Patents by Inventor Michael N. Alekshun

Michael N. Alekshun has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS OF INCREASING ORAL BIOAVAILABILITY OF TETRACYCLINES
    Publication number: 20160030453
    Abstract: Methods for increasing the oral bioavailability of tetracycline compounds are described.
    Type: Application
    Filed: July 1, 2015
    Publication date: February 4, 2016
    Inventors: Michael N. Alekshun, Adel Bakhtyari, Sean M. Johnston, Masha Pukshansky
  • SUBSTITUTED TETRACYCLINE COMPOUNDS FOR TREATMENT OF BACILLUS ANTHRACIS INFECTIONS
    Publication number: 20160030451
    Abstract: Methods and compositions for the treatment of Bacillus anthracis infections are described.
    Type: Application
    Filed: May 13, 2013
    Publication date: February 4, 2016
    Inventors: Michael N. Alekshun, S. Ken Tanaka
  • Methods of increasing oral bioavailability of tetracyclines
    Patent number: 9078811
    Abstract: Methods for increasing the oral bioavailability of tetracycline compounds are described.
    Type: Grant
    Filed: January 24, 2007
    Date of Patent: July 14, 2015
    Assignee: Paratek Pharmaceuticals, Inc.
    Inventors: Michael N. Alekshun, Adel Bakhtyari, Sean Johnston, Masha Pukshansky
  • CRYSTAL STRUCTURE OF A MarR FAMILY POLYPEPTIDE
    Publication number: 20130144038
    Abstract: The crystal structure of the product, crystals of the MarR protein, a regulator of multiple antibiotic resistance in Escherichia coli, and methods of crystallization of the MarR protein are described.
    Type: Application
    Filed: May 15, 2012
    Publication date: June 6, 2013
    Applicants: Trustees of Boston University, Trustees of Tufts College
    Inventors: Michael N. Alekshun, Stuart B. Levy, James F. Head, Barbara A. Seaton
  • Substituted tetracycline compounds for treatment of infections
    Patent number: 8440646
    Abstract: Methods and compositions for the treatment of Bacillus anthracis infections are described.
    Type: Grant
    Filed: October 10, 2007
    Date of Patent: May 14, 2013
    Assignee: Paratek Pharmaceuticals, Inc.
    Inventors: Michael N. Alekshun, S. Ken Tanaka
  • SUBSTITUTED TETRACYCLINE COMPOUNDS FOR TREATMENT OF BACILLUS ANTHRACIS INFECTIONS
    Publication number: 20130109617
    Abstract: Methods and compositions for the treatment of Bacillus anthracis infections are described.
    Type: Application
    Filed: October 10, 2007
    Publication date: May 2, 2013
    Inventors: Michael N. Alekshun, S. Ken Tanaka
  • METHODS FOR IDENTIFYING AND USING MarR FAMILY POLYPEPTIDE BINDING COMPOUNDS
    Publication number: 20120209003
    Abstract: Methods for identifying MarR family inhibiting compounds are described. The methods include the use of computer aided rational based drug design programs and three dimensional structures of MarR family polypeptides.
    Type: Application
    Filed: September 9, 2011
    Publication date: August 16, 2012
    Applicant: Paratek Pharmaceuticals, Inc.
    Inventors: Michael N. Alekshun, Stuart B. Levy, Brent L. Podlogar, Roger Frechette
  • Transcription factor modulating compounds and methods of use thereof
    Publication number: 20110306611
    Abstract: Substituted benzoimidazole compounds useful as anti-infectives that decrease resistance, virulence, or growth of microbes are provided. Methods of making and using substituted benzoimidazole compounds, as well as pharmaceutical preparations thereof, in, e.g., reducing antibiotic resistance and inhibiting biofilms.
    Type: Application
    Filed: August 3, 2009
    Publication date: December 15, 2011
    Applicant: Paratek Pharmaceuticals, Inc.
    Inventors: Michael N. Alekshun, Victor Amoo, Oak K. Kim, Atul K. Verma
  • Methods for identifying and using MarR family polypeptide binding compounds
    Patent number: 8039221
    Abstract: Methods for identifying MarR family inhibiting compounds are described. The methods include the use of computer aided rational based drug design programs and three dimensional structures of MarR family polypeptides.
    Type: Grant
    Filed: June 18, 2009
    Date of Patent: October 18, 2011
    Assignee: Paratek Pharmaceuticals, Inc.
    Inventors: Michael N. Alekshun, Stuart B. Levy, Brent L. Podlogar, Roger Frechette
  • TRANSCRIPTION FACTOR MODULATING COMPOUNDS AND METHODS OF USE THEREOF
    Publication number: 20110230523
    Abstract: Substituted benzoimidazole compounds useful as anti-infectives that decrease resistance, virulence, or growth of microbes are provided. Methods of making and using substituted benzoimidazole compounds, as well as pharmaceutical preparations thereof, in, e.g., reducing antibiotic resistance and inhibiting biofilms.
    Type: Application
    Filed: August 6, 2009
    Publication date: September 22, 2011
    Applicant: Paratek Pharmaceuticals, Inc.
    Inventors: Stuart B. LEVY, Michael N. ALEKSHUN, Brent L. PODLOGAR, Kwasi OHEMENG, Atul K. VERMA, Tadeusz WARCHOL, Beena BHATIA, Todd BOWSER, Mark GRIER
  • SUBSTITUTED POLYAMINES AS INHIBITORS OF BACTERIAL EFFLUX PUMPS
    Publication number: 20110218168
    Abstract: Disclosed are methods of treating bacterial infections including those caused by multidrug resistant bacteria using polyamine efflux pump inhibiting compounds, including for example N-benzylated polyazaalkanes, N-benzylated polyaminoalkanes, or mixed N-benzylated poly(aza/amino)alkanes, optionally in combination with other drugs such as antibiotics, as well as pharmaceutical compositions thereof.
    Type: Application
    Filed: September 29, 2010
    Publication date: September 8, 2011
    Applicant: Paratek Pharmaceuticals, Inc.
    Inventors: Mark L. Nelson, Michael N. Alekshun
  • TRANSCRIPTION FACTOR MODULATING COMPOUNDS AND METHODS OF USE THEREOF
    Publication number: 20110059962
    Abstract: Substituted benzoimidazole compounds useful as anti-infectives that decrease resistance, virulence, or growth of microbes are provided. Methods of using substituted benzimidazole compounds, in, e.g., reducing virulence and infectivity, inhibiting biofilms and treating bacterial infections, are also provided.
    Type: Application
    Filed: April 22, 2010
    Publication date: March 10, 2011
    Inventors: MICHAEL N. ALEKSHUN, VICTORIA BARTLETT, MICHAEL P. DRAPER, LYNNE GARRITY-RYAN, RAINA GAY, MARK GRIER, OAK K. KIM, STUART B. LEVY
  • Methods for Identifying and Using MarR Family Polypeptide Binding Compounds
    Publication number: 20110015375
    Abstract: Methods for identifying MarR family inhibiting compounds are described. The methods include the use of computer aided rational based drug design programs and three dimensional structures of MarR family polypeptides.
    Type: Application
    Filed: June 18, 2009
    Publication date: January 20, 2011
    Applicant: Paratek Pharmaceuticals, Inc.
    Inventors: Michael N. Alekshun, Stuart B. Levy, Brent L. Podlogar, Roger Frechette
  • Crystal Structure of a MarR Family Polypeptide
    Publication number: 20100298540
    Abstract: The crystal structure of the product, crystals of the MarR protein, a regulator of multiple antibiotic resistance in Escherichia coli, and methods of crystallization of the MarR protein are described.
    Type: Application
    Filed: June 19, 2009
    Publication date: November 25, 2010
    Applicants: Trustees of Tufts College, Boston University
    Inventors: Michael N. Alekshun, Stuart B. Levy, James F. Head, Barbara A. Seaton
  • Substituted polyamines as inhibitors of bacterial efflux pumps
    Patent number: 7829543
    Abstract: Disclosed are methods of treating bacterial infections including those caused by multidrug resistant bacteria using polyamine efflux pump inhibiting compounds, including for example N-benzylated polyazaalkanes, N-benzylated polyaminoalkanes, or mixed N-benzylated poly(aza/amino)alkanes, optionally in combination with other drugs such as antibiotics, as well as pharmaceutical compositions thereof.
    Type: Grant
    Filed: January 7, 2004
    Date of Patent: November 9, 2010
    Assignee: Paratek Pharmaceuticals, Inc.
    Inventors: Mark L. Nelson, Michael N. Alekshun
  • METHODS FOR PREVENTING AND TREATING MICROBIAL INFECTIONS BY MODULATING TRANSCRIPTION FACTORS
    Publication number: 20100227850
    Abstract: The current invention is based, inter alia, on the finding that the transcription factor MarA, and homologues of MarA, e.g., Rob and SoxS, are virulence factors. Accordingly, the invention discloses methods for screening compounds for their ability to modulate these virulence factors. The invention further describes methods for treating and preventing bacterial infections by modulating the expression and/or activity of transcription factors. In addition, the invention provides a method for identifying other virulence factors.
    Type: Application
    Filed: November 24, 2009
    Publication date: September 9, 2010
    Applicant: PARATEK PHARMACEUTICALS, INC.
    Inventors: MICHAEL N. ALEKSHUN, STUART B. LEVY
  • Transcription factor modulating compounds and methods of use thereof
    Publication number: 20090170812
    Abstract: Substituted benzoimidazole compounds useful as anti-infectives that decrease resistance, virulence, or growth of microbes are provided. Methods of making and using substituted benzoimidazole compounds, as well as pharmaceutical preparations thereof, in, e.g., reducing antibiotic resistance and inhibiting biofilms.
    Type: Application
    Filed: June 25, 2007
    Publication date: July 2, 2009
    Applicant: Paratek Pharmaceuticals, Inc.
    Inventors: Michael N. Alekshun, Victoria Bartlett, Lynne Garrity-Ryan, Mark Grier, Oak K. Kim, Atul K. Verma
  • Transcription factor modulating compounds and methods of use thereof
    Publication number: 20090131401
    Abstract: Substituted benzoimidazole compounds useful as anti-infectives that decrease resistance, virulence, or growth of microbes are provided. Methods of making and using substituted benzoimidazole compounds, as well as pharmaceutical preparations thereof, in, e.g., reducing antibiotic resistance and inhibiting biofilms.
    Type: Application
    Filed: February 12, 2008
    Publication date: May 21, 2009
    Applicant: Paratek Pharmaceuticals, Inc.
    Inventors: Stuart B. Levy, Michael N. Alekshun, Brent L. Podlogar, Kwasi Ohemeng, Atul K. Verma, Tadeusz Warchol, Beena Bhatia, Todd Bowser, Mark Grier
  • Transcription Factor Modulating Compounds and Methods of Use Thereof
    Publication number: 20090131481
    Abstract: Substituted benzimidazole compounds useful as anti-infectives that decrease resistance, virulence, or growth of microbes are provided. Methods of using substituted benzimidazole compounds, in, e.g., reducing virulence and infectivity, inhibiting biofilms and treating bacterial infections are also provided.
    Type: Application
    Filed: March 27, 2008
    Publication date: May 21, 2009
    Applicant: Paratek Pharmaceuticals, Inc.
    Inventors: Michael N. Alekshun, Victoria Bartlett, Michael Draper, Lynne Garrity-Ryan, Raina Gay, Mark Grier, Oak K. Kim, Stuart B. Levy
  • Transcription factor modulating compounds and methods of use thereof
    Patent number: 7405235
    Abstract: Substituted benzoimidazole compounds useful as anti-infectives that decrease resistance, virulence, or growth of microbes are provided. Methods of making and using substituted benzoimidazole compounds, as well as pharmaceutical preparations thereof, in, e.g., reducing antibiotic resistance and inhibiting biofilms.
    Type: Grant
    Filed: November 3, 2003
    Date of Patent: July 29, 2008
    Assignee: Paratek Pharmaceuticals, Inc.
    Inventors: Stuart B. Levy, Michael N. Alekshun, Brent L. Podlogar, Kwasi Ohemeng, Atul K. Verma, Tadeusz Warchol, Beena Bhatia, Todd Bowser, Mark Grier