Abstract: Among the various aspects of the present disclosure is the provision of compositions of NRF2 inhibiting agents and methods of use thereof. These agents can be useful for cancer treatment, including as radiosensitizing agents and as chemotherapeutic sensitizing agents.

Abstract: The invention provides methods for inhibiting tumor cell proliferation by inhibiting FoxM1B activity, expression, or nuclear localization in a tumor cell. The invention also provides methods for preventing tumor progression in an animal comprising inhibiting FoxM1B activity, expression, or nuclear localization. Furthermore, the invention provides methods for inhibiting tumor cell growth in an animal comprising inhibiting FoxM1B activity, expression, or nuclear localization in tumor cells in the animal.

Abstract: Novel processes for the purification of an imino or amino sugar, such as D-1-deoxygalactonojirimycin (DGJ). Particularly, there are described processes for the purification of multi-kilogram scale sugars using hydrochloric acid.

Abstract: The invention provides methods for inhibiting tumor cell proliferation by inhibiting FoxM1B activity, expression, or nuclear localization in a tumor cell. The invention also provides methods for preventing tumor progression in an animal comprising inhibiting FoxM1B activity, expression, or nuclear localization. Furthermore, the invention provides methods for inhibiting tumor cell growth in an animal comprising inhibiting FoxM1B activity, expression, or nuclear localization in tumor cells in the animal.

Abstract: The invention provides methods for inhibiting tumor cell proliferation by inhibiting FoxM1B activity, expression, or nuclear localization in a tumor cell. The invention also provides methods for preventing tumor progression in an animal comprising inhibiting FoxM1B activity, expression, or nuclear localization. Furthermore, the invention provides methods for inhibiting tumor cell growth in an animal comprising inhibiting FoxM1B activity, expression, or nuclear localization in tumor cells in the animal.

Abstract: A hearing aid body is provided that contains electronic hearing aid components and that is attachable to the user's body outside the ear canal. A conduit connects the hearing aid body to the flexible plug. The conduit enables sound emitted by the hearing aid to travel via the conduit to the flexible plug so that the user's able to hear a sound that is amplified by the hearing aid and received by the plug via the conduit. The conduit can be a flexible hollow tube or an electronic conduit that transmit electrical signals between the hearing aid and the plug. A stent embedded in the plug is provided, the stent having a first smaller diameter at a temperature below body temperature and being expandable to a second greater diameter when subjected to the user's body temperature, such as the temperature in the ear canal of a user.

Abstract: The invention provides methods for inhibiting tumor cell proliferation by inhibiting FoxM1B activity, expression, or nuclear localization in a tumor cell. The invention also provides methods for preventing tumor progression in an animal comprising inhibiting FoxM1B activity, expression, or nuclear localization. Furthermore, the invention provides methods for inhibiting tumor cell growth in an animal comprising inhibiting FoxM1B activity, expression, or nuclear localization in tumor cells in the animal.

Abstract: A hearing aid instrument of the in-the-ear type (and preferably CIC) provides a plate member with electronic hearing aid components mounted thereto. The plate member is preferably of a harder material such as hard plastic. A soft polymeric body is bonded to the plate member and encapsulates preferably a plurality of the electronic hearing aid components. The body is soft and is shaped to conform to the ear canal of the user. The soft polymeric body and encapsulated electronic hearing aid components define a soft structure compliant to the ear canal during use and that is substantially solid and free of void spaces between at least some of the components and the ear canal. This combination of soft compliant structure and encapsulated electronic hearing aid components addresses problems of peripheral leakage, poor fit, pivotal displacement that occurs with jaw motion and internal cross talk of components housed in prior art hollow type hearing aids.

Abstract: A hearing aid body is provided that contains electronic hearing aid components and that is attachable to the user's body outside the ear canal. A conduit connects the hearing aid body to the flexible plug. The conduit enables sound emitted by the hearing aid to travel via the conduit to the flexible plug so that the user's able to hear a sound that is amplified by the hearing aid and received by the plug via the conduit. The conduit can be a flexible hollow tube or an electronic conduit that transmit electrical signals between the hearing aid and the plug. A stent embedded in the plug is provided, the stent having a first smaller diameter at a temperature below body temperature and being expandable to a second greater diameter when subjected to the user's body temperature, such as the temperature in the ear canal of a user.

Abstract: A method of manufacturing a hearing aid preferably includes the steps of: placing a moldable material in the ear canal of a patient to cast a form; using the form to form a hollow shell with an outer surface that approximates the shape of the patient's ear canal, the shell being of a soft polymeric material providing a mounting member; mounting electronic hearing aid components to the mounting member; joining the mounting member to the hollow shell to define a mold cavity; and filling the shell with a soft polymeric material that substantially encapsulates at least one of the electronic components and bonds to the mounting member, wherein the combination of shell, electronic components and soft polymeric material define a soft structure that is compliant to ear canal movement during use.

Abstract: A front loading washing machine includes an integrated motor and controller assembly. In various embodiment, the controller is mounted directly to one of a pair of opposing endshields of the electric motor and the endshields are mounted directly to a stator of the motor. Additional embodiments include a rotor shaft of the motor having each of opposing ends supported within a bearing mounted within a respective one of the opposing endshields. In other embodiments, the controller can include an insulating shield positioned between a controller circuit board and the motor endshield to which the controller is mounted. The insulating shield providing electrical arcing protection, thermal insulation and/or electromagnetic insulation between the circuit board and the endshield.

Abstract: A method and apparatus for cleaning a hearing aid provides a housing having a motor drive and speed control. A rotary chamber is mounted to the housing and driven by the motor drive. A drive shaft can be provided connecting the motor drive and the rotary chamber. The rotary chamber has a wall with at least one receptacle for holding a hearing aid. The rotary chamber can have two openings, one for a hearing aid and a second opening for another hearing aid or a counterweight. The rotary chamber can be counterweighted to compensate for the weight of a single hearing aid or any other arrangements of multiple hearing aids. Each receptacle is configured to hold a hearing aid. The motor drive is powered sufficiently to rotate the hearing aid at the speed of between about 2800 and 3200 rpm in order to generate a G-force on the hearing aid of about 270 G's.

Abstract: Novel processes for the purification of an imino or amino sugar, such as D-1-deoxygalactonojirimycin (DGJ). Particularly, there are described processes for the purification of multi-kilogram scale sugars using hydrochloric acid.

Abstract: Described are novel processes for the synthesis triflated sugars. These sugars are useful for the production of compounds, such as D-1-deoxynojirimycin (DNJ) and D-1-deoxygalactonojirimycin (DGJ). In particular, described is a multi-kilogram scale stabilization method for the synthesis of imino sugars.

Abstract: Described are novel crystalline pivaloyl furanoses and methods of crystallizing the pivaloyl furanoses. These compounds are useful as intermediates in the synthesis of compounds such as the deoxyjirimycins and nojirimycins and are particularly useful as intermediates for production on a multi-kg scale. Particular crystalline compounds include 1,2,3,6-tetrapivaloyl-?-D-galactofuranose, 1,2,3,6-tetrapivaloyl-?-L-altrofuranose, and 5-azido-5-deoxy-1,2,3,6-tetrapivaloyl-?-D-galactofuranose.

Abstract: A soft-solid ear piece is formed to fit the typical human ear canal and will self form to fill the ear cavity by having an internal structure, endoskeleton, or bladder to expand to precisely fit the ear piece securely and comfortably in the ear canal. This self forming ear piece will enable ready-ware and custom molded hearing aids, hearing protectors, audio ear pieces, cell phone ear pieces and assistive listening devices to fit comfortably, securely, and free of acoustic feedback in the external ear canal. It creates an acoustic seal to optimally reduce peripheral leakage and intermodulation distortion delivering excellent acoustic performance while keeping environmental sounds blocked out.

Abstract: The invention provides methods for inhibiting tumor cell proliferation by inhibiting FoxM1B activity, expression, or nuclear localization in a tumor cell. The invention also provides methods for preventing tumor progression in an animal comprising inhibiting FoxM1B activity, expression, or nuclear localization. Furthermore, the invention provides methods for inhibiting tumor cell growth in an animal comprising inhibiting FoxM1B activity, expression, or nuclear localization in tumor cells in the animal.

Abstract: This invention relates to a family of phenylbenzimidazole analogs, which are inhibitors of the IgE response to allergens. These compounds are useful in the treatment of allergy and/or asthma or any diseases where IgE is pathogenic.

Abstract: A hearing aid instrument of the in-the-ear type (and preferably CIC) provides a plate member with electronic hearing aid components mounted thereto. The plate member is preferably of a harder material such as hard plastic. A soft polymeric body is bonded to the plate member and encapsulates preferably a plurality of the electronic hearing aid components. The body is soft and is shaped to conform to the ear canal of the user. The soft polymeric body and encapsulated electronic hearing aid components define a soft structure compliant to the ear canal during use and that is substantially solid and free of void spaces between at least some of the components and the ear canal. This combination of soft compliant structure and encapsulated electronic hearing aid components addresses problems of peripheral leakage, poor fit, pivotal displacement that occurs with jaw motion and internal cross talk of components housed in prior art hollow type hearing aids.

Abstract: This invention relates to a family of benzimidazole analogs, which are inhibitors of the IgE response to allergens. These compounds are useful in the treatment of allergy, asthma, or any diseases where IgE is pathogenic.