Patents by Inventor Michael McLachlan

Michael McLachlan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS TO PREVENT RAPID SILENCING OF GENES IN PLURIPOTENT STEM CELLS
    Publication number: 20220389436
    Abstract: Provided herein are methods of producing cell lines with stable expression of a transgene by removal of CpG motifs. In further methods, there are provided methods for cell lines with stable expression of a transgene by driving expression by novel promoters or by tagging endogenous genes.
    Type: Application
    Filed: May 26, 2022
    Publication date: December 8, 2022
    Applicant: FUJIFILM Cellular Dynamics, Inc.
    Inventors: Sarah DICKERSON, Sarah BURTON, Christie MUNN, Madelyn GOEDLAND, Michael MCLACHLAN, Deepika RAJESH, Tom BURKE
  • METHODS FOR THE PRODUCTION OF MULTIPLE LINEAGES FROM INDUCED PLURIPOTENT STEM CELLS USING CHARGED SURFACES
    Publication number: 20220251516
    Abstract: The present disclosure provides methods of producing progenitor cells from induced pluripotent stem cells, wherein the progenitor cells comprise endothelial cells, pericytes, brain microvascular endothelial cells (BMECs), mesenchymal stem cells (MSCs), hematopoietic precursor cells (HPCs), microglia or neural precursor cells (NPCs).
    Type: Application
    Filed: June 15, 2020
    Publication date: August 11, 2022
    Applicants: FUJIFILM Cellular Dynamics, Inc., FUJIFILM Holdings America Corporation
    Inventors: Deepika RAJESH, Christie MUNN, Sarah BURTON, Madelyn GOEDLAND, Michael McLACHLAN, Abbey MUSINSKY, Kwi Hye KIM, Michael HANCOCK, Makiko OHSHIMA, Anne STROUSE, Sarah DICKERSON
  • METHODS FOR CELL REPROGRAMMING AND GENOME ENGINEERING
    Publication number: 20160281063
    Abstract: Methods for producing engineered induced pluripotent stem (iPS) cells are provided comprising introducing a first nucleic acid into somatic cells for integration into their genome and reprogramming the cells to produce engineered iPS cells having the nucleic acid integrated into their genome. For example, in certain aspects the cells are reprogrammed by introduction of a genetic element that expresses one or more reprogramming factor and culturing of the cells under conditions sufficient to produce reprogrammed cells.
    Type: Application
    Filed: February 23, 2016
    Publication date: September 29, 2016
    Applicant: Cellular Dynamics International, Inc.
    Inventors: Thomas J. BURKE, Michael MILLER, Michael McLACHLAN, Sarah Jane DICKERSON, Anne STROUSE
  • METHODS FOR CELL REPROGRAMMING AND GENOME ENGINEERING
    Publication number: 20130040302
    Abstract: Methods for producing engineered induced pluripotent stem (iPS) cells are provided comprising introducing a first nucleic acid into somatic cells for integration into their genome and reprogramming the cells to produce engineered iPS cells having the nucleic acid integrated into their genome. For example, in certain aspects the cells are reprogrammed by introduction of a genetic element that expresses one or more reprogramming factor and culturing of the cells under conditions sufficient to produce reprogrammed cells.
    Type: Application
    Filed: July 11, 2012
    Publication date: February 14, 2013
    Inventors: Thomas J. Burke, Michael Miller, Michael McLachlan, Sarah Jane Dickerson, Anne Strouse
  • ENGINEERED PHOSPHITE DEHYDROGENASE MUTANTS
    Publication number: 20100151529
    Abstract: Phosphite dehydrogenase mutant enzymes provide relaxed cofactor specificity, increased thermostability, increased activity, solubility, and expression over the wild-type enzyme. The mutant enzymes are useful for nicotinamide cofactor regeneration.
    Type: Application
    Filed: April 18, 2008
    Publication date: June 17, 2010
    Applicant: BIOTECHNOLOGY RESEARCH AND DEVELOPMENT CORPORATION
    Inventors: Huimin Zhao, Michael McLachlan, Tyler Johannes