Abstract: According to one aspect, an electric toothbrush may include a handle, a brush head, a rechargeable battery, an electric motor, and a pair of electrical contacts. The handle may have a first end region and a second end region defining a longitudinal axis therebetween, the handle defining a volume from the first end region to the second end region. The brush head may include bristles, the brush head releasably securable to the first end region of the handle. The rechargeable battery may be in the volume. The electric motor may be at least partially disposed in the volume, the electric motor in electrical communication with the rechargeable battery, the electric motor in mechanical communication with the brush head. The pair of electrical contacts may be in electrical communication with the rechargeable battery, and the pair of electrical contacts axially and radially spaced from one another, relative to the longitudinal axis.

Abstract: A system for predicting a leak of a HVAC/Refrigeration system includes a critically charged HVAC/Refrigeration system configured to circulate a refrigerant to cool a space, and processing circuitry. The processing circuitry is configured to obtain the subcooling data from the critically charged HVAC/Refrigeration system. The processing circuitry is configured to predict a leak event by providing the subcooling data as an input to a neural network. The neural network is trained using historical data of one or more subcooling parameters of a plurality of critically charged HVAC/Refrigeration systems. The processing circuitry is configured to operate a display to provide a notification to a technician or a manager regarding the predicted leak event at the critically charged HVAC/Refrigeration system.

Abstract: A method for tracking amount of refrigerant added or removed from an HVAC/refrigeration system includes fluidly coupling a service tool with an inner volume of the refrigeration system. The service tool includes a reservoir that stores and discharges a refrigerant into the refrigeration system or receives the refrigerant from the refrigeration system, and a sensing portion positioned along a fluid flow path between the reservoir and the inner volume of the refrigeration system. The method includes operating the service tool to transfer an amount of refrigerant between the inner volume of the refrigeration system and the reservoir of the service tool. The method includes obtaining a signal from a sensor of the sensing portion indicative of a flow rate of the amount of refrigerant over a time period that the refrigerant is transferred. The method includes determining the amount of refrigerant based on the signal obtained from the sensor.

Abstract: A method includes determining, based on a signal from a sensor of a service tool that couples with a service port of the HVAC/Refrigeration system to add refrigerant to the HVAC/Refrigeration system or remove refrigerant from the HVAC/Refrigeration system, an amount of refrigerant added to the HVAC/Refrigeration system or an amount of refrigerant removed from the HVAC/Refrigeration system. The method includes determining a current refrigerant level in the HVAC/Refrigeration system. The method also includes performance monitoring for a fleet of units, and predicting an indication of a leak at the HVAC/Refrigeration system. The method includes building or using a database along with artificial intelligence (AI) or machine learning (ML) to predict leaks. The method includes operating a display to provide at least one of the amount of refrigerant added, the amount or refrigerant removed, or the current refrigerant level of the HVAC/Refrigeration system to a user.

Abstract: A patient interface for delivery of a supply of pressurised air or breathable gas to an entrance of a patient's airways comprising: a cushion member that includes a retaining structure and a seal-forming structure permanently connected to the retaining structure; a frame member attachable to the retaining structure; and a positioning and stabilising structure attachable to the frame member.

Abstract: Systems, techniques, and devices are described that may be used in a minimally invasive bone realignment procedure. In some examples, a method of performing a minimally invasive metatarsal correction procedure involves using a bone preparation guide having a guide surface with a length less than a diameter of a bone to be cut using the guide surface. The clinician can guide a bone preparation instrument along the guide surface and angle the bone preparation instrument beyond one or both ends of the guide surface to cut the end of the underlying bone beyond one or both of the ends.

Abstract: A diffuser for use with a wound retractor and configured to deliver gases includes an interface tube for connecting to a gases supply and a diffuser interface positioned at a proximal end of the interface tube, the diffuser interface configured for delivering gases received from the gases supply through the interface tube, and the diffuser interface comprising a diffusion mechanism configured to deliver gases in a diffusion direction. A wound retractor with an integrated diffuser is also disclosed. The wound retractor includes an upper ring, a lower ring, a sleeve extending between and connecting the upper ring to the lower ring, and an integrated diffuser interface having a gases inlet and a diffusion mechanism.

Abstract: The invention relates to Conditional Bispecific Redirected Activation constructs, or COBRAs, that are administered in an active pro-drug format. Upon exposure to tumor proteases, the constructs are cleaved and activated, such that they can bind one or more tumor target antigens (TTAs) as well as CD3, thus recruiting T cells expressing CD3 to the tumor, resulting in treatment. In some embodiments, the tumor target antigen includes B7H3, CA9 (CAIX), EGFR, EpCAM, FOLR1, HER2, LyPD3, and/or Trop2.

Abstract: The present invention provides antibodies and antibody-drug conjugates that bind to the extra domain B splice variant of fibronectin 1 and methods for preparing and using the same.

Abstract: The invention relates to COnditional Bispecific Redirected Activation constructs, or COBRAs, that are administered in an active pro-drug format. Upon exposure to tumor proteases, the constructs are cleaved and activated, such that they can bind one or more tumor target antigens (TTAs) as well as CD3, thus recruiting T cells expressing CD3 to the tumor, resulting in treatment. In some embodiments, the tumor target antigen includes B7H3, CA9 (CAIX), EGFR, EpCAM, FOLR1, HER2, LyPD3, and/or Trop2.

Abstract: The present invention provides antibodies and antibody-drug conjugates that bind to the extra domain B splice variant of fibronectin 1 and methods for preparing and using the same.

Abstract: A pharmaceutical composition that is orally applied and that counteracts reproduction and the spread of influenza viruses, in particular influenza viruses of the so-called covid species and their mutations, comprises a pharmaceutically acceptable carrier and at least a first virucidal component designed to unfold antiviral activity when activated, which first virucidal component is sodium chlorite that is dissolved in saliva when the pharmaceutical composition has been applied to a person.

Abstract: A method for producing a plurality of chips each comprising an individualisation region, each chip comprising at least: a first and a second level of the electrical tracks, and an interconnections level comprising vias. The method includes producing on the dielectric layer covering the first level a mask having openings located in line with the electrical tracks and making the dielectric layer accessible. The method includes producing, in a region of the chip comprising the individualisation region, patterns conformed so that: first openings of the hard mask are not masked by the patterns, and second openings of the hard mask are masked by the patterns. The method includes producing via openings in the dielectric layer in line solely with the first openings. The method further includes filling in the via openings with an electrically conductive material, and producing the second level of the electrical tracks on the vias.

Abstract: A process for producing a hybrid structured surface, including depositing, on a substrate, a layer of mineral resin including a proportion of Si and/or of SiO2 includes between 1% and 30% by molar mass; forming a structure including a plurality of pattern motifs in that layer, having at least one dimension, measured parallel or perpendicular to the substrate, includes between 50 nm and 500 ?m; forming a roughness on at least part of the surface of the pattern motifs.

Abstract: A method for producing an individualisation area includes providing at least a first level of the electrical tracks. The method includes depositing a dielectric layer and a deformable layer on the interconnection level. The method includes producing, in an area of the deformable layer, recessed patterns, by penetrating an imprint mould into the deformable layer, the production of the patterns being configured so that the patterns have a randomness in the deformable layer, thus forming random patterns. The method includes transferring the random patterns into the dielectric layer to form transferred random patterns therein and exposing the vias located in line with the transferred random patterns. The method includes filling the transferred random patterns with an electrically conductive material so as to form electrical connections between vias. The method includes producing a second level of the electrical tracks on the vias and the electrical connections.

Abstract: Systems and techniques may be used for providing artificial intelligence regarding orthopedic patients. A technique may include using sensor data generated over a period of time by a patient an input to a machine learning model. The machine learning model may be trained based on labeled sensor data and labeled outcome data. The machine learning model may generate a predicted outcome for the patient. The technique may include output at least one medical intervention recommendation based on the predicted outcome.

Abstract: Disclosed is a method of delivering a product comprising receiving from a user device, an order, a preferred delivery location, and a user device location, assigning the order a preparation time, receiving an updated user device location at predetermined intervals, using the user device location and order preparation time, placing the order in a production queue to be prepared for delivery, determining if the user device is at the preferred delivery location, when the user device is at the preferred delivery location, delivering the order.

Abstract: The invention relates to a method for visualizing the automation of a drive system for a technical system, wherein the technical system consists of a plurality of modules. Module type data objects that are assigned to module types are stored in a data storage device, wherein the module type data objects include a graphical representation of the module type data relating to the particular module types. First, the module types of the modules of which the technical system is composed are selected by a user via a user interface. Module data objects assigned to the modules are generated by means of a data processing device, which module data objects contain module data, wherein the module data contain data relating to the graphical representation of the module type of each module, and wherein a data processing device generates a visualization of the assembled technical system based on the module data, which visualization is presented to the user by means of a visualization device, in particular a display.

Abstract: A method for producing a plurality of chips each comprising an individualisation region, each chip comprising at least: a first and a second level of the electrical tracks, and an interconnections level comprising vias. The method includes producing on the dielectric layer covering the first level a mask having openings located in line with the electrical tracks and making the dielectric layer accessible. The method includes producing, in a region of the chip comprising the individualisation region, patterns conformed so that: first openings of the hard mask are not masked by the patterns, and second openings of the hard mask are masked by the patterns. The method includes producing via openings in the dielectric layer in line solely with the first openings. The method further includes filling in the via openings with an electrically conductive material, and producing the second level of the electrical tracks on the vias.

Abstract: A method for producing an individualisation area includes providing at least a first level of the electrical tracks. The method includes depositing a dielectric layer and a deformable layer on the interconnection level. The method includes producing, in an area of the deformable layer, recessed patterns, by penetrating an imprint mould into the deformable layer, the production of the patterns being configured so that the patterns have a randomness in the deformable layer, thus forming random patterns. The method includes transferring the random patterns into the dielectric layer to form transferred random patterns therein and exposing the vias located in line with the transferred random patterns. The method includes filling the transferred random patterns with an electrically conductive material so as to form electrical connections between vias. The method includes producing a second level of the electrical tracks on the vias and the electrical connections.