Abstract: Assembling jig for mounting panel structure elements onto a surface of a CFRP-panel, comprising a base frame on which several positioning boards are transversely attached, which are parallel arranged one to another for supporting the CFRP-panel on an upper mounting surface, wherein the base frame comprises at least one metal bar for coupling the positioning boards consisting of a material having a thermal expansion coefficient which corresponds to the thermal expansion coefficient of the CFRP-material of the panel in order to provide a tolerance compensation system in at least longitudinal direction of the base frame.

Abstract: Bispecific heterodimeric diabody molecules and uses thereof in the treatment of cancer. The bispecific heterodimeric diabody molecules comprise two polypeptide chains that associate to form two epitope binding sites recognizing the P-cadherin tumor cell associated antigen and the CD3 T cell antigen.

Abstract: Systems and methods for chronic disease management are disclosed. In some embodiments, a method includes, at a server having one or more processors and memory storing one or more programs for execution by the one or more processors, obtaining one or more user-specific socio-cognitive vectors corresponding to a first user. The method further includes creating a user-specific engagement model in accordance with the one or more obtained socio-cognitive vectors, and generating a user-specific chronic disease management plan for the first user, in accordance with the user-specific engagement model.

Abstract: A self-guided geosteering assembly having an on-board, automated guidance system that incorporates a detailed subsurface earth model and well path to geosteer the assembly along a formation. While advancing along the formation, the guidance system continually monitors data related to formation characteristics and the formation/tool location, compares the data to the earth model and well path, and adjusts the direction of the assembly accordingly. In addition, the data may be utilized to update the earth model in real-time.

Abstract: A vertebral rod connector includes a first portion configured to engage a fastener construct and define a first longitudinal axis. A second portion is configured to engage a vertebral rod and define a second longitudinal axis disposed transverse to the first longitudinal axis. A flexible linking portion is disposed for connecting the first portion with the second portion. The linking portion has a bifurcated configuration oriented transverse to the first longitudinal axis. Methods of use are disclosed.

Abstract: A pharmaceutical composition for use as medicament that inhibits inhibits autocrine Human Chorionic Gonadotropin (HCG) production and thus carcinogenesis in adult human cells, the composition comprising at least a first pharmaceutically acceptable carrier and an active agent that is a competitively binding progesterone antagonist binding to steroid receptors of human cells, wherein the composition is provided in units designed for the monthly, semi-annual or annual application of the active agent in annual dosages in the range between 0.1 mg to 10.0 mg per kg of person/body-weight.

Abstract: A system for determining if a tire of a vehicle is improperly inflated. The system includes a radar, a wheel speed sensor, and a controller. The radar is configured to emit a signal to detect a reflection of the signal off of an object positioned perpendicular to the vehicle, and to output an indication of a speed of the vehicle. The wheel speed sensor is configured to sense a speed of a wheel of the vehicle. The controller is configured to receive the indication of the speed of the vehicle from the radar, to calculate a speed of the vehicle based on the sensed speed of the wheel, and to determine a tire of the wheel is improperly inflated when the speed of the vehicle calculated using the wheel speed sensor varies by more than a predetermined amount from the speed of the vehicle determined using the radar signal.

Abstract: The present invention is concerned with methods for the de novo sequencing of polypeptides from data obtained from mass spectrometry devices, particularly from (MS)n devices.

Abstract: Skeletal stabilization systems include a base, a longitudinal member, and a retaining member. The base includes an engagement surface with a surface area that is positionable in contact with a bone to atraumatically or traumatically engage the base to the bone. The retaining member engages the base to retain the longitudinal member relative to the base so that the longitudinal member can provide a desired stabilization effect to one or more adjacent bony portions.

Abstract: A process for electrolyzing a material to change at least a portion of the material from a first chemical state to a second chemical state includes placing a known quantity of a first substance into either a mixing chamber or an electrolysis chamber of an integrated electrochemical reactor, placing a known quantity of a second substance into the other chamber free of the first substance; sealing an opening to isolate an internal volume within the reactor; rotating the reactor to form a mixture, rotating the reactor again such that the mixture is transferred to the electrolysis chamber; electrolyzing the mixture in the electrolysis chamber to change at least a portion of the mixture from the first chemical state to the second chemical state; and analyzing the first substance, or analyzing the second substance, or analyzing the first chemical state, or analyzing the second chemical state, or any analytical combinations thereof.

Abstract: The present invention is concerned with methods for the de novo sequencing of polypeptides from data obtained from mass spectrometry devices, particularly from (MS)n devices.

Abstract: The invention relates to compositions and methods for treating an activated B-Cell Diffuse Large B-Cell Lymphoma (ABC-DLBCL). Specifically, the invention relates to treating ABC-DLBCL by administering an NF-?B Essential Modulator (NEMO) Binding Domain (NBD) peptide or a mimetic thereof that inhibits NF-?B activation.

Abstract: One nonlimiting embodiment is directed to an anchor extender releasably engaged with an anchor configured for engagement with one or more bones or bony portions. The anchor extender generally includes a first member and a second member positioned about and movable relative to the first member. The anchor extender is positionable adjacent the anchor and movement of the second member relative to the first member toward the anchor as the anchor extender is engaged with the anchor results in lateral displacement of the anchor extender relative to the anchor while the first member engages with a first side of the anchor and the second member engages with an opposite second side of the anchor. However, in other embodiments, different forms and applications are envisioned.

Abstract: In-line inspection methods are provided. The methods comprise measuring at least two parameters/properties of a prepreg and/or laminate during the manufacture thereof. In some embodiments, the data collected using the inline inspection methods may be processed and/or provided to a manual or automated controller, in order to provide a closed loop method for the manufacture of the prepregs and/or laminates. Apparatus for carrying out the methods are also provided, as are articles comprising a prepreg and/or laminate made using the apparatus.

Abstract: A method can include, for a predetermined route, automatically processing a first set of machine instructions to create a visual travel guide for the predetermined route, the visual travel guide comprising a second set of machine instructions adapted to cause an information device to render: an identification of a destination of the predetermined route; a plurality of videos, each video corresponding to a road intersection located approximately on the predetermined route, each video adapted to substantially reproduce a view of a driver of an automobile approaching the road intersection; a plurality of textual descriptions associated with the plurality of videos; at least one of an identification of an origin of the predetermined route and an identification of an approach to the destination; and an advertisement associated with at least a portion of the predetermined route.

Abstract: A method can include, for a predetermined route, automatically processing a first set of machine instructions to create a visual travel guide for the predetermined route, the visual travel guide comprising a second set of machine instructions adapted to cause an information device to render: an identification of a destination of the predetermined route; a plurality of videos, each video corresponding to a road intersection located approximately on the predetermined route, each video adapted to substantially reproduce a view of a driver of an automobile approaching the road intersection; a plurality of textual descriptions associated with the plurality of videos; at least one of an identification of an origin of the predetermined route and an identification of an approach to the destination; and an advertisement associated with at least a portion of the predetermined route.

Abstract: One non-limiting embodiment is directed to a reduction instrument releasably engageable with a bone anchor and structured to reduce a connecting element into a receiving member of the bone anchor. The reduction instrument includes a first member and a second member laterally movable relative to the first member between a first position for receiving a portion of the bone anchor and a second position for engaging the reduction instrument with the bone anchor. The reduction instrument also includes an actuating member axially displaceable relative to the first and second members. Additionally, the second member is moved between the first and second positions upon displacement of the actuating member relative to the first and second members, and the second member extends substantially parallel to the first member as it is moved between the first and second positions.

Abstract: The invention relates to a windshield wiper device (100) comprising a driving means (110) and a control unit (130) for the driving means (110). An operating characteristic map (140) is provided, in which a maximum torque to be output by the driving means (110) and a minimum rotational speed of the driving means (110) are stored.

Abstract: An apparatus for attachment to a vertebral body for correcting spinal deformities. The apparatus has a plate member having an upper surface and a lower surface. The upper surface having at least one receiving member defining a channel for receiving a flexible connection member. The at least one receiving member having a proximal portion and a distal portion. The proximal and distal portions interfacing along a frangible connection such that the at least one receiving member extends axially from the upper surface a first distance when the frangible connection is unbroken and the at least one receiving member extends axially from the upper surface a second distance when the frangible connection is broken. The second distance is less than the first distance.

Abstract: The present invention is concerned with methods for the selection of precursor ions of a sample polypeptide for fragmentation in mass spectrometry, together with methods for determining at least one putative amino acid sequence for a sample polypeptide, apparatus and computer programs for same.