Abstract: Some embodiments include reception of a time-series of a respective data value generated by each of a plurality of sensors, calculation of a regression associated with a first sensor of the plurality of sensors based on the received plurality of time-series, the regression being a function of the respective data values of the others of the plurality of data sources, reception of respective data values associated with a time from and generated by each the plurality of respective sensors, determination of a predicted value associated with the time for the first sensor based on the regression associated with the first sensor and on the respective data values associated with the time, comparison of the predicted value with the received value associated with the time and generated by the first sensor, and determination of a value indicating a likelihood of an anomaly based on the comparison.

Abstract: The invention relates to bivalent bispecific monoclonal antibodies (bbmAb) or variants thereof, and methods of manufacturing such antibodies by co-expressing modified Fc-mutated derivatives of two different monoclonal antibodies in mammalian cell lines.

Abstract: A walk-behind aerator with hydrostatic drives is disclosed herein. The aerator includes a frame, an engine, a first and a second hydrostatic drive, a first and a second drive wheel, a first and a second idler wheel, and a first and a second tine assembly. The first hydrostatic drive may power the first drive wheel and the first tine assembly and the second hydrostatic drive may power the second drive wheel and the second tine assembly. In some embodiments, the aerator may further include a first and a second drive chain, a first and a second tine shaft, one or more control levers, and one or more covers. The one or more control levers may be linked to the hydrostatic drives by one or more linkages through the frame. The covers may be located between the tine assemblies and the drive chains and linkages.

Abstract: The wheelbarrow of the present embodiments provides a frame and a tub wherein the tub has a recess for receiving at least a portion of a wheel. Additionally, at least a portion of the frame and a portion of the tub may extend forward of the wheel. Further, a distance between a center of gravity of the tub and a vertical line or plane bisecting a rotational axis of the wheel when the wheelbarrow is in a resting position may be approximately equal to or less than a radius of the wheel. Also, the wheelbarrow may be powered by an engine or motor. The wheelbarrow may also include a transmission capable of rotating the wheel in a forward or reverse direction. Moreover, the wheelbarrow may contain control levers located adjacent handle grips for controlling the motor or engine, or the transmission.

Abstract: The invention relates to a guide assembly for an instrument comprising two legs, in particular forceps, the guide assembly comprising first and second guide elements, wherein the guide elements each comprise a base body, provision being made in each case on the outer side of the base body for an arrangement for snapping into place in an opening on an inner side of the legs of the instrument, provision being made on the inner side of the base body in the case of the first guide element for a protrusion and in the case of the second guide element for a recess, which is complementary to the protrusion, and provision being made in each case for a hollow on the outer side of the base body of the first as well as the second guide elements.

Abstract: Some embodiments include reception of a time-series of a respective data value generated by each of a plurality of sensors, calculation of a regression associated with a first sensor of the plurality of sensors based on the received plurality of time-series, the regression being a function of the respective data values of the others of the plurality of data sources, reception of respective data values associated with a time from and generated by each the plurality of respective sensors, determination of a predicted value associated with the time for the first sensor based on the regression associated with the first sensor and on the respective data values associated with the time, comparison of the predicted value with the received value associated with the time and generated by the first sensor, and determination of a value indicating a likelihood of an anomaly based on the comparison.

Abstract: The present disclosure generally relates to semiconductor structures and, more particularly, to back gate tuning circuits and methods of manufacture. The method includes applying a voltage to a back gate of a device; and selectively controlling the applied voltage to deactivate at least one trap within an insulating layer of the device to reduce noise contribution from the at least one trap.

Abstract: Some embodiments include reception of a time-series of a respective data value generated by each of a plurality of sensors, calculation of a regression associated with a first sensor of the plurality of sensors based on the received plurality of time-series, the regression being a function of the respective data values of the others of the plurality of data sources, reception of respective data values associated with a time from and generated by each the plurality of respective sensors, determination of a predicted value associated with the time for the first sensor based on the regression associated with the first sensor and on the respective data values associated with the time, comparison of the predicted value with the received value associated with the time and generated by the first sensor, and determination of a value indicating a likelihood of an anomaly based on the comparison.

Abstract: The present disclosure generally relates to semiconductor structures and, more particularly, to back gate tuning circuits and methods of manufacture. The method includes applying a voltage to a back gate of a device; and selectively controlling the applied voltage to deactivate at least one trap within an insulating layer of the device to reduce noise contribution from the at least one trap.

Abstract: IL-18 participates in both innate and acquired immunity. The bioactivity of IL-18 is negatively regulated by the IL-18 binding protein (IL18BP), a naturally occurring and highly specific inhibitor. This soluble protein forms a complex with free IL-18 preventing its interaction with the IL-18 receptor, thus neutralizing and inhibiting its biological activity. The present invention discloses binding molecules, in particular antibodies or fragments thereof, which bind IL-18 and do not bind IL-18 bound to IL-18BP (IL-18/IL-18BP complex). Apart from its physiological role, IL-18 has been shown to mediate a variety of autoimmune and inflammatory diseases. The binding molecules of the inventions may be used as therapeutic molecules for treating IL-18-related autoimmune and inflammatory diseases or as diagnostic tools for characterizing, detecting and/or measuring IL-18 not bound to IL-18BP as component of the total IL-18 pool.

Abstract: The invention relates to bivalent bispecific monoclonal antibodies (bbmAb) or variants thereof, and methods of manufacturing such antibodies by co-expressing modified Fc-mutated derivatives of two different monoclonal antibodies in mammalian cell lines.

Abstract: Interleukin-18 (IL-18) participates in both innate and acquired immunity. The bioactivity of IL-18 is negatively regulated by the IL-18 binding protein (IL18BP), a naturally occurring and highly specific inhibitor. This soluble protein forms a complex with free IL-18 preventing its interaction with the IL-18 receptor, thus neutralizing and inhibiting its biological activity. The present invention discloses binding molecules, in particular antibodies or fragments thereof, which bind IL-18 and do not bind IL-18 bound to IL-18BP (IL-18/IL-18BP complex). Apart from its physiological role, IL-18 has been shown to mediate a variety of autoimmune and inflammatory diseases. The binding molecules of the inventions may be used as therapeutic molecules for treating IL-18-related autoimmune and inflammatory diseases or as diagnostic tools for characterizing, detecting and/or measuring IL-18 not bound to IL-18BP as component of the total IL-18 pool.

Abstract: The present disclosure relates to semiconductor structures and, more particularly, to circuits with logical back-gate switching and methods of operation. The circuit includes at least one front-gate contact and digital back-gate potentials for logical function implementation on a back side of at least one device. The digital back-gate potentials are switchable between two logic levels.

Abstract: Some embodiments include reception of a time-series of a respective data value generated by each of a plurality of sensors, calculation of a regression associated with a first sensor of the plurality of sensors based on the received plurality of time-series, the regression being a function of the respective data values of the others of the plurality of data sources, reception of respective data values associated with a time from and generated by each the plurality of respective sensors, determination of a predicted value associated with the time for the first sensor based on the regression associated with the first sensor and on the respective data values associated with the time, comparison of the predicted value with the received value associated with the time and generated by the first sensor, and determination of a value indicating a likelihood of an anomaly based on the comparison.

Abstract: The invention relates to a connector plug for a medical instrument, in particular a bipolar electrode or forceps, comprising an insulating body for connecting two limbs of the instrument, wherein the insulating body has openings for receiving, inserting or sliding in the limbs, wherein in each of the openings a latching or spring element is provided for fastening one of the limbs of the instrument in the insulating body.

Abstract: The present disclosure relates to semiconductor structures and, more particularly, to circuits with logical back-gate switching and methods of operation. The circuit includes at least one front-gate contact and digital back-gate potentials for logical function implementation on a back side of at least one device. The digital back-gate potentials are switchable between two logic levels.

Abstract: The invention relates to a guide assembly for an instrument comprising two legs, in particular forceps, the guide assembly comprising first and second guide elements, wherein the guide elements each comprise a base body, provision being made in each case on the outer side of the base body for an arrangement for snapping into place in an opening on an inner side of the legs of the instrument, provision being made on the inner side of the base body in the case of the first guide element for a protrusion and in the case of the second guide element for a recess, which is complementary to the protrusion, and provision being made in each case for a hollow on the outer side of the base body of the first as well as the second guide elements.

Abstract: The present disclosure relates to semiconductor structures and, more particularly, to circuits with logical back-gate switching and methods of operation. The circuit includes at least one front-gate contact and digital back-gate potentials for logical function implementation on a back side of at least one device. The digital back-gate potentials are switchable between two logic levels.

Abstract: IL-18 participates in both innate and acquired immunity. The bioactivity of IL-18 is negatively regulated by the IL-18 binding protein (IL18BP), a naturally occurring and highly specific inhibitor. This soluble protein forms a complex with free IL-18 preventing its interaction with the IL-18 receptor, thus neutralizing and inhibiting its biological activity. The present invention discloses binding molecules, in particular antibodies or fragments thereof, which bind IL-18 and do not bind IL-18 bound to IL-18BP (IL-18/IL-18BP complex). Apart from its physiological role, IL-18 has been shown to mediate a variety of autoimmune and inflammatory diseases. The binding molecules of the inventions may be used as therapeutic molecules for treating IL-18-related autoimmune and inflammatory diseases or as diagnostic tools for characterizing, detecting and/or measuring IL-18 not bound to IL-18BP as component of the total IL-18 pool.

Abstract: A device including a plurality of static random-access memory (SRAM) bitcells arranged in rows and columns, wherein the SRAM bitcells comprise fully depleted silicon-on-insulator field effect transistors (FDSOI-FETs). The FDSOI-FETs comprise P-channel-pull-up-transistors, wherein each P-channel-pull-up-transistor comprises a back gate. The device further includes a plurality of bitlines, wherein each bitline is electrically connected to the SRAM bitcells of one of the columns and a plurality of wordlines, wherein each wordline is electrically connected to the SRAM bitcells of one of the rows. The device further includes a bitline control circuit configured to select at least one column for writing, wherein during a write operation a first control signal is applied to the back gates of the P-channel-pull-up-transistors of the at least one column selected for writing and a second control signal to the back gates of the P-channel-pull-up-transistors of the columns not selected for writing.