Patents by Inventor Michael Nehls

Michael Nehls has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Antibodies to novel lipoxygenase proteins
    Publication number: 20080125578
    Abstract: The nucleotide and corresponding amino acid sequences are reported for a novel class of mammalian lipoxygenase proteins. The novel lipoxygenase encoding polynucleotides were obtained from human gene trap clones and human cDNA libraries.
    Type: Application
    Filed: November 16, 2006
    Publication date: May 29, 2008
    Inventors: C. Alexander Turner, Brian Zambrowicz, Michael Nehls, Glenn Friedrich, Arthur T. Sands
  • Novel human secreted proteins and polynucleotides encoding the same
    Publication number: 20080044896
    Abstract: Novel human polynucleotide and polypeptide sequences are disclosed that can be used in therapeutic, diagnostic, and pharmacogenomic applications.
    Type: Application
    Filed: February 13, 2006
    Publication date: February 21, 2008
    Inventors: Gregory Donoho, Carl Friddle, Glenn Friedrich, Erin Hilbun, Yi Hu, Brian Mathur, Maricar Miranda, Michael Nehls, Nghi Nguyen, Arthur Sands, John Scoville, C. Turner, D. Walke, Xiaoming Wang, Frank Wattler, Nathaniel Wilganowski, Qiongshu Xie, Xuanchuan Yu, Brian Zambrowicz
  • Novel human proteases and polynucleotides encoding the same
    Publication number: 20080003673
    Abstract: Novel human polynucleotide and polypeptide sequences are disclosed that can be used in therapeutic, diagnostic, and pharmacogenomic applications.
    Type: Application
    Filed: September 6, 2005
    Publication date: January 3, 2008
    Inventors: Alejandro Abuin, Gregory Donoho, Carl Friddle, Glenn Friedrich, Brenda Gerhardt, Erin Hilbun, Yi Hu, James Kieke, Maricar Miranda, Michael Nehls, Boris Nepomnichy, Andrew Olson, Arthur Sands, John Scoville, C. Turner, D. Walke, Nathaniel Wilganowski, Xuanchuan Yu, Brian Zambrowicz
  • Novel human membrane proteins and polynucleotides encoding the same
    Publication number: 20070298489
    Abstract: Novel human polynucleotide and polypeptide sequences are disclosed that can be used in therapeutic, diagnostic, and pharmacogenomic applications.
    Type: Application
    Filed: October 5, 2005
    Publication date: December 27, 2007
    Inventors: Alejandro Abuin, Michael Burnett, Gregory Donoho, Carl Friddle, Glenn Friedrich, Brenda Gerhardt, Erin Hilbun, Yi Hu, Brian Mathur, Michael Nehls, Boris Nepomnichy, Arthur Sands, John Scoville, C. Turner, D. Walke, Xiaoming Wang, Frank Wattler, Nathaniel Wilganowski, Brian Zambrowicz
  • Novel human polynucleotides and polypeptides encoded thereby
    Publication number: 20070178475
    Abstract: Novel human polynucleotides are disclosed that correspond to human gene trapped sequences, or GTSs. The disclosed GTSs are useful for gene discovery and as markers for, inter alia, gene expression analysis, identifying and mapping the coding regions of the mammalian, and particularly human, genome, forensic analysis, and determining the genetic basis of human disease.
    Type: Application
    Filed: May 12, 2005
    Publication date: August 2, 2007
    Inventors: Michael Nehls, Brian Zambrowicz, Arthur Sands
  • Novel lipoxygenase proteins and polynucleotides encoding the same
    Publication number: 20070136832
    Abstract: The nucleotide and corresponding amino acid sequences are reported for a novel class of mammalian lipoxygenase proteins. The novel lipoxygenase encoding polynucleotides were obtained from human gene trap clones and human cDNA libraries.
    Type: Application
    Filed: November 16, 2006
    Publication date: June 14, 2007
    Inventors: C. Turner, Brian Zambrowicz, Michael Nehls, Glenn Friedrich, Arthur Sands
  • Lipoxygenase proteins and polynucleotides encoding the same
    Patent number: 7144730
    Abstract: The nucleotide and corresponding amino acid sequences are reported for a novel class of mammalian lipoxygenase proteins. The novel lipoxygenase encoding polynucleotides were obtained from human gene trap clones and human cDNA libraries.
    Type: Grant
    Filed: April 23, 2003
    Date of Patent: December 5, 2006
    Assignee: Lexicon Genetics Incorporated
    Inventors: C. Alexander Turner, Jr., Brian Zambrowicz, Michael Nehls, Glenn Friedrich, Arthur T. Sands
  • Novel human polynucleotides and the polypeptides encoded thereby
    Publication number: 20060216717
    Abstract: Novel human polynucleotides are disclosed that correspond to human gene trapped sequences, or GTSs. The disclosed GTSs are useful for gene discovery and as markers for, inter alia, gene expression analysis, forensic analysis, and determining the genetic basis of human disease.
    Type: Application
    Filed: December 30, 2004
    Publication date: September 28, 2006
    Inventors: Michael Nehls, Brian Zambrowicz, Arthur Sands
  • Novel human genes and proteins encoded thereby
    Publication number: 20060090212
    Abstract: The present invention relates to novel human genes involved in the regulation of signal transduction pathways, and the proteins and polypeptides encoded thereby. In particular, the invention relates to polynucleotides that encode the polypeptides, the polypeptides, antibodies directed to the polypeptides, and methods of diagnosis and treatment of various disorders, including disorders involving the inappropriate regulation of a signal transduction mechanism, for example cancer.
    Type: Application
    Filed: December 18, 2002
    Publication date: April 27, 2006
    Inventors: Alexander Turner, Brian Zambrowicz, Michael Nehls, Glenn Friedrich, Arthur Sands
  • Novel human ATPase proteins and polynucleotides encoding the same
    Publication number: 20050182248
    Abstract: Novel human polynucleotide and polypeptide sequences are disclosed that can be used in therapeutic, diagnostic, and pharmacogenomic applications.
    Type: Application
    Filed: January 3, 2005
    Publication date: August 18, 2005
    Inventors: Gregory Donoho, C. Turner, Erin Hilbun, Michael Nehls, Glenn Friedrich, Brian Zambrowicz, Arthur Sands
  • Novel human proteins and polynucleotides encoding the same
    Publication number: 20050170384
    Abstract: Novel human amino acid sequences are reported and nucleotide sequences encoding the same.
    Type: Application
    Filed: November 29, 2004
    Publication date: August 4, 2005
    Inventors: C. Turner, Gregory Donoho, Michael Nehls, Erin Hilbun, Brian Zambrowicz, Arthur Sands
  • Novel human notch ligand proteins and polynucleotides encoding the same
    Publication number: 20050170389
    Abstract: Novel human polynucleotide and polypeptide sequences are disclosed that can be used in therapeutic, diagnostic, and pharmacogenomic applications.
    Type: Application
    Filed: December 27, 2004
    Publication date: August 4, 2005
    Inventors: C. Turner, Michael Nehls, Glenn Friedrich, Brian Zambrowicz, Arthur Sands
  • Method of constructing vectors for homologous recombination directed mutagenesis
    Patent number: 6924146
    Abstract: The present invention provides a novel vector system and thereby a novel method for the simplified construction of recombinant vectors for directed mutagenesis. Said vector system is used to modify the eukaryotic genome, particularly of embryonic stem cells, at precise and predefined loci by the means of homologous recombination. Furthermore, said system finds its usage in the generation of new strategies for gene therapy and in the generation of genetically modified higher eukaryotic organisms.
    Type: Grant
    Filed: February 20, 1998
    Date of Patent: August 2, 2005
    Inventors: Sigrid Wattler, Michael Nehls
  • Novel human endothelin converting enzyme-like proteins and polynucleotides encoding the same
    Publication number: 20050143569
    Abstract: Novel human polynucleotide and polypeptide sequences are disclosed that can be used in therapeutic, diagnostic, and pharmacogenomic applications.
    Type: Application
    Filed: November 15, 2004
    Publication date: June 30, 2005
    Inventors: Gregory Donoho, C. Turner, Michael Nehls, Glenn Friedrich, Brian Zambrowicz, Arthur Sands
  • Novel human membrane proteins and polynucleotides encoding the same
    Publication number: 20050124802
    Abstract: Novel human polynucleotide and polypeptide sequences are disclosed that can be used in therapeutic, diagnostic, and pharmacongenomic applications.
    Type: Application
    Filed: September 16, 2004
    Publication date: June 9, 2005
    Inventors: C. Turner, Brian Mathur, Michael Nehls, Glenn Friedrich, Brian Zambrowicz, Arthur Sands
  • Novel human 7TM protein and polynucleotides encoding the same
    Publication number: 20050090000
    Abstract: The nucleotide and amino acid sequences of a novel human G protein-coupled receptor (NGPCR) is disclosed. The NGPCR is somewhat similar to the vasopressin G protein-coupled receptor family, and is preferentially expressed in the hypothalamus.
    Type: Application
    Filed: August 26, 2004
    Publication date: April 28, 2005
    Inventors: C. Turner, Michael Nehls, Glenn Friedrich, Brian Zambrowicz, Arthur Sands
  • Novel human protease inhibitor-like proteins and polynucleotides encoding the same
    Publication number: 20050089892
    Abstract: Novel human polynucleotide and polypeptide sequences are disclosed that can be used in therapeutic, diagnostic, and pharmacogenomic applications.
    Type: Application
    Filed: July 29, 2004
    Publication date: April 28, 2005
    Inventors: Gregory Donoho, C. Turner, Frank Wattler, Michael Nehls, Glenn Friedrich, Brian Zambrowicz, Arthur Sands
  • Novel human proteins and polynucleotides encoding the same
    Publication number: 20050079580
    Abstract: Novel human polynucleotide and polypeptide sequences are disclosed that can be used in therapeutic, diagnostic, and pharmacogenomic applications.
    Type: Application
    Filed: September 7, 2004
    Publication date: April 14, 2005
    Inventors: C. Turner, Brian Zambrowicz, Glenn Friedrich, Michael Nehls, Arthur Sands
  • Novel human polynucleotides and the polypeptides encoded thereby
    Publication number: 20050059060
    Abstract: Novel human polynucleotides are disclosed that correspond to human gene trapped sequences, or GTSs. The disclosed GTSs are useful for gene discovery and as markers for, inter alia, gene expression analysis, forensic analysis, and determining the genetic basis of human disease.
    Type: Application
    Filed: August 4, 2004
    Publication date: March 17, 2005
    Inventors: Michael Nehls, Brian Zambrowicz, Arthur Sands
  • Novel human genes and proteins encoded thereby
    Publication number: 20050053953
    Abstract: The present invention relates to novel human genes involved in the regulation of signal transduction pathways, and the proteins and polypeptides encoded thereby. In particular, the invention relates to polynucleotides that encode the polypeptides, the polypeptides, antibodies directed to the polypeptides, and methods of diagnosis and treatment of various disorders, including disorders involving the inappropriate regulation of a signal transduction mechanism, for example cancer.
    Type: Application
    Filed: October 8, 2003
    Publication date: March 10, 2005
    Inventors: Alex Turner, Brian Zambrowicz, Michael Nehls, Glenn Friedrich, Arthur Sands