.

Abstract: A system and method utilizes a machine readable garment identification tag at a first station to enter information on the specific garment into a computer system. The garment data from the garment identification tag is assigned to a garment identifier which is printed or formed on a hanger neck sleeve member. The hanger neck sleeve member provides a consistent scan point through all the subsequent sorting stations in the system. This eliminates the need to search for the position of the garment tag to scan in sort stations subsequent to the initial station. Each hanger neck sleeve member has a machine readable code that is assigned to the associated garment and is placed on the neck of the hanger for that garment. The position of the hanger neck sleeve member on the neck of the hanger makes it readily accessible and readable, significantly more so than the garment tag in these regards.

Abstract: A sealant composition suited to forming a sealant layer in a tire includes 100 phr elastomers, including at least 60 phr of an isobutylene-based elastomer component, and at least 5 phr of a conjugated diene-based elastomer component. The sealant composition further includes at least 5 phr of particulate filler, at least 0.5 phr of an organic peroxide, and optionally a colorant which provides the sealant with a non-black color.

Abstract: A fiber optic connection system is disclosed. The fiber optic connection system includes a pre-terminated fiber optic connector assembly adapted to be optically spliced to a fiber optic cable at a splice location. A robust splice protection package configured for field installation is adapted to be installed over the splice location.

Abstract: The present disclosure generally relates to modified relaxin polypeptides, such as modified human relaxin 2 polypeptides, comprising a non-naturally encoded amino acid which is linked to a pharmacokinetic enhancer, and therapeutic uses of such polypeptides, such as for the treatment of cardiovascular conditions (such as heart failure) and/or conditions relating to fibrosis.

Abstract: The invention provides novel benzamides of pyrazolyl-amino-pyrimidinyl derivatives of Formula (I) as selective and potent JAK inhibitors for treating various diseases and disorders. The invention also provides pharmaceutical composition of these compounds and methods of their preparation and use thereof.

Abstract: The present disclosure generally relates to modified relaxin polypeptides, such as modified human relaxin 2 polypeptides, comprising a non-naturally encoded amino acid which is linked to a pharmacokinetic enhancer, and therapeutic uses of such polypeptides, such as for the treatment of cardiovascular conditions (such as heart failure) and/or conditions relating to fibrosis.

Abstract: The present disclosure provides methods, devices, and systems that utilize dental appliance etch templates prior to or during dental treatment. One dental appliance etch template includes a removable shell having one or more cavities formed therein, where the one or more cavities are shaped to receive teeth of a patient, and the shell includes a well, the well including a wafer, where the wafer includes etch material to etch a tooth of the patient.

Abstract: The present invention provides thiazole compounds of Formula I wherein W, Y, R0, R2, R4, R5, R6, R7, X1, X2, X3 and X4 are as defined herein, or a stereoisomer, tautomer, pharmaceutically acceptable salt, prodrug ester or solvate form thereof, wherein all of the variables are as defined herein. These compounds are inhibitors of platelet aggregation and thus can be used as medicaments for treating or preventing thromboembolic disorders.

Abstract: The present disclosure relates to a hardened power and optical connection system for use with hybrid cables. The hardened power and optical connection system includes electrical pin and socket contacts for providing power connections, and ferrules for providing optical connections. The hardened power and optical connection system has an integrated fiber alignment provided through a mating relationship between a plug and a socket.

Abstract: An implantation tool for implanting a paranasal sinus fluid access implant device through a surgical path between a lacrimal apparatus in an orbit and a paranasal sinus in an implantation procedure to provide direct fluid communication access from the lacrimal apparatus in the orbit to the paranasal sinus through an internal passage of the implant device. The implantation assembly comprises the implant device and an implantation tool wherein the implant device is mounted in a mounting orientation on a mounting portion of a carrier member of the implantation tool with a securement mechanism of the implantation tool in a securement configuration. The securement mechanism is reconfigurable to a released configuration to release the implant device from securement to the mounting portion of the carrier member.

Abstract: Embodiments described herein relate to electrochemical cells with one or more current collectors divided into segments, and methods of producing the same. A current collector divided into segments comprises a substantially planar conductive material including a connection region and an electrode region. The electrode region includes one or more dividers defining a plurality of electron flow paths. The plurality of electron flow paths direct the flow of electrons from the electrode region to the connection region. In some embodiments, the current collector includes a fuse section disposed between the electrode region and the connection region. In some embodiments, the fuse section can include a thin strip of conductive material, such that the thin strip of conductive material melts at a melting temperature and substantially prevent electron movement between the electrode region and the connection region.

Abstract: A method of forming a flexible interconnect circuit is described. A method may involve laminating a substrate to a conductive layer followed by patterning the conductive layer. This patterning operation forms individual conductive portions, which may be also referred to as traces or conductive islands. The substrate supports these portions relative to each other during and after patterning. After patterning, an insulator may be laminated to the exposed surface of the patterned conductive layer. At this point, the conductive layer portions are also supported by the insulator, and the substrate may optionally be removed, e.g., together with undesirable portions of the conductive layer. Alternatively, the substrate may be retained as a component of the circuit and the undesirable portions of the patterned conductive layer may be removed separately. These approaches allow using new patterning techniques as well as new materials for substrates and/or insulators.