Abstract: A brace clamp includes a first jaw; a second jaw pivotably coupled to the first jaw, wherein a clamp channel is defined between the first jaw and the second jaw, the clamp channel configured to receive a sway brace pipe therethrough; and a clamp fastener coupled to the first jaw; w the brace clamp is configurable in a disengaged configuration and an engaged configuration; and wherein, in the disengaged configuration, the first jaw is pivoted away from the second jaw and the clamp fastener is disengaged from the second jaw, and in the engaged configuration, the first jaw is pivoted towards the second jaw and the clamp fastener is engaged with the second jaw.

Abstract: The present invention provides N-methylated cyclic hexapeptides comprising RGD and at least one alanine residue. The present invention further provides prodrugs comprising the cyclic hexapeptides. Pharmaceutical compositions comprising said cyclic hexapeptides are also disclosed as well as methods of their production and use in treating integrin related conditions and diseases.

Abstract: The invention relates to an electromagnetic actuator, which is designed to be connected to a backside of a plate like structure and which comprises an annular coil arrangement and a magnet system being designed to generate a magnetic field transverse to the annular coil arrangement. The annular coil arrangement and the magnet system are connected to each other by a plurality of springs, which are arranged inside of the annular coil arrangement. Furthermore, the invention relates to an output device, comprising a plate like structure and an electromagnetic actuator of the above kind connected to a backside of the plate like structure.

Abstract: Various examples are provided related to attachment of bands about a garment opening. In one example, among others, a sleeve band can be attached to a garment by loading the sleeve band on a band guide, aligning an opening of a garment over the sleeve band, and attaching the band to the garment along the edge of the opening. Alignment of the edges of the opening and the sleeve band can be maintained by ply aligners during attachment. In another example, a garment holding system includes a garment holder that can receive a garment and a band positioning system includes a band guide that can receive a band. Edges of the opening of the garment and the band can be controlled and maintained with ply aligners of the band positioning system.

Abstract: A mounting device for mounting a sample separation unit configured for separating, preferably chromatographically separating, compounds in a fluidic sample includes a first fluid connector configured for being mechanically and fluidically coupled with a first fluid interface of the sample separation unit, a second fluid connector configured for being mechanically and fluidically coupled with a second fluid interface of the sample separation unit, and a swivel mechanism configured for swivelling the first fluid connector between a mounting orientation for mounting the first fluid interface of the sample separation unit at the first fluid connector and an alignment orientation for aligning the second fluid interface of the mounted sample separation unit with the second fluid connector for subsequently coupling the second fluid interface with the second fluid connector.

Abstract: Described herein are multispecific antibodies targeting IL-13 and IL-18. The multispecific antibodies can be antagonistic and/or therapeutic antibodies targeting IL-13 and IL-18. Also described herein are methods of making said multispecific antibodies, methods of inhibiting IL-13 and IL-18 simultaneously with said multispecific antibodies, and methods of treating an IL-13/IL-18 mediated disorder, such as atopic dermatitis, by administering a multispecific antibody described herein.

Abstract: The invention relates to a connector plug for a medical instrument, in particular a bipolar electrode or forceps, comprising an insulating body for connecting two limbs of the instrument, wherein the insulating body has openings for receiving, inserting or sliding in the limbs, wherein in each of the openings a latching or spring element is provided for fastening one of the limbs of the instrument in the insulating body.

Abstract: The present invention comprises an apparatus (1) for arranging a file (2) above a keyboard (4) which is located on a desk (3) comprising a base (5), a slide (6) and an inclined support (7) for supporting the file (2), wherein the support (7) is mounted on the slide (6) and the base (5) is adapted to be arranged on the desk (3) and/or on the keyboard (4) and to guide the inclined support (7) above the keyboard (4) during a horizontal motion of the slide with respect to the base (5) from a front position to a back position, wherein an arrestor is provided in the front position.

Abstract: A method for producing a model mould core blank uses a ceramic blank fixed to a processing holder. During fixing, a lost core is manufactured from the ceramic blank based on a CNC manufacturing process 3D model, the processing holder being fastened in the running CNC machine. A model blank is produced by casting model material around the lost core while fixing persists. The model blank becomes part of another method for producing a model mould core, wherein an outer contour of a lost model is produced from and/or on the model blank on the basis of a second CNC manufacturing process 3D model, wherein fixing and processing holder fastening also occurs. Another method produces a precision casting mould, in which a ceramic mould is applied to the outer contour of the lost model, and a cast part having a hollow cavity structure is produced by the precision casting mould.

Abstract: A belt fitting for a safety belt device, having a base section and a latch plate projecting from same. The base section has a belt eyelet with a belt strap running surface, which is in sliding contact with a belt strap guided through the belt eyelet when the safety belt is being worn, wherein, in the transverse direction of the belt strap, the belt strap running surface transitions on both sides at lateral corner regions into a belt eyelet edge opposite the belt strap running surface. The belt strap running surface has a surface contour which provides stable transverse guidance of the belt strap in the belt eyelet under loading conditions, which counteracts a transverse load component acting on the belt strap. A displacement body is formed on the belt eyelet edge-opposite the belt strap running surface, which reduces a gap width of the belt eyelet.

Abstract: A power seeder may include a frame, one or more wheels, one or more blades capable of cutting into soil, an engine capable of powering the one or more blades, and a seed hopper. The seed hopper may have an opening capable of dispensing seed located forward of the one or more blades. The one or more blades may rotate in an opposite direction to a forward rotation of the one or more wheels. In some embodiments, the seeder may further include a handle for adjusting the height of the one or more blades, a plurality of interlocking teeth, and a spring. The spring may provide a load to counteract the force of gravity on the one or more blades. The aerator may also include a flap located between the opening and the one or more blades.

Abstract: A power seeder may include a frame, one or more wheels, one or more blades capable of cutting into soil, an engine capable of powering the one or more blades, and a seed hopper. The seed hopper may have an opening capable of dispensing seed located forward of the one or more blades. The one or more blades may rotate in an opposite direction to a forward rotation of the one or more wheels. In some embodiments, the seeder may further include a handle for adjusting the height of the one or more blades, a plurality of interlocking teeth, and a spring. The spring may provide a load to counteract the force of gravity on the one or more blades. The aerator may also include a flap located between the opening and the one or more blades.

Abstract: IL-18 participates in both innate and acquired immunity. The bioactivity of IL-18 is negatively regulated by the IL-18 binding protein (IL18BP), a naturally occurring and highly specific inhibitor. This soluble protein forms a complex with free IL-18 preventing its interaction with the IL-18 receptor, thus neutralizing and inhibiting its biological activity. The present invention discloses binding molecules, in particular antibodies or fragments thereof, which bind IL-18 and do not bind IL-18 bound to IL-18BP (IL-18/IL-18BP complex). Apart from its physiological role, IL-18 has been shown to mediate a variety of autoimmune and inflammatory diseases. The binding molecules of the inventions may be used as therapeutic molecules for treating IL-18-related autoimmune and inflammatory diseases or as diagnostic tools for characterizing, detecting and/or measuring IL-18 not bound to IL-18BP as component of the total IL-18 pool.

Abstract: Techniques and solutions are described for analyzing data collections to determine if they may be anomalous as compared with other data collections. For example, one or more values for data elements of a data collection may be unusually high or low, or may represent infrequently occurring values. Or, values of data elements in a data collection may not be anomalous when considered individually, but may be anomalous in combination. A machine learning model is trained with training data collections, where the training data collections include a plurality of data elements. An inference data collection, also having the data elements of the training data collections, is analyzed using the trained machine learning model to provide an anomaly score. The anomaly score can be based at least in part on feature anomaly scores, which indicate anomality of individual data elements of the inference data collection.

Abstract: A method for producing a model mould core blank uses a ceramic blank fixed to a processing holder. During fixing, a lost core is manufactured from the ceramic blank based on a CNC manufacturing process 3D model, the processing holder being fastened in the running CNC machine. A model blank is produced by casting model material around the lost core while fixing persists. The model blank becomes part of another method for producing a model mould core, wherein an outer contour of a lost model is produced from and/or on the model blank on the basis of a second CNC manufacturing process 3D model, wherein fixing and processing holder fastening also occurs. Another method produces a precision casting mould, in which a ceramic mould is applied to the outer contour of the lost model, and a cast part having a hollow cavity structure is produced by the precision casting mould.

Abstract: Interleukin-18 (IL-18) participates in both innate and acquired immunity. The bioactivity of IL-18 is negatively regulated by the IL-18 binding protein (IL18BP), a naturally occurring and highly specific inhibitor. This soluble protein forms a complex with free IL-18 preventing its interaction with the IL-18 receptor, thus neutralizing and inhibiting its biological activity. The present invention discloses binding molecules, in particular antibodies or fragments thereof, which bind IL-18 and do not bind IL-18 bound to IL-18BP (IL-18/IL-18BP complex). Apart from its physiological role, IL-18 has been shown to mediate a variety of autoimmune and inflammatory diseases. The binding molecules of the inventions may be used as therapeutic molecules for treating IL-18-related autoimmune and inflammatory diseases or as diagnostic tools for characterizing, detecting and/or measuring IL-18 not bound to IL-18BP as component of the total IL-18 pool.

Abstract: The present invention comprises an apparatus (1) for arranging a file (2) above a keyboard (4) which is located on a desk (3) comprising a base (5), a slide (6) and an inclined support (7) for supporting the file (2), wherein the support (7) is mounted on the slide (6) and the base (5) is adapted to be arranged on the desk (3) and/or on the keyboard (4) and to guide the inclined support (7) above the keyboard (4) during a horizontal motion of the slide with respect to the base (5) from a front position to a back position, wherein an arrestor is provided in the front position.

Abstract: A riding hydraulically driven aerator is disclosed herein. The aerator includes a frame, an engine, one or more hydraulic pumps, one or more drive wheels, and one or more tine assemblies. The one or more tine assemblies may be driven by one or more hydraulic tine motors. The one or more hydraulic tine motors may be directly coupled to the one or more tine assemblies. In various embodiments, the one or more drive wheels are driven by one or more hydraulic wheel motors. The one or more hydraulic tine motors and the one or more hydraulic wheel motors may be driven in series by the one or more hydraulic pumps.

Abstract: Some embodiments include reception of a time-series of a respective data value generated by each of a plurality of sensors, calculation of a regression associated with a first sensor of the plurality of sensors based on the received plurality of time-series, the regression being a function of the respective data values of the others of the plurality of data sources, reception of respective data values associated with a time from and generated by each the plurality of respective sensors, determination of a predicted value associated with the time for the first sensor based on the regression associated with the first sensor and on the respective data values associated with the time, comparison of the predicted value with the received value associated with the time and generated by the first sensor, and determination of a value indicating a likelihood of an anomaly based on the comparison.

Abstract: The invention relates to bivalent bispecific monoclonal antibodies (bbmAb) or variants thereof, and methods of manufacturing such antibodies by co-expressing modified Fc-mutated derivatives of two different monoclonal antibodies in mammalian cell lines.