Abstract: Provided herein are novel anti-CD28×anti-B7H3 (also referred to as “?CD28×?B7H3”) heterodimeric bispecific antibodies and methods of using such antibodies for the treatment of cancers. Subject ?CD28×?B7H3 antibodies are capable of agonistically binding to CD28 costimulatory molecules on T cells and targeting to B7H3 on tumor cells. Thus, such antibodies selectively enhance anti-tumor activity at tumor sites while minimizing peripheral toxicity. The subject antibodies provided herein are particularly useful for enhancing anti-tumor activity when used in combination with other anti-cancer therapies.

Abstract: Systems and methods for dynamically assessing and displaying quality features of electronic messages, while composed on client devices, can include one or more processors monitoring the process of composing the electronic message. The one or more processors can retrieve, upon detecting a pause event, data associated with the composed electronic message from a message composing container, and determine a plurality of feature values for a plurality of features of the electronic message based on the retrieved data. The one or more processors can determine, based on the plurality of feature values, a likelihood of receiving a response from a receiving entity once the electronic message is sent to that receiving entity. The one or more processors can provide an indication of the determined likelihood of receiving a response and indications of the plurality of determined feature values for display in association with a message composing window displaying the text received.

Abstract: A power circuit breaker has a housing defining a first passage and a cross passage through the housing. A bus bar extends through the cross passage and is configured to transmit electric power and/or break transmission of the electric power through the housing. The bus bar includes at least an input section, a coin or center section, and an output section that are separable from each other. The housing aligns a solenoid piston within the first passage of the housing. The solenoid has a piston with two opposite ends, and one of the ends operates as a plunger to separate the sections of the bus bar when the solenoid is actuated. The plunger moves the coin or center section of the bus bar out of contact with the input section and the output section of the bus bar to break electrical transmission across the bus bar.

Abstract: An electric vehicle system includes an electric vehicle and a delivery charger. The electric vehicle includes a chassis, a cab coupled to a front end of the chassis, and a battery supported by the chassis. The delivery charger includes a support, a power generator coupled to the support, a fuel tank coupled to the support and fluidly coupled to the power generator, and a mounting assembly coupled to the support. The power generator is configured to receive a fuel from the fuel tank and generate electricity to charge the battery. The mounting assembly is configured to facilitate releasably mounting the delivery charger at least one of (i) directly to the chassis, (ii) within a body assembly coupled to the chassis, or (iii) to a lift assembly coupled to the body assembly.

Abstract: Systems and methods are provided for estimating charge time for an electric vehicle. A current vehicle range of the electric vehicle may be determined, and a range selection of the electric vehicle may be determined. Based on the current vehicle range and a charging range associated with the range selection, an intermediate charging range between the current vehicle range and the charging range associated with the range selection is determined. An estimated charge time to charge the electric vehicle to the intermediate charging range may be determined, and an indication of the intermediate charging range and the estimated charge time to reach the intermediate charging range may be generated for presentation.

Abstract: Disclosed is a vascular stent-graft which includes a tubular body having a tubular wall which is comprised of at least a first layer of a fabric, said body including a proximal anchor section of a cylindrical form, preformed with a first diameter and a first length, a distal treatment section of a tapered form and having a second length, and a transition section which tapers the tubular body from the anchor segment to the treatment segment, at least one stent of a first set engaged with the anchor section, adapted to bias the anchor section from the first diameter to a second diameter which exceeds the first diameter.

Abstract: Systems and methods for determining a head pose of a user are described. Images captured by a head-mounted camera worn by the user are received, the images comprising captured markers, wherein each captured marker is one of a plurality of markers on a surface that are in the FOV of the head-mounted camera. Stored markers having a predetermined orientation and corresponding to each captured marker are identified from a database, the stored markers comprising coordinates for its corresponding surface marker. An orientation of the captured marker relative to its corresponding stored marker is calculated and the stored marker is obtained. Based on the stored marker and the orientation, an absolute pose of each marker is determined. Based on the absolute pose of each marker, the head pose of the user relative to the surface is calculated.

Abstract: There is disclosed a composition for protection against pathogens, the composition comprising: predetermined amount of at least one type of plant-derived oil; predetermined amount of extracts from shea tree; predetermined amount of extracts from aloe vera; predetermined amount of wax; predetermined amount of chitosan; wherein the composition is in a form suitable to be applied to intranasal cavity. A method is disclosed herein.

Abstract: An electric vehicle system includes an electric vehicle and a delivery charger. The electric vehicle includes a chassis, a cab coupled to a front end of the chassis, and a battery supported by the chassis. The delivery charger includes a support, a power generator coupled to the support, a fuel tank coupled to the support and fluidly coupled to the power generator, and a mounting assembly coupled to the support. The power generator is configured to receive a fuel from the fuel tank and generate electricity to charge the battery. The mounting assembly is configured to facilitate releasably mounting the delivery charger at least one of (i) directly to the chassis, (ii) within a body assembly coupled to the chassis, or (iii) to a lift assembly coupled to the body assembly.

Abstract: Systems and methods for providing activity recommendations to occupants of a vehicle are provided, particularly for the intent of motivating the occupants to engage in certain physically and/or mentally beneficial activities. A method, according to one implementation, includes the step of detecting when a vehicle has been driven to a vehicle servicing facility. The method also includes the step of providing activity recommendations to one or more people present in the vehicle when the vehicle has been driven to the vehicle servicing facility.

Abstract: A vehicle includes a chassis, a body coupled to the chassis and having a front surface, the body defining a recess positioned along the front surface and extending rearward from the front surface, a port coupled to the body and positioned within the recess, and a door movably coupled to the body and selectively repositionable between a closed position and an open position. In the closed position, the door extends across the recess and obstructs access to the port. In the open positon, the door permits access to the port.

Abstract: A power circuit breaker has a housing defining a first passage and a cross passage through the housing. A bus bar extends through the cross passage and is configured to transmit electric power and/or break transmission of the electric power through the housing. The bus bar includes at least an input section, a coin or center section, and an output section that are separable from each other. The housing aligns a solenoid piston within the first passage of the housing. The solenoid has a piston with two opposite ends, and one of the ends operates as a plunger to separate the sections of the bus bar when the solenoid is actuated. The plunger moves the coin or center section of the bus bar out of contact with the input section and the output section of the bus bar to break electrical transmission across the bus bar.

Abstract: Otologic materials and methods are provided. For example, a cell-adhesive, biodegradable hydrogel scaffold loaded with time-released drugs for repairing chronic tympanic membrane perforations is disclosed, methods of making same and administering same are provided. This hydrogel may promote vascular in-growth and epithelial cell growth of the tympanic membrane with the purpose of closing the perforation and providing a barrier between the external and middle ear. The hydrogel is initially a liquid polymer that only gels upon exposure to specific conditions, such as exposure to light. This scaffold may simultaneously induce repair of the tympanic membrane while preventing or alleviating middle ear infection, thus filling a void in current tympanic membrane perforation therapies.

Abstract: A thermal management solution in a mobile computing system is bonded to an integrated circuit component by a thermal interface material layer (TIM layer) that does not require the application of a permanent force to ensure a reliable thermally conductive connection. A leaf spring or other loading mechanism that can apply a permanent force to a TIM layer can be secured to a printed circuit board by fasteners that extend through holes in the board in the vicinity of the integrated circuit component. These holes consume area that could otherwise be used for signal routing. In devices that use a TIM layer that does not require the application of a permanent force, the thermal management solution can be attached to a printed circuit board or chassis at a location remote to the integrated circuit component, where the attachment mechanism does not or minimally interferes with integrated circuit component signal routing.

Abstract: A method for implanting a prosthesis centrally within a curved lumen includes loading a prosthesis into a delivery sheath, advancing the sheath in a patient towards the curved lumen to place at least the proximal end of the prosthesis within the curved lumen, and centering the proximal end of the prosthesis and/or the distal end of the sheath within the curved lumen. In a first advancing step, the outer catheter containing the inner sheath is advanced together towards the curved lumen to a location proximal of the curved lumen and, in a second advancing step, the inner sheath containing the prosthesis is advanced into the curved lumen to place at least the proximal end within the curved lumen while the outer catheter substantially remains at the location. After centering, the proximal end of the prosthesis is deployed centered within the curved lumen.

Abstract: Methods and apparatus for packaging and shipping wine. A shipping container includes: a vacuum molded base component having a plurality of cylindrical concave columns within which respective bottles are received; a substantially planar corrugated separator sheet having a plurality of receptors aligned with the axes of the columns and configured to slidably receive respective bottle necks associated with the bottles; a vacuum molded cap component for receiving the bottle necks therewithin; and an outer corrugated box within which the bottles, base component, separator, cap component components are securely disposed.

Abstract: A warning tag and process of making the warning tag are provided. The warning tag has a substrate layer, a reflective layer laid on top of the substrate layer, and a negatively printed message on the reflective layer. In some embodiments, the reflective layer is covered with non-reflective ink to form the non-reflective ink coating such that a warning indicia message is left exposed while the surrounding area thereto is covered. A process of making such warning tags is also provided.

Abstract: A method includes positioning, by a robot, a servo press proximate one or more reference identifiers of the vehicle. The method includes applying, by the servo press, a known weight to the vehicle. The method includes calibrating the payload monitoring system of the vehicle based on data from a plurality of payload sensors in response to applying the known weight.

Abstract: A method for installing a liquid quality system into a containment structure, wherein the liquid quality system includes a liquid quality device and at least one drag-inducing assembly, wherein the at least one drag-inducing assembly includes at least one supporting portion and at least one drag-inducing portion, wherein when the liquid quality device is installed a sump region is formed below, is provided. The method may include mounting, at least partially in the sump region, the at least one supporting portion onto a sidewall of the containment structure. The method may also include attaching the at least one drag-inducing portion to the at least one supporting portion. The method may also include mounting the liquid quality device in the containment structure.

Abstract: Devices, systems and methods are provided for treating migraine headaches and other conditions by non-invasive electrical stimulation of nerves and other tissue. A hand-held device includes a housing with a controller having a signal generator, an electrode for delivering electrical signals, and a conductive surface configured as a return path for the electrical signals. In certain implementations, the electrode is repositionable with respect to the housing. The patient can self-apply the hand-held device by pressing it against areas in need of pain relief. The device may include a pressure-sensitive gating switch to control delivery of the stimulation therapy. In certain embodiments, the electrode is a rollerball electrode. The device may include a chamber for retaining and dispensing conductive gel to the therapy site. In certain approaches, the device includes an electrode support for coupling an electrical stimulation system to the head for hands-free electrical stimulation therapy.