Patents by Inventor Michael Michaelides

Michael Michaelides has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20230399340
    Abstract: The present disclosure provides for compounds of Formula (I) wherein A2, A3, A4, A6, A7, A8, A15, RA, R5, R9, R10A, R10B, R11, R12, R13, R14, R16, W, X, and Y have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions, including cancer. Also provided are pharmaceutical compositions comprising compounds of Formula (I).
    Type: Application
    Filed: October 12, 2022
    Publication date: December 14, 2023
    Inventors: Wilfried Braje, George Doherty, Katja Jantos, Cheng Ji, Andrew Judd, Aaron Kunzer, Anthony Mastracchio, Xiaohong Song, Andrew Souers, Gerard Sullivan, Zhi-Fu Tao, Chunqiu Lai, Andreas Kling, Frauke Pohlki, Jesse Teske, Michael Wendt, Patrick Brady, Xilu Wang, Thomas Penning, Michael Michaelides
  • Patent number: 11811613
    Abstract: Systems, methods, and computer-readable media for identifying a spanning tree loop in a network environment. Spanning tree loop indicators occurring in a network environment that utilizes a spanning tree protocol are identified. The spanning tree loop indicators are correlated to identify correlated spanning tree loop indicators within the network environment. A potential spanning tree loop is recognized from a plurality of the correlated spanning tree loop indicators based on indicator types of the correlated spanning tree loop indicators. The potential spanning tree loop is remedied in the network environment in response to recognizing the potential spanning tree loop in the network environment.
    Type: Grant
    Filed: November 14, 2022
    Date of Patent: November 7, 2023
    Assignee: Cisco Technology, Inc.
    Inventors: Zachariah Cherian, Samer Salam, Ajay Madhavan, Tarunesh Ahuja, Michael Michaelides, Smruti Dilip Lele
  • Patent number: 11739063
    Abstract: Disclosed is a compound of formula (I) in which R1, R2, and R3 are as described herein. Also provided are pharmaceutical compositions comprising the compound of formula (I) and methods of using the compound of formula (I), including a method of treating a disease or disorder and a method for effectuating a G-protein coupled receptor (GPCR)-mediated response in a subject.
    Type: Grant
    Filed: February 6, 2019
    Date of Patent: August 29, 2023
    Assignees: The United States of America, as represented by the Secretary, Department of Health and Human Services, The Johns Hopkins University
    Inventors: Jordi Bonaventura, Juan Luis Gomez, Andrew Horti, Feng Hu, Michael Michaelides, Martin Pomper, Marta Sanchez-Soto
  • Publication number: 20230075769
    Abstract: Systems, methods, and computer-readable media for identifying a spanning tree loop in a network environment. Spanning tree loop indicators occurring in a network environment that utilizes a spanning tree protocol are identified. The spanning tree loop indicators are correlated to identify correlated spanning tree loop indicators within the network environment. A potential spanning tree loop is recognized from a plurality of the correlated spanning tree loop indicators based on indicator types of the correlated spanning tree loop indicators. The potential spanning tree loop is remedied in the network environment in response to recognizing the potential spanning tree loop in the network environment.
    Type: Application
    Filed: November 14, 2022
    Publication date: March 9, 2023
    Inventors: Zachariah Cherian, Samer Salam, Ajay Madhavan, Tarunesh Ahuja, Michael Michaelides, Smruti Dilip Lele
  • Patent number: 11516086
    Abstract: Systems, methods, and computer-readable media for identifying a spanning tree loop in a network environment. Spanning tree loop indicators occurring in a network environment that utilizes a spanning tree protocol are identified. The spanning tree loop indicators are correlated to identify correlated spanning tree loop indicators within the network environment. A potential spanning tree loop is recognized from a plurality of the correlated spanning tree loop indicators based on indicator types of the correlated spanning tree loop indicators. The potential spanning tree loop is remedied in the network environment in response to recognizing the potential spanning tree loop in the network environment.
    Type: Grant
    Filed: September 4, 2019
    Date of Patent: November 29, 2022
    Assignee: Cisco Technology, Inc.
    Inventors: Zachariah Cherian, Samer Salam, Ajay Madhavan, Tarunesh Ahuja, Michael Michaelides, Smruti Dilip Lele
  • Patent number: 11394604
    Abstract: The present technology addresses a need in the art for a closed-loop automation system of a managed network that detects and fixes an issue in the managed network with minimal to no human intervention. The closed-loop automation system employs a domain-independent semantic machine reasoning engine as an underlying engine. After detecting the issue in the managed network, the system searches through a knowledge base to find a match for the detected issue. The knowledge base includes previously collected knowledge from subject matter experts and maintenance teams. The system then proposes a remedial action to a user of the managed network for approval. After approval by the user, the system implements the remedial action.
    Type: Grant
    Filed: September 10, 2020
    Date of Patent: July 19, 2022
    Assignee: CISCO TECHNOLOGY, INC.
    Inventors: Ammar Rayes, Arun Mammen Thomas, Samer Salam, Michael Michaelides, Arabinda Samantaray, Madhavan Kasthurirangan, Ram Prasanna Govind Krishnan, Asad Ghayas Ahmed, Thuan Quang Truong, Ajay Madhavan, Xixi Luo, Samhith Venkatesh
  • Publication number: 20220078072
    Abstract: The present technology addresses a need in the art for a closed-loop automation system of a managed network that detects and fixes an issue in the managed network with minimal to no human intervention. The closed-loop automation system employs a domain-independent semantic machine reasoning engine as an underlying engine. After detecting the issue in the managed network, the system searches through a knowledge base to find a match for the detected issue. The knowledge base includes previously collected knowledge from subject matter experts and maintenance teams. The system then proposes a remedial action to a user of the managed network for approval. After approval by the user, the system implements the remedial action.
    Type: Application
    Filed: September 10, 2020
    Publication date: March 10, 2022
    Inventors: Ammar Rayes, Arun Mammen Thomas, Samer Salam, Michael Michaelides, Arabinda Samantaray, Madhavan Kasthurirangan, Ram Prasanna Govind Krishnan, Asad Ghayas Ahmed, Thuan Quang Truong, Ajay Madhavan, Xixi Luo, Samhith Venkatesh
  • Publication number: 20200399228
    Abstract: Disclosed is a compound of formula (I) in which R1, R2, and R3 are as described herein. Also provided are pharmaceutical compositions comprising the compound of formula (I) and methods of using the compound of formula (I), including a method of treating a disease or disorder and a method for effectuating a G-protein coupled receptor (GPCR)-mediated response in a subject.
    Type: Application
    Filed: February 6, 2019
    Publication date: December 24, 2020
    Applicants: The United States of America,as represented by the Secretary,Department of Health and Human Services, The Johns Hopkins University
    Inventors: Jordi Bonaventura, Juan Luis Gomez, Andrew Horti, Feng Hu, Michael Michaelides, Martin Pomper, Marta Sanchez-Soto
  • Publication number: 20200239494
    Abstract: The present disclosure provides for compounds of Formula (I) wherein A2, A3, A4, A6, A7, A8, A15, RA, R5, R9, R10A, R10B, R11, R12, R13, R14, R16, W, X, and Y have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions, including cancer. Also provided are pharmaceutical compositions comprising compounds of Formula (I).
    Type: Application
    Filed: August 15, 2018
    Publication date: July 30, 2020
    Inventors: Wilfried BRAJE, George DOHERTY, Katja JANTOS, Cheng JI, Andrew JUDD, Aaron KUNZER, Anthony MASTRACCHIO, Xiaohong SONG, Andrew SOUERS, Gerard SULLIVAN, Zhi-Fu TAO, Chunqiu LAI, Andreas KLING, Frauke POHLKI, Jesse TESKE, Michael WENDT, Patrick BRADY, Xilu WANG, Thomas PENNING, Michael Michaelides
  • Patent number: 10093624
    Abstract: Disclosed are isoindoline carboxamide, dihydropyrrolopyridine carboxamide, and dihydropyrrolopyrimidine carboxamide compounds which inhibit the activity of NAMPT, compositions containing the compounds and methods of treating diseases during which NAMPT is expressed. Disclosed are isoindoline carboxamide, dihydropyrrolopyridine carboxamide, and dihydropyrrolopyrimidine carboxamide compounds which inhibit the activity of ROCK, compositions containing the compounds and methods of treating diseases during which ROCK is expressed.
    Type: Grant
    Filed: October 12, 2015
    Date of Patent: October 9, 2018
    Assignee: AbbVie Inc.
    Inventors: Rick F. Clark, Michael L. Curtain, Todd M. Hansen, Howard R. Heyman, Helmut Mack, Michael Michaelides, Marina A. Pliushchev, Omar J. Shah, Bryan K. Sorensen, Ramzi Sweis, Chris Tse, Anil Vasudevan, Kevin R. Woller
  • Publication number: 20180093956
    Abstract: The invention provides for compounds of formula (I) wherein R1, R2, R3, R4, R5, and R6 have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions mediated and modulated by SUV420H1. Also provided are pharmaceutical compositions comprised of one or more compounds of formula (I).
    Type: Application
    Filed: February 6, 2015
    Publication date: April 5, 2018
    Inventors: Yujia Dai, Michael Michaelides
  • Patent number: 9796708
    Abstract: Disclosed are compounds of Formula (IIa), wherein R1, R2, R3A, R3B, R3C, R3D, R3E, and R4 are as defined in the specification, and pharmaceutically acceptable salts thereof. The compounds may be used as agents in the treatment of diseases, including cancer. Also provided are pharmaceutical compositions comprising one or more compounds of Formula (IIa).
    Type: Grant
    Filed: March 13, 2014
    Date of Patent: October 24, 2017
    Assignee: AbbVie Inc.
    Inventors: Yunsong Tong, Milan Bruncko, Richard F. Clark, Michael Curtin, Alan S. Florjancic, Robin R. Frey, Jianchun Gong, Todd M. Hansen, Zhiqin Ji, Chunqiu Lai, Anthony Mastracchio, Michael Michaelides, Juliem Miyashiro, Roberto M. Risi, Xiaohong Song, Zhi-fu Tao, Keith W. Woods, Guidong Zhu, Thomas Penning, Andrew Souers, Rajeev Goswami, Omprakash Reddy Iguturi, Madhu Babu Dabbeeru
  • Publication number: 20170135994
    Abstract: Disclosed are compounds which inhibit the activity of NAMPT, compositions containing the compounds and methods of treating diseases during which NAMPT is expressed.
    Type: Application
    Filed: October 8, 2015
    Publication date: May 18, 2017
    Applicant: AbbVie Inc.
    Inventors: Richard F. Clark, Bryan Sorensen, Augustine T. Osuma, Robin Frey, Kenton Longenecker, George Doherty, Michael L. Curtin, Michael Michaelides, Ramzi Sweis, Marina Pliushchev, Andrew Judd, Todd Hansen, Howard R. Heyman
  • Publication number: 20160184282
    Abstract: Disclosed are compounds which inhibit the activity of NAMPT, compositions containing the compounds and methods of treating diseases during which NAMPT is expressed.
    Type: Application
    Filed: October 8, 2015
    Publication date: June 30, 2016
    Applicant: AbbVie Inc.
    Inventors: Richard F. Clark, Bryan Sorensen, Augustine T. Osuma, Robin Frey, Kenton Longenecker, George Doherty, Michael L. Curtin, Michael Michaelides, Ramzi Sweis, Marina Pliushchev, Andrew Judd, Todd Hansen, Howard R. Heyman
  • Publication number: 20160184281
    Abstract: Disclosed are compounds which inhibit the activity of NAMPT, compositions containing the compounds and methods of treating diseases during which NAMPT is expressed.
    Type: Application
    Filed: October 8, 2015
    Publication date: June 30, 2016
    Applicant: ABBVIE INC.
    Inventors: Richard F. Clark, Bryan Sorensen, Augustine T. Osuma, Robin Frey, Kenton Longenecker, George Doherty, Michael L. Curtin, Michael Michaelides, Ramzi Sweis, Marina Pliushchev, Andrew Judd, Todd Hansen, Howard R. Heyman
  • Patent number: 9302989
    Abstract: Disclosed are 1,3-dihydro-2H-isoindole compounds which inhibit the activity of NAMPT, compositions containing the compounds and methods of using the compounds to treat diseases during which NAMPT is expressed, e.g., cancer, metabolic disorders, and inflammatory disorders. Disclosed are 1,3-dihydro-2H-isoindole compounds which inhibit the activity of ROCK, compositions containing the compounds and methods of using the compounds to treat diseases during which ROCK is expressed, e.g., cancer, cardiovascular disorders, and inflammatory disorders.
    Type: Grant
    Filed: November 11, 2011
    Date of Patent: April 5, 2016
    Assignee: AbbVie Inc.
    Inventors: Michael L. Curtin, Bryan K. Sorensen, Howard R. Heyman, Richard F. Clark, Kevin R. Woller, Omar J. Shah, Michael Michaelides, Chris Tse, Anil Vasudevan, Helmut Mack, Todd M. Hansen, Ramzi Sweis, Marina A. Pliushchev
  • Publication number: 20160060257
    Abstract: Disclosed are compounds of Formula (IIa), wherein R1, R2, R3A, R3B, R3C, R3D, R3E, and R4 are as defined in the specification, and pharmaceutically acceptable salts thereof. The compounds may be used as agents in the treatment of diseases, including cancer. Also provided are pharmaceutical compositions comprising one or more compounds of Formula (IIa).
    Type: Application
    Filed: March 13, 2014
    Publication date: March 3, 2016
    Applicant: ABBVIE INC.
    Inventors: Yunsong Tong, Milan Bruncko, Richard F. Clark, Michael Curtin, Alan S. Florjancic, Robin R. Frey, Jianchun Gong, Todd M. Hansen, Zhiqin Ji, Chunqiu Lai, Anthony Mastracchio, Michael Michaelides, Juliem Miyashiro, Roberto M. Risi, Xiaohong Song, Zhi-fu Tao, Keith W. Woods, Guidong Zhu, Thomas Penning, Andrew Souers, Rajeev Goswami, Omprakash Reddy Iquturi, Madhu Babu Dabbeeru
  • Publication number: 20160031880
    Abstract: Disclosed are compounds which inhibit the activity of NAMPT, compositions containing the compounds and methods of treating diseases during which NAMPT is expressed. Disclosed are compounds which inhibit the activity of ROCK, compositions containing the compounds and methods of treating diseases during which ROCK is expressed.
    Type: Application
    Filed: October 12, 2015
    Publication date: February 4, 2016
    Applicant: ABBVIE INC.
    Inventors: Rick F. Clark, Michael L. Curtain, Todd M. Hansen, Howard R. Heyman, Helmut Mack, Michael Michaelides, Marina A. Pliushchev, Omar J. Shah, Bryan K. Sorensen, Ramzi Sweis, Chris Tse, Anil Vasudevan, Kevin R. Woller
  • Publication number: 20120122842
    Abstract: Disclosed are compounds which inhibit the activity of NAMPT, compositions containing the compounds and methods of treating diseases during which NAMPT is expressed. Disclosed are compounds which inhibit the activity of ROCK, compositions containing the compounds and methods of treating diseases during which ROCK is expressed.
    Type: Application
    Filed: November 11, 2011
    Publication date: May 17, 2012
    Applicant: Abbott Laboratories
    Inventors: Michael L. Curtin, Bryan K. Sorensen, Howard R. Heyman, Richard F. Clark, Kevin R. Woller, Omar J. Shah, Michael Michaelides, Chris Tse, Anil Vasudevan, Helmut Mack, Todd M. Hansen, Ramzi Sweis, Marina A. Pliushchev
  • Publication number: 20120122924
    Abstract: Disclosed are compounds which inhibit the activity of NAMPT, compositions containing the compounds and methods of treating diseases during which NAMPT is expressed.
    Type: Application
    Filed: November 11, 2011
    Publication date: May 17, 2012
    Applicant: ABBOTT LABORATORIES
    Inventors: Michael L. Curtin, Bryan K. Sorensen, Howard R. Heyman, Rick F. Clark, Michael Michaelides, Chris Tse