Patents by Inventor Michael McKenna
Michael McKenna has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 12275960Abstract: Provided herein are methods that include introducing into an inner ear of a mammal a therapeutically effective amount of an adeno-associated virus (AAV) vector that includes a nucleotide sequence encoding (a) a polypeptide including an antibody heavy chain variable domain operably linked to a signal peptide and a polypeptide including an antibody light chain variable domain operably linked to a signal peptide; (b) a polypeptide including an antigen-binding antibody fragment operably linked to a signal peptide; or (c) a soluble vascular endothelial growth factor receptor operably linked to a signal peptide.Type: GrantFiled: June 13, 2023Date of Patent: April 15, 2025Assignee: Akouos, Inc.Inventors: Emmanuel John Simons, Robert Ng, Michael McKenna
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Publication number: 20250111385Abstract: Disclosed embodiments may include a method for intelligent bookout discrepancy detection. The system may receive bookout data from an automotive dealer, which may include dealer-provided vehicle information that includes a dealer price and dealer-listed features. The system may identify a vehicle identification number from the dealer-provided vehicle information. The system may retrieve third-party vehicle information including at least one of a third-party price and third-party listed features from one or more third party sources using the vehicle identification number. The system may aggregate the third-party vehicle information from the one or more third party sources. The system may determine that a bookout discrepancy exists by comparing the dealer price to the third-party price and comparing dealer-listed features to third-party listed features. The system may flag a contract associated with the bookout data for further review.Type: ApplicationFiled: September 29, 2023Publication date: April 3, 2025Inventors: Michael Garner, Bria Burchianti, Michael McKenna
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Publication number: 20250010016Abstract: A humidification system can include a heater base, a chamber, and a breathing circuit. The heater base includes a heater plate positioned in a recessed region, and a heat conductive portion of the chamber is configured to contact the heater plate. The heater base includes a guard configured to control movement of the chamber into and out of the recessed region. The guard includes an anti-racking mechanism. The chamber includes an inlet port, an outlet port. A downward extension extends into the chamber from the inlet port, and a baffle is disposed at a lower end of the downward extension. A component of the breathing circuit can include a conduit hanging end cap for shipping and storage. The end cap can include a hanging component to allow the breathing circuit component to be hung from a medical stand. The system can detect when breathing circuits are connected in reverse.Type: ApplicationFiled: June 21, 2024Publication date: January 9, 2025Inventors: John James JACKSON, Barry Shack MANON, Victor Rosales CORRALES, Stefan Leo VAN WORKUM, Michael John ANDRESEN, Stephen David EVANS, Mark Samuel HAMILTON, Paul Fleming BUCKLEY, Jason Allan KLENNER, Hamish OSBORNE, Samuel Graham BOGGS, James William STANTON, Joseph Nathaniel GRIFFITHS, Jonathan Andrew George LAMBERT, Nicholas Edward VAUGHAN, James Owen KEHOE, Francisco Ernesto DE LA PENA DE LA FUENTE, Nicholas James Michael MCKENNA, Rachael PORTER, Simon Mordechai STAM, David Robert KEMPS, Edwin Joseph LYONS, Madeleine Bess MARTIN, Ada Yiwen SHOU, Huang-Ku LIU
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Patent number: 12077783Abstract: Provided herein are methods that include introducing into an inner ear of a mammal a therapeutically effective amount of an adeno-associated virus (AAV) vector that includes a nucleotide sequence encoding (a) a polypeptide including an antibody heavy chain variable domain operably linked to a signal peptide and a polypeptide including an antibody light chain variable domain operably linked to a signal peptide; (b) a polypeptide including an antigen-binding antibody fragment operably linked to a signal peptide; or (c) a soluble vascular endothelial growth factor receptor operably linked to a signal peptide.Type: GrantFiled: March 17, 2022Date of Patent: September 3, 2024Assignee: Akouos, Inc.Inventors: Emmanuel John Simons, Robert Ng, Michael McKenna
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Patent number: 12053589Abstract: A humidification system can include a heater base, a chamber, and a breathing circuit. The heater base includes a heater plate positioned in a recessed region, and a heat conductive portion of the chamber is configured to contact the heater plate. The heater base includes a guard configured to control movement of the chamber into and out of the recessed region. The guard includes an anti-racking mechanism. The chamber includes an inlet port, an outlet port. A downward extension extends into the chamber from the inlet port, and a baffle is disposed at a lower end of the downward extension. A component of the breathing circuit can include a conduit hanging end cap for shipping and storage. The end cap can include a hanging component to allow the breathing circuit component to be hung from a medical stand. The system can detect when breathing circuits are connected in reverse.Type: GrantFiled: October 12, 2022Date of Patent: August 6, 2024Assignee: Fisher & Paykel Healthcare LimitedInventors: John James Jackson, Barry Shack Manon, Victor Rosales Corrales, Stefan Leo Van Workum, Michael John Andresen, Stephen David Evans, Mark Samuel Hamilton, Paul Fleming Buckley, Jason Allan Klenner, Hamish Osborne, Samuel Graham Boggs, James William Stanton, Joseph Nathaniel Griffiths, Jonathan Andrew George Lambert, Nicholas Edward Vaughan, James Owen Kehoe, Francisco Ernesto De La Peña De La Fuente, Nicholas James Michael Mckenna, Rachael Porter, Simon Mordechai Stam, David Robert Kemps, Edwin Joseph Lyons, Madeleine Bess Martin, Ada Yiwen Shou, Huang-Ku Liu
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Publication number: 20240108844Abstract: A humidification system can include a heater base, a humidification chamber, and a breathing circuit. A cartridge can be removably coupled to the heater base. The cartridge can include various sensors, probes, sensor wire connectors, heater wire connectors, and/or other features. The cartridge can include features configured to mate with corresponding features on the humidification chamber and the heater base. The cartridge includes a memory, such as an EEPROM, or other suitable storage device. When the cartridge is installed on the heater base, the memory is electrically connected to a processor and/or memory of the heater base. Various models of cartridges can be produced for use with different humidification chambers, breathing circuits, and/or therapies. A connector can be configured to couple an inspiratory conduit to an outlet port of the humidification chamber. The connector can provide a pneumatic connection to the outlet port and an electrical connection to the cartridge.Type: ApplicationFiled: September 20, 2023Publication date: April 4, 2024Inventors: Hamish Adrian OSBORNE, Gavin Walsh Millar, Stephen David Evans, Bruce Gordon Holyoake, James William Stanton, David Leon McCauley, Gareth Thomas McDermott, Nicholas James Michael McKenna, Myfanwy Jane Antica Norton, Adrian John Elsworth, Michael John Andresen, Jonathan Andrew George Lambert, Sandeep Singh Gurm, Tessa Hazel Paris, Joseph Nathaniel Griffiths, Ping Si, Christopher Gareth Sims, Elmo Benson Stoks, Dexter Chi Lun Cheung, Peter Alan Seekup, Po-Yen Liu, Richard Edward Lang, Paul James Tonkin, Ian Lee Wai Kwan
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Publication number: 20240100316Abstract: A circuit connector for a humidification system, the system comprising a base unit configured to be engaged by a humidification chamber. The circuit connector comprises an inlet to fluidly connect to an outlet of the humidification chamber to receive humidified gases therefrom, an outlet to sealably connect to or integral with a conduit for directing the humidified gases to a user, and an electrical terminal for electrically coupling the circuit connector to an electrical terminal associated with the base unit. The circuit connector may be releasably and lockably connectable to the outlet of the humidification chamber and/or orientation features may control orientation of component parts of the system as they are assembled.Type: ApplicationFiled: September 28, 2023Publication date: March 28, 2024Inventors: Hamish Adrian OSBORNE, James William STANTON, Bruce Gordon HOLYOAKE, Stephen David EVANS, David Leon MCCAULEY, Nicholas James Michael MCKENNA, Gareth Thomas MCDERMOTT, Myfanwy Jane Antica NORTON, Gavin Walsh MILLAR, Thomas Jacques Fernand MAECKELBERGHE
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Publication number: 20240101970Abstract: Provided herein are methods that include introducing into an inner ear of a mammal a therapeutically effective amount of an adeno-associated virus (AAV) vector that includes a nucleotide sequence encoding (a) a polypeptide including an antibody heavy chain variable domain operably linked to a signal peptide and a polypeptide including an antibody light chain variable domain operably linked to a signal peptide; (b) a polypeptide including an antigen-binding antibody fragment operably linked to a signal peptide; or (c) a soluble vascular endothelial growth factor receptor operably linked to a signal peptide.Type: ApplicationFiled: June 13, 2023Publication date: March 28, 2024Inventors: Emmanuel John Simons, Robert Ng, Michael McKenna
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Patent number: 11826538Abstract: A circuit connector for a humidification system, the system comprising a base unit configured to be engaged by a humidification chamber. The circuit connector comprises an inlet to fluidly connect to an outlet of the humidification chamber to receive humidified gases therefrom, an outlet to sealably connect to or integral with a conduit for directing the humidified gases to a user, and an electrical terminal for electrically coupling the circuit connector to an electrical terminal associated with the base unit. The circuit connector may be releasably and lockably connectable to the outlet of the humidification chamber and/or orientation features may control orientation of component parts of the system as they are assembled.Type: GrantFiled: October 1, 2020Date of Patent: November 28, 2023Assignee: Fisher & Paykel Healthcare LimitedInventors: Hamish Adrian Osborne, James William Stanton, Bruce Gordon Holyoake, Stephen David Evans, David Leon McCauley, Nicholas James Michael McKenna, Gareth Thomas McDermott, Myfanwy Jane Antica Norton, Gavin Walsh Millar, Thomas Jacques Fernand Maeckelberghe
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Patent number: 11801360Abstract: A humidification system can include a heater base, a humidification chamber, and a breathing circuit. A cartridge can be removably coupled to the heater base. The cartridge can include various sensors, probes, sensor wire connectors, heater wire connectors, and/or other features. The cartridge can include features configured to mate with corresponding features on the humidification chamber and the heater base. The cartridge includes a memory, such as an EEPROM, or other suitable storage device. When the cartridge is installed on the heater base, the memory is electrically connected to a processor and/or memory of the heater base. Various models of cartridges can be produced for use with different humidification chambers, breathing circuits, and/or therapies. A connector can be configured to couple an inspiratory conduit to an outlet port of the humidification chamber. The connector can provide a pneumatic connection to the outlet port and an electrical connection to the cartridge.Type: GrantFiled: February 8, 2019Date of Patent: October 31, 2023Assignee: Fisher & Paykel Healthcare LimitedInventors: Hamish Adrian Osborne, Gavin Walsh Millar, Stephen David Evans, Bruce Gordon Holyoake, James William Stanton, David Leon McCauley, Gareth Thomas McDermott, Nicholas James Michael McKenna, Myfanwy Jane Antica Norton, Adrian John Elsworth, Michael John Andresen, Jonathan Andrew George Lambert, Sandeep Singh Gurm, Tessa Hazel Paris, Joseph Nathaniel Griffiths, Ping Si, Christopher Gareth Sims, Elmo Benson Stoks, Dexter Chi Lun Cheung, Peter Alan Seekup, Po-Yen Liu, Richard Edward Lang, Paul James Tonkin, Ian Lee Wai Kwan
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Publication number: 20230295287Abstract: The present disclosure provides a construct comprising a coding sequence operably linked to a promoter, wherein the coding sequence encodes a vascular endothelial growth factor (VEGF) binding agent or a portion thereof. In some embodiments, a construct is an AAV construct. In some embodiments, an AAV construct is a part of an AAV particle. Compositions comprising constructs and AAV particles described herein can be useful in treating hearing loss, for example, hearing loss associated with vestibular schwannoma.Type: ApplicationFiled: April 13, 2023Publication date: September 21, 2023Inventors: Emmanuel John Simons, Robert Ng, Michael McKenna
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Patent number: 11697801Abstract: Provided herein are methods that include introducing into an inner ear of a mammal a therapeutically effective amount of an adeno-associated virus (AAV) vector that includes a nucleotide sequence encoding (a) a polypeptide including an antibody heavy chain variable domain operably linked to a signal peptide and a polypeptide including an antibody light chain variable domain operably linked to a signal peptide; (b) a polypeptide including an antigen-binding antibody fragment operably linked to a signal peptide; or (c) a soluble vascular endothelial growth factor receptor operably linked to a signal peptide.Type: GrantFiled: August 3, 2021Date of Patent: July 11, 2023Assignee: Akouos, Inc.Inventors: Emmanuel John Simons, Robert Ng, Michael McKenna
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Publication number: 20230201484Abstract: A device (10) to deliver fluid to an ear includes: a handle portion (12) including a proximal end and a distal end; a needle sub-assembly (26) coupled to the distal end of the handle portion (12) and including a bent needle (38); and tubing (36) coupled to the proximal end of the handle portion (12). The bent needle (38) extends through the handle portion (12) and fluidly connects directly to the tubing (36).Type: ApplicationFiled: May 26, 2021Publication date: June 29, 2023Inventors: Michael McKenna, John Connelly
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Publication number: 20230181866Abstract: A humidification system can include a heater base, a chamber, and a breathing circuit. The heater base includes a heater plate positioned in a recessed region, and a heat conductive portion of the chamber is configured to contact the heater plate. The heater base includes a guard configured to control movement of the chamber into and out of the recessed region. The guard includes an anti-racking mechanism. The chamber includes an inlet port, an outlet port. A downward extension extends into the chamber from the inlet port, and a baffle is disposed at a lower end of the downward extension. A component of the breathing circuit can include a conduit hanging end cap for shipping and storage. The end cap can include a hanging component to allow the breathing circuit component to be hung from a medical stand. The system can detect when breathing circuits are connected in reverse.Type: ApplicationFiled: October 12, 2022Publication date: June 15, 2023Inventors: John James JACKSON, Barry Shack MANON, Victor Rosales CORRALES, Stefan Leo VAN WORKUM, Michael John ANDRESEN, Stephen David EVANS, Mark Samuel HAMILTON, Paul Fleming BUCKLEY, Jason Allan KLENNER, Hamish OSBORNE, Samuel Graham BOGGS, James William STANTON, Joseph Nathaniel GRIFFITHS, Jonathan Andrew George LAMBERT, Nicholas Edward VAUGHAN, James Owen KEHOE, Francisco Ernesto DE LA PEÑA DE LA FUENTE, Nicholas James Michael MCKENNA, Rachael PORTER, Simon Mordechai STAM, David Robert KEMPS, Edwin Joseph LYONS, Madeleine Bess MARTIN, Ada Yiwen SHOU, Huang-Ku LIU
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Patent number: 11511069Abstract: A humidification system can include a heater base, a chamber, and a breathing circuit. The heater base includes a heater plate positioned in a recessed region, and a heat conductive portion of the chamber is configured to contact the heater plate. The heater base includes a guard configured to control movement of the chamber into and out of the recessed region. The guard includes an anti-racking mechanism. The chamber includes an inlet port, an outlet port. A downward extension extends into the chamber from the inlet port, and a baffle is disposed at a lower end of the downward extension. A component of the breathing circuit can include a conduit hanging end cap for shipping and storage. The end cap can include a hanging component to allow the breathing circuit component to be hung from a medical stand. The system can detect when breathing circuits are connected in reverse.Type: GrantFiled: September 15, 2014Date of Patent: November 29, 2022Assignee: Fisher & Paykel Healthcare LimitedInventors: John James Jackson, Barry Shack Manon, Victor Rosales Corrales, Stefan Leo Van Workum, Michael John Andresen, Stephen David Evans, Mark Samuel Hamilton, Paul Fleming Buckley, Jason Allan Klenner, Hamish Osborne, Samuel Graham Boggs, James William Stanton, Joseph Nathaniel Griffiths, Jonathan Andrew George Lambert, Nicholas Edward Vaughan, James Owen Kehoe, Francisco Ernesto De La Pe{hacek over (n)}a De La Fuente, Nicholas James Michael McKenna, Rachael Porter, Simon Mordechai Stam, David Robert Kemps, Edwin Joseph Lyons, Madeleine Bess Martin, Ada Yiwen Shou, Huang-Ku Liu
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Patent number: 11511948Abstract: A method, electromagnetic switch, controller and program product, when energizing an electromagnetic coil to urge a selected shoe into a diverting path downstream of the electromagnetic switch, reverse current flow during at least a portion of the time that the electromagnetic coil is energized to recover energy from the electromagnetic coil.Type: GrantFiled: July 31, 2020Date of Patent: November 29, 2022Assignee: LAFAYETTE ENGINEERING, INC.Inventors: Robert Bruce Robbins, Timothy Lee Johnson, II, Michael Mckenna, Charles O. Burdine, II, Daniel Blake Robbins
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Publication number: 20220267739Abstract: Provided herein are methods that include introducing into an inner ear of a mammal a therapeutically effective amount of an adeno-associated virus (AAV) vector that includes a nucleotide sequence encoding (a) a polypeptide including an antibody heavy chain variable domain operably linked to a signal peptide and a polypeptide including an antibody light chain variable domain operably linked to a signal peptide; (b) a polypeptide including an antigen-binding antibody fragment operably linked to a signal peptide; or (c) a soluble vascular endothelial growth factor receptor operably linked to a signal peptide.Type: ApplicationFiled: March 17, 2022Publication date: August 25, 2022Inventors: Emmanuel John Simons, Robert Ng, Michael McKenna
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Patent number: 11298267Abstract: The present disclosure discussed a handpiece for trans-canal delivery of a therapeutic substance to the inner ear. The handpiece can be inserted into the middle ear via a surgical tympanotomy approach. The handpiece can enable a controlled injection of a therapeutic substance directly through the round window membrane and into the inner ear. The direct delivery of the therapeutic substance to the inner ear can enable the delivery of a precise amount of therapeutic substance into the inner ear. Because the therapeutic substance is delivery directly to the inner ear the delivery of the therapeutic substance is not subject to limitations on molecule size and inconsistent diffusion rates that are present when therapeutic substances are diffused across the round window membrane.Type: GrantFiled: February 11, 2019Date of Patent: April 12, 2022Assignee: The Charles Stark Draper Laboratory, Inc.Inventors: Ernest S. Kim, Michael McKenna, Ruwan Kiringoda
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Publication number: 20220037103Abstract: A method, electromagnetic switch, controller and program product, when energizing an electromagnetic coil to urge a selected shoe into a diverting path downstream of the electromagnetic switch, reverse current flow during at least a portion of the time that the electromagnetic coil is energized to recover energy from the electromagnetic coil.Type: ApplicationFiled: July 31, 2020Publication date: February 3, 2022Inventors: Robert Bruce Robbins, Timothy Lee Johnson, II, Michael Mckenna, Charles O. Burdine, II, Daniel Blake Robbins
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Publication number: 20210363499Abstract: Provided herein are methods that include introducing into an inner ear of a mammal a therapeutically effective amount of an adeno-associated virus (AAV) vector that includes a nucleotide sequence encoding (a) a polypeptide including an antibody heavy chain variable domain operably linked to a signal peptide and a polypeptide including an antibody light chain variable domain operably linked to a signal peptide; (b) a polypeptide including an antigen-binding antibody fragment operably linked to a signal peptide; or (c) a soluble vascular endothelial growth factor receptor operably linked to a signal peptide.Type: ApplicationFiled: August 3, 2021Publication date: November 25, 2021Inventors: Emmanuel John Simons, Robert Ng, Michael McKenna