Patents by Inventor Michael McKenna

Michael McKenna has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 12275960
    Abstract: Provided herein are methods that include introducing into an inner ear of a mammal a therapeutically effective amount of an adeno-associated virus (AAV) vector that includes a nucleotide sequence encoding (a) a polypeptide including an antibody heavy chain variable domain operably linked to a signal peptide and a polypeptide including an antibody light chain variable domain operably linked to a signal peptide; (b) a polypeptide including an antigen-binding antibody fragment operably linked to a signal peptide; or (c) a soluble vascular endothelial growth factor receptor operably linked to a signal peptide.
    Type: Grant
    Filed: June 13, 2023
    Date of Patent: April 15, 2025
    Assignee: Akouos, Inc.
    Inventors: Emmanuel John Simons, Robert Ng, Michael McKenna
  • Publication number: 20250111385
    Abstract: Disclosed embodiments may include a method for intelligent bookout discrepancy detection. The system may receive bookout data from an automotive dealer, which may include dealer-provided vehicle information that includes a dealer price and dealer-listed features. The system may identify a vehicle identification number from the dealer-provided vehicle information. The system may retrieve third-party vehicle information including at least one of a third-party price and third-party listed features from one or more third party sources using the vehicle identification number. The system may aggregate the third-party vehicle information from the one or more third party sources. The system may determine that a bookout discrepancy exists by comparing the dealer price to the third-party price and comparing dealer-listed features to third-party listed features. The system may flag a contract associated with the bookout data for further review.
    Type: Application
    Filed: September 29, 2023
    Publication date: April 3, 2025
    Inventors: Michael Garner, Bria Burchianti, Michael McKenna
  • Publication number: 20250010016
    Abstract: A humidification system can include a heater base, a chamber, and a breathing circuit. The heater base includes a heater plate positioned in a recessed region, and a heat conductive portion of the chamber is configured to contact the heater plate. The heater base includes a guard configured to control movement of the chamber into and out of the recessed region. The guard includes an anti-racking mechanism. The chamber includes an inlet port, an outlet port. A downward extension extends into the chamber from the inlet port, and a baffle is disposed at a lower end of the downward extension. A component of the breathing circuit can include a conduit hanging end cap for shipping and storage. The end cap can include a hanging component to allow the breathing circuit component to be hung from a medical stand. The system can detect when breathing circuits are connected in reverse.
    Type: Application
    Filed: June 21, 2024
    Publication date: January 9, 2025
    Inventors: John James JACKSON, Barry Shack MANON, Victor Rosales CORRALES, Stefan Leo VAN WORKUM, Michael John ANDRESEN, Stephen David EVANS, Mark Samuel HAMILTON, Paul Fleming BUCKLEY, Jason Allan KLENNER, Hamish OSBORNE, Samuel Graham BOGGS, James William STANTON, Joseph Nathaniel GRIFFITHS, Jonathan Andrew George LAMBERT, Nicholas Edward VAUGHAN, James Owen KEHOE, Francisco Ernesto DE LA PENA DE LA FUENTE, Nicholas James Michael MCKENNA, Rachael PORTER, Simon Mordechai STAM, David Robert KEMPS, Edwin Joseph LYONS, Madeleine Bess MARTIN, Ada Yiwen SHOU, Huang-Ku LIU
  • Patent number: 12077783
    Abstract: Provided herein are methods that include introducing into an inner ear of a mammal a therapeutically effective amount of an adeno-associated virus (AAV) vector that includes a nucleotide sequence encoding (a) a polypeptide including an antibody heavy chain variable domain operably linked to a signal peptide and a polypeptide including an antibody light chain variable domain operably linked to a signal peptide; (b) a polypeptide including an antigen-binding antibody fragment operably linked to a signal peptide; or (c) a soluble vascular endothelial growth factor receptor operably linked to a signal peptide.
    Type: Grant
    Filed: March 17, 2022
    Date of Patent: September 3, 2024
    Assignee: Akouos, Inc.
    Inventors: Emmanuel John Simons, Robert Ng, Michael McKenna
  • Patent number: 12053589
    Abstract: A humidification system can include a heater base, a chamber, and a breathing circuit. The heater base includes a heater plate positioned in a recessed region, and a heat conductive portion of the chamber is configured to contact the heater plate. The heater base includes a guard configured to control movement of the chamber into and out of the recessed region. The guard includes an anti-racking mechanism. The chamber includes an inlet port, an outlet port. A downward extension extends into the chamber from the inlet port, and a baffle is disposed at a lower end of the downward extension. A component of the breathing circuit can include a conduit hanging end cap for shipping and storage. The end cap can include a hanging component to allow the breathing circuit component to be hung from a medical stand. The system can detect when breathing circuits are connected in reverse.
    Type: Grant
    Filed: October 12, 2022
    Date of Patent: August 6, 2024
    Assignee: Fisher & Paykel Healthcare Limited
    Inventors: John James Jackson, Barry Shack Manon, Victor Rosales Corrales, Stefan Leo Van Workum, Michael John Andresen, Stephen David Evans, Mark Samuel Hamilton, Paul Fleming Buckley, Jason Allan Klenner, Hamish Osborne, Samuel Graham Boggs, James William Stanton, Joseph Nathaniel Griffiths, Jonathan Andrew George Lambert, Nicholas Edward Vaughan, James Owen Kehoe, Francisco Ernesto De La Peña De La Fuente, Nicholas James Michael Mckenna, Rachael Porter, Simon Mordechai Stam, David Robert Kemps, Edwin Joseph Lyons, Madeleine Bess Martin, Ada Yiwen Shou, Huang-Ku Liu
  • Publication number: 20240108844
    Abstract: A humidification system can include a heater base, a humidification chamber, and a breathing circuit. A cartridge can be removably coupled to the heater base. The cartridge can include various sensors, probes, sensor wire connectors, heater wire connectors, and/or other features. The cartridge can include features configured to mate with corresponding features on the humidification chamber and the heater base. The cartridge includes a memory, such as an EEPROM, or other suitable storage device. When the cartridge is installed on the heater base, the memory is electrically connected to a processor and/or memory of the heater base. Various models of cartridges can be produced for use with different humidification chambers, breathing circuits, and/or therapies. A connector can be configured to couple an inspiratory conduit to an outlet port of the humidification chamber. The connector can provide a pneumatic connection to the outlet port and an electrical connection to the cartridge.
    Type: Application
    Filed: September 20, 2023
    Publication date: April 4, 2024
    Inventors: Hamish Adrian OSBORNE, Gavin Walsh Millar, Stephen David Evans, Bruce Gordon Holyoake, James William Stanton, David Leon McCauley, Gareth Thomas McDermott, Nicholas James Michael McKenna, Myfanwy Jane Antica Norton, Adrian John Elsworth, Michael John Andresen, Jonathan Andrew George Lambert, Sandeep Singh Gurm, Tessa Hazel Paris, Joseph Nathaniel Griffiths, Ping Si, Christopher Gareth Sims, Elmo Benson Stoks, Dexter Chi Lun Cheung, Peter Alan Seekup, Po-Yen Liu, Richard Edward Lang, Paul James Tonkin, Ian Lee Wai Kwan
  • Publication number: 20240100316
    Abstract: A circuit connector for a humidification system, the system comprising a base unit configured to be engaged by a humidification chamber. The circuit connector comprises an inlet to fluidly connect to an outlet of the humidification chamber to receive humidified gases therefrom, an outlet to sealably connect to or integral with a conduit for directing the humidified gases to a user, and an electrical terminal for electrically coupling the circuit connector to an electrical terminal associated with the base unit. The circuit connector may be releasably and lockably connectable to the outlet of the humidification chamber and/or orientation features may control orientation of component parts of the system as they are assembled.
    Type: Application
    Filed: September 28, 2023
    Publication date: March 28, 2024
    Inventors: Hamish Adrian OSBORNE, James William STANTON, Bruce Gordon HOLYOAKE, Stephen David EVANS, David Leon MCCAULEY, Nicholas James Michael MCKENNA, Gareth Thomas MCDERMOTT, Myfanwy Jane Antica NORTON, Gavin Walsh MILLAR, Thomas Jacques Fernand MAECKELBERGHE
  • Publication number: 20240101970
    Abstract: Provided herein are methods that include introducing into an inner ear of a mammal a therapeutically effective amount of an adeno-associated virus (AAV) vector that includes a nucleotide sequence encoding (a) a polypeptide including an antibody heavy chain variable domain operably linked to a signal peptide and a polypeptide including an antibody light chain variable domain operably linked to a signal peptide; (b) a polypeptide including an antigen-binding antibody fragment operably linked to a signal peptide; or (c) a soluble vascular endothelial growth factor receptor operably linked to a signal peptide.
    Type: Application
    Filed: June 13, 2023
    Publication date: March 28, 2024
    Inventors: Emmanuel John Simons, Robert Ng, Michael McKenna
  • Patent number: 11826538
    Abstract: A circuit connector for a humidification system, the system comprising a base unit configured to be engaged by a humidification chamber. The circuit connector comprises an inlet to fluidly connect to an outlet of the humidification chamber to receive humidified gases therefrom, an outlet to sealably connect to or integral with a conduit for directing the humidified gases to a user, and an electrical terminal for electrically coupling the circuit connector to an electrical terminal associated with the base unit. The circuit connector may be releasably and lockably connectable to the outlet of the humidification chamber and/or orientation features may control orientation of component parts of the system as they are assembled.
    Type: Grant
    Filed: October 1, 2020
    Date of Patent: November 28, 2023
    Assignee: Fisher & Paykel Healthcare Limited
    Inventors: Hamish Adrian Osborne, James William Stanton, Bruce Gordon Holyoake, Stephen David Evans, David Leon McCauley, Nicholas James Michael McKenna, Gareth Thomas McDermott, Myfanwy Jane Antica Norton, Gavin Walsh Millar, Thomas Jacques Fernand Maeckelberghe
  • Patent number: 11801360
    Abstract: A humidification system can include a heater base, a humidification chamber, and a breathing circuit. A cartridge can be removably coupled to the heater base. The cartridge can include various sensors, probes, sensor wire connectors, heater wire connectors, and/or other features. The cartridge can include features configured to mate with corresponding features on the humidification chamber and the heater base. The cartridge includes a memory, such as an EEPROM, or other suitable storage device. When the cartridge is installed on the heater base, the memory is electrically connected to a processor and/or memory of the heater base. Various models of cartridges can be produced for use with different humidification chambers, breathing circuits, and/or therapies. A connector can be configured to couple an inspiratory conduit to an outlet port of the humidification chamber. The connector can provide a pneumatic connection to the outlet port and an electrical connection to the cartridge.
    Type: Grant
    Filed: February 8, 2019
    Date of Patent: October 31, 2023
    Assignee: Fisher & Paykel Healthcare Limited
    Inventors: Hamish Adrian Osborne, Gavin Walsh Millar, Stephen David Evans, Bruce Gordon Holyoake, James William Stanton, David Leon McCauley, Gareth Thomas McDermott, Nicholas James Michael McKenna, Myfanwy Jane Antica Norton, Adrian John Elsworth, Michael John Andresen, Jonathan Andrew George Lambert, Sandeep Singh Gurm, Tessa Hazel Paris, Joseph Nathaniel Griffiths, Ping Si, Christopher Gareth Sims, Elmo Benson Stoks, Dexter Chi Lun Cheung, Peter Alan Seekup, Po-Yen Liu, Richard Edward Lang, Paul James Tonkin, Ian Lee Wai Kwan
  • Publication number: 20230295287
    Abstract: The present disclosure provides a construct comprising a coding sequence operably linked to a promoter, wherein the coding sequence encodes a vascular endothelial growth factor (VEGF) binding agent or a portion thereof. In some embodiments, a construct is an AAV construct. In some embodiments, an AAV construct is a part of an AAV particle. Compositions comprising constructs and AAV particles described herein can be useful in treating hearing loss, for example, hearing loss associated with vestibular schwannoma.
    Type: Application
    Filed: April 13, 2023
    Publication date: September 21, 2023
    Inventors: Emmanuel John Simons, Robert Ng, Michael McKenna
  • Patent number: 11697801
    Abstract: Provided herein are methods that include introducing into an inner ear of a mammal a therapeutically effective amount of an adeno-associated virus (AAV) vector that includes a nucleotide sequence encoding (a) a polypeptide including an antibody heavy chain variable domain operably linked to a signal peptide and a polypeptide including an antibody light chain variable domain operably linked to a signal peptide; (b) a polypeptide including an antigen-binding antibody fragment operably linked to a signal peptide; or (c) a soluble vascular endothelial growth factor receptor operably linked to a signal peptide.
    Type: Grant
    Filed: August 3, 2021
    Date of Patent: July 11, 2023
    Assignee: Akouos, Inc.
    Inventors: Emmanuel John Simons, Robert Ng, Michael McKenna
  • Publication number: 20230201484
    Abstract: A device (10) to deliver fluid to an ear includes: a handle portion (12) including a proximal end and a distal end; a needle sub-assembly (26) coupled to the distal end of the handle portion (12) and including a bent needle (38); and tubing (36) coupled to the proximal end of the handle portion (12). The bent needle (38) extends through the handle portion (12) and fluidly connects directly to the tubing (36).
    Type: Application
    Filed: May 26, 2021
    Publication date: June 29, 2023
    Inventors: Michael McKenna, John Connelly
  • Publication number: 20230181866
    Abstract: A humidification system can include a heater base, a chamber, and a breathing circuit. The heater base includes a heater plate positioned in a recessed region, and a heat conductive portion of the chamber is configured to contact the heater plate. The heater base includes a guard configured to control movement of the chamber into and out of the recessed region. The guard includes an anti-racking mechanism. The chamber includes an inlet port, an outlet port. A downward extension extends into the chamber from the inlet port, and a baffle is disposed at a lower end of the downward extension. A component of the breathing circuit can include a conduit hanging end cap for shipping and storage. The end cap can include a hanging component to allow the breathing circuit component to be hung from a medical stand. The system can detect when breathing circuits are connected in reverse.
    Type: Application
    Filed: October 12, 2022
    Publication date: June 15, 2023
    Inventors: John James JACKSON, Barry Shack MANON, Victor Rosales CORRALES, Stefan Leo VAN WORKUM, Michael John ANDRESEN, Stephen David EVANS, Mark Samuel HAMILTON, Paul Fleming BUCKLEY, Jason Allan KLENNER, Hamish OSBORNE, Samuel Graham BOGGS, James William STANTON, Joseph Nathaniel GRIFFITHS, Jonathan Andrew George LAMBERT, Nicholas Edward VAUGHAN, James Owen KEHOE, Francisco Ernesto DE LA PEÑA DE LA FUENTE, Nicholas James Michael MCKENNA, Rachael PORTER, Simon Mordechai STAM, David Robert KEMPS, Edwin Joseph LYONS, Madeleine Bess MARTIN, Ada Yiwen SHOU, Huang-Ku LIU
  • Patent number: 11511069
    Abstract: A humidification system can include a heater base, a chamber, and a breathing circuit. The heater base includes a heater plate positioned in a recessed region, and a heat conductive portion of the chamber is configured to contact the heater plate. The heater base includes a guard configured to control movement of the chamber into and out of the recessed region. The guard includes an anti-racking mechanism. The chamber includes an inlet port, an outlet port. A downward extension extends into the chamber from the inlet port, and a baffle is disposed at a lower end of the downward extension. A component of the breathing circuit can include a conduit hanging end cap for shipping and storage. The end cap can include a hanging component to allow the breathing circuit component to be hung from a medical stand. The system can detect when breathing circuits are connected in reverse.
    Type: Grant
    Filed: September 15, 2014
    Date of Patent: November 29, 2022
    Assignee: Fisher & Paykel Healthcare Limited
    Inventors: John James Jackson, Barry Shack Manon, Victor Rosales Corrales, Stefan Leo Van Workum, Michael John Andresen, Stephen David Evans, Mark Samuel Hamilton, Paul Fleming Buckley, Jason Allan Klenner, Hamish Osborne, Samuel Graham Boggs, James William Stanton, Joseph Nathaniel Griffiths, Jonathan Andrew George Lambert, Nicholas Edward Vaughan, James Owen Kehoe, Francisco Ernesto De La Pe{hacek over (n)}a De La Fuente, Nicholas James Michael McKenna, Rachael Porter, Simon Mordechai Stam, David Robert Kemps, Edwin Joseph Lyons, Madeleine Bess Martin, Ada Yiwen Shou, Huang-Ku Liu
  • Patent number: 11511948
    Abstract: A method, electromagnetic switch, controller and program product, when energizing an electromagnetic coil to urge a selected shoe into a diverting path downstream of the electromagnetic switch, reverse current flow during at least a portion of the time that the electromagnetic coil is energized to recover energy from the electromagnetic coil.
    Type: Grant
    Filed: July 31, 2020
    Date of Patent: November 29, 2022
    Assignee: LAFAYETTE ENGINEERING, INC.
    Inventors: Robert Bruce Robbins, Timothy Lee Johnson, II, Michael Mckenna, Charles O. Burdine, II, Daniel Blake Robbins
  • Publication number: 20220267739
    Abstract: Provided herein are methods that include introducing into an inner ear of a mammal a therapeutically effective amount of an adeno-associated virus (AAV) vector that includes a nucleotide sequence encoding (a) a polypeptide including an antibody heavy chain variable domain operably linked to a signal peptide and a polypeptide including an antibody light chain variable domain operably linked to a signal peptide; (b) a polypeptide including an antigen-binding antibody fragment operably linked to a signal peptide; or (c) a soluble vascular endothelial growth factor receptor operably linked to a signal peptide.
    Type: Application
    Filed: March 17, 2022
    Publication date: August 25, 2022
    Inventors: Emmanuel John Simons, Robert Ng, Michael McKenna
  • Patent number: 11298267
    Abstract: The present disclosure discussed a handpiece for trans-canal delivery of a therapeutic substance to the inner ear. The handpiece can be inserted into the middle ear via a surgical tympanotomy approach. The handpiece can enable a controlled injection of a therapeutic substance directly through the round window membrane and into the inner ear. The direct delivery of the therapeutic substance to the inner ear can enable the delivery of a precise amount of therapeutic substance into the inner ear. Because the therapeutic substance is delivery directly to the inner ear the delivery of the therapeutic substance is not subject to limitations on molecule size and inconsistent diffusion rates that are present when therapeutic substances are diffused across the round window membrane.
    Type: Grant
    Filed: February 11, 2019
    Date of Patent: April 12, 2022
    Assignee: The Charles Stark Draper Laboratory, Inc.
    Inventors: Ernest S. Kim, Michael McKenna, Ruwan Kiringoda
  • Publication number: 20220037103
    Abstract: A method, electromagnetic switch, controller and program product, when energizing an electromagnetic coil to urge a selected shoe into a diverting path downstream of the electromagnetic switch, reverse current flow during at least a portion of the time that the electromagnetic coil is energized to recover energy from the electromagnetic coil.
    Type: Application
    Filed: July 31, 2020
    Publication date: February 3, 2022
    Inventors: Robert Bruce Robbins, Timothy Lee Johnson, II, Michael Mckenna, Charles O. Burdine, II, Daniel Blake Robbins
  • Publication number: 20210363499
    Abstract: Provided herein are methods that include introducing into an inner ear of a mammal a therapeutically effective amount of an adeno-associated virus (AAV) vector that includes a nucleotide sequence encoding (a) a polypeptide including an antibody heavy chain variable domain operably linked to a signal peptide and a polypeptide including an antibody light chain variable domain operably linked to a signal peptide; (b) a polypeptide including an antigen-binding antibody fragment operably linked to a signal peptide; or (c) a soluble vascular endothelial growth factor receptor operably linked to a signal peptide.
    Type: Application
    Filed: August 3, 2021
    Publication date: November 25, 2021
    Inventors: Emmanuel John Simons, Robert Ng, Michael McKenna