Patents by Inventor Michael Nehls

Michael Nehls has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20050053953
    Abstract: The present invention relates to novel human genes involved in the regulation of signal transduction pathways, and the proteins and polypeptides encoded thereby. In particular, the invention relates to polynucleotides that encode the polypeptides, the polypeptides, antibodies directed to the polypeptides, and methods of diagnosis and treatment of various disorders, including disorders involving the inappropriate regulation of a signal transduction mechanism, for example cancer.
    Type: Application
    Filed: October 8, 2003
    Publication date: March 10, 2005
    Inventors: Alex Turner, Brian Zambrowicz, Michael Nehls, Glenn Friedrich, Arthur Sands
  • Publication number: 20050053969
    Abstract: Novel human polynucleotide and polypeptide sequences are disclosed that can be used in therapeutic, diagnostic, and pharmacogenomic applications.
    Type: Application
    Filed: March 30, 2004
    Publication date: March 10, 2005
    Inventors: Gregory Donoho, C. Turner, Michael Nehls, Glenn Friedrich, Brian Zambrowicz, Arthur Sands
  • Publication number: 20050042626
    Abstract: Novel human polynucleotide and polypeptide sequences are disclosed that can be used in therapeutic, diagnostic, and pharmacogenomic applications.
    Type: Application
    Filed: January 28, 2004
    Publication date: February 24, 2005
    Inventors: Gregory Donoho, C. Turner, Michael Nehls, Glenn Friedrich, Brian Zambrowicz, Arthur Sands
  • Publication number: 20050003443
    Abstract: Novel human polynucleotides are disclosed that correspond to human gene trapped sequences, or GTSs. The disclosed GTSs are useful for gene discovery and as markers for, inter alia, gene expression analysis, forensic analysis, and determining the genetic basis of human disease.
    Type: Application
    Filed: August 5, 2004
    Publication date: January 6, 2005
    Inventors: Michael Nehls, Brian Zambrowicz, Arthur Sands
  • Publication number: 20050003444
    Abstract: Novel human polynucleotides are disclosed that correspond to human gene trapped sequences, or GTSs. The disclosed GTSs are useful for gene discovery and as markers for, inter alia, gene expression analysis, forensic analysis, and determining the genetic basis of human disease.
    Type: Application
    Filed: August 6, 2004
    Publication date: January 6, 2005
    Inventors: Michael Nehls, Brian Zambrowicz, Arthur Sands
  • Publication number: 20040077078
    Abstract: The nucleotide and amino acid sequences of several novel human G protein coupled receptors are described.
    Type: Application
    Filed: May 22, 2003
    Publication date: April 22, 2004
    Inventors: Frank Wattler, Gregory Donoho, C. Alexander Turner, Erin Hilbun, Michael Nehls, Brian Zambrowicz, Arthur T. Sands
  • Publication number: 20040043487
    Abstract: The present invention provides a novel vector system and thereby a novel method for the simplified construction of recombinant vectors for directed mutagenesis. Said vector system is used to modify the eukaryotic genome, particularly of embryonic stem cells, at precise and predefined loci by the means of homologous recombination. Further more, said system finds its usage in the generation of new strategies for gene therapy and in the generation of genetically modified higher eukaryotic organisms.
    Type: Application
    Filed: August 6, 2003
    Publication date: March 4, 2004
    Inventors: Michael Nehls, Sigrid Wattler
  • Publication number: 20040038345
    Abstract: The nucleotide and amino acid sequences of several novel human G protein coupled receptors are described.
    Type: Application
    Filed: March 17, 2003
    Publication date: February 26, 2004
    Applicant: Lexicon Genetics Incorporated
    Inventors: Michael Nehls, Frank Wattler
  • Publication number: 20030172391
    Abstract: The nucleotide and corresponding amino acid sequences are reported for a novel class of mammalian lipoxygenase proteins. The novel lipoxygenase encoding polynucleotides were obtained from human gene trap clones and human cDNA libraries.
    Type: Application
    Filed: April 23, 2003
    Publication date: September 11, 2003
    Applicant: Lexicon Genetics Incorporated
    Inventors: C. Alexander Turner, Brian Zambrowicz, Michael Nehls, Glenn Friedrich, Arthur T. Sands
  • Publication number: 20030162713
    Abstract: The present invention provides two novel families of novel human transporter proteins (NTPs). The invention additionally provides for agonists, antagonists, antibodies, antisense molecules that are specific for the NTPs, and further provides genetically engineered expression vectors for the NTPs and host comprising the same. The invention further provides for processes for identifying/producing molecules that effect NTP activity which comprise the use of the disclosed NTPs or genes encoding the same.
    Type: Application
    Filed: February 14, 2003
    Publication date: August 28, 2003
    Inventors: Alex Turner, Brian Zambrowicz, Michael Nehls, Glenn A. Friedrich, Arthur T. Sands
  • Patent number: 6582957
    Abstract: The nucleotide and corresponding amino acid sequences are reported for a novel class of mammalian lipoxygenase proteins. The novel lipoxygenase encoding polynucleotides were obtained from human gene trap clones and human cDNA libraries.
    Type: Grant
    Filed: April 12, 2000
    Date of Patent: June 24, 2003
    Assignee: Lexicon Genetics Incorporated
    Inventors: C. Alexander Turner, Jr., Brian Zambrowicz, Michael Nehls, Glenn Friedrich, Arthur T. Sands
  • Publication number: 20030108746
    Abstract: Fire resistant adhesive resins that include a halogen-free and bromine-free flame retardant ingredient and conductive foils coated with the halogen-free fire resistant adhesive resin coated compositions of this invention as well as printed circuit boards manufactured using the adhesive resin coated conductive foils.
    Type: Application
    Filed: December 26, 2002
    Publication date: June 12, 2003
    Inventors: Isola Laminate Systems Corp, Martin T. Choate, Barbara Ormond, Michael Nehls, Georg Czerny
  • Patent number: 6548271
    Abstract: The present invention provides two novel families of novel human transporter proteins (NTPs). The invention additionally provides for agonists, antagonists, antibodies, antisense molecules that are specific for the NTPs, and further provides genetically engineered expression vectors for the NTPs and host comprising the same. The invention further provides for processes for identifying/producing molecules that effect NTP activity which comprise the use of the disclosed NTPs or genes encoding the same.
    Type: Grant
    Filed: April 21, 2000
    Date of Patent: April 15, 2003
    Assignee: Lexicon Genetics Incorporated
    Inventors: Alex Turner, Brian Zambrowicz, Michael Nehls, Glenn A. Friedrich, Arthur T. Sands
  • Patent number: 6440567
    Abstract: Fire resistant adhesive resins that include a halogen-free and bromine-free flame retardant ingredient and conductive foils coated with the halogen-free fire resistant adhesive resin coated compositions of this invention as well as printed circuit boards manufactured using the adhesive resin coated conductive foils.
    Type: Grant
    Filed: November 17, 2000
    Date of Patent: August 27, 2002
    Assignee: Isola Laminate Systems Corp.
    Inventors: Martin T. Choate, Barbara Ormond, Michael Nehls, Georg Czerny
  • Patent number: 6218123
    Abstract: A new technology is described that allows for the rapid and efficient construction of complex cDNA libraries from cultured eukaryotic cells. The technology exploits eukaryotic biology by using transgenic constructs that have been nonspecifically inserted into the genome to facilitate the expression of nuclear genes as fusion transcripts. The invention further allows one to specifically subclone the corresponding fusion transcripts into highly complex cDNA libraries. The libraries are easily characterized by molecular analysis techniques such as hybridization, and individual clones can be directly sequenced to generate a sequence database of the cellular portion of the fusion transcripts.
    Type: Grant
    Filed: August 10, 1999
    Date of Patent: April 17, 2001
    Assignee: Lexicon Genetics Incorporated
    Inventors: Michael Nehls, Brian Zambrowicz, Glenn Friedrich, H. Earl Ruley, Arthur T. Sands, Sigrid Wattler