Abstract: Components for constructing a ceiling grid across a span free of or with a limited number of suspension wires including main runners with a relatively high moment of inertia secured at their ends with brackets to wall moldings on opposing walls.

Abstract: The present invention relates to compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors. The compounds of this invention have formula I: or a pharmaceutically acceptable salt, wherein the variables R1, R2, R3, and R4 are as defined herein.

Abstract: A flywheel assembly may include first and second flywheels having respective first and second flywheel parasitic load profiles. Operating speeds of the first and second flywheels may be selected based at least in part on the first and second flywheel parasitic loads. The operating speeds may be determined such that an aggregate of the first and second flywheel parasitic loads is minimized, thereby increasing the efficiency of the flywheel assembly.

Abstract: A computing system may provide guidance to a vehicle with hybrid power systems on how to efficiently engage the hybrid systems and the primary power source on a given plan. As a result, additional efficiency may be obtained.

Abstract: A hybrid engine assembly may include an engine having a crankshaft, a supplemental shaft mechanically coupled to the crankshaft, a flywheel energy storage assembly, and an auxiliary device. A flywheel clutch may selectively couple the flywheel assembly to the crankshaft. The assembly may be selectively operated in an engine restart mode by directly coupling the flywheel energy storage assembly to the crankshaft prior to starting the engine, and in an auxiliary power mode by directly coupling the flywheel energy storage assembly to the auxiliary device.

Abstract: Disclosed herein are methods and systems for deriving, storing, querying, retrieving and visualizing one or more numeric baselines for time-series numeric data which considers the time, coincidental events and relevance of the time-series data points as part of the baseline derivation and visualization. According to an aspect, a method includes receiving one of time-series numeric data and event data in one or more formats from one or more other computing devices. The method also includes standardizing the one of time-series numeric data and event data to a common format. The method also includes analyzing the standardized data in the common format.

Abstract: The present invention relates to compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors. The compounds of this invention have formula I: or a pharmaceutically acceptable salt, wherein the variables R1, R2, R3, and R4 are as defined herein.

Abstract: The present invention relates to compounds useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.

Abstract: The present invention relates to pyrazine compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors. The compounds of this invention have formula II: wherein the variables are as defined herein.

Abstract: The present invention relates to pyrazine compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors. The compounds of this invention have formula I: wherein the variables are as defined herein.

Abstract: The present invention relates to pyrazine compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors. The compounds of this invention have formula I: wherein the variables are as defined herein.

Abstract: A wind turbine device may include turbine blades being radially spaced and extending vertically, diverter panels being respectively adjacent and radially outward of the turbine blades, an inner support ring coupled to the turbine blades, and an axle coupled to the turbine blades.

Abstract: A control system is disclosed for use with a machine. The control system may have a first work tool connected at an end of a linkage arrangement, and a first interface device configured to receive input indicative of a desired movement of the first work tool and to generate a corresponding signal. The control system may also have a plurality of actuators operatively connected to the first work tool via the linkage arrangement, a plurality of valves associated with the plurality of actuators, and a controller in communication. The controller may be configured to determine a combination of the plurality of actuators that should be activated together to generate linkage movements that compound to produce the desired movement of the first work tool based on the signal, and to selectively command movement of a combination of the plurality of valves corresponding to the combination of the plurality of actuators.

Abstract: A control system is disclosed for use with a machine. The control system may have a first linkage arrangement, a first actuator, a first interface device, and a first control element. The control system may also have a second linkage arrangement, a second actuator, a second interface device, and a second control element. The control system may further have an input device selectively activated to generate a mode signal, and a controller. The controller may be configured to selectively generate commands directed to the first control element based on only the first actuator signals, and to selectively generate commands directed to the second control element based on only the second actuator signals. The controller may also be configured to selectively generate commands directed to both of the first and second control elements based on only the first actuator signals an in response to the mode signal.

Abstract: The present invention relates to pyrazine compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors. The compounds of this invention have formula I: wherein the variables are as defined herein.

Abstract: The present invention relates to compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors. The compounds of this invention have formula I: or a pharmaceutically acceptable salt, wherein the variables R1, R2, R3, and R4 are as defined herein.

Abstract: The present invention relates to compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors. The compounds of this invention have formula I: or a pharmaceutically acceptable salt, wherein the variables are as defined herein. Moreover, The compounds of this invention have formula I-A: or a pharmaceutically acceptable salt, wherein the variables are as defined herein.

Abstract: A hybrid engine assembly may include an engine having a crankshaft, a supplemental shaft mechanically coupled to the crankshaft, a flywheel energy storage assembly, and an auxiliary device. A flywheel clutch may selectively couple the flywheel assembly to the crankshaft. The assembly may be selectively operated in an engine restart mode by directly coupling the flywheel energy storage assembly to the crankshaft prior to starting the engine, and in an auxiliary power mode by directly coupling the flywheel energy storage assembly to the auxiliary device.

Abstract: The present invention relates to compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors. The compounds of this invention have formula I: or a pharmaceutically acceptable salt, wherein the variables are as defined herein. Moreover, The compounds of this invention have formula I-A: or a pharmaceutically acceptable salt, wherein the variables are as defined herein.

Abstract: A computing system may provide guidance to a vehicle with hybrid power systems on how to efficiently engage the hybrid systems and the primary power source on a given plan. As a result, additional efficiency may be obtained.