Patents by Inventor Michael O'Neil

Michael O'Neil has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ANTIVIRAL COMPOUNDS
    Publication number: 20150080569
    Abstract: The invention is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
    Type: Application
    Filed: June 23, 2014
    Publication date: March 19, 2015
    Applicant: Gilead Sciences, Inc.
    Inventors: Aesop Cho, Michael O'Neil Hanrahan Clarke, Choung U. Kim, John O. Link, Hyung-Jung Pyun, Xiaoning C. Sheng, Qiaoyin Wu
  • Spinal disc preparation tool
    Patent number: 8936598
    Abstract: A spinal disc preparation tool is provided that includes an elongate shaft having an inner lumen extending therethrough along a longitudinal axis between proximal and distal ends thereof. A lower jaw is located on a distal end of the elongate shaft for receiving tissue and delivering tissue to the inner lumen, and an upper jaw is pivotally movable relative to the lower jaw. The tool can include various features to facilitate removal and/or collection of tissue.
    Type: Grant
    Filed: January 14, 2009
    Date of Patent: January 20, 2015
    Assignee: DePuy Synthes Products, LLC
    Inventors: Tony Tannoury, Michael O'Neil, Hassan A. Serhan, Anwar M. Upal, Michael A. Slivka, John Riley Hawkins
  • Antiviral compounds
    Patent number: 8927484
    Abstract: The present application includes novel inhibitors of HCV, compositions containing such compounds, therapeutic methods that include the administration of such compounds.
    Type: Grant
    Filed: December 1, 2010
    Date of Patent: January 6, 2015
    Assignee: Gilead Sciences, Inc.
    Inventors: Zhenhong R. Cai, Michael O'Neil Hanrahan Clarke, Edward Doerffler, Mingzhe Ji, Choung U. Kim, Hyung-jung Pyun, Xiaoning C. Sheng, Qiaoyin Wu
  • Facet fixation and fusion screw and washer assembly and method of use
    Patent number: 8894685
    Abstract: A spinal implant including a stabilization member coupled to an elongate member is herein provided. The implant can be configured for placement within a facet joint in an intra-facet or trans-facet configuration. Also, the implant can include a fusion-promoting bioactive material thereby providing a single device capable of spinal stabilization and/or fusion. Furthermore, a method of placing such an implant within a facet joint in an intra-facet or trans-facet orientation is hereby provided.
    Type: Grant
    Filed: April 13, 2007
    Date of Patent: November 25, 2014
    Assignee: DePuy Synthes Products, LLC
    Inventors: Christopher Mickiewicz, Michael Alan Fisher, Michael O'Neil, Paul Birkmeyer, Sean Selover, Michael Mahoney, Holly Brideau, Katherine Herard
  • Inhibitors of viruses
    Patent number: 8884030
    Abstract: Provided are compounds of Formula I: and pharmaceutically acceptable salts and esters thereof. The compounds, compositions, and methods provided are useful for the treatment of Flaviviridae virus infections, particularly hepatitis C infections.
    Type: Grant
    Filed: August 2, 2013
    Date of Patent: November 11, 2014
    Assignee: Gilead Sciences, Inc.
    Inventors: Eda Canales, Lee S. Chong, Michael O'Neil Hanrahan Clarke, Edward Doerffler, Scott E. Lazerwith, Willard Lew, Michael Mertzman, Philip A. Morganelli, William J. Watkins
  • Antiviral compounds
    Patent number: 8809266
    Abstract: The invention is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
    Type: Grant
    Filed: March 11, 2013
    Date of Patent: August 19, 2014
    Assignee: Gilead Sciences, Inc.
    Inventors: Aesop Cho, Michael O'Neil Hanrahan Clarke, Choung U. Kim, John O. Link, Hyung-jung Pyun, Xiaoning C. Sheng, Qiaoyin Wu
  • 2'-FLUORO SUBSTITUTED CARBA-NUCLEOSIDE ANALOGS FOR ANTIVIRAL TREATMENT
    Publication number: 20140200188
    Abstract: Provided are methods for treating Orthomyxoviridue virus infections by administering ribosides, riboside phosphates and prodrugs thereof, of Formula I: wherein R2 is halogen. The compounds, compositions, and methods provided are particularly useful for the treatment of Human Influenza virus infections.
    Type: Application
    Filed: January 24, 2014
    Publication date: July 17, 2014
    Inventors: Michael O'Neil Hanrahan Clarke, Choung U. Kim, Willard Lew
  • Inhibitors of flaviviridae viruses
    Patent number: 8765722
    Abstract: Provided are compounds of Formula I: and pharmaceutically acceptable salts and esters thereof. The compounds, compositions, and methods provided are useful for the treatment of Flaviviridae virus infections, particularly hepatitis C infections.
    Type: Grant
    Filed: June 26, 2013
    Date of Patent: July 1, 2014
    Assignee: Gilead Sciences, Inc.
    Inventors: Aesop Cho, Lee S. Chong, Michael O'Neil Hanrahan Clarke, Edward Doerffler, Choung U. Kim, Qi Liu, William J. Watkins, Jennifer R. Zhang
  • Inhibitors of flaviviridae viruses
    Patent number: 8741946
    Abstract: Provided are compounds of Formula I: and pharmaceutically acceptable salts and esters thereof. The compounds, compositions, and methods provided are useful for the treatment of Flaviviridae virus infections (e.g. hepatitis C infections), particularly drug resistant Flaviviridae virus infections.
    Type: Grant
    Filed: July 13, 2012
    Date of Patent: June 3, 2014
    Assignee: Gilead Sciences, Inc.
    Inventors: William J. Watkins, Eda Canales, Michael O'Neil Hanrahan Clarke, Edward Doerffler, Scott E. Lazerwith
  • Enhanced Surgical Driver
    Publication number: 20140128878
    Abstract: Devices, systems, and methods are provided for applying a controlled amount of torque during a surgical procedure. In one exemplary embodiment, after the amount of torque applied reaches a threshold amount, a modular driver tip can be deformed, for instance by breaking into pieces. A containment shield disposed around at least a portion of the tip is configured to receive at least a portion of the tip after it is deformed. In one aspect, multiple modular driver tips can be disposed in a cartridge, with a distal-most tip being held by a driver tip holder that has a holding force that is greater than a threshold torque value of the tip. Exemplary methods for operating surgical drivers and systems that include tips that deform at a threshold torque value, and a multitude of embodiments of tools and systems, are also provided.
    Type: Application
    Filed: November 5, 2012
    Publication date: May 8, 2014
    Applicant: DEPUY SPINE, INC.
    Inventors: Michael O'Neil, Andrew Topulous, Robert Hurley
  • SYSTEMS AND METHODS FOR SURGICAL AND INTERVENTIONAL PLANNING, SUPPORT, POST-OPERATIVE FOLLOW-UP, AND, FUNCTIONAL RECOVERY TRACKING
    Publication number: 20140088990
    Abstract: Various systems and methods are provided for surgical and interventional planning, support, post-operative follow-up, and functional recovery tracking. In general, a patient can be tracked throughout medical treatment including through initial onset of symptoms, diagnosis, non-surgical treatment, surgical treatment, and recovery from the surgical treatment. In one embodiment, a patient and one or more medical professionals involved with treating the patient can electronically access a comprehensive treatment planning, support, and review system. The system can provide recommendations regarding diagnosis, non-surgical treatment, surgical treatment, and recovery from the surgical treatment based on data gathered from the patient and the medical professional(s).
    Type: Application
    Filed: September 19, 2013
    Publication date: March 27, 2014
    Inventors: Namal Nawana, William C. Horton, Max Reinhardt, Jonathan Bellas, Cody Cranson, Jennifer DiPietro, Mary L. Fowler, William J. Frasier, John P. Griffin, Mark T. Hall, David D. Konieczynski, Michelle LeClerc, Thomas Martin, Christopher Nordstrom, Michael O'Neil, James Paiva, Matthew Parsons, Nicholas Pavento, Douglas Raymond, James J. Roveda, Sean P. Selover, Hassan A. Serhan, Michael A. Slivka, Robert E. Sommerich
  • SYSTEMS AND METHODS FOR SURGICAL AND INTERVENTIONAL PLANNING, SUPPORT, POST-OPERATIVE FOLLOW-UP, AND FUNCTIONAL RECOVERY TRACKING
    Publication number: 20140081659
    Abstract: Various systems and methods are provided for surgical and interventional planning, support, post-operative follow-up, and functional recovery tracking. In general, a patient can be tracked throughout medical treatment including through initial onset of symptoms, diagnosis, non-surgical treatment, surgical treatment, and recovery from the surgical treatment. In one embodiment, a patient and one or more medical professionals involved with treating the patient can electronically access a comprehensive treatment planning, support, and review system. The system can provide recommendations regarding diagnosis, non-surgical treatment, surgical treatment, and recovery from the surgical treatment based on data gathered from the patient and the medical professional(s).
    Type: Application
    Filed: March 14, 2013
    Publication date: March 20, 2014
    Applicant: DePuy Orthopaedics, Inc.
    Inventors: Namal Nawana, William C. Horton, William J. Frasier, Michael O'Neil, Robert E. Sommerich, Jennifer DiPietro, Matthew Parsons
  • INHIBITORS OF FLAVIVIRIDAE VIRUSES
    Publication number: 20140030223
    Abstract: Provided are compounds of Formula I: and pharmaceutically acceptable salts and esters thereof. The compounds, compositions, and methods provided are useful for the treatment of Flaviviridae virus infections, particularly hepatitis C infections.
    Type: Application
    Filed: September 25, 2013
    Publication date: January 30, 2014
    Applicant: Gilead Sciences, Inc.
    Inventors: Eda Canales, Lee S. Chong, Michael O'Neil Hanrahan Clarke, Edward Doerffler, Scott E. Lazerwith, Willard Lew, Qi Liu, Michael Martzman, Philip Anthony Morganelli, William J. Watkins, Hong Ye
  • INHIBITORS OF FLAVIVIRIDAE VIRUSES
    Publication number: 20130323203
    Abstract: Provided are compounds of Formula I: and pharmaceutically acceptable salts and esters thereof. The compounds, compositions, and methods provided are useful for the treatment of Flaviviridae virus infections, particularly hepatitis C infections.
    Type: Application
    Filed: August 2, 2013
    Publication date: December 5, 2013
    Applicant: Gilead Sciences, Inc.
    Inventors: Eda Canales, Lee S. Chong, Michael O'Neil Hanrahan Clarke, Edward Doerffler, Scott E. Lazerwith, Willard Lew, Michael Mertzman Belmont, Philip Anthony Morganelli, William J. Watkins
  • INHIBITORS OF FLAVIVIRIDAE VIRUSES
    Publication number: 20130315861
    Abstract: Provided are compounds of Formula I: and pharmaceutically acceptable salts and esters thereof. The compounds, compositions, and methods provided are useful for the treatment of Flaviviridae virus infections, particularly hepatitis C infections.
    Type: Application
    Filed: July 11, 2013
    Publication date: November 28, 2013
    Inventors: Eda Canales, Michael O'Neil Hanrahan Clarke, Scott E. Lazerwith, Willard Lew, Philip Anthony Morganelli, William J. Watkins
  • INHIBITORS OF FLAVIVIRIDAE VIRUSES
    Publication number: 20130302280
    Abstract: Provided are compounds of Formula I: and pharmaceutically acceptable salts and esters thereof. The compounds, compositions, and methods provided are useful for the treatment of Flaviviridae virus infections, particularly hepatitis C infections.
    Type: Application
    Filed: June 26, 2013
    Publication date: November 14, 2013
    Inventors: Aesop Cho, Lee S. Chong, Michael O'Neil Hanrahan Clarke, Edward Doerffler, Choung U. Kim, Qi Liu, William J. Watkins, Jennifer R. Zhang
  • Inhibitors of flaviviridae viruses
    Patent number: 8569302
    Abstract: Provided are compounds of Formula I: and pharmaceutically acceptable salts and esters thereof. The compounds, compositions, and methods provided are useful for the treatment of Flaviviridae virus infections, particularly hepatitis C infections.
    Type: Grant
    Filed: July 19, 2010
    Date of Patent: October 29, 2013
    Assignee: Gilead Sciences, Inc.
    Inventors: Eda Canales, Lee S. Chong, Michael O'Neil Hanrahan Clarke, Edward Doerffler, Scott E. Lazerwith, Willard Lew, Qi Liu, Michael Mertzman, Philip A. Morganelli, William J. Watkins, Hong Ye
  • METHODS FOR THE PREPARATION OF DIASTEROMERICALLY PURE PHOSPHORAMIDATE PRODRUGS
    Publication number: 20130281686
    Abstract: Provided are methods and intermediates for preparing diastereomerically pure phosphoramidate prodrugs of nucleosides of Formulas Ia and Ib: The compounds of Formula Ia and Ib are useful for the treatment Hepatitis C infections.
    Type: Application
    Filed: July 19, 2011
    Publication date: October 24, 2013
    Applicant: GILEAD SCIENCES, INC.
    Inventors: Aesop Cho, Michael O'Neil Hanrahan Clarke, Scott Alan Wolckenhauer
  • 2'-SUBSTITUTED CARBA-NUCLEOSIDE ANALOGS FOR ANTIVIRAL TREATMENT
    Publication number: 20130243725
    Abstract: Provided are compounds of Formula I, as well as pharmaceutical compositions containing compounds of Formula I and methods for treating Orthomyxoviridae virus infections by administering these compounds. The compounds, compositions, and methods provided are particularly useful for the treatment of Human Influenza virus infections.
    Type: Application
    Filed: March 11, 2013
    Publication date: September 19, 2013
    Applicant: GILEAD SCIENCES, INC.
    Inventor: Michael O'Neil Hanrahan Clarke
  • 2,4,6-trisubstituted pyrido(3,2-d)pyrimidines useful for treating viral infections
    Patent number: 8536187
    Abstract: Pyrido(3,2-d)pyrimidine derivatives represented by the structural formula (Ia): wherein, R1, R2 and R3 are defined herein, pharmaceutical acceptable addition salts, stereochemical isomeric forms, N-oxides, solvates and pro-drugs thereof, for use in the treatment of hepatitis C.
    Type: Grant
    Filed: July 1, 2009
    Date of Patent: September 17, 2013
    Assignee: Gilead Sciences, Inc.
    Inventors: Eda Canales, Lee S. Chong, Michael O' Neil Hanrahan Clarke, Scott E. Lazerwith, Willard Lew, Qi Liu, Michael L. Mitchell, William J. Watkins, Jennifer R. Zhang