Patents by Inventor Michael O'Neil

Michael O'Neil has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for the preparation of diasteromerically pure phosphoramidate prodrugs
    Patent number: 9487544
    Abstract: Provided are methods and intermediates for preparing diastereomerically pure phosphoramidate prodrugs of nucleosides of Formulas Ia and Ib: The compounds of Formula Ia and Ib are useful for the treatment Hepatitis C infections.
    Type: Grant
    Filed: June 22, 2015
    Date of Patent: November 8, 2016
    Assignee: Gilead Sciences, Inc.
    Inventors: Aesop Cho, Michael O'Neil Hanrahan Clarke, Scott Alan Wolckenhauer
  • 2?-substituted carba-nucleoside analogs for antiviral treatment
    Patent number: 9481704
    Abstract: Provided are compounds of Formula I, as well as pharmaceutical compositions containing compounds of Formula I and methods for treating Orthomyxoviridae virus infections by administering these compounds. The compounds, compositions, and methods provided are particularly useful for the treatment of Human Influenza virus infections.
    Type: Grant
    Filed: March 11, 2013
    Date of Patent: November 1, 2016
    Assignee: GILEAD SCIENCES, INC.
    Inventor: Michael O'Neil Hanrahan Clarke
  • INTERVERTEBRAL DISC PUNCTURE AND TREATMENT SYSTEM
    Publication number: 20160213367
    Abstract: A pre-assembled, telescoping needle system comprising an outer needle surrounding a finer gauge needle which, after percutaneous penetration by the outer needle, extends to penetrate the intervertebral disc into which the injectable is to be delivered.
    Type: Application
    Filed: March 4, 2016
    Publication date: July 28, 2016
    Inventors: Mohamed Attawia, Cynthia Lee, Hassan Serhan, Michael O'Neil
  • Pyrrolo[1,2-f][1,2,4]triazines useful for treating respiratory syncitial virus infections
    Patent number: 9388208
    Abstract: Provided herein are formulations, methods and substituted tetrahydrofuranyl-pyrrolo[1,2-f][1,2,4]triazine-4-amine compounds of Formula (I) for treating Pneumovirinae virus infections, including respiratory syncytial virus infections, as well as methods and intermediates for synthesis of tetrahydrofuranyl-pyrrolo[1,2-f][1,2,4]triazine-4-amine compounds.
    Type: Grant
    Filed: November 6, 2014
    Date of Patent: July 12, 2016
    Assignee: GILEAD SCIENCES, INC.
    Inventors: Michael O'Neil Hanrahan Clarke, Edward Doerffler, Richard L Mackman, Dustin Siegel
  • Control of transmission latch valve
    Patent number: 9353853
    Abstract: A transmission includes a latch valve with latched and de-latched states. In the de-latched state, the latch valve directs a control pressure to a clutch apply circuit. In the latched state, which is entered in response to a control pressure higher than a latch pressure, the latch valve directs a line pressure to the clutch apply circuit. A controller manages the transition from latched to de-latched differently depending upon the transmission input torque and gear state. At high transmission input torque, the controller first reduces the control pressure to rapidly accelerate a spool in the latch valve, and then increases the control pressure to prevent clutch slip. At low torque, the controller reduced the pressure to an intermediate value during the transition and then reduces it again. At moderate torques, the controller reduces the pressure directly to a target pressure in a single step.
    Type: Grant
    Filed: October 1, 2014
    Date of Patent: May 31, 2016
    Assignee: Ford Global Technologies, LLC
    Inventors: Alexander Phillip McDonnell, Kendrick Morrison, Cory LaRoche, Derek Kinch, John Armstead, Brian Michael O'Neil, Pramod Kumar Jain
  • METHODS FOR TREATING FILOVIRIDAE VIRUS INFECTIONS
    Publication number: 20160122374
    Abstract: Provided are compounds, methods, and pharmaceutical compositions for treating Filoviridae virus infections by administering ribosides, riboside phosphates and prodrugs thereof, of Formula IV: The compounds, compositions, and methods provided are particularly useful for the treatment of Marburg virus, Ebola virus and Cueva virus infections.
    Type: Application
    Filed: October 29, 2015
    Publication date: May 5, 2016
    Inventors: Byoung Kwon Chun, Michael O' Neil Hanrahan Clarke, Edward Doerffler, Hon Chung Hui, Robert Jordan, Richard L. Mackman, Jay P. Parrish, Adrian S. Ray, Dustin Siegel
  • Inhibitors of viruses
    Patent number: 9321753
    Abstract: Provided are compounds of Formula I: and pharmaceutically acceptable salts and esters thereof. The compounds, compositions, and methods provided are useful for the treatment of Flaviviridae virus infections, particularly hepatitis C infections.
    Type: Grant
    Filed: July 11, 2013
    Date of Patent: April 26, 2016
    Assignee: Gilead Sciences, Inc.
    Inventors: Eda Canales, Michael O'Neil Hanrahan Clarke, Scott E. Lazerwith, Willard Lew, Philip Anthony Morganelli, William J. Watkins
  • Control of Transmission Latch Valve
    Publication number: 20160097448
    Abstract: A transmission includes a latch valve with latched and de-latched states. In the de-latched state, the latch valve directs a control pressure to a clutch apply circuit. In the latched state, which is entered in response to a control pressure higher than a latch pressure, the latch valve directs a line pressure to the clutch apply circuit. A controller manages the transition from latched to de-latched differently depending upon the transmission input torque and gear state. At high transmission input torque, the controller first reduces the control pressure to rapidly accelerate a spool in the latch valve, and then increases the control pressure to prevent clutch slip. At low torque, the controller reduced the pressure to an intermediate value during the transition and then reduces it again. At moderate torques, the controller reduces the pressure directly to a target pressure in a single step.
    Type: Application
    Filed: October 1, 2014
    Publication date: April 7, 2016
    Inventors: Alexander Phillip McDonnell, Kendrick Morrison, Cory LaRoche, Derek Kinch, John Armstead, Brian Michael O'Neil, Pramod Kumar Jain
  • SURGICAL TOOL WITH FEEDBACK
    Publication number: 20160089154
    Abstract: Surgical feedback systems and methods include a surgical tool having a functional tool and a handle for manipulation by a surgeon in a surgical environment. At least one sensor connected to the surgical tool generates a signal indicative of an acoustic signal and/or a vibration signal generated by the functional tool. The signal may be modified and supplied to an output device.
    Type: Application
    Filed: September 26, 2014
    Publication date: March 31, 2016
    Inventors: Dennis Chien, Michael O'Neil, Mark Hall, Riley Hawkins, Roman Lomeli
  • 2'-CHLORO AMINOPYRIMIDINONE AND PYRIMIDINE DIONE NUCLEOSIDES
    Publication number: 20160052953
    Abstract: Provided herein are formulations, methods and substituted 2?-chloro aminopyrimidinone and pyrimidine dione compounds of Formula (I) for treating Pneumovirinae virus infections, including respiratory syncytial virus infections, as well as methods and intermediates for synthesis of substituted 2?-chloro aminopyrimidinone and pyrimidine dione compounds.
    Type: Application
    Filed: August 19, 2015
    Publication date: February 25, 2016
    Inventors: Michael O'Neil Hanrahan Clarke, Richard L. Mackman, Dustin Siegel
  • THIENO[3,2-d]PYRIMIDINE, FURO[3,2-d]PYRIMIDINE, AND PYRROLO[3,2-D]PYRIMIDINES USEFUL FOR TREATING RESPIRATORY SYNCITIAL VIRUS INFECTIONS
    Publication number: 20160024107
    Abstract: Provided herein are formulations, methods and substituted thieno[3,2-d]pyrimidine, furo[3,2-d]pyrimidine, and pyrrolo[3,2-d]pyrimidine compounds of Formula (I) for treating Pneumovirinae virus infections, including respiratory syncytial virus infections, as well as methods and intermediates for synthesis of substituted thieno[3,2-d]pyrimidine, furo[3,2-d]pyrimidine, and pyrrolo[3,2-d]pyrimidine compounds.
    Type: Application
    Filed: July 22, 2015
    Publication date: January 28, 2016
    Inventors: Michael O'Neil Hanrahan Clarke, Richard L. Mackman, Dustin Siegel
  • METHODS FOR THE PREPARATION OF DIASTEROMERICALLY PURE PHOSPHORAMIDATE PRODRUGS
    Publication number: 20160016980
    Abstract: Provided are methods and intermediates for preparing diastereomerically pure phosphoramidate prodrugs of nucleosides of Formulas Ia and Ib: The compounds of Formula Ia and Ib are useful for the treatment Hepatitis C infections.
    Type: Application
    Filed: June 22, 2015
    Publication date: January 21, 2016
    Inventors: Aesop Cho, Michael O' Neil Hanrahan Clarke, Scott Alan Wolckenhauer
  • Systems And Methods For Surgical And Interventional Planning, Support, Post-Operative Follow-Up, And, Functional Recovery Tracking
    Publication number: 20150282796
    Abstract: Various systems and methods are provided for surgical and interventional planning, support, post-operative follow-up, and functional recovery tracking. In general, a patient can be tracked throughout medical treatment including through initial onset of symptoms, diagnosis, non-surgical treatment, surgical treatment, and recovery from the surgical treatment. In one embodiment, a patient and one or more medical professionals involved with treating the patient can electronically access a comprehensive treatment planning, support, and review system. The system can provide recommendations regarding diagnosis, non-surgical treatment, surgical treatment, and recovery from the surgical treatment based on data gathered from the patient and the medical professional(s).
    Type: Application
    Filed: June 9, 2015
    Publication date: October 8, 2015
    Inventors: Namal Nawana, Michael Gorhan, William J. Frasier, Cody Cranson, Hassan Serhan, Michael O'Neil, Matthew Parsons, Jennifer DiPietro, Christopher Nordstrom, John Griffin, Sean Selover, Jonathan Bellas, Michelle LeClerc
  • Systems And Methods For Surgical And Interventional Planning, Support, Post-Operative Follow-Up, And Functional Recovery Tracking
    Publication number: 20150261922
    Abstract: Various systems and methods are provided for surgical and interventional planning, support, post-operative follow-up, and functional recovery tracking. In general, a patient can be tracked throughout medical treatment including through initial onset of symptoms, diagnosis, non-surgical treatment, surgical treatment, and recovery from the surgical treatment. In one embodiment, a patient and one or more medical professionals involved with treating the patient can electronically access a comprehensive treatment planning, support, and review system. The system can provide recommendations regarding diagnosis, non-surgical treatment, surgical treatment, and recovery from the surgical treatment based on data gathered from the patient and the medical professional(s).
    Type: Application
    Filed: May 20, 2015
    Publication date: September 17, 2015
    Inventors: Namal Nawana, William C. Horton, William J. Frasier, Hassan A. Serhan, Michael O'Neil, Robert E. Sommerich, Jennifer DiPietro, Christopher Nordstrom, Matthew Parsons, Thomas Martin
  • Systems and methods for surgical and interventional planning, support, post-operative follow-up, and, functional recovery tracking
    Patent number: 9129054
    Abstract: Various systems and methods are provided for surgical and interventional planning, support, post-operative follow-up, and functional recovery tracking. In general, a patient can be tracked throughout medical treatment including through initial onset of symptoms, diagnosis, non-surgical treatment, surgical treatment, and recovery from the surgical treatment. In one embodiment, a patient and one or more medical professionals involved with treating the patient can electronically access a comprehensive treatment planning, support, and review system. The system can provide recommendations regarding diagnosis, non-surgical treatment, surgical treatment, and recovery from the surgical treatment based on data gathered from the patient and the medical professional(s).
    Type: Grant
    Filed: September 19, 2013
    Date of Patent: September 8, 2015
    Assignee: DePuy Synthes Products, Inc.
    Inventors: Namal Nawana, William C. Horton, Max Reinhardt, Jonathan Bellas, Cody Cranson, Jennifer DiPietro, Mary Louise Fowler, William J. Frasier, John Paul Griffin, Mark T. Hall, David D. Konieczynski, Michelle LeClerc, Thomas Martin, Christopher Nordstrom, Michael O'Neil, James Paiva, Matthew Parsons, Nicholas Pavento, Douglas Raymond, James J. Roveda, Sean P. Selover, Hassan A. Serhan, Michael A. Slivka, Robert E. Sommerich
  • Methods for the preparation of diasteromerically pure phosphoramidate prodrugs
    Patent number: 9090642
    Abstract: Provided are methods and intermediates for preparing diastereomerically pure phosphoramidate prodrugs of nucleosides of Formulas Ia and Ib: The compounds of Formula Ia and Ib are useful for the treatment Hepatitis C infections.
    Type: Grant
    Filed: July 19, 2011
    Date of Patent: July 28, 2015
    Assignee: Gilead Sciences, Inc.
    Inventors: Aesop Cho, Michael O'Neil Hanrahan Clarke, Scott Alan Wolckenhauer
  • Pedicular facet fusion screw with plate
    Patent number: 9089372
    Abstract: Spinal implants and methods for spinal stabilization and/or fusion are provided. Exemplary implants described herein can be configured for delivery to a facet joint to stabilize and/or fuse the facet joint, and can optionally be anchored within the pedicle for added fixation. The implant can optionally include a fusion-promoting bioactive material thereby providing a single device capable of spinal stabilization and/or fusion. Furthermore, a method of placing such an implant within a facet joint is provided.
    Type: Grant
    Filed: July 12, 2010
    Date of Patent: July 28, 2015
    Assignee: DePuy Synthes Products, Inc.
    Inventors: Michael O'Neil, John R. Hawkins, Michael A. Fisher, Robert A. Hart, Richard Fessler, Robert D. Labrom, Hassan A. Serhan, Shawn D. Stad
  • Pedicular facet fusion screw with plate
    Patent number: 9044277
    Abstract: Spinal implants and methods for spinal stabilization and/or fusion are provided. Exemplary implants described herein can be configured for delivery to a facet joint to stabilize and/or fuse the facet joint, and can optionally be anchored within the pedicle for added fixation. The implant can optionally include a fusion-promoting bioactive material thereby providing a single device capable of spinal stabilization and/or fusion. Furthermore, a method of placing such an implant within a facet joint is provided.
    Type: Grant
    Filed: July 12, 2010
    Date of Patent: June 2, 2015
    Assignee: DePuy Synthes Products, Inc.
    Inventors: Michael O'Neil, John R. Hawkins, Michael A. Fisher, Robert A. Hart, Henri Defossez, Richard Fessler, Robert D. Labrom, Hassan A. Serhan, Duncan Betts, Shawn D. Stad
  • Enhanced surgical driver
    Patent number: 9044286
    Abstract: Devices, systems, and methods are provided for applying a controlled amount of torque during a surgical procedure. In one exemplary embodiment, after the amount of torque applied reaches a threshold amount, a modular driver tip can be deformed, for instance by breaking into pieces. A containment shield disposed around at least a portion of the tip is configured to receive at least a portion of the tip after it is deformed. In one aspect, multiple modular driver tips can be disposed in a cartridge, with a distal-most tip being held by a driver tip holder that has a holding force that is greater than a threshold torque value of the tip. Exemplary methods for operating surgical drivers and systems that include tips that deform at a threshold torque value, and a multitude of embodiments of tools and systems, are also provided.
    Type: Grant
    Filed: November 5, 2012
    Date of Patent: June 2, 2015
    Inventors: Michael O'Neil, Andrew Topulous, Robert Hurley
  • PYRROLO[1,2-f][1,2,4]TRIAZINES USEFUL FOR TREATING RESPIRATORY SYNCITIAL VIRUS INFECTIONS
    Publication number: 20150133395
    Abstract: Provided herein are formulations, methods and substituted tetrahydrofuranyl-pyrrolo[1,2-f][1,2,4]triazine-4-amine compounds of Formula (I) for treating Pneumovirinae virus infections, including respiratory syncytial virus infections, as well as methods and intermediates for synthesis of tetrahydrofuranyl-pyrrolo[1,2-f][1,2,4]triazine-4-amine compounds.
    Type: Application
    Filed: November 6, 2014
    Publication date: May 14, 2015
    Inventors: Michael O'Neil Hanrahan Clarke, Edward Doerffler, Richard L. Mackman, Dustin Siegel