Abstract: The present disclosure includes substituted 1-aryl-1?-heteroaryl compounds, substituted 1,1?-biheteroaryl compounds, analogues thereof, and compositions comprising the same. Such compounds and analogues comprises compounds of formula (I). In one aspect, the compounds contemplated in the disclosure can be used to treat, ameliorate, and/or prevent hepatitis B virus (HBV) and/or hepatitis D virus (HDV) infections in a patient. In another aspect, the compounds contemplated in the disclosure can be used to treat, ameliorate, and/or prevent cancer in a patient.

Abstract: Automation solutions for event logging and debugging on KUBERNETES are disclosed. A method for identifying and clustering events on a distributed application cluster includes providing a distributed agent configured to run on the distributed application cluster, the distributed application cluster including a plurality of nodes, wherein at least one distributed application runs on each node of the plurality of nodes, and providing a plurality of edge modules, each edge module being configured to run on a corresponding node of the plurality of nodes. A plurality of data coresets corresponding to each node of the plurality of nodes are tracked via the plurality of edge modules. A unified data coreset is generated by merging the plurality of data coresets and the unified data coreset is transferred to the distributed agent to train an unsupervised model configured to identify and cluster events across the distributed application cluster.

Abstract: An lithium extraction process can include a solvent extraction unit configured to receive an aqueous feed stream from an upstream flow path, the aqueous feed stream including lithium cations and at least one additional monovalent species of cation; a waste-salt separation unit configured to receive an aqueous waste-water stream from a first downstream flow path, the first downstream flow path connecting the waste-salt separation unit in fluid communication with the solvent extraction unit; and a lithium carbonate production unit configured to receive an aqueous lithium-rich stream from a second downstream flow path, the second downstream flow path connecting the lithium carbonate production unit in fluid communication with the solvent extraction unit.

Abstract: The invention is a composition of human insulin or insulin analog that includes specific concentrations of citrate, chloride, in some cases including the addition of sodium chloride, zinc and, optionally, magnesium chloride and/or surfactant, and that has faster pharmacokinetic and/or pharmacodynamic action than commercial formulations of existing insulin analog products.

Abstract: Systems and methods for enhancing surgical outcomes by providing generators having optimal RF output for sealing, fusing and/or cutting tissue or vessels under all dynamic conditions are described. Examples of dynamic conditions may include varying tissue impedance load due to electrosurgical operations or tissue affects, any operational conditions and commands determined by the surgeon, surgical procedure and/or device script. This is achieved by implementing a digital closed-loop control system within the electrosurgical generator to regulate voltage, current, and power of the RF output. The digital closed-loop control system may include an RF amplifier for generating RF energy, a feedback system for constantly monitoring the electrical characteristics, e.g.

Abstract: In exemplary embodiments, methods and systems are provided that include: sensors configured to obtain sensor data for a vehicle having both friction braking and regenerative braking capabilities and coupled to a trailer, the sensor data including: friction braking data as to a vehicle friction braking force for the vehicle; and regenerative braking sensor data as to a vehicle regenerative braking force for the vehicle; and a processor coupled to the sensors and configured to at least facilitate controlling braking of the trailer by providing trailer braking force, via instructions provided by the processor, based on both the friction braking data and the regenerative braking sensor data, with a sensitivity toward the vehicle regenerative braking force such that the trailer braking force is affected differently by the vehicle regenerative braking force versus the vehicle friction braking force.

Abstract: A timepiece component (1) for a watch case, notably a bezel, comprising an axis (A), a first ring (10), a second ring (11) and a connecting element (12) for connecting the first and second rings, the connecting element being elastic and positioned between the first and second rings, the first ring and/or the second ring comprising an element (31) for retention on the rest of a watch case (200), particularly on a watch middle (4).

Abstract: Systems and methods for enhancing surgical outcomes by providing generators having optimal RF output for sealing, fusing and/or cutting tissue or vessels under all dynamic conditions are described. Examples of dynamic conditions may include varying tissue impedance load due to electrosurgical operations or tissue affects, any operational conditions and commands determined by the surgeon, surgical procedure and/or device script. This is achieved by implementing a digital closed-loop control system within the electrosurgical generator to regulate voltage, current, and power of the RF output. The digital closed-loop control system may include an RF amplifier for generating RF energy, a feedback system for constantly monitoring the electrical characteristics, e.g.

Abstract: The present disclosure provides aromatic-solvent-free supported catalyst compounds and catalyst systems comprising asymmetric bridged metallocenes containing a ligand having at least one saturated ring, catalyst systems including such compounds, and uses thereof. These supported catalyst compounds and catalyst systems can be used to prepare polymer comprising no aromatic solvent.

Abstract: Disclosed are methods, systems and apparatuses in which a diagnostic instrument analyzes data collected over time, and based on that information, disables a bay, suggests a bay, puts a bay on standby or combinations thereof. In some embodiments, the method, system and apparatus allows the diagnostic instrument to have higher validity rates in the field and allows the provider to set up service calls, schedule maintenance and perform remote maintenance, as well as other functions based on the data collected over time.

Abstract: A catalyst compound and process for olefin polymerization.

Abstract: A method for dampening trailer sway, includes: receiving, by a controller of a vehicle system that is coupled to a trailer, a vehicle speed signal of the vehicle system, wherein the vehicle speed signal is indicative of a vehicle speed of the vehicle system; determining a friction force to be applied to the trailer by an actuator using the vehicle speed of the vehicle system and a graph that establishes a relationship between the friction force to be applied to the trailer and the vehicle speed; and adjusting, by the controller, the graph that establishes the relationship between the friction force and the vehicle speed using the decay rate of the plurality of oscillation amplitudes to create an updated graph.

Abstract: A towing configuration of a vehicle coupled to a trailer may be evaluated by rolling a tire of the coupled vehicle and trailer over a compressible region of a pressure vessel filled with a hydraulic fluid. A peak pressure of the hydraulic fluid as the tire rolls over the compressible region of the pressure vessel may be determined. The tire load may be determined based upon the peak pressure. Based at least in part on the tire load, a determination may be made whether the towing configuration satisfies a predetermined set of criteria.

Abstract: A catalyst compound and process for olefin polymerization.

Abstract: A method for dampening trailer sway, includes: receiving, by a controller of a vehicle system that is coupled to a trailer, a vehicle speed signal of the vehicle system, wherein the vehicle speed signal is indicative of a vehicle speed of the vehicle system; determining a friction force to be applied to the trailer by an actuator using the vehicle speed of the vehicle system and a graph that establishes a relationship between the friction force to be applied to the trailer and the vehicle speed; and adjusting, by the controller, the graph that establishes the relationship between the friction force and the vehicle speed using the decay rate of the plurality of oscillation amplitudes to create an updated graph.

Abstract: Method and composition for identifying cognate nucleotides in a Sequencing By Binding™ procedure, wherein one or more labeled nucleotides are detected in ternary complexes but never incorporated. Labeled nucleotides can be incorporable nucleotides that contact preformed blocked primed template nucleic acids. Alternatively, labeled nucleotides are labeled non-incorporable nucleotides. Labeled nucleotides, including labeled non-incorporable nucleotides, can be detected in ternary complexes in the same reaction mixture that incorporates a reversible terminator nucleotide to create a blocked primed template nucleic acid. Detection of ternary complexes can take place in the presence of a catalytic metal ion.

Abstract: A towing configuration of a vehicle coupled to a trailer may be evaluated by rolling a tire of the coupled vehicle and trailer over a compressible region of a pressure vessel filled with a hydraulic fluid. A peak pressure of the hydraulic fluid as the tire rolls over the compressible region of the pressure vessel may be determined. The tire load may be determined based upon the peak pressure. Based at least in part on the tire load, a determination may be made whether the towing configuration satisfies a predetermined set of criteria.

Abstract: Method and composition for identifying cognate nucleotides in a Sequencing By Binding™ procedure, wherein one or more labeled nucleotides are detected in ternary complexes but never incorporated. Labeled nucleotides can be incorporable nucleotides that contact preformed blocked primed template nucleic acids. Alternatively, labeled nucleotides are labeled non-incorporable nucleotides. Labeled nucleotides, including labeled non-incorporable nucleotides, can be detected in ternary complexes in the same reaction mixture that incorporates a reversible terminator nucleotide to create a blocked primed template nucleic acid. Detection of ternary complexes can take place in the presence of a catalytic metal ion.

Abstract: A timepiece component (1) for a watch case, notably a bezel, comprising an axis (A), a first ring (10), a second ring (11) and a connecting element (12) for connecting the first and second rings, the connecting element being elastic and positioned between the first and second rings, the first ring and/or the second ring comprising an element (31) for retention on the rest of a watch case (200), particularly on a watch middle (4).

Abstract: There is provided a method of predicting defects likely to occur in a vehicle over a predetermined period. The method includes receiving vehicle characteristic data regarding a vehicle under consideration, and comparing the received vehicle characteristic data with a defect database. The defect database includes information related to defects that have occurred in different vehicles and the mileage at which such defects occurred. The method additionally includes identifying defects that occurred in vehicles corresponding to the vehicle under consideration, and the mileage at which such defects occurred. Defects which fail to satisfy minimum count requirements are then filtered out, and the defects are then sorted in order of the highest defect count.