Patents by Inventor Michael N. Alekshun

Michael N. Alekshun has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Crystals of MarR polypeptides, regulators of multiple antibiotic resistance
    Patent number: 7202339
    Abstract: The crystal structure of the product, crystals of the MarR protein, a regulator of multiple antibiotic resistance in Escherichia coli, and methods of crystallization of the MarR protein are described.
    Type: Grant
    Filed: July 15, 2002
    Date of Patent: April 10, 2007
    Assignees: Trustees of Tufts College, Trustees of Boston University
    Inventors: Michael N. Alekshun, Stuart B. Levy, James F. Head, Barbara A. Seaton
  • Methods for identifying and using MarR family polypeptide binding compounds
    Patent number: 7075582
    Abstract: Methods for identifying MarR family inhibiting compounds are described. The methods include the use of computer aided rational based drug design programs and three dimensional structures of MarR family polypeptides.
    Type: Grant
    Filed: July 15, 2002
    Date of Patent: July 11, 2006
    Assignee: Paratek Pharmaceuticals, Inc.
    Inventors: Michael N. Alekshun, Stuart B. Levy, Brent L. Podlogar, Roger Frechette
  • Substituted polyamines as inhibitors of bacterial efflux pumps
    Publication number: 20040204378
    Abstract: Disclosed are methods of treating bacterial infections including those caused by multidrug resistant bacteria using polyamine efflux pump inhibiting compounds, including for example N-benzylated polyazaalkanes, N-benzylated polyaminoalkanes, or mixed N-benzylated poly(aza/amino)alkanes, optionally in combination with other drugs such as antibiotics, as well as pharmaceutical compositions thereof.
    Type: Application
    Filed: January 7, 2004
    Publication date: October 14, 2004
    Applicant: Paratek Pharmaceuticals, Inc.
    Inventors: Mark L. Nelson, Michael N. Alekshun
  • Methods for preventing and treating microbial infections by modulating transcription factors
    Publication number: 20040106553
    Abstract: The current invention is based, inter alia, on the finding that the transcription factor MarA, and homologues of MarA, e.g., Rob and SoxS, are virulence factors. Accordingly, the invention discloses methods for screening compounds for their ability to modulate these virulence factors. The invention further describes methods for treating and preventing bacterial infections by modulating the expression and/or activity of transcription factors. In addition, the invention provides a method for identifying other virulence factors.
    Type: Application
    Filed: June 24, 2003
    Publication date: June 3, 2004
    Inventors: Michael N. Alekshun, Stuart B. Levy
  • Transcription factor modulating compounds and methods of use thereof
    Publication number: 20030229065
    Abstract: Methods for identifying compound useful as anti-infectives that decrease resistance, virulence, or growth of microbes are provided. In one embodiment, the method comprises contacting a microbial cell comprising: 1) a selectable marker under the control of a transcription factor responsive element and 2) a transcription factor, with a compound under conditions which allow interaction of the compound with the microbial cell; and measuring the ability of the compound to affect the growth or survival of the microbial cell as an indication of whether the test compound modulates the activity of a transcription factor.
    Type: Application
    Filed: August 14, 2002
    Publication date: December 11, 2003
    Inventors: Stuart B. Levy, Michael N. Alekshun, Brent L. Podlogar, Kwasi Ohemeng, Atul K. Verma, Tadeusz Warchol, Beena Bhatia
  • Methods for identifying and using MarR family polypeptide binding compounds
    Publication number: 20030215873
    Abstract: Methods for identifying MarR family inhibiting compounds are described. The methods include the use of computer aided rational based drug design programs and three dimensional structures of MarR family polypeptides.
    Type: Application
    Filed: July 15, 2002
    Publication date: November 20, 2003
    Inventors: Michael N. Alekshun, Stuart B. Levy, Brent L. Podlogar, Roger Frechette
  • Crystal structure of a MarR family polypeptide
    Publication number: 20030148492
    Abstract: The crystal structure of the MarR protein, a regulator of multiple antibiotic resistance in Escherichia coli, is described.
    Type: Application
    Filed: July 15, 2002
    Publication date: August 7, 2003
    Inventors: Michael N. Alekshun, Stuart B. Levy, James F. Head, Barbara A. Seaton