Abstract: Disclosed are compounds of Formula (I), Formula (II), or a salt thereof: Formula (I) Formula (II) which compounds have properties for inhibiting Nav 1.7 ion channels found in peripheral and sympathetic neurons. Also described are pharmaceutical formulations comprising the compounds of Formula (I), Formula (II) or their salts, and methods of treating pain disorders, cough, and itch using the same.

Abstract: A software defined button includes a force sensor and a haptic output element. The button further includes an immutable logic core and a mutable logic core. The mutable logic core is configured to define one or more thresholds against which input received from the force sensor can be compared to determine whether a user input has been provided. The immutable logic core is configured to verify actual force input has been received when the mutable logic core signals that user input has been received. In response to receiving a verified force input, the haptic output element can be caused to be driven by one of the mutable or immutable logic cores to provide a haptic output to a user.

Abstract: A planetary roller mill for processing a feed material includes a vessel with a grinding ring having an opening and a first area. The grinding ring is in sealing engagement with an inside surface of the vessel. At least two non-circular support plates are secured to a rotatable shaft. Each plate has an axially facing surface. A plurality of rollers are rotatably mounted to and positioned between the two support plates. Each of the plurality of rollers are in grinding communication with the grinding surface. The planetary roller mill includes an air supply system having an outlet in communication with the opening in the grinding ring. Areas of the two support plates are of magnitudes configuring a flow area through the opening of at least 30 percent of the first area to provide a predetermined quantity of heated air to remove moisture from the feed material in the mill.

Abstract: In one embodiment, a system includes a first device rendering image data, a second device storing the image data, and a display panel that displays the image data stored in the memory. The first device renders multiple frames of the image data, compresses the multiple frames into a single superframe, and transports the single superframe. The second device receives the single superframe, decompresses the single superframe into the multiple frames of image data, and stores the image data on a memory of the second device.

Abstract: Dialysis systems and methods are described which can include a number of features. The dialysis systems described can be to provide dialysis therapy to a patient in the comfort of their own home. The dialysis system can be configured to prepare purified water from a tap water source in real-time that is used for creating a dialysate solution. The dialysis systems described also include features that make it easy for a patient to self-administer therapy. For example, the dialysis systems include disposable cartridge and patient tubing sets that are easily installed on the dialysis system and automatically align the tubing set, sensors, venous drip chamber, and other features with the corresponding components on the dialysis system. Methods of use are also provided, including automated priming sequences, blood return sequences, and dynamic balancing methods for controlling a rate of fluid transfer during different types of dialysis, including hemodialysis, ultrafiltration, and hemodiafiltration.

Abstract: An impact mill using hammers to strike particles and reduce their size as the material progresses through a grinding chamber. Baffles are provided in the grinding chamber, adjacent the interior wall thereof, concentrically about the drive shaft of the mill. The baffles are adjacent to the hammers in the area of hammer sweep and form a path for the material using the flow of air through the mill and the swing of hammers to keep material from falling within the mill and remaining in the hammer sweep area. A variable speed motor varies the rate of movement of the hammers to increase or decrease the rate of strike of hammers to more efficiently and effectively reduce the material passing therethrough. The baffles can be retrofit into existing mills and can be created in angular sections with the lining of the grinding chamber for modular installation and removal.

Abstract: A system for conditioning stucco particulate material includes a vessel having separation chamber in communication with a holding chamber having a holding volume therein. The conditioning system includes the holding volume sufficient to condition the stucco particulate material therein and/or a control system configured to delay discharge of the stucco particulate material from the holding chamber. The system for conditioning stucco particulate material is configured to increase residence time of the stucco particulate material in the holding chamber to promote calcining conditioning therein.

Abstract: A planetary roller mill for processing a feed material includes a vessel with a grinding ring having an opening therethrough and a first area. The grinding ring is in sealing engagement with the inside surface of the vessel assembly. At least two non-circular support plates are secured to a rotatable shaft. Each plate has an axially facing surface. A plurality of rollers rotatably are mounted to and positioned between the two support plates. Each of the plurality of rollers are in grinding communication with the grinding surface. The planetary roller mill includes an air supply system having an outlet in communication with the opening in the grinding ring. Areas of the two support plates are of magnitudes which configure a flow area through the opening of at least 30 percent of the first area to provide a predetermined quantity of heated air to remove moisture from the feed material in the grinding assembly.

Abstract: A base and ring assembly for a grinding mill includes a base structure with a support plate, an annular support-ring fixedly secured to and positioned above the support plate. The support-ring has a radially inward facing convex surface that extends from a support-ring lower axial end to a support-ring upper axial end. The assembly includes an annular grinding-ring that has a radially outward facing concave surface which extends from a grinding-ring lower axial end to a grinding-ring upper axial end. The grinding ring has a radially inward facing grinding surface. The radially outward facing concave surface is complementary in shape to and engages the radially inward facing convex surface.

Abstract: A planetary roller mill for processing a feed material includes a vessel with a grinding ring having an opening therethrough and a first area. The grinding ring is in sealing engagement with the inside surface of the vessel assembly. At least two non-circular support plates are secured to a rotatable shaft. Each plate has an axially facing surface. A plurality of rollers rotatably are mounted to and positioned between the two support plates. Each of the plurality of rollers are in grinding communication with the grinding surface. The planetary roller mill includes an air supply system having an outlet in communication with the opening in the grinding ring. Areas of the two support plates are of magnitudes which configure a flow area through the opening of at least 30 percent of the first area to provide a predetermined quantity of heated air to remove moisture from the feed material in the grinding assembly.

Abstract: A base and ring assembly for a grinding mill includes a base structure with a support plate, an annular support-ring fixedly secured to and positioned above the support plate. The support-ring has a radially inward facing convex surface that extends from a support-ring lower axial end to a support-ring upper axial end. The assembly includes an annular grinding-ring that has a radially outward facing concave surface which extends from a grinding-ring lower axial end to a grinding-ring upper axial end. The grinding ring has a radially inward facing grinding surface. The radially outward facing concave surface is complementary in shape to and engages the radially inward facing convex surface.

Abstract: A system for conditioning stucco particulate material includes a vessel having separation chamber in communication with a holding chamber having a holding volume therein. The conditioning system includes the holding volume sufficient to condition the stucco particulate material therein and/or a control system configured to delay discharge of the stucco particulate material from the holding chamber. The system for conditioning stucco particulate material is configured to increase residence time of the stucco particulate material in the holding chamber to promote calcining conditioning therein.

Abstract: A planetary roller mill for processing a feed material includes a vessel with a grinding ring having an opening therethrough and a first area. The grinding ring is in sealing engagement with the inside surface of the vessel assembly. At least two non-circular support plates are secured to a rotatable shaft. Each plate has an axially facing surface. A plurality of rollers rotatably are mounted to and positioned between the two support plates. Each of the plurality of rollers are in grinding communication with the grinding surface. The planetary roller mill includes an air supply system having an outlet in communication with the opening in the grinding ring. Areas of the two support plates are of magnitudes which configure a flow area through the opening of at least 30 percent of the first area to provide a predetermined quantity of heated air to remove moisture from the feed material in the grinding assembly.

Abstract: An impact mill using hammers to strike particles and reduce their size as the material progresses through a grinding chamber. Baffles are provided in the grinding chamber, adjacent the interior wall thereof, concentrically about the drive shaft of the mill. The baffles are adjacent to the hammers in the area of hammer sweep and form a path for the material using the flow of air through the mill and the swing of hammers to keep material from falling within the mill and remaining in the hammer sweep area. A variable speed motor varies the rate of movement of the hammers to increase or decrease the rate of strike of hammers to more efficiently and effectively reduce the material passing therethrough. The baffles can be retrofit into existing mills and can be created in angular sections with the lining of the grinding chamber for modular installation and removal.

Abstract: A roller mill system includes a vessel having an inlet, an outlet, a grinding zone and a classifier zone. The grinding zone includes a grinding assembly configured for grinding the material into fine particles. The grinding zone also includes a rejects capture and discharge system that includes one or more discharge conduits for conveying rejects away from the vessel. The rejects capture and discharge system includes: 1) a collection trough located under the grinding assembly and in communication with one of the discharge conduits, for discharging rejects from the grinding zone; and/or 2) a turbine classifier mounted in the classifier zone. The turbine classifier is rotatable about a central axis. Another outlet is formed in a side wall of the classifier zone. The turbine classifier is configured to expel the rejects radially outward therefrom, through the side wall outlet and into another one of the discharge conduits.

Abstract: A bowl mill for producing coarse ground particles has a substantially closed body, a bowl assembly, a plurality of grinding rolls, and a coarse particle transport enabling area. The substantially closed body has an interior area. The bowl assembly includes a rotatable grinding table mounted for rotation in a direction of rotation in the interior area. The grinding table has a grinding surface thereon. The plurality of grinding rolls are positioned proximate the grinding surface. The grinding rolls and the grinding surface define a grinding area therebetween. The coarse particle transport enabling area is located radially outward from the grinding area. The coarse particle transport enabling area is configured to allow the coarse particles to freely exit the grinding area and to mitigate the coarse particles from being circulated back into the grinding area.

Abstract: A roller mill system includes a vessel having an inlet, an outlet, a grinding zone and a classifier zone. The grinding zone includes a grinding assembly configured for grinding the material into fine particles. The grinding zone also includes a rejects capture and discharge system that includes one or more discharge conduits for conveying rejects away from the vessel. The rejects capture and discharge system includes: 1) a collection trough located under the grinding assembly and in communication with one of the discharge conduits, for discharging rejects from the grinding zone; and/or 2) a turbine classifier mounted in the classifier zone. The turbine classifier is rotatable about a central axis. Another outlet is formed in a side wall of the classifier zone. The turbine classifier is configured to expel the rejects radially outward therefrom, through the side wall outlet and into another one of the discharge conduits.

Abstract: A bowl mill for producing coarse ground particles has a substantially closed body, a bowl assembly, a plurality of grinding rolls, and a coarse particle transport enabling area. The substantially closed body has an interior area. The bowl assembly includes a rotatable grinding table mounted for rotation in a direction of rotation in the interior area. The grinding table has a grinding surface thereon. The plurality of grinding rolls are positioned proximate the grinding surface. The grinding rolls and the grinding surface define a grinding area therebetween. The coarse particle transport enabling area is located radially outward from the grinding area. The coarse particle transport enabling area is configured to allow the coarse particles to freely exit the grinding area and to mitigate the coarse particles from being circulated back into the grinding area.

Abstract: The disclosure relates to engineered P450 polypeptides and use of such polypeptides in chemoenzymatic methods to construct selectively protected carbohydrates, which are useful as building blocks for preparation of carbohydrate derivatives and oligosaccharides