Abstract: The present invention relates to pyrazine compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors. The compounds of this invention have formula II: wherein the variables are as defined herein.

Abstract: The present invention relates to pyrazine and pyridine compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors. The compounds of this invention have formula I: wherein the variables are as defined herein.

Abstract: The present invention of one embodiment includes a combined microclimate, thermal management, life-support system for care of patient and system for measurement of vital signs. The system of one embodiment, provides active external heating and simultaneously provides active internal heating.

Abstract: The present invention of one embodiment includes a combined microclimate, thermal management, life-support system for care of patient and system for measurement of vital signs. The system of one embodiment, provides active external heating and simultaneously provides active internal heating.

Abstract: A vascular filter device (1) has a perfusion balloon (3) with a through-hole for blood flow. There is a distal filter (4) for trapping emboli, and the filter (4) is configured to filter an annular cross-sectional area extending from a vessel wall, while leaving an un-filtered central passageway. The filter (4) may be substantially frusto-conical in shape when deployed, and have a proximal tubular part (41) which is attached to the perfusion balloon or a support for the perfusion balloon. The filter has a retainer (5) to retain an end of the filter in an in-use position abutting a vessel wall. The retainer may comprise wires (5) or an inflated ring (8). The device may have an internal support (2, 12, 22, 96, 112) for the perfusion balloon (3, 11, 21, 95, 111). The balloon inflates and expands the inner arterial wall, and the filter captures emboli released during the procedure while leaving a channel that allows blood to flow to tissues distal to the blockage, maintaining antegrade flow.

Abstract: An Internet system for disseminating information regarding works or authorship, including a server and a client device connected to the Internet and wherein when any one web page out of a set of web pages is displayed on the client device and when a work of authorship is displayed as part of the web page, an image is also displayed near the work of authorship, as part of the webpage and when a user clicks on the image, copyright information concerning the work of authorship is presented in a user-perceivable manner.

Abstract: The present invention relates to compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising those compounds and methods of using the compounds and compositions in the treatment of various disease, conditions, and disorders. The invention also provides processes for preparing compounds of the invention.

Abstract: The present invention relates to pyrazine compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors. The compounds of this invention have formula I: wherein the variables are as defined herein.

Abstract: The present invention relates to compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising those compounds and methods of using the compounds and compositions in the treatment of various disease, conditions, and disorders. The invention also provides processes for preparing compounds of the invention.

Abstract: The present invention relates to compounds useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.

Abstract: The present invention relates to compounds useful as inhibitors of Aurora protein kinases. The invention also provides pharmaceutically acceptable compositions comprising those compounds and methods of using the compounds and compositions in the treatment of various disease, conditions, and disorders. The invention also provides processes for preparing compounds of the invention.

Abstract: The present invention provides a compound of formula I: wherein the variables are as defined herein. The present invention also provides processes for preparing the compounds of formula I, and intermediates thereof, pharmaceutical compositions comprising those compounds, and methods of using the compounds and compositions.

Abstract: A system for use on the Internet to allow automated licensing of works of authorship and access to information about licenses which have been granted. A unique work identifier is issued to each of a large number of works of authorship, most of which are available on the Internet, but some of which are not. When the works are published, whether or not on the Internet, the unique work identifier is included. The work identifier may also identify a distributor, or chain-of-distributors, through which the work has been licensed. The unique identifier leads to a web page where a user can accept an offered license to do one or more of: reproduce, distribute, perform, display, or prepare derivative works. The system then automatically generates a unique license identifier which is placed in each copy of the work prepared by the licensee. The license identifier permits tracking of further licensing.

Abstract: Method for assisting a person in changing a behavior, e.g., smoking, by employing multiple steps, including e.g., having the person assess, quantitatively, the degree of readiness to change, having the person assess, quantitatively, the difficulty of changing a given behavior, having the person list benefits and obstacles involved in changing the behavior, and devising a strategy for changing the behavior, that includes positive reinforcement and self-efficacy.

Abstract: The present invention provides a compound of formula I: wherein the variables are as defined herein. The present invention also provides processes for preparing the compounds of formula I, and intermediates thereof, pharmaceutical compositions comprising those compounds, and methods of using the compounds and compositions.

Abstract: The present invention relates to compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising those compounds and methods of using the compounds and compositions in the treatment of various disease, conditions, and disorders. The invention also provides processes for preparing compounds of the invention.

Abstract: The duplex DNA of chromosomes is replicated in a multicomponent process. A helicase unwinds the DNA, a replicase synthesizes new DNA, and primase repeatedly synthesizes new primed starts on the lagging strand. The present invention is directed to the genes from Gram positive bacterium encoding these proteins, and their characterization.

Abstract: The present invention relates to compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising those compounds and methods of using the compounds and compositions in the treatment of various disease, conditions, and disorders. The invention also provides processes for preparing compounds of the invention.

Abstract: A gas burner including a burner body having a lower housing, an inlet conduit and a combustion surface element attached to the lower housing. A diffuser/reflector positioned within the body encourages even distribution and mixing of a combustible gas/air mixture. The diffuser/reflector is preferably of a sheet metal construction and includes a plurality of stamped openings with each of these openings having an overhanging guide plate. The combustion surface element includes a plurality of integrally formed rigidizing ribs and is made from a high temperature steel alloy wire cloth. The inlet conduit is secured directly or indirectly to an access door/bulkhead that is used to close off an access opening formed in a water heater wall through which the burner is installed. In one construction, an air scoop shrouds the inlet conduit and at least partially defines a flow path of primary air, substantially isolated from the combustion chamber.

Abstract: A heat exchanger tube having an integral restricting and turbulating structure consisting of dimples formed by confronting indentations pressed into the sides of the heat exchanger tube. The dimples are comprised of indentations disposed in pairs which extend into the tube to such a depth as is necessary to significantly reduce the cross sectional area of the heat exchanger tube. The dimples of a pair are staggered or offset, longitudinally with respect to each other such that a restrictive passage is defined between each pair of offset dimples. The turbulence characteristics of the tube can be controlled by varying the depth to which the dimples project into the tube and the longitudinal spacing between the dimples that comprise the pair. Adjacent pairs of dimples may be rotated 90° with respect to each other or alternately can be arranged in a helix pattern.